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Ocular tuberculosis in acquired immune deficiency syndrome (AIDS).

AIM: To determine the prevalence and clinical features of ocular tuberculosis in patients with the acquired immune deficiency syndrome (AIDS). DESIGN: Prospective cross-sectional study. METHODS: Detailed history and ocular examination of 46 patients (92 eyes) in the outpatient department of an AIDS clinic. RESULTS: Seventeen of 46 (36.9%) patients had clinical and radiological evidence of pulmonary tuberculosis. Of these, four (23.5%) showed findings consistent with ocular tuberculosis. Lesions included tubercles (1 eye of 3 patients) and chorioretinitis (1 eye of 1 patient). Commonly, these patients had evidence of abdominal tuberculosis. Hemorrhages, cotton-wool spots, herpes zoster ophthalmicus (HZO), cytomegalovirus retinitis (CMVR), and disc edema were other non-tubercular AIDS-related lesions and were seen in seven of the remaining 42 patients (16.2%). CONCLUSION: Ocular tuberculosis was a common finding in this study and was found in profoundly immunocompromised patients with disseminated tuberculosis. Diagnosis of ocular tuberculosis may help reduce HIV/tuberculosis co-infection mortality.

Acquired Immunodeficiency Syndrome↗

[Vitrectomy in treatment of ocular tuberculosis--case report].

The authors present a case of ocular tuberculosis in otherwise healthy young men, diagnosed with positive tuberculin test and positive PCR for Mycobacterium tuberculosis in conjunctiva and vitreous samples. An early vitrectomy and typical systemic treatment (tuberculostatic drugs) resulted in regression of the disease.

Adult↗

[Basic directions in enhancing the efficiency of the diagnosis and treatment of ocular tuberculosis].

The paper describes the basic methods for the diagnosis and treatment of ocular tuberculosis, which are based on the studied mechanisms of its pathogenesis. It updates the pathomorphism of the disease, the results of experimental studies dealing with new diagnostic techniques, including an objective estimation of a focal response to tuberculin. The results of studies of ocular tuberculosis in children, as well as the efficacy of the new Russian immunotropic drugs glutoxim and betaleukin are outlined.

Antigens, CD↗