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At least 91 records · Page 5Linked to original sources
PubMed1987

A novel nigrostriatal dopaminergic disorder in sheep affected by Tribulus terrestris staggers.

An investigation was carried out into the pathogenesis of a unique locomotory disorder of sheep. Thirty sheep which had exhibited clinical signs for more than 15 months were examined for the presence of muscle atrophy, limb paresis, and spontaneous rotational behaviour. A single large dose of levodopa was administered to 12 normal and 12 affected sheep, and the drug-related effects of sedation and excitation were monitored continuously for three hours. The striatum was removed from eight normal and eight affected sheep and assayed for dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC). The findings of asymmetrical atrophy of pelvic limb extensor muscles, asymmetrical paresis of the limbs, a left:right dominance ratio of 50:50, spontaneous rotational behaviour, decreased response to levodopa loading, and decreased levels of DA (19 per cent reduction) and DOPAC (30 per cent reduction) in the striatum of affected sheep, were interpreted as indicative of a primary nigrostriatal dopaminergic disorder. It is suggested that a striatal presynaptic receptor malfunction has occurred.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1994

Activity of certain fractions of Tribulus terrestris fruits against experimentally induced urolithiasis in rats.

An ethanolic extract of the fruits of T. terrestris showed significant dose dependent protection against uroliths induced by glass bead implantation in albino rats. On subsequent fractionation of the ethanol extract, maximum activity was localised in the 10% aqueous methanol fraction. It provided significant protection against deposition of calculogenic material around the glass bead. It also protected leucocytosis and elevation in serum urea levels. Further, fractionation lead to decreased activity. This could be either due to loss of active compounds during fractionation, or the antiurolithiatic activity of T. terrestris being a combined effect of several constituents present in the methanolic fraction.

Animals↗
PubMed2000

Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions.

Traditional herbs have been a revolutionary breakthrough in the management of erectile dysfunction and have become known world-wide as an 'instant' treatment. The modern view of the management of erectile dysfunction subscribes to a single etiology, i.e. the mechanism of erection. A large number of pharmacological agents are orally consumed and vasoactive agents inserted intraurethrally or injected intrapenially to regain good erection. Modern phytochemicals have developed from traditional herbs. Phytochemicals focus their mechanism of healing action to the root cause, i.e. the inability to control the proper function of the whole body system. Hence phytochemicals manage erectile dysfunction in the frame of sexual dysfunction as a whole entity. Protodioscin is a phytochemical agent derived from Tribulus terrestris L plant, which has been clinically proven to improve sexual desire and enhance erection via the conversion of protodioscine to DHEA (De-Hydro-Epi-Androsterone). Preliminary observations suggest that Tribulus terrestris L grown on different soils does not consistently produce the active component Protodioscin. Further photochemical studies of many other herbal plants are needed to explain the inconsistent results found with other herbal plants, such as in diversities of Ginseng, Eurycoma longifolia, Pimpinella pruacen, Muara puama, Ginkgo biloba, Yohimbe etc.

Clinical Trials as Topic↗
PubMed1995

The clinical differentiation of nervous and muscular locomotor disorders of sheep in Australia.

Many of the nervous and muscular locomotor disorders that affect sheep throughout Australia are commonly referred to as "staggers" syndromes. The range of clinical signs displayed by sheep suffering these disorders is sufficiently diverse to enable each syndrome to be graded into one of 5 progressive clinical groups. The first group, the limb paresis syndromes, includes the primary myopathies associated with the ingestion of Ixiolaena brevicompta, Malva parviflora, and Trachymene ochracea, as well as selenium and Vitamin E disorders, Paroo virus staggers, congenital progressive muscular dystrophy, humpy back, hypocalcaemic muscle weakness, Tribulus terrestris staggers and tetanus. The second group is characterised by limb paresis with knuckling of the fetlocks, and includes the plant-associated toxicities of Romulea rosea, Stachys arvensis, Trachyandra divaricata, and Tribulus micrococcus, together with haloxon toxicity, enzootic ataxia (copper deficiency), and the probably genetic disorders of segmental axonopathy, neuroaxonal dystrophy, and degenerative thoracic myelopathy. Other locomotor disorders that fit more loosely into this group are listerial myelitis (post-dipping staggers), vitamin A deficiency, cervico-thoracic vertebral subluxation Stypandra glauca toxicity, Ipomoea spp toxicity, ivermectin toxicity, and botulism. The third group, the falling syndromes, includes the probably genetic disorders of thalamic cerebellar neuropathy, cerebellar abiotrophy, and globoid cell leucodystrophy, together with Swainsona spp toxicity. The fourth group, the falling syndromes, includes the plant associated toxicities of phalaris staggers, perennial rye grass staggers and nervous ergotism (Claviceps paspali).(ABSTRACT TRUNCATED AT 250 WORDS)

Animal Feed↗
PubMed2004

Dependence of 1H NMR chemical shifts of geminal protons of glycosyloxy methylene (H2-26) on the orientation of the 27-methyl group of furostane-type steroidal saponins.

An approach based on the difference (Delta(ab) = delta(a) - delta(b)) between the 1H NMR chemical shifts (delta(a), delta(b)) of the geminal protons of glycosyloxy methylene (H2-26) (Delta(ab) = <0.48 for 25R; Delta(ab) = >0.57 for 25S) is proposed for ascertaining 25R/25S orientation of the 27-methyl group of furostane-type steroidal saponins. These studies suggested the 25R-orientation of the 27-Me group for the furostanol glycosides isolated by Wu et al. from Tribulus terrestris.

Hydrocarbons↗
PubMed2004

Structural analysis of saponins from medicinal herbs using electrospray ionization tandem mass spectrometry.

The underivatized saponins from Tribulus terrestris and Panax ginseng have been investigated by electrospray ionization multi-stage tandem mass spectrometry (ESI-MS(n)). In ESI-MS spectra, a predominant [M + Na](+) ion in positive mode and [M - H](-) ion in negative mode were observed for molecular mass information. Multi-stage tandem mass spectrometry of the molecular ions was used for detailed structural analysis. Fragment ions from glycoside cleavage can provide information on the mass of aglycone and the primary sequence and branching of oligosaccharide chains in terms of classes of monosaccharides. Fragment ions from cross-ring cleavages of sugar residues can give some information about the linkages between sugar residues. It was found that different alkali metal-cationized adducts with saponins have different degrees of fragmentation, which may originate from the different affinity of a saponin with each alkali metal in the gas phase. ESI-MS(n) has been proven to be an effective tool for rapid determination of native saponins in extract mixtures, thus avoiding tedious derivatization and separation steps.

Carbohydrate Sequence↗
PubMed1998

[Investigation on resources and commodities of Chinese medicinal herbs of Jili].

OBJECTIVE: To make clear the current situation of application of the Chinese medicinal herbs of Jili. METHOD: The medicinal resources and commodities of the berbs in some provinces and cities in China were investigated. RESULT: The species Tribulus terrestris included in is widely distributed in China. The fruit of T. terrestris which is widely used in China as a traditional medicine is commonly called Yingjili. Being only the fruit of Atriplex entralasiatica Ruanjili is produced mainly in Shandong Province and customarily used as Fructus Tribuli in some areas of Shandong and Hebei Provinces. CONCLUSION: The current situation of medicinal application of Jili basically conforms to the requirements of . The main variety is Yingjili.

China↗
PubMed1998

Rapid analysis of steroidal saponin mixture using electrospray ionization mass spectrometry combined with sequential tandem mass spectrometry.

Using electrospray ionization mass spectrometry (MS) combined with sequential tandem MS(ESI-MSn), two major steroidal saponins extracted from Tribulus terrestris were studied, and considerable useful structural information was obtained. The structure of the proposed known steroidal saponin was verified, and the structure of the unknown saponin was investigated using MSn experiments. Some special fragment ions were also observed, and the corresponding fragmentation mechanisms were investigated which are characteristic for steroidal saponins and can give some information on the linkage position of some sugar groups in saponins. This methodology has been established as a powerful tool for the rapid, comparative analysis of mixtures such as crude plant extracts.

Carbohydrate Sequence↗