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PubMed1986

[Neurophysiologic analysis of disorders of the functional activity of projection systems of the brain in patients with neuroses].

To study the neurophysiological mechanisms of neurasthenia, hysterical neurosis and obsession neurosis with a view to the practical employment of the results, the authors examined 100 patients and 40 normal subjects using the method of evoked potentials (EP). EP changes indicated an neurasthenia-related decrease in the functional activity of the cortex, weakening of its inhibitive functions and an increase in the reactivity of the system of negative-emotional support. Patients with hysterical neurosis displayed the greatest excitability of the structures of the projective pathways and insufficiency of programme-integrating effects of the higher portions of the brain. Neurosis of obsessive states was characterized by an increase in the activity of specific cortical zones and, to a larger degree, of the centres of negative-emotional reactivity. The time-course of EP during treatment is outlined. The findings obtained may serve as additional criteria in the diagnosis and treatment of neurosis.

Adult↗

PubMed1982

[Experience with the therapeutic use of grandaxin in neuroses].

The use of the drug grandaxin (made in Hungary) has demonstrated its high activity in the treatment of psychopathological disturbances of neurotic origin. Its administration is preferable when vegetative and hyposthenic disturbances are prevalent in the neurosis clinical picture. At the same time it alleviates the intensity of phobic and senestho-hypochondriacal experiences, however, its administration as the sole means for eliminating these disturbances seems undesirable. Neither can grandaxin be the drug of choice in controlling anxious and agrypnic disturbances. Psychogenic somatic syndromes have also appeared to be insensitive to the treatment with this drug. The side-effects produced by grandaxin are mild. The most persistent are nausea and headaches which develop in patients receiving high doses and subside in most cases spontaneously on reduction of the latter. No complications were noted.

Adult↗

PubMed1981

Confirmation of deviant EEG-evoked potential relationships in the neuroses.

A previous study of relationships between EEG and somatosensory evoked potential (SEP) measurements in psychiatric patients showed correlations between EEG and SEP amplitudes to be negative in nine neurotic patients and positive in nine age- and sex-matched nonpatients. The present study attempted to replicate this finding in 35 neurotics and 35 age- and sex-matched nonpatients. Data involved amplitudes of SEPs to right median nerve stimuli from frontal, central, and parietal leads and central and parietal EEG amplitudes (eyes open and closed), both obtained in the context of our comprehensive EP recording procedure. Correlations between SEP and EEG amplitudes in controls were generally positive, while those in patients tended to be negative or close to zero. No specific neurosis group differed from the others. The results confirm the previous finding in showing absence of normal EEG-SEP amplitude relationships in neurotic disorders.

Adult↗