[Studies on substances with presumable antituberculous chemotherapeutic action. II. Thiosemicarbazones of p-aminosalicylic aldehyde and some of its derivatives].
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The virostatic activity of isatin-beta-isothiosemicarbazones can be described quantitatively by hydrophobic, electronic, and steric substituent constants using multivariate regression analysis. A preceding Free-Wilson analysis allows data smoothening, and thus improved adaptation. Predictions made on the basis of the quantitative structure-action relationships obtained could be confirmed experimentally by synthesizing and testing the corresponding compounds.
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