PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “THROMBELASTOGRAPHY”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 901 records · Page 50Linked to original sources
PubMed1971

Identification of a congenital defect of factor VII in a colony of beagle dogs: the clinical use of the plasma.

A severe, pure deficiency of factor VII has been defined in haematological and biochemical terms in the Alderley Park colony of beagle dogs. By modification of the conventional factor VII assay to improve its specificity an apparent low activity of between 1 and 2.5% of the normal beagle has been found. When this plasma is used as a substrate for factor VII assays it compares well with human factor VII-deficient plasma in the measurement of both raised and depressed factor VII activity. It also appears to be a valuable reagent in the quality control of tissue thromboplastin extracts.

Animals↗
PubMed1973

Experimental hypercalcaemia and whole blood clotting.

Experimental hypercalcaemia was induced in rats by (1) transplantation of the solid Walker 256 tumour, and (2) intraperitoneal injections of calcium gluconate. Whole blood clotting was studied by means of thromboelastography and whole blood clotting times in polystyrene and glass test tubes. At serum calcium levels between 10.3 and 11.5 m-equiv/l a slight delay in clot formation was found which was reversible by the addition of EDTA to whole blood. Acute, calcium-gluconate-induced hypercalcaemia, however, leads to a significant shortening of the clotting time in the polystyrene tube and to a lesser degree in the glass tube. Maximal factor XII activation in vitro with ellagic acid levels the difference of clotting times again. From these experiments it is concluded that acute hypercalcaemia induces a hypercoagulable state, possibly by partial contact activation, and thus may favour thrombus formation in vivo.

Animals↗
PubMed1996

Hyperfibrinolysis.

Explore the source record for details and available documents.

Antifibrinolytic Agents↗
PubMed1995

Hyperfibrinolysis during intracranial surgery: effect of high dose aprotinin.

A patient undergoing intracranial surgery developed disseminated intravascular coagulation with life threatening peroperative bleeding. Thromboelastography established the diagnosis of hyperfibrinolysis, usually a fatal complication of a neurosurgical operation. With the administration of a high dose regimen of aprotinin (Trasylol) the haemorrhage was controlled and the hyperfibrinolytic state reversed. Evaluation of blood samples from the jugular bulb suggested that there was a pronounced local release of tissue plasminogen activator into the circulation.

Aged↗
PubMed1997

Haemostatic changes during surgery for primary brain tumours.

OBJECTIVE: Primary brain tumours may be associated with coagulation disorders which can pose intraoperative and postoperative management difficulties. The aim was to evaluate the coagulation profile of patients with brain tumours undergoing surgery using thromboelastography (TEG) in combination with simple laboratory tests. METHODS: Fifty adult patients with primary brain tumours larger than 4 cm in maximum diameter and no history of coagulation disorders were studied in a prospective, observational manner over a one year period. Preoperative, intraoperative, and postoperative measurements included haemoglobin concentration, platelet count, prothrombin and partial thromboplastin times, fibrin(ogen) degradation product concentration, D-dimer concentration, and TEG. RESULTS: Eleven patients (22%) had abnormal intraoperative TEGs, of whom six (12%) subsequently developed haematomas requiring surgical evacuation. The coagulopathy seemed to be hyperfibrinolysis in two cases (4%) and disseminated intravascular coagulation in four (8%). There was no preoperative difference in reaction time (R time) for clot formation between the non-haematoma and haematoma groups(mean 11.44 (SD 3.42) v 12.33 (2.50) min, P=0.46). However, when other preoperative indices were compared, in the non-haematoma group, K time (time to reach a clot amplitude of 20 mm) was shorter (6.72 (2.15) v 10.56 (3.50) min, P=0.001), rate of clot growth (å) was faster (43.67 degrees (7.53) v 27.11 degrees (5.42), P<0.0001) and maximum amplitude of clot strength (MA) was greater (52.64 (7.85) v 40.33 (6.59) mm, P<0.001). Intraoperatively, R time was significantly shortened in the non-haematoma group, (7.67 (1.78) min, P<0.0001) unlike the haematoma group (10.67 (1.58) minutes, P=0.11). CONCLUSIONS: Although these results indicate a general hypercoagulability during brain tumour surgery, in certain cases, a predisposition towards hypocoagulability may exist even before surgery, detectable only when the physical characteristics of clot formation are studied by TEG. Judicious replacement of clotting factors, platelets, and antifibrinolytic agents should be considered intraoperatively if the TEG is abnormal, without waiting for laboratory test results.

Adolescent↗
PubMedDate not supplied

Alterations of the global haemostatic function test 'resonance thrombography' in spontaneously traumatised dogs.

Samples taken from 30 dogs with spontaneously acute trauma were investigated with two different resonance thrombographs (instrument 2: 28 dogs), a global method for examination of the haemostatic system. Reaction time of the resonance thrombogram (RTG-r), fibrin generation time (RTG-f), fibrin amplitude (RTG-F) and parameters of platelet function [amplitude of the platelet leg (RTG-P) and descending time of the platelet leg (RTG-p)] were evaluated statistically and compared with a normal control as well as with the results of individual components of the haemostatic system and other screening tests. Comparison of the results of the RTG of dogs suffering from trauma with the normal control revealed differences only for RTG-r, which was longer when measured with instrument 1 and lower RTG-F values measured with both instruments. Depending on the RTG parameter and instrument, only 1-6 samples showed values outside the reference ranges. Only 4 out of 26 cases (resonance thrombograph 2: 2 out of 24 cases) with mild to moderate deficiency in individual coagulation factor activity showed a prolongation of RTG-r which was significantly less sensitive than activated partial thromboplastin time (p < 0.001). Of the 26 samples having mainly mildly to moderately increased fibrin(ogen) degradation product (FDP) levels (median: 39 microg/ml, range: 2-90 microg/ml, reference values: <18 microg/ml) only between 1 and 5 showed abnormalities of the parameters RTG-f and/or RTG-F. The results of this study show in particular the limited sensitivity of the method for detecting individual coagulation factor deficiencies and minimal to moderate increases of FDP concentrations. Remarkable alterations of fibrin generation as measured by the resonance thrombograph are a rare condition in dogs with acute accidental trauma.

Accidents, Traffic↗
PubMed1977

Use of a modified thromboelastograph to evaluate effects of acetylcysteine on sputum.

This work deals with a modification of a thromboelastograph which enables to measure both in vitro and in vivo effectiveness of mucolytic substances. A simple method is described for building up a comparative diagram of the effectiveness of several drugs; a diagram which is of interest from both a pharmacological and a clinical point of view.

Acetylcysteine↗