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At least 919 records · Page 51Linked to original sources
PubMed1978

Hormonal content of plasma and endometrium of women taking oral contraceptives.

A total of 134 women were studied, 75 of whom were using cyclic steroid contraception (ethinyl estradiol, 0.05 mg plus norgestrel, 0.5 mg) and 59 of whom had normal ovaulatory cycles. By radioimmunoassay techniques simultaneous determinations were made of total estrogens (TE) and progesterone (P) in both plasma and endometrium and of FSH and LH in plasma, covering all days of the pseudomenstrual and true menstrual cycles. As expected, the ovulating women showed a midcycle peak of plasma TE and an increase in plasma P thereafter, while no cyclic variations were observed in the treated group. Correlations of endometrial concentrations of TE and P with plasma FSH and LH levels are discussed. In 13 of the 75 treated women elevations of endometrial P concentrations were present, presumably demonstrating the "escape phenomenon." The possible future value of endometrial hormone determinations is suggested.

Adult↗
PubMedDate not supplied

[Characteristics of lipoprotein metabolic disorders during treatment with oral contraceptives].

It has been shown in rat experiments that ethinyl estradiol and estradiol dipropionate increase hepatic biosynthesis of phospholipids, free fatty acids and their esterification to form mono-, di- and triglycerides. Cholesterol biosynthesis is enhanced only by ethinyl estradiol. The specific radioactivity of VLDL- and HLD-apoproteins increases in plasma. This is the result of enhanced lipoprotein formation and secretion. Injections of ethinyl estradiol to rats lead to less pronounced metabolic disturbances compared to those induced by the action of estradiol dipropionate. The activating effect of ethinyl estradiol on hepatic lipoprotein biosynthesis is one of the pathogenetic events of hyperlipoproteinemia development.

Animals↗