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At least 919 records · Page 51Linked to original sources
PubMed2005

Ganglioneuromatous paraganglioma of the cauda equina--a pathological case study.

This study presents a rare case of compound paraganglioma/ganglioneuroma with comprehensive immunohistochemical studies that reveal strong cytokeratin expression in all components. A 74-year-old woman presented with a mass lesion of the cauda equina. The 1.8-cm tumor showed 3 histomorphologically and immunohistochemically distinct components: typical paragangliomatous neuroendocrine areas, mature ganglion cell-like neuronal areas, and a "neuromatous" proliferation of Schwann cells with admixed axons. As often seen in cauda equina paragangliomas, the neuroendocrine cells were cytokeratin-positive. In addition, immunoreactivity for cytokeratins was also observed in the neurons and axons. This tumor illustrates the broad spectrum of divergent differentiation that can be seen in cells of sympathoadrenal lineage.

Aged↗
PubMed2006

Corticotropin-producing pulmonary gangliocytic paraganglioma associated with Cushing's syndrome.

Gangliocytic paraganglioma (GP) is an unusual tumor in the wide spectrum of neuroendocrine neoplasms. The biologic behavior and histogenesis of this tumor is uncertain because, despite its benign histologic features, there have been reports of metastases to regional lymph nodes and distant metastases. Although most of these tumors have been reported in the duodenum, examples of GP arising in extra-ampullary sites have been well documented. Herein, we report the case of a lung GP corticotropin producing and presenting as Cushing's syndrome. After removal of the tumor, there was a significant drop in cortisol and corticotropin levels. To our knowledge, this is the first report of a GP causing Cushing's syndrome.

Adrenocorticotropic Hormone↗
PubMed2003

On the association of succinate dehydrogenase mutations with hereditary paraganglioma.

Hereditary paraganglioma (PGL) is characterized by the development of slow-growing, highly vascularized tumors that can present either as hormonally silent head and neck tumors or as abdominal pheochromocytomas. PGL tumors are caused by germline inactivating heterozygous mutations in the SDHB, SDHC and SDHD genes, which encode three of the four subunits of succinate dehydrogenase (SDH; succinate:ubiquinone oxidoreductase; mitochondrial complex II). Here, potential mechanisms by which SDH mutations could lead to tumor development are discussed. Mechanisms that lead to variations in the prevalence, penetrance and expressivity of SDH subunit mutations remain to be clarified to improve the clinical management of PGL patients. Recently, germline mutations in the FH gene, the product of which (fumarate hydratase) catalyzes the conversion of fumarate to malate in the Krebs cycle, have been detected in a distinct hereditary tumor syndrome, which is characterized by uterine and skin leiomyomatosis and papillary renal cancer. Although the exact mechanisms of tumorigenesis in both disorders are unknown, SDH and FH could be involved in the control of cell proliferation under normal physiological conditions in the affected tissue types. Whereas SDH might be involved in hypoxic proliferation of paraganglia, FH might play an important role in the regulation of ammonium metabolism in smooth muscle cells.

Animals↗
PubMed2004

[Malignant neck paraganglioma with a rare localization].

We report a clinical case of a man with a cervical paraganglioma, originated from ectopic paraganglionic tissue, with metastasis to cervical lymph nodes. We carry out a reviw of the symptoms, diagnosis and treatment of this type of neoplasm.

Adult↗
PubMed2003

Nonfunctioning paraganglioma of the aortopulmonary window.

Aortopulmonary paraganglioma is a rare tumor of the mediastinum. The only effective treatment is complete resection, which may pose a surgical challenge because of its proximity to the heart, great vessels, and trachea, often rendering a complete resection difficult to achieve. We report a case in which the tumor was excised under cardiopulmonary bypass and resulted in massive bleeding only controlled by means of packing the pleural cavity during 48 hours, known as damage control strategy. The patient survived and has been disease-free for 2 years.

Aorta, Thoracic↗
PubMed1997

Resection of multiple mediastinal paragangliomas with cardiopulmonary bypass.

The case of a patient who underwent simultaneous resection of two separate mediastinal paragangliomas is presented. The tumors were located in the aortopulmonary window and in the right atrioventricular groove. The patient had previously undergone resection of a glomus vagale tumor. The mediastinal lesions were removed with the aid of cardiopulmonary bypass, and the patient is doing well postoperatively.

Adult↗
PubMed1992

Ultrasonic and computed tomographic appearances of paraganglioma simulating pancreatic mass.

We report two cases of paraganglioma in which the tumour was situated adjacent to the head of the pancreas simulating a pancreatic mass lesion. The absence of biliary or pancreatic duct dilatation on ultrasound in the presence of a large mass suggested a retroperitoneal tumour rather than a pancreatic adenocarcinoma. Functional activity in these tumours is common and should be excluded before biopsy.

Diagnosis, Differential↗
PubMed1992

Case report: paraganglioma of the cauda equina.

The clinical, radiological and pathological features of a paraganglioma of the cauda equina are described, including magnetic resonance imaging features. The literature is reviewed and discussed.

Cauda Equina↗
PubMed1990

Malignant jugulotympanic paraganglioma in a dog.

An invasive malignant epithelial neoplasm was diagnosed as a paraganglioma by light and electron microscopy and immunohistochemically by a positive reaction with anti-neuron-specific enolase. Due to the extensive involvement of the middle ear, a primary origin in the jugulotympanic or jugular paraganglia is suggested.

Animals↗
PubMed1993

Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs.

Extra-adrenal paragangliomas associated with vertebral pain and clinical neurological abnormalities as a result of metastasis to the vertebral column were diagnosed in four dogs of different breeds by light microscopy. All were males (two intact and two neutered) aged 8 years. Metastatic neoplasms occurred as extradural masses with associated bone lysis at vertebrae C4 (2 cases), T12-L1 (1 case) and L4 (1 case). The neoplastic cells exhibited similar morphology with little variation between cases. All neoplasms showed cytoplasmic granules after staining with the Churukian-Schenk modification of the Pascual argyrophil stain for neurosecretory granules or for membrane bound electron-dense granules (dense-core granules). On immunohistochemical examination the neoplastic cells gave positive results for neuron-specific enolase and negative results for chromogranin and epithelial membrane antigen. Multiple organ metastasis and metastasis to bone have been reported previously, but these cases were unusual due to the involvement of the spine as an apparent predilection site for metastasis, and the sex (male) and age of the animals affected.

Animals↗
PubMed1985

Nonchromaffin paraganglioma of the retroperitoneum.

We reviewed 37 cases described previously in the literature to provide a patient operated upon for a retroperitoneal nonchromaffin paraganglioma with qualified advice concerning followup examinations and prognosis. This type of tumor apparently grows slowly and metastasizes late. A radical operation is the treatment of choice and provides a good prognosis. We suggested that our patient undergo clinical followup and ultrasound investigations at 3 to 6-month intervals.

Adult↗
PubMed1979

Malignant paraganglioma of the prostate and retroperitoneum.

A case of malignant paraganglioma of the prostate, metastatic to the retroperitoneal area, is reported. The literature is reviewed and the possible origin of the disease is discussed. We believe that this is the first report of this entity of prostatic origin.

Adult↗
PubMed1977

Vesical-related paragangliomas.

A review is presented of vesical-related paragangliomas and 3 cases are reported. Methods for early diagnosis, including selective angiographic demonstration, and treatment of these rare tumors are discussed. A multi-team approach by the urologist, endocrinologist and anesthesiologist is stressed for better control of potentially dangerous vasomotor changes during diagnosis and surgical treatment of this tumor.

Adolescent↗
PubMed1975

Paraganglioma of the bladder: report of a case.

A patient with a most unusual neoplasm of the bladder, a paraganglioma, is presented herein. A combination of episodes of hypertension during or immediately after micturition associated with hematuria is almost pathognomonic of this condition. The patient presented with hematuria only. Less than 7 per cent of all reported cases have a malignant course. The proper treatment appears to be partial cystectomy with wide margins of the affected area, being prepared for wide fluctuations in blood pressure in those patients who have elevated catecholamine levels preoperatively.

Female↗
PubMed2001

Head and neck paragangliomas: an overview.

Paragangliomas of the head and neck are unique tumors. Their pathology, tissue of origin, location, genetics, potential for bio-chemical activity, multicentricity, and growth pattern are unusual compared with more common head and neck tumors. Because these tumors are widespread and can appear in the ear, neck, larynx, nose, orbit, and chest, they cross subspecialties of otolaryngology.

Female↗