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[Radiographic semeiotics of bone metastasis in thyroid carcinoma].

It's well-known that thyroid malignant cancer often metastatizes to skeletal structures. Analysing a wide casuistry of the National Cancer Institute of Milan, we thought right not only consider most common iconographic findings of these bone metastases, but rarest too. Therefore, we studied many radiological symptoms: osteolysis and its shape; extension in the next soft tissues; absence of the periosteal reaction; some resemblances with other primitive cancer or secondary too and dysplasic focus; the changes after therapy usually give a not univocal interpretation of the pictures regarding these peculiar alterations.

Bone Neoplasms↗

Lymphangiomatosis of bone and soft tissue (results of lymphangiographic examinations).

The results of clinical roentgenologic examination of 2 patients with lymphangiomatosis are discussed. The analysis of angiographic findings has shown that arteries and veins remained unchanged in affected area. Lymphography revealed fully changed lymphatics in affected areas. Numerous markedly dilated lymph vessels and cystic cavities of different shape and size were noted. In bony spongiosus substance the fissural spaces were filled with oily contrast medium. Roentgenologically, they appeared as numerous small conglomerates limited to bone contours.

Adolescent↗

[Significance of the venous system of the spine in the formation of metastases].

The vertebral veins and their anastomoses to the other venous vascular regions are represented in their anatomy, physiological and pathophysiological function, with a special reference to the spreading of tumor cells through the veins of the vertebral column. The causes of the accumulation of metastases in the trunk skeleton and brain is pointed out by malignant tumors of the prostata, of the ren, of the lung, of the mamma, of the genital organs and the thyroid gland. The signification of the vertebral venous system as a spread of metastases is emphasized under consideration of the tumor cell kinetics in the blood-flow and the different forms of the metastatic formations, and is verifying by experienced clinical cases and reviews of the literature.

Brain Neoplasms↗

Neuroblastoma presenting as central nervous system disease.

Neuroblastoma may be extremely difficult to recognize, particularly when the tumor presents as a primary central nervous system disease. Central nervous system involvement may be considered as primary intracerebral neuroblastoma, metastases to the cranium from an occult primary, primary intraorbital neuroblastoma originating in the ciliary ganglion, metastatic intraorbital neuroblastoma from an occult primary, primary intraspinal neuroblastoma originating in dorsal root ganglia, intraspinal metastatic disease, and distant effects such as myoclonic encephalopathy. Primary neuroblastoma within the ciliary ganglion and primary intraspinal neuroblastoma are extremely rare entities. Illustrative cases the demonstrate the broad spectrum of neurologic presentations are offered. The second known report of neuroblastoma in association with primary pulmonary hypoventilation (Ondine curse) is included.

Brain Neoplasms↗

[Clinical value of lumbar tap in the diagnosis of obliteration of vertebral canal by intraspinal tumors].

The author analyses the clinical data and pathological manifestations in 29 cases of intraspinal tumours in which the results of preoperative lumbar tap were equivocal or excluded presence of vertebral canal obliteration. On the other hand, myelography showed presence of complete or incomplete contrast stop at the level of the tumour, despite misleading information of the diagnostic lumbar tap.

Humans↗

Radiology of sacrococcygeal chordoma. Difficulties in detecting soft tissue extension.

Plain radiographs of seven patients with sacrococcygeal chordomas showed sacral destruction, enlarged sacral neural foramina, and, usually, a presacral mass. Conventional tomograms clarified these bone abnormalities, which were often poorly visible on the plain radiographs. Two radionuclide bone scans showed increased peripheral uptake around the lesion, and one showed decreased uptake in the area of destroyed bone. Angiograms demonstrated only vessel displacement, and barium enemas showed only displacement of bowel by large soft tissue masses. Five myelograms were normal. Adequate surgical treatment of sacral chordomas requires a wide radical resection that avoids contaminating the wound with tumor. Therefore, thorough preoperative radiologic evaluation of the anatomic extent of a chordoma is essential. Although computed tomograms in three patients provided the best delineation of the total extent of bone and soft tissue involvement, tumor extension into gluteal muscles and other tissues eluded radiographic detection. The widespread infiltrative growth pattern along soft tissue planes and nerves and into vessels, undetectable by the above listed studies, mandates a cautious approach and a wide surgical margin, to prevent wound contamination and subsequent recurrence.

Aged↗