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At least 919 records · Page 51Linked to original sources
PubMed1999

Bronchial mucormycosis with progressive air trapping.

A previously healthy 70-year-old woman developed fever, cough, and exertional dyspnea. Her symptoms progressed over a 2-month period despite treatment by her primary care physician with 2 courses of oral antibiotics and the addition of prednisone. Hypoxemia and the finding of hyperglycemia with mild ketoacidosis led to hospital admission. Serial chest radiographs demonstrated diffuse heterogeneous pulmonary opacities and progressive air trapping in the right lower lobe. Fiberoptic bronchoscopy revealed a deep penetrating ulcer with exposed bronchial cartilage of the bronchus intermedius and dynamic airway obstruction with complete closure during expiration. Biopsy of the ulcer revealed Rhizopus arrhizus. Respiratory failure stabilized with the patient on conventional mechanical ventilation and receiving amphotericin B. Before surgery could be performed, Pseudomonas aeruginosa pneumonia and septic shock developed, and the patient died.

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PubMed1997

Pathology of mucormycosis of cane toads in Australia.

The gross and microscopic pathology of a fungal septicaemia caused by the zygomycete. Mucor amphibiorum in 27 free-ranging cane toads, Bufo marinus, in Australia is described. Seven of the 27 toads had clinical signs of illness when discovered and five of these seven were moribund. Multiple granulomas were found in many organs, and in massive infections granulomas tended to coalesce. Liver, spleen, kidneys, urinary bladder, heart and lung were most commonly involved, but granulomas also occurred in subcutaneous lymph spaces, skin, gastro-intestinal tract, voluntary muscle, bone, cranial cavity and the oral cavity. Single lesions appeared grossly as a lemon coloured nodule < or = 5 mm in diameter. Histologically, the primary lesion was a granuloma composed of multinucleate giant cells, macrophages, occasional lymphocytes and eosinophils surrounding the distinctive sphaerules of M. amphibiorum. Fibroblasts occurred in greater numbers at the periphery and collagen formed a dense fibrous capsule around some nodules. A less common lesion resembled a microabscess and consisted of mononuclear cells, neutrophils and eosinophils surrounded by macrophages. Many of the centrally placed mixed inflammatory cells appeared necrotic. This reaction appeared to be more acute. Both types of lesions sometimes occurred concurrently, but the latter was less common. The pattern of lesions and natural history of M. amphibiorum suggested that ingestion of contaminated soil may have been the route of infection.

Animals↗
PubMed1997

Mucormycosis in a free-ranging green tree frog from Australia.

Mucor amphibiorum is reported for the first time from a free-ranging native amphibian, a green tree frog (Litoria caerulea) from Queensland, Australia. The nasal cavity was largely replaced by granulomatous inflammatory tissue, and most internal organs had nodular granulomas. Typical mother and daughter sphaerules of M. amphibiorum occurred in these nodules which were due to granulomatous inflammation as well as areas of more active mixed inflammation with necrosis. Tissue homogenate from the spleen was inoculated into two cane toads (Bufo marinus), and one toad became infected with M. amphibiorum.

Animals↗