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PubMed1986

Age-related changes of the normal visual field.

We prospectively studied the age-related changes of the visual fields obtained from a selected group of 25 normal patients. The OCTOPUS automated perimeter was used to test both eyes of each patient using Program 32. We calculated the mean threshold sensitivity, volume, and surface area of the visual field and measured a linear decline with age for all three characteristics. The age-related decline in threshold sensitivity and the SE of this decline increased with eccentricity from fixation. Sensitivity declined approximately twice as rapidly at 30 degrees eccentricity as it did at fixation. The general decline in sensitivity of the visual field and the increased rate of decline with eccentricity may be related to a functional or anatomic loss of photoreceptors, ganglion cells, and higher structures.

Adult↗

PubMed1988

Visual field constriction caused by colored contact lenses.

Goldmann visual field testing was performed on ten patients while they were wearing the recently released DuraSoft 3 colored soft contact lenses. All patients but one had visual field constriction ranging from 5 degrees to 20 degrees. When the areas inside the three tested isopters were averaged, the amount of field loss ranged from 21% to 47%. Contact lens fitters as well as wearers should be warned of this potential complication.

Color↗

PubMed1994

[Study on risk factors for progression of visual field damage in normal-tension glaucoma].

We investigated the risk factors for progression of visual field damage in normal-tension glaucoma (NTG), using multiple regression analysis with the proportional hazard model and the life-table method. Seventy-six eyes of 56 patients with untreated NTG showing minor visual-field defects, with a mean deviation (MD) of > - 5 dB by the Humphrey (30-2) STATPAC program at entry, were included in the study. Endpoints of study follow-up were defined as follows: in HFA STATPAC 2 Glaucoma Change Probability Analysis, more than 5 points which significantly deteriorated at p < 0.05 were found at 2 consequent examinations (Criterion 1) or a significant decrease in the MD value at p < 0.025 was encountered at one examination or that at p < 0.05 at 2 consecutive examinations (Criterion 2). During the follow-up period (37 months, mean), 33 eyes (42%) satisfied Criterion 1 and 23 eyes (29%) Criterion 2. When Criterion 1 was employed, peripapillary chorio-retinal atrophy/disc ratio (p = 0.023), intraocular pressure (IOP) (p = 0.03) and cup/disc ratio (p = 0.035) were identified as significant risk factors for progression of visual-field damage. When Criterion 2 was employed, Contribution of cup/disc ratio (p = 0.065) and IOP (p = 0.145) was relatively high, but not significant. These results suggested an association of IOP and local vascular risk factors with progression of visual-field damage in NTG.

Female↗

PubMed2006

A pharmacogenetic exploration of vigabatrin-induced visual field constriction.

INTRODUCTION: Use of the antiepileptic drug (AED) vigabatrin is severely limited by irreversible visual field constriction, an adverse reaction to the drug reported in approximately 40% of patients. Given the evidence suggesting an idiosyncratic drug response, we set out to detect genetic variation of strong, clinically relevant effect that might guide clinicians in the safe, controlled prescribing of this otherwise usefuldrug. METHODS: Patients with a history of at least 1-year exposure to vigabatrin were enrolled at two independent referral centers. Using Goldmann perimetry, visual fields and the extent of constriction were calculated for each patient. We examined the correlation between the extent of vigabatrin induced visual field constriction and genetic variation across six candidate genes (SLC6A1, SLC6A13, SCL6A11, ABAT, GABRR1 and GABRR2). We availed of HapMap data and used a tagging SNP technique in an effort to efficiently capture all common variation within these genes. We attempted to replicate any positive associations before drawing conclusions from our results. RESULTS: The degree of visual field constriction correlated with three SNPs and one haplotype in a cohort of 73 patients. However we were unable to replicate these findings in a second independent cohort consisting of 58 patients, suggesting the initial results were possibly false positives, or variants of weak effect. CONCLUSION: Common variants of strong, clinically relevant effect do not appear to reside in the candidate genes studied here. This does not rule out the presence of genetic variants of weak effect in these genes, nor of variants of strong effect in other genes.

4-Aminobutyrate Transaminase↗

PubMed2005

A long-term prospective study of risk factors for glaucomatous visual field loss in patients with ocular hypertension.

PURPOSE: To evaluate the importance of baseline risk factors for development of glaucomatous visual field loss in patients with high-risk ocular hypertension. METHODS: In the Malmö Ocular Hypertension Study, 90 patients were randomized to topical timolol or placebo treatment and observed prospectively for up to 10 years. Patients with elevated intraocular pressure (IOP) and with open angles and normal visual fields, plus at least one extra risk factor, were eligible. Risk factors were suspect disc or known disc hemorrhage, positive family history of glaucoma, pseudoexfoliation or pigment dispersion syndrome, diabetes, and mean IOP on DTC > or = 27 mm Hg. These risk factors and also the mean baseline IOP and IOP fluctuation, sex, age, and blood pressure were evaluated as predictors for development of reproducible glaucomatous visual field loss. In addition to the prospective data, post-study data were retrieved from patients' records extending maximum follow-up to 17 years. RESULTS: Thirty-seven patients developed glaucomatous visual field loss. Of all factors included in the analysis, disc appearance, older age, and higher IOP came out as significant risks. Suspect disc appearance increased the risk approximately three times, with a hazard ratio of 2.90, and CI: 1.34-6.30, the hazard ratio was 1.05 and CI: 1.03-1.09 per year of age, while mean baseline IOP increased the risk with 14% per mm Hg (CI: 1.01-1.28). CONCLUSION: Patients with ocular hypertension were at higher risk for developing glaucomatous visual field loss if discs were suspect, if IOP was high, and if the patient was older in age.

Adult↗

PubMed1993

Effect of uncorrected refractive errors upon central visual field testing.

An investigation of the effects of uncorrected refractive errors upon a central visual field examination has been made with a view to establishing what the likely effects would be of omitting a refractive correction when screening the visual field with a threshold related, supra-threshold strategy on the Henson CFA3000. The results indicate that, while a linear relationship exists between the extent of threshold elevation and the product of residual refractive error and pupil size, the scatter in the results means that accurate predictions cannot be made in individual cases. The threshold elevation was found to be independent of eccentricity (within the central 21 degrees from fixation) and did not increase the variability of results. These last two findings indicate that uncorrected refractive errors are unlikely to affect the sensitivity of the threshold related, supra-threshold strategy to localized visual field defects.

Adult↗

PubMed1987

[Quantification and progression of the visual field defect in glaucoma without hypertension, glaucoma simplex and pigmentary glaucoma. A clinical study with the Delta Program of the 201 Octopus perimeter].

Visual field defects of stages I-IV, in 451 eyes of 451 glaucoma patients, were examined with the Octopus 201 perimeter: 83 patients with low-tension glaucoma (LTG), 316 patients with primary open-angle glaucoma (POAG), and 52 patients with pigmentary glaucoma (PG). Program 31 or 33 was used, with an eccentricity range of up to 30 degrees, 73 test points, and a 6 degrees grid. The mean total field loss (TL) as well as the mean loss per test point (TL/TP) in the 30 degrees field, in the field quadrants, and in the eccentricity ranges from 0-10 degrees, 10-20 degrees, and 20-30 degrees were calculated for each patient with Program Delta. In addition, for each visual field the quotient of total loss and of the number of disturbed test points was calculated, providing a measurement of the mean depth of the field defects. For definition and comparison of visual fields in the different glaucomas at identical stages of the disease according to the amount of TL, the 3 patient groups were subdivided into 4 stages of sensitivity loss: Stage 1: TL less than or equal to 100 dB; Stage 2: TL 101-400 dB; Stage 3: TL 401-800 dB; Stage 4: 801-1600 dB. The results of a comparison of eyes with LTG, POAG, and PG at the same stage of disease were as follows: I. Location of scotomas: 1. Defects more frequent in the lower field in LTG as compared to POAG in stage 2. 2. Defects more frequent in the upper than in the lower field in POAG. 3. Almost equal number of defects in the upper and lower halves in PG. 4. In all 3 glaucoma types the defects are more frequently found in the nasal than in the temporal half of the visual field. 5. In LTG and POAG of all stages the defects are most frequently found in the upper nasal and most seldom in the lower temporal quadrant. 6. In all glaucoma types the defects occur on average most frequently between 10 degrees and 20 degrees of eccentricity. 7. With increasing IOP in POAG the scotomas tend to be equally distributed in the upper and lower quadrants. II. Depth of scotomas: 1. Scotomas are deepest in LTG; they are less deep in POAG, and least deep in PG. 2. In PG the mean scotoma depth depends significantly on maximum IOP.(ABSTRACT TRUNCATED AT 400 WORDS)

Computers↗

PubMed1997

Dehydration injury as a possible cause of visual field defect after pars plana vitrectomy for macular hole.

PURPOSE: To present the hypothesis that a visual field defect after pars plana vitrectomy for macular hole may be caused by dehydration injury to the nerve fiber layer during the fluid-air exchange. METHODS: In a consecutive nonrandomized series of 45 operations on 35 eyes of 34 patients with full-thickness macular hole, the surgical method was changed with postoperative visual field testing performed. RESULT: The incidence and location of the post-operative visual field defect was affected only by changing the location of the infusion cannula. CONCLUSION: Dehydration injury of the nerve fiber layer during the fluid-air exchange should be considered as a possible cause of visual field defect after pars plana vitrectomy for macular hole.

Desiccation↗

PubMedDate not supplied

A pilot study of glaucoma visual field screening in diabetes.

Because people with diabetes may be at increased risk of glaucoma, we performed a pilot study using automated visual field testing for screening them. One hundred and seventy-six diabetic persons who had participated in the Wisconsin Epidemiologic Study of Diabetic Retinopathy were tested with the Armaly-Drance screening pattern on the Humphrey Visual Field Analyzer. Individuals with moderate diabetic retinopathy or worse tended to have lower sensitivity of the central visual field and missed more points than those with no or only mild retinopathy. People with a history of glaucoma had slightly less sensitivity and missed more points than controls. These preliminary findings suggest that although people with diabetes and glaucoma may more frequently have visual field defects than people with diabetes but no glaucoma, a larger study is needed. This pilot study shows that such a study would be feasible and should be designed to indicate the sensitivity, specificity, and cost-benefit ratio of a screening program so as to assess the utility of the screening visual field test for finding glaucoma amongst people with diabetes.

Adult↗

PubMed1996

Visual field defects after macular hole surgery. A new finding.

PURPOSE: The purpose of the study is to report the problem of a temporal visual field defect occurring after macular hole surgery. METHODS: The authors reviewed the records of 13 patients found to have visual field defects after vitrectomy for macular holes. Fluorescein angiograms (13 patients), optic nerve photographs (13 patients), focal electroretinograms (3 patients), and nerve fiber analyses (8 patients) were performed in patients with visual field defects. RESULTS: An absolute, temporal, usually inferior field defect was noted in 13 patients. In eight patients, the defect was detected because of specific reports or retrospective field examination results. Five patients examined in a prospective manner were found to have field defects. No history of abnormal intraocular pressure or direct trauma to the optic nerve or retinal vessels was identified. Four patients showed optic nerve pallor and three had an anomalous-appearing disc. Focal electroretinograms were of similar amplitude in the involved retina compared to corresponding areas in the healthy fellow eye. Nerve fiber analysis showed a reduction in nerve fiber layer thickness correlating to the visual field defect in those eight patients in which this test was used. CONCLUSION: A significant temporal field defect may occur in patients after otherwise uncomplicated surgery for macular holes. The cause is unclear; however, reductions in nerve fiber layer thickness from the superior and nasal peripapillary area suggest that acute surgical release of the posterior hyaloid and the use of long-acting intraocular gas may in certain patients result in visual field defects.

Aged↗

PubMed1988

Visual fields of young children.

A light-emitting diode (LED) perimeter and forced-choice procedures are described that enable quantitative assessment of peripheral visual fields of young children. The visual fields of normal children, aged 2-5 years, and adults are compared. There are no significant differences in the extent of the LED visual field of the children and the adults. For selected neuro-ophthalmology patients, results of LED and kinetic Goldmann perimetry have been compared. The patients' LED and Goldmann fields are similar in overall extent. In all cases, field defects demonstrated by Goldmann perimetry are detected by LED perimetry. However, discrepancies in the severity of quandrantanopic defects of a patient have been discovered that may be stimulus-dependent.

Adolescent↗

PubMed2004

Effects of background color on detecting spot stimuli in the upper and lower visual fields.

Participants were required to detect spot stimuli briefly presented to the upper, central, or lower visual fields. The stimuli were presented either on a green or a red background. Results showed that reaction time (RT) was shorter for the lower visual field (LVF) compared to the upper visual field (UVF). Furthermore, this LVF advantage was significantly reduced in the red background condition compared to the green one. A red light is known to suppress activity of the magno-dominated stream. Therefore, the LVF advantage in RT can be explained as resulting from the biased representation of the magno-dominated stream in the LVF.

Adult↗

PubMed1985

The recognition of tachistoscopically presented words, varying in imagery, part of speech and word frequency, in the left and right visual fields.

Previous research has shown conflicting findings when subjects have performed some task involving words varying in imagery, part of speech (nouns versus verbs) and word frequency presented to the left and right visual fields. This problem was investigated in the present paper. In the first investigation, a group of subjects rated 308 words for imagery and part of speech. It showed that nouns tended to be of higher imagery than verbs. This implies that it is important to control for part of speech while investigating imagery, and vice versa. Experiments 2 and 3 investigated the effects of imagery and part of speech on recognition performance using different sets of words and subjects while keeping other aspects of the experiments identical. Conflicting results were found when the analysis regarded words as being a 'fixed effect' rather than a 'random effect' (cf. Clark, 1973). A quasi-F analysis revealed no significant effects due to either variable. When the data were combined from the two experiments, a quasi-F analysis revealed that imagery had an equal effect in both visual fields. Thus we can draw the conclusion that the effect of imagery in both visual fields is reliable across both new subjects and new words. However, a sufficiently large sample is required in order to demonstrate this. No other effects were significant. Experiment 4 investigated the effect of frequency on report from the two visual fields. Quasi-F analysis revealed that the effect of frequency was larger in the right visual field than in the left visual field. We can conclude that this effect is reliable across both new subjects and new words--if a sufficiently large sample is used. The findings are discussed. in terms of whether one could ever draw conclusions on the basis of previous work, when the analysis had regarded words as a fixed effect. It was concluded that it was possible to draw tentative conclusions, but a firm conclusion could only be based on an experiment in which large numbers of words had been used and in which the results were significant on a quasi-F analysis.

Adolescent↗

PubMed1992

Rotary Diamond Chart--a new visual field screening device.

The Rotary Diamond Chart (RDC) is presented as a new clinical method suitable for screening general optometry patients for visual field defects. A pilot study was conducted using both the rotary diamond chart and a central 76-point threshold-related screening test (Allergan-Humphrey) on 21 consecutive clinical patients. Full-threshold field testing was then completed on those subjects failing either screening test. The RDC detected five of six visual field defects including one very subtle defect which was not detected by the automated screening test. The sensitivity of the RDC visual field screening assessment was 83.33 percent with a specificity of 100 percent. These results suggest that the RDC is an effective clinical visual field screening test. It is easy for the clinician to use and for the patient to understand.

Adult↗

PubMed2005

[Location and frequency of visual field defects as measured by SITA (Swedish Interactive Threshold Algorithm) strategy in primary open angle glaucoma].

PURPOSE: To evaluate the frequency, location and pattern of visual field defects as measured by SITA strategy in primary open angle glaucoma (POAG). METHODS: Six thousand and two-hundred charts were reviewed. One hundred and fifty two patients who fulfilled the inclusion criteria were included. They were stratified according to severity into early, moderate and severe. The following visual field defects were defined: nasal step, paracentral scotomata, arcuate defect, Seidel scotomata, temporal defect, general reduction of sensitivity, annular scotomata and central island. Each examination was divided into sectors corresponding to optic disc regions. Student's t test was used to compare differences in frequency. RESULTS: In the early glaucoma group, the nasal superior step was the most frequent visual field defect, followed by paracentral scotoma and inferior nasal step. General reduction of sensitivity was noted in 7.8%. Defects were more common in the superior hemifield (p<0.05). CONCLUSION: The superior nasal step and paracentral scotoma were the most commun visual field defects in early primary open angle glaucoma as evaluated by SITA strategy, and the superior hemifield comprises most of the defects. General reduction of sensitivity was an early and rare visual field defect.

Adult↗

PubMed1989

The effect of Ca2(+) -antagonist on visual field in low-tension glaucoma.

A prospective study was conducted to evaluate the effects of Ca2(+)-antagonist on the visual field in low-tension glaucoma (LTG). Twenty-five consecutive patients (50 eyes) with LTG received nifedipine at 30 mg/day per os for 6 months. Visual field was tested with an Octopus 201 (program G1) prior to and each month during the period of nifedipine administration. In addition to tonometry and the measurements of systemic blood pressure and pulse rate, the reactivity of peripheral vessels was estimated by determining the response of skin temperature of a finger to cold water (4 degrees C). Twelve eyes (six patients) showed a constant improvement of visual field as expressed by an increase in mean sensitivity (MS). Canonical discriminant analysis demonstrated that the visual field is likely to improve with systemic nifedipine in patients who are young, have a higher initial MS and lower intraocular pressure, and have less decrease in diastolic blood pressure with the nifedipine administration and better cold recovery of skin temperature after their hand is soaked in cold water.

Administration, Oral↗

PubMed1989

[Automatic static quantitative perimetry of the central 30 degrees visual field in normal subjects].

131 normal volunteers (131 eyes) with visual acuities of 20/20 or better were tested by automatic static quantitative perimetry (Octopus-500E) for the central 30 degrees visual field. The results revealed that only 35 eyes (26.7%) had sensitivities at all points tested equal to or better than the age-corrected norms established for the device, and 96 eyes (73.3%) were 5 dB or more below the age adjusted norms at one point at least in areas not adjacent to the blind spot; the farther from the point of fixation, the sensitivity drop became more obvious and with higher frequency. When the central 30 degrees field was divided into five concentric circles, the greatest sensitivity drops appeared in the area between 25-30 degrees. The authors put forward more reasonable criteria for defects in the central 25 degrees visual field by Octopus-500 E Program 36.

Adolescent↗

PubMed2000

Evaluation of patients with visual field defects following macular hole surgery using multifocal electroretinography.

PURPOSE: To investigate patients with visual field defects following macular hole surgery to determine the cause of such defects, specifically with reference to ischemic damage versus mechanical trauma. METHODS: Five patients with known visual field defects following macular hole surgery were studied with Goldmann perimetry, Humphrey automated perimetry, and multifocal electroretinography (MERG). Three patients returned at a later date for nerve fiber layer analysis. RESULTS: None of the five patients demonstrated evidence of a- or b-wave loss on MERG in the regions corresponding to the visual field defects. Two of three patients studied with the nerve fiber layer analyzer demonstrated significant loss of nerve fiber layer thickness in the quadrant corresponding to the field defect. CONCLUSION: The normal MERG results indicate that the possibility of an arteriolar occlusion as the principal cause for the defects is unlikely in most cases. Data suggest that the site of damage is in the nerve fiber layer, although the specific cause of this damage remains to be determined.

Aged↗