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Analgesic effect of fentiazac after tooth extraction or minor oral surgery.

A new nonsteroidal anti-inflammatory agent, fentiazac, was used for analgesia after tooth extractions and minor oral surgery in two Japanese dental hospitals. The drug was administered as a single oral dose of either 50 mg or 100 mg. The 50-mg dose provided rapid analgesic effect, but its effect lasted only two to three hours in a number of patients. At a dose of 100 mg, fentiazac proved effective for 85% of 53 patients, usually providing marked reduction of disappearance of pain within one hour or less. Among patients in whom pain reappeared, the mean time for recurrence was four hours, indicating a satisfactory duration of analgesic effect. One side effect--loss of appetite--was reported by one patient in the entire series of 71 subjects. It is concluded that fentiazac is a highly effective analgesic agent with a wide margin of safety for use after dental procedures that produce pain.

Acetates

A biochemical study of aminopeptidases in the palatal mucosa of the rat following tooth extractions.

Aminopeptidase activities were studied biochemically from the supernatants of the homogenates prepared from the normal and post extraction palatal mucosa of the rat. The determinations were carried out at 0.5, 1, 2, 4, 8 and 16 hours and 1, 2, 3, 5 and 7 days following extraction using N-L-aminoacyl-2-naphthylamines of arginine, glycine, leucine, proline and valine as the substrates. In addition, in the second part of the study the hydrolysis of N-L-aminoacyl-2-naphthylamines of alanine, histidine, isoleucine, lysine, phenylalanine, serine, threonine, tyrosine and valine was tested at 1, 3 and 5 days following extraction. The effect of chloride ions (0.2 M NaCl) on the hydrolysis of arginine and lysine derivatives was also tested. The specific activities of aminopeptidases obtained from the extraction-wound side were compared to those of the control side at each time interval. Tooth extraction caused a considerable reduction in the specific activities of aminopeptidases in the surrounding palatal mucosa immediately after extraction (at 0.5 hr.). The specific activities in the wound tissue remained generally below the control levels for 24 hours and reached their maximum within 5 days following extractions. The highest relative increase was obtained with N-L-valyl-2-naphthylamine. Arginine aminopeptidase was activated by chloride ions on an average 20 per cent more in the wound tissue than the control. This effect can be considered suggestive of the activation of aminopeptidase B in the post extraction palatal mucosa.

Aminopeptidases

Painful, nonhealing, tooth extraction socket.

The oral signs and symptoms of acute leukemia include gingival hypertrophy, gingival hemorrhage, petechiae and ecchymoses, mucosal ulceration, paresthesia, tooth pain, and oral infections. This case was unusual in that the diagnosis of acute leukemia was made only after a biopsy specimen of tissue protruding from the socket of a recently extracted tooth disclosed malignant cells suggestive of leukemia or lymphoma. The diagnosis of epulis granulomatosa should be made only after clinical, radiographic, and microscopic studies have been performed to rule out a malignant process.

Diagnosis, Differential

Reasons for tooth extraction among Tanzanians.

In 1988 a study was carried out among Tanzanians of different age groups to determine the reasons for tooth extraction. The major reason was found to be dental caries or its associated complications (81%) while periodontal diseases was the runner-up (13%). The molars teeth were the most commonly extracted. The results of this study are important in planning resources for and provision of emergency oral health care especially for the rural population.

Adolescent

Protein synthesis in wound after tooth extraction in pancreatectomized diabetic rats.

The incorporation of alanine C14 in protein synthesis was analyzed in recently formed alveolar tissue after tooth extraction in partially-pancreatectomized diabetic rats. The incorporation of alanine C14 was higher in diabetic animals than in treated diabetic and control groups. The results can be explained by a delay in bone tissue repair.

Alanine

[Vivisection studies on the effects of unilateral tooth extraction on growth of the skull and masticatory musculature. I. Overall skull, orbita, zygomatic arch, rear skull (author's transl)].

Skull growth is affected by numerous factors, including dentition. Animal experiments have assumed considerable importance in connection with such studies. This series of publications deals with the response of the skull skeleton and masticatory muscles to extraction of each emerging tooth in the right half of the jaws of Vietnamese belly pigs. The animals were slaughtered at various ages ranging from 6 to 12 months, throughout an important phase of post-natal skull development. Biomathematical methods were used to analyse the macerated skull and the masticatory musculature. Linear differential equations have proved useful for describing growth processes. The 1st report deals with the distances measured for the overall and rear skull, the orbita and the zygomatic arch. Differences between the right and left sides are slight with respect to these distances. Significant differences were found only in the range of the front part of the zygomatic arch during the 6th, 7th, 8th, 11th and 12th month of life.

Animals

Articulatory behavior pre and post full-mouth tooth extraction and alveoloplasty: a cinefluorographic study.

High speed cinefluorography was used to track articulatory movements preceding and following full-mouth tooth extraction and alveolplasty in two subjects. Films also were made of a control subject on two separate days. The purpose of the study was to determine the effects of dramatically altering the structural dimensions of the oral cavity on the kinematic parameters of speech. The results showed that the experimental subjects performed differently pre and postoperatively though the changes were in different directions for the two subjects. Differences in both means and variabilities of kinematic parameters were larger between days for the experimental (operated) subjects than for the control subject. The results for the control subject also showed significant differences in the mean values of kinematic variables between days though these day-to-day differences could not account for the effects found pre- and postoperatively. The results of the kinematic analysis, particularly the finding that transition time was most stable over the experimental conditions for the operated subjects, are used to speculate about the coordination of normal speech.

Alveoloplasty

[Tooth extraction in patients suffering from hemophilia A under the cover of cryoprecipitates and epsilon-aminocaproic acid].

Tooth extractions were carried out in 75 patients with haemophilia A after infusion of a single dose of cryoprecipitate and 4 g of epsilon-aminocaproic acid. During the 7-10 day period of follow-up, the patients received epsilon-aminocaproic acid by mouth. In 32 of 44 patients with severe or moderate haemophilia and in 22 of 31 patients with mild haemophilia, healing was uneventful and no bleeding complications occurred. Only in 5 patients with severe haemophilia and in 1 patient with mild heamophilia bleeding from tooth sockets was extensive enough to require further replacement therapy. The results show that epsilon-aminocaproic acid in conjunction with a single infusion of cryoprecipitate can insure hemostasis after dental extraction in patients with haemophilia A.

Adolescent

The application of a frequency oscillation method for tooth extraction in dogs.

A tooth-grasping forceps with a gas-driven oscillating headpiece was designed for dental extractions in the dog, Compared with the conventional method, the extraction time was shortened considerably, and preliminary results indicate it may cause less trauma to alveolar bone and periodontal ligament.

Anesthesia, General

Tooth extraction in patients with heart disease.

A combination of fear and declining compensation may induce cardiovascular accidents in the elderly with heart disease. An accurate cardiac diagnosis and relief of stress and pain during tooth extraction are important. The range of cardiac abnormalities and the regime followed in two clinics in the People's Republic of China are reviewed, together with the precautions which are taken to avoid emergencies or manage them should they arise.

Adolescent

Brain stem degeneration patterns following tooth extractions: visualization of dental and periodontal afferents.

The terminal central nervous system distribution of those primary afferent neurons from the teeth and periodontium in cats was studied by degeneration methods. Lesions were created by combinations of tooth extractions and the brain stem was examined at 14, 30 and 60 days survival for degeneration patterns, with 30 days being the optimal survival time. Degenerating axons and terminals are seen bilaterally, but somewhat less on the side contralateral to the lesions and are concentrated in the ventral half of pars interpolaris and pars caudalis near obex. The results are discussed with regard to the current controversies concerning the primary central termination of these trigeminal neurons.

Afferent Pathways

Effects of various antiseptics on bacteremia following tooth extraction.

The effect of local irrigation of the gingival sulcus, which is considered an important source of bacteremia following dental procedures, with three different antiseptic solutions including hydrogen peroxide, chlorhexidine and povidone iodine, on the frequency of bacteremia after tooth extraction was determined, and the efficacies of the three antiseptics were compared. Although all the antiseptic solutions reduced the frequency of bacteremia to various degrees, povidone iodine was the most effective, and seemed to be the best choice since the decrease was statistically significant. Local administration of antiseptic solutions is therefore recommended as an adjuvant to systemic antibiotic prophylaxis.

Adult

[The comparison of blood levels between peripheral vein and tooth extraction wound after the oral administration of antibiotics (author's transl)].

The oral administration of 300 mg of clindamycin was undertaken on 23 patients, of 500 mg of cefadroxil on 11 patients and of 250 mg of talampicillin on 12 patients, and then tooth extraction was performed under local anesthesia. Blood samples were taken from the extraction wound and the peripheral vein at the same time and assayed by the bioassay method. The blood levels of clindamycin and cefadroxil indicated a similar pattern between the extraction wound and the peripheral vein, but the blood level of talampicillin reached peek level rapider than clindamycin and cefadroxil. The blood levels of the extraction wound were 60 - 80% as compared with the venous blood levels with each antimicrobial agent.

Administration, Oral

Changes in collagen types during the healing of rabbit tooth extraction wounds.

Three alpha chains of type V collagen--alpha 1 (V), alpha 2 (V), and alpha 3 (V)--were initially demonstrated together with the expected collagen types I and III in the pepsin-soluble fraction of both normal mandibular bone and tooth extraction wound tissues of rabbits, as analyzed by sodium dodecyl sulfate-gel electrophoresis. The total collagen content of each extraction wound, as determined by the hydroxyproline assay, was observed to increase continuously from day 5 through day 17 and then leveled off or decreased. The ratio of type V to type I collagen was significantly higher in the initial stage of wound healing and decreased sharply down to the level of mandibular bone by day 5. The ratio of type III to type I collagen in the pepsin-soluble fraction increased and reached a maximum on day 5, whereas it was maximal on day 7 in the cyanogen bromide-soluble fraction, and thereafter decreased gradually in both fractions. The ratio for the pepsin-soluble fraction was, however, significantly higher than that for the cyanogen bromide-soluble fraction in the early stage of wound healing.

Alveolar Process