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PubMed2003

Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism.

Decision making and risk taking are interrelated processes that are important for daily functioning. The somatic marker hypothesis has provided a conceptual basis for processes involved in risk-taking decision making and has been used to link discrete neural substrates to risk-related behaviors. This investigation examined the hypothesis that the degree of risk-taking is related to the degree of activation in the insular cortex. Seventeen healthy, right-handed subjects performed a risk-taking decision-making task during functional magnetic resonance imaging (fMRI) using a fast event-related design. This investigation yielded three main findings. First, right insula (BA 13) activation was significantly stronger when subjects selected a "risky" response versus selecting a "safe" response. Second, the degree of insula activation was related to the probability of selecting a "safe" response following a punished response. Third, the degree of insula activation was related to the subjects' degree of harm avoidance and neuroticism as measured by the TCI and NEO personality questionnaires, respectively. These results are consistent with the hypothesis that insula activation serves as a critical neural substrate to instantiate aversive somatic markers that guide risk-taking decision-making behavior.

Adult↗
PubMed2007

HIV in prisons.

Explore the source record for details and available documents.

Communicable Disease Control↗
PubMed2004

[Effect of temperament, effect of alcohol expectancies and peer group on amount of drinking and alcohol-related problems in adolescence].

OBJECTIVE: The purpose of this longitudinal study was to investigate the relationship between temperament (novelty seeking, harm avoidance and reward dependence), alcohol expectancies, membership in a deviant/substance-using peergroup and drinking behaviour of adolescents drawn from a general population. METHODS: 147 adolescents about 15 years of age were interviewed and completed several self-rating questionnaires. We gathered additional information by interviewing their parents. One year after the initial assessment the adolescents only were interviewed and given questionnaires again. RESULTS: Adolescents with alcohol problems at the time of the second interview reported less harm avoidance, less reward dependence, and were more likely to be a member of a deviant/substance-using peergroup a year before, compared to offspring without alcohol problems. Furthermore, they held more positive alcohol expectancies than adolescents without alcohol problems. Taking into account the quantity of alcohol consumed per occasion, all results were confirmed, but temperament did not predict the extend of alcohol consumed after one year. CONCLUSIONS: Alcohol expectancies and peer group deviance/substance-use are strongly associated to alcohol problems and the amount of alcohol consumed. Therefore, they should be the focus of prevention and intervention in this age group.

Adolescent↗
PubMed2006

Impact of a social influence intervention on condom use and sexually transmitted infections among establishment-based female sex workers in the Philippines: a multilevel analysis.

The authors assessed the relative impact of structural and social influence interventions on reducing sexually transmitted infections (STIs) and HIV risk behavior among female sex workers in the Philippines (N = 897). Four conditions included manager influence, peer influence, combined manager-peer influence, and control. Intervention effects were assessed at the establishment level in multilevel models because of statistical dependencies among women employed within the same establishments. Control group membership predicted greater perceived risk, less condom use, less HIV/AIDS knowledge, and more negative condom attitudes. Combination participants reported more positive condom attitudes, more establishment policies favoring condom use, and fewer STIs. Manager-only participants reported fewer STIs, lower condom attitudes, less knowledge, and higher perceived risk than peer-only participants. Because interventions were implemented at the city level, baseline and follow-up city differences were analyzed to rule out intervention effects due to preexisting differences.

Acquired Immunodeficiency Syndrome↗
PubMed2004

Temperament in the rat: sex differences and hormonal influences on harm avoidance and novelty seeking.

This study showed large and consistent individual differences in 64 rats (32 males) in the hole board and canopy test, which are considered to measure exploration and anxiety, respectively. Nonestrous females were more active than males and nose poked more in the hole board. In the canopy test, nonestrous females, compared with males, showed greater intraindividual variability in time spent outside the protective canopy. Estrous females spent significantly more time outside the canopy. Gonadectomy reduced nose poking in males and hole board locomotion in both sexes. Principal-components analysis disclosed 2 temperamental dimensions reflecting harm avoidance and novelty seeking. More males had high levels of psychometric harm avoidance, and fewer males than females had a low-harm-avoidance/high-novelty-seeking, sanguine profile.

Adrenalectomy↗
PubMed2006

Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations.

The neuropeptide galanin (GAL) is widely expressed in the central nervous system. Animal studies have implicated GAL in alcohol abuse and anxiety: chronic ethanol intake increases hypothalamic GAL mRNA; high levels of stress increase GAL release in the central amygdala. The coding sequence of the galanin gene, GAL, is highly conserved and a functional polymorphism has not yet been found. The aim of our study was, for the first time, to identify GAL haplotypes and investigate associations with alcoholism and anxiety. Seven single-nucleotide polymorphisms (SNPs) spanning GAL were genotyped in 65 controls from five populations: US and Finnish Caucasians, African Americans, Plains and Southwestern Indians. A single haplotype block with little evidence of historical recombination was observed for each population. Four tag SNPs were then genotyped in DSM-III-R lifetime alcoholics and nonalcoholics from two population isolates: 514 Finnish Caucasian men and 331 Plains Indian men and women. Tridimensional Personality Questionnaire harm avoidance (HA) scores, a dimensional measure of anxiety, were obtained. There was a haplotype association with alcoholism in both the Finnish (P=0.001) and Plains Indian (P=0.004) men. The SNPs were also significantly associated. Alcoholics were divided into high and low HA groups (>or= and <mean HA of population). In the Finns, haplotype (P<0.0001) and diplotype (P<0.0001) distributions differed between high HA alcoholics, low HA alcoholics and nonalcoholics. Our results from two independent populations suggest that GAL may contribute to vulnerability to alcoholism, perhaps mediated by dimensional anxiety.

Alcoholism↗
PubMed2004

Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness.

Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5-HT(2A)) receptor, which could contribute to disturbances of appetite and behavior in AN and BN. To avoid the confounding effects of malnutrition, we studied 10 women recovered from bulimia-type AN (REC AN-BN, > 1 year normal weight, regular menstrual cycles, no binging, or purging) compared with 16 healthy control women (CW) using PET imaging and a specific 5-HT(2A) receptor antagonist, [18F]altanserin. REC AN-BN women had significantly reduced [18F]altanserin binding potential relative to CW in the left subgenual cingulate, the left parietal cortex, and the right occipital cortex. [18F]altanserin binding potential was positively related to harm avoidance and negatively related to novelty seeking in cingulate and temporal regions only in REC AN-BN subjects. In addition, REC AN-BN had negative relationships between [18F]altanserin binding potential and drive for thinness in several cortical regions. In conclusion, this study extends research suggesting that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions. Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders. It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects.

Adult↗
PubMed1997

Charting WHO--goals for licit and illicit drugs for the year 2000: are we 'on track'?

Both on a global and a regional basis, the World Health Organization (WHO) has set prominent goals for the turn of the millennium on the reduction of harms associated with licit and illicit drugs. Gauging what the world and its different regions are doing with respect to these specific public health goals is hindered by a conceptual problem: there is no clear concept and consistent way of defining or measuring 'harm' related to drugs, licit or illicit. In many instances, 'harm' is equated with substance use prevalence. Often, especially outside the developed world, basic harm data is not even available. Globally, a conceptually clear and consistently applied scheme of harm measurement related to licit and illicit drugs is needed, acknowledging the fact that drug-related harms occur at different individual and social levels as well as over different periods of time. Harms must also be recognized as an outcome of interactions between the substance user, the drug itself, and the physical and social environment. Looking at available macro-indicators of harm, it must be concluded with, we do not seem to be 'on track' globally in reducing harms related to drugs in accordance with the WHO goals. For alcohol and tobacco, trends for increased harm are just starting to show in the developing world, and will worsen over the next couple of decades. For illicit drugs, failing drug control policies have result in dramatically negative developments for public health, especially with respect to HIV infections and drug-related deaths, in the developed as well as developing world.

Alcohol Drinking↗
PubMed1996

Changing society, changing drinking: solitary drinking as a non-pathological behaviour.

This study describes solitary drinking as it appears in a general population. The data are derived from a telephone survey carried out in April 1993 on a representative sample of 2015 adult drinkers from the Montréal metropolitan area. Thirty-one percent of the respondents (n = 633) reported drinking without being in the company of other people. First, solitary drinking is described according to drinking contexts and drinking patterns. Secondly, a comparison of solitary drinkers with those who did not report this behaviour is presented according to socio-demographic characteristics, social representations of drinking and overall drinking patterns. Finally, a logistic regression analysis is performed to identify the main characteristics of the drinkers associated with solitary drinking. The results show that solitary drinking occurs mainly at home, at the end of the day, to accompany a meal, to mark a transition between work and leisure or to accompany a rest time. The quantity involved in solitary drinking is generally moderate. The results also show that solitary drinking is associated with gender, living alone, employment status, tension-reduction and harmful representations of drinking. However, the main predictor of solitary drinking is overall drinking frequency, indicating the constituent place of alcohol in solitary drinkers' life-style.

Adult↗
PubMedDate not supplied

Demystifying the injection drug user: willingness to participate in traditional drug treatment services among participants in a needle exchange program.

Injection drug users have been vilified in our culture as being wild-eyed and willing to do anything for the next hit. These individuals are typically seen as being unemployed, uneducated and completely disinterested in making any changes in their lives. Sixty-one participants in a syringe exchange program in Cleveland, Ohio were interviewed using the NIDA Risk Behavior Assessment. Fifty (81%) of the respondents were either in an abstinence-based program or reported a willingness to participate in such a program. Importantly, although the sample consisted of long-term daily users of injection drugs (m=19.95 years), the majority of the sample was employed (69%) and were high school graduates (51%). The results of this study suggest that injection drug users are willing to make changes in their use-related behaviors, involvement in a needle exchange program does not preclude involvement in abstinence-based programming, and needle exchange services may serve as an important component in a continuum of care when coupled with traditional abstinence-based services.

Adult↗
PubMed2006

Rationale and design of the MEMA kwa Vijana adolescent sexual and reproductive health intervention in Mwanza Region, Tanzania.

Large-scale innovative, integrated, multifaceted adolescent sexual and reproductive health (ASRH) interventions are urgently needed in sub-Saharan Africa. Implementation through schools and health facilities may maximize intervention coverage and sustainability, however the impact of the use of these structures on intervention content and delivery is not well documented. This paper describes the rationale and design of a large-scale multifaceted ASRH intervention, which was developed and evaluated over three years in rural communities in Mwanza Region, North West Tanzania. The intervention comprised community mobilization, participatory reproductive health education in primary schools, youth-friendly reproductive health services and community-based condom provision for youth. We examine the effect of socioeconomic, cultural and infrastructural factors on intervention content and implementation. This paper demonstrates the means by which such interventions can be feasibly and sustainably implemented to a high standard through existing government health and school structures. However, the use of these structures involves compromise on some key aspects of intervention design and requires the development of complementary strategies to access out-of-school youth and the wider community.

Adolescent↗
PubMed2005

The legacy of a community mobilisation project to reduce alcohol related harm.

The Community Mobilisation for the Prevention of Alcohol Related Injury (COMPARI) project was established to investigate how alcohol related harm could be reduced within the Geraldton community through community action. Twenty-two major component activities were carried out over three years. On completion of the demonstration phase the project was taken over by the community and evolved into the region's main alcohol and drug service provider. This research seeks to identify the legacy of COMPARI from interviews with 23 key informants and from serial measures of alcohol consumption and harm. Key informants indicated that the original community prevention focus of the project has been diluted and there is more emphasis on individual prevention through education and training. A culture of intersectoral collaboration on alcohol issues has endured and this contributes to better use of resources and higher levels of treatment referral. There was also strong acknowledgement that the local committee was crucial in sustaining the project. Since the inception of COMPARI, local alcohol consumption has decreased and a proxy measure of alcohol harm, weekend, night, hospital accident and emergency occasions of service, also indicates better outcomes in Geraldton. The original project initiated cultural and structural change in the way alcohol problems are dealt with in Geraldton and this has produced on-going benefit for the community.

Alcohol Drinking↗
PubMed2006

'Individual' harms, Community 'harms': reconciling Indigenous values with drug harm minimisation policy.

This paper uses data on the social context of drug-related harms in the Melbourne Aboriginal Community to inform an alternative model of harm minimisation, and discusses its potential application in programme development. The paper involves a secondary analysis of interviews and focus group discussions with 62 Community members who participated in a qualitative injecting drug use study conducted at the Victorian Aboriginal Health Service in Melbourne. Individuals and families within the Melbourne Aboriginal Community experience significant levels of harm associated with injecting drug use, and face restricted access to appropriate service options. This experience of drug use contributes to a broad range of values within the Community around harm minimisation approaches to programme delivery. We propose a fundamentally distinct harm minimisation model which explicitly acknowledges this range of conflicting values, and reflects the need for a breadth of services and programmes that address these tensions. Policies and funding must support Aboriginal Communities to negotiate through these conflicting Community values to actively create spaces in the service system for both using and non-using Community members. This includes the development of regional approaches which articulate an appropriate mix of services and the roles of Aboriginal and mainstream services in their delivery.

Focus Groups↗
PubMed2006

Fact or fiction? A critique of the National Aboriginal and Torres Strait Islander Social Survey 2002.

The ability of policy makers, practitioners and the broader public to respond appropriately in reducing the harms caused by alcohol misuse depends in large part on our understanding of the nature of the problem. In the case of consumption patterns and associated harms among indigenous minority peoples--in Australia and elsewhere--such an understanding is often difficult to achieve. There are a host of reasons for this including cultural differences between indigenous peoples and the broader populations within which they are located, cultural heterogeneity among indigenous peoples themselves, political and economic disadvantages which exacerbate misuse and its effects, methodological difficulties in the appropriate design of data collection instruments, sampling issues and the issues in the interpretation of data. All these difficulties mean that we need to subject any studies of substance misuse among indigenous peoples to a high level of scrutiny. This is particularly the case when such studies are conducted by organisations that are generally regarded as 'authoritative' sources of information. Chikritzhs & Brady have done this in the case of the National Aboriginal and Torres Strait Islander Social Survey 2002, conducted by the Australian Bureau of Statistics. In their review of this and other surveys, they demonstrate that to produce valid information about indigenous alcohol misuse, as well as having the skills to conduct broad population surveys, it is necessary to have an understanding of both methods of collecting data on alcohol consumption and Indigenous cultures themselves.

Alcoholism↗