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At least 919 records · Page 51Linked to original sources
PubMed1993

Long-term follow-up in patients with autonomous thyroid adenoma.

A group of 375 untreated euthyroid patients with solitary autonomous adenoma of the thyroid were studied in a long-term follow-up (observation period 52.8 (mean)/46 (median), range 3-204 months). During the period of observation, 133 (34.2%) of all initially untreated patients underwent treatment (surgery, radioiodine, antithyroid medication) because of hyperthyroidism, mechanical problems, or at the patient's request. Sixty-seven patients developed hyperthyroidism resulting in a mean incidence of 4.1% per year. The incidence of hyperthyroidism increased during follow-up (3% in the first seven years, 10% in the following years). Age, sex, nodule size, initial scintigraphic appearance and the TRH test were of no individual prognostic value in predicting hyperthyroidism. Eleven of 14 patients with untreated hyperthyroidism became euthyroid without treatment during the time of follow-up. After iodine excess (by history or elevated iodine levels in urine, N = 45), 14 patients (31%) developed hyperthyroidism. In conclusion, we recommend a definitive treatment of autonomous adenoma at least in patients with advanced age, concomitant diseases and a higher probability of iodine exposure.

Adenoma↗
PubMed1994

Recovery from unilateral vestibular nerve section in human subjects evaluated by physiological, psychological and questionnaire assessments.

Patients undergoing vestibular nerve section for vertigo or acoustic neuroma surgery were compared pre- and post-operatively and during long-term follow-up using a range of tests including: nystagmography, impulsive rotational testing of the vestibulo-ocular reflex (VOR), ability to estimate and reproduce imposed rotational displacements, validated questionnaires rating vertigo, imbalance, autonomic reactivity and somatisation, and clinical and self-assessment scales of overall outcome in terms of symptoms and disability. Correlations were found between rating scale assessments, questionnaire scores and estimates of self-rotation. Neither nystagmography nor VOR tests correlated with the presence or severity of vertigo or imbalance. Post-operatively, vertigo patients reported that they had received significant relief, although they had higher incidences of residual complaints of imbalance and vertigo than patients after acoustic neuroma surgery. Factors impeding rehabilitation in patients with vertigo are discussed.

Adaptation, Physiological↗
PubMed2006

Role of flap thickness in laser in situ keratomileusis enhancement for refractive undercorrection.

PURPOSE: To determine which preoperative and/or perioperative factors determine the need for an enhancement for refractive undercorrection in laser in situ keratomileusis (LASIK) for spherical or spherocylindrical myopia. SETTING: Clinical refractive surgery outpatient facility. METHODS: In this nested case-control study within a retrospective cohort, 3850 of the 9777 eyes operated on between January 1996 and August 2005 who met the selection criteria were studied. Only patients whose refractive goal was plano were included. Control eyes were those whose latest spherical equivalent (SE) refraction was within +/-0.37 diopters (D) of emmetropia. Cases were defined as enhancements for undercorrection with an SE refraction worse than or equal to -0.50 D performed less than 6 months following the primary surgery. RESULTS: Factors associated with enhancement included increasing patient age (odds ratio [OR] = 1.048, P<.001), decreasing follow-up time (OR = 0.994, P<.001), increasing minus laser sphere (OR = 0.700, P<.001) and cylinder settings (OR = 0.718, P<.001), female sex (OR = 1.112, P = .046), and corneal toricity (OR = 1.237, P = .012). The Summit laser had a significant risk for enhancement (OR = 1.726, P<.001) compared with the Visx laser, whereas the Wavelight Allegretto had a lowered risk (OR = 0.630, P = .049). Enhancement risk with the Autonomous was no different from that with the Visx (OR = 1.120, P = .342). Increasing flap thickness (OR = 1.009, P<.001) was more strongly associated with enhancement risk than residual stromal bed thickness. CONCLUSIONS: After controlling for patient age, time to follow-up or surgery, corneal cylinder, sphere and cylinder laser settings, laser manufacturer, patient sex, and corneal thickness, increasing flap thickness was found to be a more important predictor of enhancement for refractive undercorrection than residual stromal thickness.

Adult↗
PubMedDate not supplied

[Postoperative digestive complications of thoracic surgery].

The authors investigated the pathologic digestive manifestations that have developed after 2000 surgical interventions in the thoracic-pulmonary field. Four categories of digestive disturbances have been considered: paresis (dynamic ileus), including acute gastric dilation; haemorrhage; mechanical ileus, and digestive perforation. The digestive pathology developed either autonomously or in association with other symptoms of shock. A total of 788 digestive complications have been recorded (39%), of which: 654 cases of dynamic ileus, 118 cases of haemorrhage, 2 cases of mechanical ileus, 4 cases of perforation and 10 cases of mixed complications. In fact haemorrhage is more frequent, haemorrhagic gastritis being found in most of the deceased patients, following prolonged postoperative evolution. The simultaneous or succesive development was noted of digestive complication and respiratory failure in a total of 126 patients (6,3% of the total number of cases investigated). Pulmonary failure became more severe after the onset of dynamic ileus, especially after acute gastric dilatation. The development of any digestive complication represented in all cases an aggravation factor, especially when accompanying respiratory failure. The decrease with time of the incidence of digestive complications, from 57% to 21,8%, is due to changes that have occured in anesthesy techniques, of which NLA appears to play the most important role.

Gastrointestinal Diseases↗
PubMed1992

Imaging of metabolism and autonomic innervation of the heart by positron emission tomography.

Positron emission tomography (PET) allows, in combination with multiple radiopharmaceuticals, unique physiological and biochemical tissue characterization. Tracers of blood flow, metabolism and neuronal function have been employed with this technique for research application. More recently, PET has emerged in cardiology as a useful tool for the detection of coronary artery disease and the evaluation of tissue viability. Metabolic tracers such as fluorine-18 deoxyglucose (FDG) permit the specific delineation of ischaemically compromised myocardium. Clinical studies have indicated that the metabolic imaging is helpful in selecting patients for coronary artery bypass surgery or coronary angioplasty. More recent research work has concentrated on the use of carbon-11 acetate as a marker of myocardial oxygen consumption. Together with measurements of left ventricular performance, estimates of cardiac efficiency can be derived from dynamic 11C-acetate studies. The non-invasive evaluation of the autonomic nervous system of the heart was limited in the past. With the introduction of radiopharmaceuticals which specifically bind to neuronal structures, the regional integrity of the autonomic nervous system of the heart can be evaluated with PET. Numerous tracers for pre- and postsynaptic binding sites have been synthesized. 11C-hydroxyephedrine represents a new catecholamine analogue which is stored in cardiac presynaptic sympathetic nerve terminals. Initial clinical studies with it suggest a promising role for PET in the study of the sympathetic nervous system in various cardiac diseases such as cardiomyopathy, ischaemic heart disease and diabetes mellitus. The specificity of the radio-pharmaceuticals and the quantitative measurements of tissue tracer distribution provided by PET make this technology a very attractive research tool in the cardiovascular sciences with great promise in the area of cardiac metabolism and neurocardiology.

Autonomic Nervous System↗
PubMed1979

[The treatment of burns--an autonomous discipline (author's transl)].

In Europe Hungary was among the initiators to establish specialised surgical departments for the treatment of burnt patients. This new element in the structure of the hospital resulted in specialisation of surgeons for skin replacement and scar surgery. Thus the surgeon treating burnt patients is becoming the "surgeon of wounds" The treatment of thermal injury needs more detailed knowledge of biochemistry, pathophysiology and internal medicine compared with other field of surgery. The specialised thermist is in many respect similar to the intensivist.

Burns↗
PubMed1978

Indications, techniques and results of surgery in nasal allergy.

The only surgical intervention that interferes in the mechanism of an allergic rhinitis reaction, is the vidian neurectomy. The reported results are excellent, also in severe cases resistant to medical treatment. In the present report we describe the autonomic innervation of the nasal mucosa, the indications, techniques and results of vidian neurectomy. Intranasal techniques to diminish the hypertrophic tissues in cases of hyperttrophic rhinopathy are also discussed. Special attention is paid to cryosurgery of the inferior turbinate.

Electrosurgery↗
PubMed1998

Pancreatic surgery: cutting-edge developments and technology.

In the 1980s, Japanese pancreatic surgeons used aggressive strategies to treat pancreatic cancer under the influence of Fortner's regional pancreatectomy and developed several surgical approaches including extended lymph node and connective tissue clearance with autonomic nerve dissection around the celiac and superior mesenteric arteries. Nagakawa's "translateral retroperitoneal approach" in extended radical pancreatectomy was accepted and used by many Japanese surgeons; however, whereas this operation prolonged postoperative survival, it also induced high rates of postoperative complications and ultimately failed to improve the quality of the patient's life. A pylorus-preserving pancreatoduodenectomy with modified extended dissection of the lymph node and connective tissues did not decrease the survival rate for resected patients but improved their quality of life. In the next decade, Takada developed duodenum-preserving total pancreatic head resection, which preserves the integrity of the digestive and biliary tracts. This operation, to anastomose the main pancreatic duct with the duodenum, is unique and is applicable to benign or low-grade malignant lesions of the pancreas. Adjuvant treatments have not offered satisfactory results as expected. Finally, it is recommended that the aggressive Japanese surgical strategies be reevaluated in a formal trial with a prospective randomized study to improve the quality and longevity of the patients' lives.

Humans↗
PubMed1998

Changes in colonic motility in dogs after a resection of the inferior mesenteric ganglion and plexus.

In a curative resection for advanced sigmoid or rectal cancer, an extensive dissection of the regional lymph nodes is generally required. This often necessitates the removal of the autonomic nerves around the inferior mesenteric artery. The present study was done in an attempt to clarify the influence of a neurectomy around the inferior mesenteric ganglion and plexus on the motility of the colon. In eight dogs, we resected the ganglion and plexus around the inferior mesenteric artery, together with an implantation of strain gauge force transducers in various parts of the colon, and 7-10 days later, colonic motility was examined. The percentage of contractile states and contractile forces increased at both the distal colon in fasting dogs, as well as at the middle colon in the late postprandial period. At the distal colon, contractile forces were noted in the early and late postprandial periods. These contractile abnormalities at the middle and distal colon may thus explain the frequent bowel movements or diarrhea often observed after extensive surgery in patients with sigmoid or rectal cancer.

Animals↗
PubMed1995

Histopathologic studies of innervation of normal and prolapsed human mitral valves.

We evaluated the distribution of the nerves in valve tissue of humans to clarify the relationship between mitral valve prolapse and autonomic nerve dysfunction. We studied 15 autopsy specimens of normal mitral valve, 10 prolapsed mitral valves, five each of normal tricuspid, aortic, and pulmonary valves, and three prolapsed mitral valves obtained at cardiac surgery. Immunohistochemical studies utilized the avidinbiotin peroxidase complex (ABC) method and several nerve-related antigens: 1) S-100 protein, glial fibrillary acidic protein (GFAP), and neurofilament protein (NFP) as markers of glial and Schwann cells of the nervous system; 2) choline acetyltransferase (ChAT) to identify cholinergic nerve endings; 3) neuropeptide Y (NPY), a neuropeptide that is distributed in accordance with sympathetic nerves; and 4) calcitonin gene-related peptide (CGRP), a neuropeptide that is distributed in accordance with afferent nerves. Distribution of adrenergic nerve fibers was also examined by fluorescence method. Morphology of nerve endings of the normal mitral valve was studied by electron microscopy. In normal valves, distributions of S-100 protein, GFAP, and NFP immunoreactivities were clearly visible along the subendocardial site on the coaptation aspect of the base-to-body portion of each valve, regardless of the kind of valve. In contrast, there was only a scanty distribution of these reactivities on the physiologic coaptation area of the tip. In prolapsed mitral valves, there was no distribution of S-100-positive protein or other nerve-related antigens in areas of the valve with myxomatous degeneration. Distribution of CGRP, ChAT, and NPY immunoreactivities, and adrenergic fluorescence, were the same as those of the nerve-related antigens in both normal and prolapsed mitral valves. Electron microscopic study of the atrial aspect of normal mitral valves revealed numerous small axons with aggregations of small clear vesicles, indicating cholinergic features. The results suggest that the subendocardial site on the atrial aspect at the middle portion of the mitral valve is rich in nerve endings, including the afferent nerves, and that mechanical stimuli from this area caused by abnormal coaptation in mitral valve prolapse may produce an improper circuit in autonomic nerve function between the central and mitral valve nervous systems.

Adult↗
PubMed1999

The Cox maze iii procedure: parallel normalization of sinus node dysfunction, improvement of atrial function, and recovery of the cardiac autonomic nervous system.

OBJECTIVE: The Cox maze III procedure includes isolation of the pulmonary veins and multiple incisions in both atria in what corresponds to partial autotransplantation and partial denervation of the heart. The aim of this prospective longitudinal study was to identify physiologic effects of reinnervation on changes in heart rate at rest and in response to various stimulations and on atrial function after the Cox maze III procedure. PATIENTS AND METHODS: Power spectral analysis of heart rate variability, exercise testing, 24-hour Holter monitoring, electrocardiography, and transthoracic and transesophageal echocardiography were performed in 30 adult patients after the combined Cox maze III procedure and mitral valve surgery (maze group). They were prospectively followed up at 1, 3, 6, and 12 months after the operation. The results were compared with those of 15 heart transplant recipients (transplant group) and normal probands (healthy adults, n = 12). RESULTS: The physiologic effects of denervation with no differences in cardiac autonomic activity between the groups were seen early after the operation. Later, evidence of autonomic reinnervation was observed only in the maze group but not in the transplant group. Inappropriate heart rate responses during physical exercise were clearly evident in both groups after 1 and 3 months, with progressive improvement seen between 6 and 12 months only in the maze group. Left atrial function after the Cox maze procedure improved parallel to the recovery of sinus node function. CONCLUSION: Progressive improvement of sinus node function and atrial contractions with significant functional normalization 1 year after the Cox maze procedure corresponded to functional reinnervation and recovery of the autonomic nervous system.

Adult↗
PubMed1997

Tourniquet-induced hypertension correlates with autonomic nervous system changes detected by power spectral heart rate analysis.

STUDY OBJECTIVE: To determine the autonomic changes associated with pneumatic tourniquet-induced hypertension as measured by power spectral heart rate analysis (PSHR). DESIGN: Prospective study. SETTING: Tertiary teaching hospital. PATIENTS: 21 healthy-patients scheduled for lower extremity surgery, during which pneumatic tourniquet inflation was expected to exceed 90 minutes. INTERVENTIONS: Hemodynamic and PSHR data collected at 5 minute intervals during inflation of the pneumatic tourniquet. Tourniquet-induced hypertension (T-HTN) defined at 30% increase above baseline. MEASUREMENTS AND MAIN RESULTS: Blood pressure, heart rate, maximum changes in low frequency variability (LFa), high frequency variability (HFa), and their ratio (LFa/HFa) were measured. Of the 21 patients, 11 had T-HTN. A significantly greater increase in LFa and LFa/HFa ratio was seen in the T-HTN group, where patients were greater in age. LFa, HFa, and ratio were not significantly different with T-HTN until 60 minutes or greater. Best correlation with T-HTN occurred with maximum increase in LFa/HFa ratio compared with increase in LFa or decrease in HFa. CONCLUSION: Tourniquet hypertension correlated with activation of the sympathetic nervous systems, as measured by PSHR variables.

Adult↗
PubMed1998

Population pharmacodynamics and pharmacokinetics of remifentanil as a supplement to nitrous oxide anesthesia for elective abdominal surgery.

BACKGROUND: Remifentanil blood concentrations necessary for adequate intraoperative anesthesia have not been defined. The goal of this study was to determine the blood concentrations of remifentanil needed for anesthesia with 66% nitrous oxide during intraabdominal surgery. In addition, the pharmacokinetics of remifentanil and the effects of covariates on both the pharmacodynamics and the pharmacokinetics were determined. METHODS: Anesthesia was induced and maintained with 66% nitrous oxide in oxygen and remifentanil. Remifentanil was administered by a computer-controlled infusion pump that rapidly attained, and then maintained, constant remifentanil blood concentrations. If the patient showed signs of inadequate anesthesia (autonomic or somatic response), the target concentration was increased by 1 or 2 ng/ml. If no response occurred during a 15-min period, the concentration was decreased by 1 or 2 ng/ml. Remifentanil pharmacodynamics and pharmacokinetics were estimated using NONMEM. RESULTS: The remifentanil blood concentration for which there is a 50% probability of adequate anesthesia during abdominal surgery (Cb50) with 66% nitrous oxide was 4.1 ng/ml in men and 7.5 ng/ml in women. The Cb50 values for prostatectomy, nephrectomy, and other abdominal procedures were 3.8, 5.6, and 7.5 ng/ml, respectively. Remifentanil pharmacokinetics were best described by a two-compartment model with lean body mass as a significant covariate, where V1 = 0.129(lean body mass-50) + 3.79 l, V2 = 6.87 l, CL1 = 0.0389(lean body mass-50) + 2.34 l/min and CL2 = 1.14 l/min. CONCLUSIONS: The Cb50 differed according to patient gender. However, because surgery type was not specified for each man or woman, this may reflect a difference in surgical procedure.

Abdomen↗
PubMed1989

Use of prolonged sympathetic blockade as an adjunct to surgery in the patient with sympathetic maintained pain.

Twenty patients with sympathetic maintained pain (SMP) underwent surgery to treat an associated nerve injury. In each patient, an axillary catheter technique was used to maintain anesthesia and sympatholysis for up to 4 days following surgery. In no instance was the SMP exacerbated by the operation. The use of prolonged sympathetic blockade as an adjunct increases the margin of safety in surgery for these patients when nonoperative measures cannot relieve the pain or restore function.

Autonomic Nerve Block↗
PubMed1993

Dorsal sympathectomy and management of thoracic outlet syndrome with VATS.

Dorsal sympathectomy and the management of the thoracic outlet syndrome have been considerably improved with the use of video assistance because it affords both magnification and an improved light system. Two techniques of video assistance were employed in the group of patients described here. One involved the sympathectomy done through three ports using standard video-assisted thoracic surgical methods. The second technique involved a transaxillary incision with removal of the first rib using video-assistance magnification and light, operating either directly or secondarily while visualizing the image on the television set. (The vast majority of cases have been performed using this latter technique.) Major indications for performing dorsal sympathectomy include (1) hyperhidrosis, (2) Raynaud's phenomenon, (3) Raynaud's disease, (4) causalgia, (5) reflex sympathetic dystrophy, and (6) vascular insufficiency of the upper extremity. Except for hyperhidrosis, all of the other indications require the usual diagnostic techniques, including cervical sympathetic blockade to assess whether the symptoms are relieved by temporary blockade of the sympathetic ganglia. In 326 patients, sympathectomy, performed either alone or in conjunction with first-rib removal for relief of the thoracic outlet syndrome, has been successful. In only 6 patients has sympathetic activity recurred in less than 6 months. Initially all of them were treated conservatively. Three of the 6 required a repeat sympathectomy. Postsympathectomy neuralgia occurred in only 2 of more than 326 patients. Both cases were managed successfully in a conservative fashion. Among the patients in whom a Horner's syndrome was not deliberately induced, the syndrome developed in 2. In both, the syndrome resolved spontaneously within several months.

Autonomic Nervous System Diseases↗
PubMed2003

Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects.

STUDY DESIGN: Literature review of current treatment options for detrusor-sphincter dyssynergia (DSD) in spinal cord injury. OBJECTIVES: To review the outcomes and complications associated with external sphincterotomy and to summarise the results and complications of alternative treatment options for detrusor-sphincter dyssynergia in spinal cord injury. In addition, we propose a potential alternative future drug treatment for external sphincter dyssynergia based upon recent research on the neuropharmacology of the external urethral sphincter. SETTING: The National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, UK. METHODS: Medline search from 1966 to 2002 using the words 'external sphincterotomy', 'detrusor-sphincter dyssynergia' and 'neurogenic bladder combined with surgery'. RESULTS: While external sphincterotomy is an effective treatment for DSD, a significant number of men following this procedure continue to have high intrarenal pressures, recurrent urinary infection or troublesome autonomic dysreflexia and a worryingly high proportion demonstrate persistently raised leak point pressures, putting them at subsequent risk of renal damage. Alternative treatments for external sphincter dyssynergia include urethral stents and balloon dilatation, both of which are effective. However, over the long term stents can undergo encrustation and there remains a definite risk of stent migration necessitating stent removal or replacement. Balloon dilatation of the external sphincter is associated with a risk of subsequent stricture formation. Intraurethral Botulinum A toxin seems to be effective though there have been no large randomised studies comparing it against placebo. However, it is not a durable treatment option and it has not found a common place in the treatment of DSD. There is now a considerable amount of experimental data from both animal and human studies to suggest that nitric oxide (NO) is an important physiological inhibitory neurotransmitter in the urethral sphincter, mediating relaxation of the external urethral sphincter. The potential role of sphincter NO augmentation for treatment of DSD is discussed. CONCLUSION: External sphincterotomy remains the mainstay of treatment for urodynamically significant detrusor-sphincter dyssynergia, but in recent years a number of effective, alternative treatment options have become available. While at present there is no effective systemic drug treatment, recent research into external sphincter neuropharmacology suggests that systemic or topical augmentation of external sphincter NO may provide an effective method for lowering sphincter pressure.

Humans↗
PubMed1994

Pituitary stone: two cases of densely calcified thyrotrophin-secreting pituitary adenomas.

Calcification is a well recognized but relatively uncommon feature of prolactin-secreting, growth hormone-secreting and non-functional pituitary tumours. It varies in extent, but rarely exceeds a tiny amount histologically or radiologically. Thyrotroph adenomas are the rarest of the secretory pituitary tumours, accounting for less than 1% of cases, and partial calcification of such lesions has been reported in only three cases. We describe two patients in whom the clinical and biochemical features indicated the presence of a TSH-secreting adenoma and radiology demonstrated a large 'pituitary stone'. One patient, a 59-year-old female, initially presented with hyperthyroidism, aged 18, and was rendered euthyroid by two subtotal thyroidectomies before a pituitary lesion was suspected, over 20 years later. Autonomous secretion of thyrotrophin was demonstrated by dynamic tests, and the failure of exogenous T3 to reduce the serum TSH. In the absence of tumour expansion and compressive symptoms, pituitary surgery was not undertaken. At the age of 56, she developed symptoms of intermittent ataxia and diplopia, culminating in a focal seizure, and was found on CT scan to have, in addition to the pituitary lesion, a parasagittal meningioma. This was successfully removed at craniotomy. In the second patient, a 42-year-old male, the finding of hyperthyroidism in association with an elevated TSH concentration led to the discovery of a pituitary stone which was removed transethmoidally, together with surrounding adenomatous tissue which stained positively for TSH on immunocytochemistry.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenoma↗