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Experimental study of the effect of prostaglandin administration on tooth movement--with particular emphasis on the relationship to the method of PGE1 administration.

Recently, the mechanism of action of prostaglandins in promoting bone resorption has received wide attention. Prostaglandins are used in orthodontics to shorten the period of tooth movement. PGE1 was administered locally (5 micrograms/kg every 12 hours) and systemically (7.5 ng/kg/min) to rats to study the difference in the efficacy of the two methods of administration in accelerating bone resorption. The Waldo method was used on 72 Wistar rats (8 weeks old) for 5 days to induce mesial movement of the first molar. The body weight of the rats was measured every 12 hours from the start of the experiment. Tissues were examined in the mesial surface of the mesial root and in the interradicular septum between the linguomesial root and the linguodistal root of the upper first molar. The pressure side of the mesial surface of the mesial root was studied, as well as the pressure side of the interradicular septum. The results showed that decrease in body weight during the experiment was more prominent in the local administration group than in the systemic administration group. In both the group receiving PGE1 through local administration and the group receiving PGE1 through systemic administration, the numbers of osteoclasts and Howship's lacunae were markedly increased over those in the control groups. Moreover, compared with local administration, systemic administration of PGE1 had a more marked effect on bone resorption.

Alprostadil

Late lower arch crowding: the effect of second molar extraction.

Mesial drift and change in crowding over a 5-year period were compared in 30 subjects whose lower second molars were extracted between ages 11 and 17 years and 30 subjects whose lower second molars were not extracted. Significant differences were found. The nonextraction subjects showed an average forward movement of first molars and an increase in crowding. The extraction group showed slight distal movement of first molars and a decrease in crowding. It is concluded that lower second molar extraction reduces the tendency to forward movement of buccal segments and increased crowding by relieving eruptive pressure from third molars and that the presence of a developing lower third molar with insufficient space can be one cause of late lower arch crowding.

Adolescent

Case report: treatment of dental asymmetry.

The treatment of dental asymmetries often comprises several treatment alternatives. This case report describes the treatment alternatives for an asymmetry generated secondary to surgical removal of an odontoma that included the germ of the lower left lateral incisor. The opening of the space was chosen based on the patient's wish. The asymmetrical biomechanical force system used for the correction of the midline is presented as free-body diagram.

Adult

Tooth displacement analysed on human autopsy material by means of a strain gauge technique.

Tooth displacement was analysed on human autopsy material for various types of orthodontic force systems using an electronic strain gauge technique. Tooth movements were registered in two dimensions with low force clip gauges on three sections of the mandible, containing the first premolar and the first molar. The sensitivity was 0.1 microns when horizontal forces of 50, 100, and 150 cN were applied at different horizontal levels producing different M/F ratios. The relationship between a force system and the resulting tooth movement was described by the position of the centre of rotation, CR, and the angle of rotation. The centre of resistance was determined for the three autopsy specimens, and depended on tooth geometry, root length, and level of bony margin. Important differences in location were found. The dynamics of initial tooth movement were analysed within the first minute of load application. Force/displacement curves were generated to evaluate the behaviour of the periodontal ligament. There was a linear correlation between the two variables. Freezing the autopsy material some days before testing had no detectable effect. The results from measurements on human autopsy material were compared with previously derived in vivo measurements.

Adolescent

The use of cranial bone grafts in the closure of alveolar and anterior palatal clefts.

A method is described for harvesting cancellous bone from the diploic space. In our opinion, this is the material of choice for bone grafting alveolar clefts in the 7- to 11-year age group. The procedure could be performed at an earlier age if the maxillary segments are under orthopedic control and in proper alignment. Success of the procedure depends on proper orthodontic preparation of the maxillary segments and careful, complete closure of the soft tissues across the anterior palatal cleft, the nasal lining defect, and the anterior alveolus. Results have been encouraging in terms of bone formation, and tooth migration into the bone graft can be expected if there has been no damage to the dental sac. Closure of the alveolar defect at the time of the primary lip closure would preclude the eventual need for a bone graft, but it cannot be accomplished without early, precise alignment of the maxillary segments if extensive periosteal denudation is to be avoided. The age beyond which periosteal closure alone will be inadequate to provide sufficient bone formation and should be supplemented by a bone graft remains to be established.

Adolescent