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PubMed2001

Ecological compensation in Dutch highway planning.

The ecological compensation principle was introduced by the Dutch government in 1993. This principle is designed to enhance the input of nature conservation interests in decision-making on large-scale development projects and to counterbalance the ecological impacts of such developments when implemented. This article evaluates the application of the Dutch compensation principle in highway planning. Six current highway projects reveal consistent implementation of this principle, although provincial policies on compensation and a national method for identifying compensation measures are still under development. As the planning process has not yet been completed for all the projects, no general conclusions can be drawn on the impact of the compensation principle on highway decision-making. Nevertheless, several examples show that the principle stimulates project initiators to develop alternative routes or route sections in order to avoid or reduce ecological impacts and the need for coherent compensation measures. If the compensation principle is to be properly implemented in the context of highway planning, particular attention should be paid to the following aspects: (1) sequential assessment of overall project legitimacy and the necessity of intersecting protected areas and compensation measures. (2) the initiator's attempts to avoid and mitigate ecological impacts in developing alternative routes prior to compensation for impacts, and (3) the role of uncertain ecological impacts in identifying compensation measures, especially those concerning habitat isolation.

Conservation of Natural Resources↗

PubMed2006

Combined influence of early sexual maturation and central adiposity on subsequent stature. A four-year follow-up of 1,605 Norwegian boys and girls: the Young-HUNT study.

INTRODUCTION: Shorter adult stature has been attributed to early sexual maturation, as well as early adiposity, but it is not clear if these factors are interrelated. RESULTS AND DISCUSSION: A number of 1,605 Norwegian adolescents were followed from early (baseline) to late adolescence (follow-up). Maturational timing was assessed by self-reports of pubertal status (pubertal development scale, PDS) in boys and age at menarche (AAM) in girls. Height, weight and waist circumference were measured at baseline and at follow-up. Differences in height at follow-up and height gain related to the timing of sexual maturation and the level of central adiposity (i.e. high or low waist circumference) at baseline were estimated using general linear modelling. At follow-up, the median height was 180 cm in boys and 167 cm in girls. Early maturing boys and girls with relatively high central adiposity at baseline were, on average, 5.7 cm (P value<0.001) and 3.6 cm (P value<0.001) taller than early maturing boys and girls with low central adiposity. Differences in stature related to central adiposity were less pronounced for intermediate and late maturing boys and girls. The height was lowest in boys (176.6 cm) and girls (163.8 cm) who had matured early and had low central adiposity at baseline. Height gain during follow-up was independent of the level of central adiposity, but was closely related to the timing of sexual maturation. The association between the early timing of sexual maturation and subsequent height was modified by the level of central adiposity in early adolescence. CONCLUSION: The results suggest that early maturity combined with adiposity yields higher stature than early maturity and leanness.

Adiposity↗

PubMed2006

Decisional balance, perceived risk and HIV testing practices.

Improving our understanding of how individuals decide to take an HIV test is essential for designing effective programs to increase testing. This paper assesses the relationship of decisional balance and perceived risk to HIV testing history in a cross-sectional community sample of 1523 HIV-negative men and women at risk due to drug use or sexual behavior. We developed scales to measure perceived advantages (pros) and perceived disadvantages (cons) of taking an HIV test and assessed their content using factor analysis. Perceived risk was highly related to the pros and cons scales. Multivariate analyses revealed that the pros scale had positive associations with having ever tested and the number of tests taken, while the cons scale had negative associations with these testing measures. Perceived risk was not related to testing practices. These results suggest that interventions to increase HIV testing need to address anticipated positive and negative outcomes of getting tested.

Adolescent↗

PubMed2005

Pre-linguistic Autism Diagnostic Observation Schedule adapted for older individuals with severe to profound mental retardation: a pilot study.

The Autism Diagnostic Observational Schedule (ADOS) is a semi-structured observational scale developed to assess social interaction, communication and play in individuals who are suspected to have autism. Since the ADOS is not suitable to be used with severely or profoundly mentally retarded adolescents and adults with very limited language skills, materials and some of the tasks of the PL-ADOS and the original ADOS (the former versions of the current ADOS) were adapted. Results indicated that almost all of the overall ratings showed good reliability and discriminative diagnostic validity. Furthermore, the combination of codings into an overall algorithm score on social/communicative behavior resulted in a sensitivity of .82 and a specificity of .85 when using a cut-off score of 15.

Adolescent↗

PubMed1983

The predictive significance of biologic risk factors for deficits in children of a high-risk population.

Two hundred forty-two high-risk children and 47 low-risk children were prospectively studied to assess the relationship between biologic risk factors that occurred during the perinatal period and the motor and cognitive deficits that were identified during the first year of life. Multiple risk factors were present in 80% of the children of the high-risk group. Provisional deficits were classified on the degree of abnormality found in a clinical and behavioral assessment that included neurological examinations, Bayley Physical and Mental Development Scales, and the Uzgiris and Hunt Scale. Provisional deficits occurred in 10% of the children of the low-risk group. High-risk children had a significantly greater incidence of provisional deficits, particularly in respect to positive deficits. In high-risk children, the probability of a deficit was 17% in those without infection or encephalopathy, 30% in those with infection, and 40% in those with encephalopathy.

Cognition Disorders↗

PubMed1993

The nature and measurement of compulsive indecisiveness.

Indecisiveness is an often mentioned symptom of obsessive compulsive disorder and obsessive compulsive personality disorder, yet very little research has been done examining its nature and measurement. Three studies are presented here which examine the nature of compulsive indecisiveness using a newly developed scale. In study 1 the Indecisiveness Scale was correlated with measures of obsessionality and compulsive checking among normal S s. It was also correlated with the maladaptive evaluative concern dimensions of perfectionism and with compulsive hoarding. In study 2 indecisive S s (as measured by the Indecisiveness Scale) were found to score higher on measures of procrastination and general psychopathology. In addition, they reported problems in making decisions in a variety of life domains (social, academic, family and everyday). In study 3 S s who scored high on the Indecisiveness Scale were found to have longer latencies on an experimental decision-making task. The implications of these findings for the nature of indecisiveness were discussed.

Adolescent↗

PubMed1981

Acute and chronic phencyclidine effects on locomotor activity, stereotypy and ataxia in rats.

Behavioral rating scales, developed to measure phencyclidine (PCP)-induced stereotypy and ataxia in rats, were tested using acute dose-response and chronic paradigms with concomitant assessment of locomotor activity by automated counters. Also, effects of chronic PCP on apomorphine-induced stereotypy were assessed as a test of dopamine supersensitivity. A linear dose-response effect was found for measures of all three behaviors through moderate dose levels (2-6 mg/kg), but only ataxia ratings continued to increase, showing a linear relationship through the higher (8 and 10 mg/kg) doses. Chronic daily PCP administration showed progressive augmentation of stereotypy, tolerance to ataxia at 10 min post-injection, and a biphasic increase followed by decrease to day 1 levels in locomotor activity over 14 days. No significant change was found in apomorphine stereotypy following chronic PCP treatment. The chronic behavioral changes demonstrated in this study may provide a model of PCP-induced psychological and cognitive changes seen following chronic usage in man.

Amphetamine↗

PubMed1983

A hospital staff support program: design and evaluation.

The literature indicates that nurses on special care units experience stress resulting from the role conflict and ambiguity to which they are exposed. Role theory predicts that such individuals will become dissatisfied with their work and will decrease their confidence in supervisors and co-workers. Consequently, it was hypothesized that a staff support program designed to assist nurses to cope with role conflict and ambiguity would result in reduced stress; increased satisfaction with work, supervision, and co-workers; and decreased staff turnover. A nine week staff support program was implemented on a hospice unit in a large, private, general hospital. The program utilized an insight-oriented approach focused on specific sources of stress combined with structured exercises designed to facilitate nurses' ability to cope with stress resulting from a role conflict and ambiguity. Data were collected from two groups to hospice nurses using a Nursing Stress Scale developed for this study, the Job Description Index, and personnel records. A quasi-experimental research design was used to assess the validity and generalizability of the results of the program. Data were analyzed in four stages: (i) pre-program levels of stress and job satisfaction were analyzed using a multivariate profile analysis; (ii) correlated t-tests were used to test for significant differences between pre- and post-program levels of stress; (iii) a repeated measures ANOVA was used to examine the effect of the program on job satisfaction; (iv) turnover among the nursing staff on four other hospital units was compared to the hospice unit. Results of the evaluation indicated that the support program was effective in reducing nursing stress, increasing job satisfaction, and decreasing staff turnover. The implications of the study for the design and evaluation of hospital staff support programs are discussed.

Conflict, Psychological↗

PubMed1996

Neurochemical correlates of antiepileptic drugs in the genetically epilepsy-prone rat (GEPR).

The GEPR model is composed of two independently derived strains of rats each characterized by a broad-based seizure predisposition. Moderate seizure GEPRs (GEPR-3s) exhibit generalized clonus with loss of righting reflex in response to a standardized sound stimulus. The same stimulus in severe seizure GEPRs (GEPR-9s) produces a tonic-clonic convulsion much like that produced by supramaximal electroshock. The numeric descriptors (3 and 9) derive from the ordinal rating scale developed by Jobe and coworkers for evaluation of convulsion intensity. GEPRs experience an anticonvulsant effect in response to all established and many experimental antiepileptic drugs and distinctions between the classes of drugs can be made. Since serotonin plays an anticonvulsant role in nearly all animal seizure models, we examined the effects of antiepileptic drugs on serotonin using microdialysis. Among clinically effective anticonvulsants, carbamazepine, antiepilepsirine (used in China) and loreclezole produced dose-related anticonvulsant effects and increases in extracellular serotonin in GEPRs. Similarly, drugs known to block serotonin reuptake and increase extracellular serotonin (fluoxetine and sertraline) produce dose related anticonvulsant effects in GEPRs and other animal models. Accentuation of serotonin release by treating GEPRs with fluoxetine and 5-hydroxytryptophan enhances the anticonvulsant effect produced by fluoxetine. Depletion of serotonin greatly decreased the anticonvulsant effect produced by carbamazepine, antiepilepsirine and fluoxetine. Phenytoin produced a dose related anticonvulsant effect in GEPRs but did not increase extracellular serotonin. Depletion of serotonin did not diminish the anticonvulsant effect produced by phenytoin. Thus, serotonin appears to play a role in the anticonvulsant effect of several but not all anticonvulsant drugs.

Animals↗

PubMed1996

Activation of 5-HT2A receptors potentiates pain produced by inflammatory mediators.

Previous results from our laboratory indicate that serotonin (5-HT) potentiates pain produced by other inflammatory mediators. To characterize the receptor subtype(s) mediating this synergistic effect of 5-HT, selective 5-HT agonists were injected, alone or with noradrenaline (NA) or prostaglandin E2 (PGE2), into the plantar surface of the paws of rats. The behavioural response (favouring, elevation and licking the paw) was recorded using the rating scale developed to quantify formalin-induced pain. The 5-HT1A and 5-HT3 agonists, 8-OH-DPAT and 2-methyl-5-HT, respectively, produced only transient responses by themselves and did not interact with PGE2 or NA. The 5-HT2 agonists, alpha-methyl-5-HT and DOI, also produced transient responses alone, but induced lifting and licking of the injected paw lasting more than 30 min when combined with PGE2 or NA. The lifting and licking response produced by 5-HT plus PGE2 was not altered by intraplantar pretreatment with the 5-HT1A and 5-HT3 antagonists, BMY 7378 and tropisetron, but was attenuated by the 5-HT2A/2C antagonist ketanserin. The pain response produced by alpha-methyl-5-HT plus PGE2 was blocked by pretreatment with the 5-HT2A/2C antagonists ketanserin and ritanserin, and the 5-HT2A antagonist spiperone (MPE50 values 1.4, 7.7 and 0.06 nmol, respectively). The second phase of the response to intraplantar formalin was also attenuated by ketanserin, ritanserin and spiperone (MPE50 values 11.3, 21.8 and 0.23 nmol, respectively). These data imply that 5-HT2A antagonists may be effective peripherally acting analgesics or analgesic adjuncts in pain associated with 5-HT release from platelets, such acute injury and, perhaps, some chronic pain states.

8-Hydroxy-2-(di-n-propylamino)tetralin↗

PubMed1995

Life fulfillment in an epilepsy sample from the United States.

This study examined the life fulfillment of a sample of 420 people with epilepsy drawn from affiliates of the Epilepsy Foundation of America in various urban and rural regions of the United States and also a private clinic. At the time of the study, all respondents were attending hospital outpatient neurological or epilepsy clinics for treatment, monitoring or advice. Life fulfillment was operationalized in terms of the discrepancy between people's desired and actual circumstances, and the scale developed for the research covered the following life domains: family and social relationships; leisure; worries; material security; employment. The findings revealed that the respondents were most fulfilled in the areas of family/social relationships, getting help with problems, leisure and housing. Health concerns seemed to be the prime source of non-fulfillment, with employment, marriage and money also appearing problematic. When factors associated with variations in overall life fulfillment were examined, unemployment, seizure predictability, polytherapy and living with a spouse/partner seemed to be of particular significance. The study findings are discussed and the need to pursue medical and vocational goals alongside each other in intervention strategies is emphasized.

Activities of Daily Living↗

PubMed1992

Finishing of amalgam restorations: a three-year clinical study.

Class I and Class II amalgam restorations were placed in the permanent teeth of 66 patients, each of whom received a minimum of three restorations. At least one of these restorations was carved-only, at least one was immediately finished (using a prophylaxis paste on rubber cups at low speed, 8 or 10 min after trituration), and at least one restoration was polished (using finishing burs and polishing points, more than 24 h after placement). The number of restorations available for assessment of marginal fracture using the 11-unit photographic scale developed by Mahler was 253 at baseline, 249 at 1-year and 2-year recalls and 228 at the 3-year recall. Although polished restorations exhibited greater initial (baseline) marginal fracture, at 1-year, 2-year and 3-year recalls the restorations were found to exhibit a similar amount of marginal fracture regardless of the finishing technique. The amount of perceived marginal fracture increased steadily after 1 year. The immediate finishing of amalgam restorations showed no long-term benefit over the other techniques and has little to commend it. The clinical finishing of amalgam restorations is discussed in the light of this and other research.

Adolescent↗

PubMedDate not supplied

Anticipatory pleasure deficit in subjects reporting physical anhedonia: slow cortical evidence.

Slow cortical and heart rate responses were recorded from anhedonic and normal control subjects during a two-stimulus anticipation paradigm. Subjects were chosen for participation in the experiment based on their scores on the Physical Anhedonia Scale developed by Chapman, Chapman and Raulin (1976). During the procedure, auditory warning stimuli were delivered which informed subjects that a visual stimulus (color slide) would follow shortly and specified the category of the slide (neutral or high-interest) which was to be presented. Results of this investigation revealed that anhedonic subjects showed less differential physiological responsivity while anticipating high and low interest stimuli than did normal controls. This was most striking in the slow cortical response (CNV) which appears particularly sensitive to such motivational and/or attentional manipulations. The data are discussed with respect to emotion and psychopathology.

Adult↗

PubMed1989

Perception of disability in chronic back pain patients: a long-term follow-up.

Long-term outcomes for 300 chronic back pain patients were assessed retrospectively by a telephone follow-up 4-6 years after the patients were evaluated by a multi-disciplinary rehabilitative program. A Perception of Disability scale, developed to rate subjective disability, was used along with objective measures of functioning. On objective measures, 56% of patients reported themselves working or work ready, 58% no longer received compensation, 62% were taking no prescription medications and 65% had no or brief medical treatment since evaluations. Perceived disability, however, suggested a bleaker outcome picture with only 29% of patients perceiving themselves as improving. There was a strong relationship between perceived disability and objective circumstances with 63% of the patients unable to work and 61% still on disability payments reporting their disability as increasing. Of the 48 patients reporting back surgery at some point after evaluation only 17% perceived themselves as improved while 58% considered themselves worse. These results are discussed in the context of the development of pain focussed lifestyles.

Adult↗

PubMed1994

Behavioural effects of intraplantar injection of inflammatory mediators in the rat.

The behavioural response to intraplantar injection of inflammatory mediators was examined using the rating scale developed to assess formalin-induced pain. Serotonin, bradykinin, prostaglandin E2, substance P and histamine induced dose-dependent favouring of the injected paw. Serotonin, bradykinin and prostaglandin E2 also induced transient dose-dependent paw elevation (lifting) and licking. Noradrenaline produced only a weak favouring response. Serotonin produced a synergistic increase in lifting and licking when combined with any of the other mediators, while all other combinations of agents taken two at a time showed additivity. There was apparent antagonism between some combinations in the favouring response; this may reflect overestimation of the baseline. The data indicate that (i) the overt spontaneous behaviour of rats can be used to evaluate spontaneous pain, (ii) the favouring response and the lifting and licking responses are qualitatively different, the former being similar to hyperalgesia and the latter possibility representing overt pain, (iii) hyperalgesia and overt pain are related, but the generation of overt pain involves specific mechanisms in addition to those required to induce hyperalgesia, and (iv) serotonin may function to enhance the pain-producing effects of inflammatory mediators, even when they lack intrinsic activity. The data show that some inflammatory mediators produce transient overt pain when high doses are injected into normal tissue in rats. Combination of inflammatory mediators with low doses of serotonin produced a synergistic increase in the pain response. The data suggest that serotonin released from platelets in injured tissue plays a central role in the pain associated with injury, and that serotonin antagonists may have promise as peripherally acting analgesics or analgesic adjuncts by blocking a synergistic process involved in algogenesis.

Animals↗

PubMed1984

The Master Questionnaire: preliminary report on an obesity assessment device.

Behavioral obesity researchers are increasingly concerned with thorough assessment of obesity. The present report describes the preliminary testing and refinement of the Master Questionnaire (MQ), a true-false scale developed expressly for use in obesity research. It was initially divided into four subscales: Spouse Support, Energy Balance Habits, Cognitive Factors, and Energy Balance Knowledge, and was intended for use as an outcome measure and as a predictor of change in obesity status. Its stability, internal consistency, sensitivity to treatment-related change, and predictive validity were examined. Test-retest reliability and sensitivity to treatment-related change were each found to be acceptable for three out of four subscales. Two subscales, Energy Balance Knowledge and Cognitive Factors, predicted outcome. The major weakness of the subscales was a lack of unidimensionality which would limit their utility. Cluster and factor analyses were used to develop five new subscales with acceptable levels of internal consistency. While some additional development and validation is still needed, the available evidence suggests that we have the nucleus of a strong assessment tool for obesity research.

Adult↗

PubMed1993

Unawareness of illness and neuropsychological performance in chronic schizophrenia.

This research attempts to explore empirically the relationship between lack of awareness of illness and neuropsychological performance in a group of chronic schizophrenic subjects. Thirty one chronic schizophrenics were administered the recently developed Scale to Assess Unawareness of Mental Disorder (SUMD) and 3 neuropsychological tests that have demonstrated ability to assess frontal lobe performance: the Wisconsin Card Sorting Test (WCST, Verbal Fluency Test and Trials A and B. The number of categories completed and the percent perseverative responses on the WCST were found to significantly correlate with lack of illness awareness as measured by the SUMD. These two WCST variables were also able to significantly discriminate between subjects of high versus low awareness. A discriminant function analysis found that a linear combination of WCST percent perseverative responses and symptom severity could successfully categorize 84% of the aware versus unaware subjects. These results are taken to support the hypothesis that at least in some of its manifestations lack of awareness among chronic schizophrenics has an organic etiology probably mediated by the frontal lobes.

Adult↗

PubMedDate not supplied

A survey of mentor relationships in academe.

The purpose of this study was to assess the frequency, characteristics, and importance of the mentor-protege relationship among 477 female nurse academicians. This descriptive study consisted of a self-administered questionnaire packet of a demographic data sheet and a modified format of five mentor scales developed by Gilbert (1985) and Pierce (1983). Findings indicated that a majority (60 per cent) of respondents had one or more mentors. This study profiled the mentor by addressing the following: mentor behaviors, characteristics of the mentor-protege relationships, power and achievement characteristics of the mentor, personal qualities of the mentor, and proteges' achievements. Mentor behaviors reported as occurring most frequently were: discussion of strategies to handle professional situations (49.1 per cent), observing the mentor in professional situations (44.9 per cent), and providing opportunities for participation in professional activities (40.9 per cent). Concerning characteristics of the mentor-protege relationship, it was important for mentors to value proteges as people (72.1 per cent), provide professional advice when needed (66.4 per cent), and believe in the potential of the protege (62.3 per cent). Power and achievement characteristics reported by the protege to be very important included mastery of concepts and ideas (55.2 per cent) and capacity to work hard (52.1 per cent). The personal qualities of the mentor of greatest importance to the proteges were integrity (81.3 per cent), professional values (72 per cent), and trustworthiness (74 per cent). The elements rated as very important in relation to the protege's achievement were gaining confidence (49.3 per cent), enjoying work (42.7 per cent), and resolving conflicts (37.5 per cent).

Adult↗