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A survey of wheelchair seating problems of the institutionalized elderly.

This study attempted to define and quantify the need for appropriate seating for elderly nursing home residents. A questionnaire was administered to 200 randomly selected nonambulatory elderly residents living in six Memphis area nursing homes. The study results supported previous findings that many nursing home residents have seating and mobility problems. Of the 139 wheelchair users analyzed, 112 (80%) experienced at least one problem related to discomfort, hindered mobility, or poor posture. Thirty-four percent of the residents had at least one problem considered to be severe. In most cases our respondents' seating and mobility problems could have been solved by the tailored application of presently available technologies.

Aged↗

Quality of life following repair of ruptured and elective abdominal aortic aneurysms.

OBJECTIVE: To find out whether patients undergoing repair of ruptured abdominal aortic aneurysms (AAA) had more emotional problems and limitations of lifestyle than those listed for elective resection. DESIGN: Retrospective study SETTING: Teaching hospital, Eire. SUBJETS: 28 patients, 14 in each group, matched for age, sex, duration of stay in the intensive care unit (ICU), hospital stay postoperatively, and length of time since operation. INTERVENTIONS: Application of structured questionnaire. MAIN OUTCOME MEASURES: Emotional problems, mobility, activities of daily living, ability to sleep, degree of psychological stress, presence of symptoms, and Rosser index to measure quality of life (QoL). RESULTS: There were no significant differences between the groups in any measure. CONCLUSIONS: Patients have few emotional difficulties or disturbances of QoL after emergency or elective repair of AAA. Survivors after repair of ruptured AAA can expect as good a quality of life as those operated on electively. These results support an aggressive approach to the treatment of ruptured AAA.

Aged↗

Applications of fluorinated compounds as phases and additives in chromatography and their uses in pharmaceutical analysis.

A review is presented of the use of fluorinated phases and fluorine-containing surfactants in chromatography. Additionally, new information is provided on the application of two nonionic perfluorosurfactants as reversed-phase mobile phase additives to enhance chromatographic performance of aromatic amines and some amines of pharmaceutical significance.

Chromatography↗

Computer simulation for the simultaneous optimization of any two variables and any chromatographic procedure.

Computer software that allows the simulation of any chromatographic separation as a function of simultaneous changes in any one or two variables that can affect sample separation order (selectivity) is described. For one example, an application is described for the simultaneous variation of the mobile phase pH and gradient time in reversed-phase liquid chromatography. The accuracy of such predictions is examined for a sample mixture of 17 substituted benzoic acids and anilines, and requirements for an acceptable predictive accuracy are summarized. In a second example, the separation of three peptides by capillary electrophoresis is optimized.

Benzoates↗

Light stimulation of cold acclimation: production of a translocatable promoter.

The light stimulation of cold acclimation of Hedera helix L. var. Thorndale has been shown to result in the production of translocatable promoters of hardiness. Movement of the promoters from an illuminated donor portion to a darkened receptor portion was demonstrated. The majority of transport was acropetal through the phloem and to a much lesser degree basipetal through the xylem. In the early stages of hardening, transport was strictly acropetal. It is suggested that acropetal transport is under the influence of a mobilizing center located in the apex of the plant. Mobilization of the promoters of hardiness was induced by applications of (6)N-benzyladenine. Attempts to characterize the light-generated promoters through fixation of (14)CO(2) and subsequent translocation of (14)C-labeled compounds from the illuminated donor to the darkened receptor indicated that the translocatable promoting material was either some component of the Dowex 1 fraction or sucrose. Furthermore, the hardiness of leaves was significantly increased by sucrose solutions but not by equi-molar solutions of glucose, galactose or mannitol.

Journal Article↗

Asynchronous BCI and local neural classifiers: an overview of the Adaptive Brain Interface project.

In this communication, we give an overview of our work on an asynchronous brain-computer interface (where the subject makes self-paced decisions on when to switch from one mental task to the next) that responds every 0.5 s. A local neural classifier tries to recognize three different mental tasks; it may also respond "unknown" for uncertain samples as the classifier has incorporated statistical rejection criteria. We report our experience with 15 subjects. We also briefly describe two brain-actuated applications we have developed: a virtual keyboard and a mobile robot (emulating a motorized wheelchair).

Adaptation, Physiological↗

Proton NMR studies of bovine serum albumin. Assignment of spin systems.

A variety of one- and two-dimensional 1H-NMR methods have been applied to the study of defatted 66.5-kDa bovine serum albumin in solution. 1. The majority of the protons gave rise to broad unresolved resonances and spectral enhancement methods for one-dimensional spectra were investigated in detail. A combination of exponential and sine-bell functions was particularly effective. 2. The presence of contaminating glycoproteins in some commercial samples of bovine serum albumin was readily detectable from their N-acetyl resonances at about 2.1 ppm. 3. The release of bound Cys (from mixed disulphide at Cys34) was observed after addition of dithiothreitol. 4. Through the use of two-dimensional shift-correlated spectroscopy, assignments of some 80 spin systems to amino acid type were made. 5. The pKa of the N-terminal Asp was measured as 7.8 (0.1 M phosphate buffer, 310 K). 6. 1H NMR spectra of bovine, human, porcine and rat serum albumins have been compared. Using sequence comparisons, specific assignments have been made for the N-terminal residues of bovine (Asp-Thr-His), human (Asp-Ala-His), porcine (Asp-Thr-Tyr) and rat (Glu-Ala-His) albumins, and for Thr189, Tyr155 and His59/377 of bovine albumin. 7. These NMR data suggest that certain local regions of bovine serum albumin are highly mobile yet structured in solution, and demonstrate that the application of both one- and and two-dimensional NMR methods will allow more detailed investigations of structural transitions in serum albumins induced by, for example, pH, drug and metal binding.

Amino Acid Sequence↗

Changes in polyurethane calcification due to antibiotics.

To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced calcification must be better understood. Calcification was examined on porous polyurethane incubated in metastable solutions of calcium phosphate, and the role of certain antibiotics in the medium was evaluated. It seems that certain aminoglycoside antibiotics can modify polyurethane surfaces and, subsequently, their mineralization process. In addition, these antibiotics may alter the calcium transport through polyurethanes. Therefore, it is conceivable that certain antibiotics can, in addition to producing their antibacterial effect, modulate surface calcium binding by changing the calcium mobilization and crystallization. Additional studies are needed to develop applications.

Aminoglycosides↗

Vasopressin-responsive adrenocortical tumor in a mild Cushing's syndrome: in vivo and in vitro studies.

We report a case of a Cushing's syndrome caused by an autonomously secreting unilateral adrenocortical tumor, characterized by a clinically and biologically mild hypercortisolemic state and an unusual response pattern to vasopressin. Laboratory tests showed normal early morning plasma cortisol and 24-h urinary cortisol excretion, but lack of nycthemeral variations and suppressed plasma ACTH. Urinary cortisol excretion was not suppressed by either the low dose or the high dose dexamethasone test. Injection of lysine vasopressin, (10 IU, im) induced a marked increase in plasma cortisol, without an elevation of plasma ACTH. Computed tomography scan revealed an adrenocortical mass of the left gland with a contralateral atrophic gland. Removal of the tumor led to complete remission of Cushing's symptoms. In vitro studies were then performed to investigate the effect of arginine vasopressin (AVP) on calcium mobilization in cultured tumor cells using a microfluorimetric technique. Application of AVP in the vicinity of the cells induced a rapid and marked increase in the intracellular calcium concentration. Preincubation of the cells with the V1 vasopressin receptor antagonist [d(CH2)5,Tyr(OMe)2]AVP totally suppressed the AVP-induced stimulation of intracellular calcium concentration. Reverse transcription followed by polymerase chain reaction of tumor ribonucleic acid with specific oligonucleotides amplified high levels of V1 receptor signal compared with normal adrenocortical ribonucleic acid. Specific oligonucleotides for the V2 or V3 receptors amplified only a faint signal. This is the first report describing a mild case of Cushing's syndrome caused by an AVP-sensitive cortisol-producing adenoma. The direct effect of AVP on cultured tumor cells was mediated through the V1 type of vasopressin receptor, similar to that previously characterized in normal human fasciculata cells, suggesting that the tumor expressed an eutopic V1 AVP receptor and exhibited overresponsiveness to AVP.

Adrenal Cortex Neoplasms↗

Forcing isolation: Medicare's "in the home" coverage standard for wheelchairs.

Older adults and people with physical disabilities can get Medicare coverage for mobility devices, like wheelchairs, walkers, and scooters, which are necessary for use in their homes. However they cannot get coverage for mobility devices that are solely for functioning outside their home. Since the institution of Medicare's coverage standards for mobility devices, and other kinds of durable medical equipment, nearly four decades ago, advances have been made in three critical areas: improvements in design of mobility devices that allow people to participate more fully in their communities; widespread societal recognition that with appropriate accommodations many limitations on functioning can and should be lifted; and recent court decisions requiring that individuals with disabilities be provided with the necessary supports to live as independently as possible in their communities. The current interpretation of Medicare's coverage standards for mobility devices does not reflect these advances. The Centers for Medicare and Medicaid Services' (CMS) interpretation of Medicare's coverage standard prevents people from getting needed medical equipment to function within their communities. By contemporary medical and legal standards, the [CMS's] interpretation is unreasonable and quite likely unlawful. The Medicare statute neither specifies that durable medical equipment is exclusively for use in the patient's home nor bars consideration of an equipment's use outside the home. There is no indication of Congressional intent to support this limitation of coverage. CMS has both the authority and the responsibility to interpret the Medicare statute so as to be consistent with historical developments in law, technology and social mores. United States Supreme Court precedent holds that agencies are "charged with the administration of [a] statute in light of everyday realities." Everyday realities have changed since Medicare was launched in 1965. Laws such as the Rehabilitation Act of 1973, the Americans with Disabilities Act of 1990 and the Ticket to Work and Work Improvements Incentives Act of 1999 reflect a broad, bipartisan commitment to increasing community integration of people with disabilities. This commitment is evident in judicial decisions, including Olmstead v. L.C. ex rel. Zimring, and executive orders, such as President George W. Bush's New Freedom Initiative, a set of proposals to promote opportunities for Americans with disabilities to learn and develop skills, engage in productive work, make choices about their daily lives, and participate fully in their communities. Developing political and legal standards are consistent with medical opinion: the costs of isolation for people with disabilities can include poorer health outcomes and higher systematic health costs. Also, scientific evidence indicates that people who get inappropriate mobility devices given their needs develop secondary medical conditions. In light of technological advances that today make appropriate equipment available and community integration possible, CMS has a responsibility to update its interpretation of the Medicare statute. While CMS must rightly be concerned with costs associated with a more modern interpretation of Medicare's coverage policy, other insurers have found that an appropriate standard has not led to an explosion in the provision of more expensive mobility devices. Specifically, the brief recommends that the Centers for Medicare and Medicaid Services: (1) correct its Medicare coverage policy to cover medically appropriate mobility devices that help maintain or improve functioning for people in the environments they are likely to encounter in their daily routines (both inside and outside of the home), and (2) guard against unnecessary expenses for Medicare by incorporating mandatory equipment evaluations to ensure that people receive equipment that matches their needs. While durable medical equipment encompasses a wide array of assistive devices, this brief will focus on wheeled mobility items, recognizing that this analysis will have varying applications to other durable medical equipment as well.

Home Care Services↗

New casting material and improved functional design for lower femoral fracture bracing.

A new water setting light plastic plaster material, Crystona, is presented and its plaster room characteristics compared with plaster of Paris. Plaster of Paris is considered better as the "acute fracture splinting material" in the Accident Service setting. Crystona, however, has considerable advantages as the "dynamic bracing material" in the post-acute fracture period and is demonstrated in the functional bracing of femoral shaft fractures. An improved functional cast brace design is presented, the "Knee Hinge Cylinder Brace" with a simple waist belt suspension to a hinged tube cast without the foot in the treatment of distal half femoral fractures. Using Crystona and the cylinder brace design, the cast weight has been reduced by half and the functional limb bracing improved with free mobilization of the knee, ankle and foot. The prescription, application technique and early clinical experiences are presented.

Acrylic Resins↗

Injuries to the subaxial cervical spine: posterior approach options.

In patients with cervical instability as the primary injury, either ligamentous or bony, a posterior approach and stabilization is the most likely definitive treatment. The goals should be to obtain and maintain satisfactory alignment, promote fusion, and allow safe and early mobilization. Many techniques that differ in safety, ease of application, cost, biomechanical strength, and postoperative requirements of immobilization are available. This article reviews different methods of posterior surgical interventions in subaxial cervical spine injuries and discusses the advantages and disadvantages of each.

Bone Screws↗

[Contribution of surgical techniques used in liver transplantation in the treatment of retroperitoneal tumors].

The authors describe the surgical technique used in liver transplantation and its application to treat retroperitoneal tumours. This technique comprises primary mobilization of the liver with easy vascular control. This technique, used in 29 patients, is simple, facilitates exposure of great vessels which can be controlled and allows excellent exposure in difficult cases. Analysis of the postoperative course emphasized the absence of hepatic and renal complications, as reflected by normal renal function and liver enzymes. The use of this technique for renal and adrenal surgery avoids the need for extracorporeal circulation and a thoracophrenoabdominal approach, thereby limiting the specific complications related to these two procedures.

Adolescent↗

Effects of different cervical traction weights on neck pain and mobility.

AIMS AND OBJECTIVES: This study investigated the effects of 3 different traction weights on neck pain and range of motion/mobility. MATERIALS AND METHODS: Ninety subjects, 42 men and 48 women, with neck pain due to cervical spondylosis participated in the study. They were assigned into three groups, each of which was subjected to a different cervical traction(CT) weight namely: group A = 7.5% total body weight(TBW), group B = 10%TBW, and group C =15%TBW CT respectively. Pain intensity and neck mobility, pre-treatment and post-treatment, were assessed using visual analogue scale(VAS) and universal goniometer respectively. RESULTS: There was no significant difference(p < 0.05) pre-treatment, but existed post-treatment (p < 0.05) between the groups for neck pain and mobility. Nineteen subjects had reactions due to the CT application: 3,5 and 11 in groups A,B and C respectively. The least reactions were recorded with the use of 7.5% TBW traction and the highest with the 15% TBW traction. The 10%TBW CT recorded the most significant pain relief and neck flexibility/mobility compared with the 7.5% TBW and 15% TBW CT therapy. CONCLUSION: This study established the 10% TBW CT as the ideal weight with minimal side effects and with highest therapeutic efficacy. Therefore clinicians could adopt this weight in managing neck disorders requiring traction.

Adult↗

Strength retention of chromic gut and monofilament synthetic absorbable suture materials in joint tissues.

The rate at which absorbable sutures lose their mechanical strength in vivo is particularly important in orthopedic applications where high physical loads, often increased by early mobilization, severely test the strength of sutures. The failure load and maximum tensile strength of chromic catgut and two monofilament absorbable synthetic suture materials (polydioxanone and polytrimethylene carbonate) were measured up to six weeks after implantation in sheep as: (1) a suture securing a synovial incision and (2) coils located either within the synovial cavity of the knee or intramuscularly. Although all synovial wounds healed satisfactorily, the performances of the different materials varied. The strength of chromic gut was largely lost within a week and fragmentation occurred at Week 4. The synthetic materials lost their strength relatively slowly. Polytrimethylene carbonate degraded in a linear manner, remaining intact but with little strength by Week 6. Polydioxanone, though losing strength at a slower rate, tended to fragment early, which may be of clinical importance in situations of delayed wound healing.

Animals↗

Cysteamine-induced duodenal ulcer is not site-specific: effect of local modulating factors.

In cysteamine-induced duodenal ulcer, an animal model for the clinical disease, lesions are characteristically produced on the anterior and posterior walls of the proximal duodenum. Using this model, we investigated factors that may affect duodenal ulcer localization and intensity. Mobilization of the gastroduodenum by severing its ligaments; circumscribed application of acetic acid to the serosa of the lateral wall of the duodenum; or placement of materials (e.g., gelfoam, parafilm) on the proximal duodenum, each decreased the intensity of anterior-posterior ulcers and resulted in formation of atypical, mostly distal duodenal ulcers. The effect of these manipulations on acid secretion suggests that their influence on the development of duodenal ulcer is not entirely due to modulation of gastric secretion. The data indicate that the localization of induced duodenal ulcer can be shifted distally and is therefore not site specific. This study provides new clues and techniques for the study of the pathogenesis of duodenal ulcer disease.

Acetates↗

Influence of the scholar.

Among the factors which will influence the emerging roles of medical libraries will be the changing needs of the medical scholars who use them. The effectiveness of the medical practitioner will be determined to an increasing extent by his capacity to mobilize information with a rapidity sufficient to permit its application in day-to-day decision-making. The practice of medicine is becoming an increasingly academic pursuit. The library and the librarian will, therefore, become more directly involved in the practice of medicine, and the library will be a more crucial resource in providing superior patient-care. Changes in undergraduate and continuing medical education will make new demands on the library. These and other related developments will create new functions, new problems, and new opportunities for the librarian.

Education, Medical↗

Open reduction of unstable thoracolumbar spinal injuries and fixation with Harrington rods.

The results of treatment of sixteen patients with unstable thoracolumbar spinal injuries are recorded. Early open reduction, stabilization with Harrington rods, spine fusion, application of a plaster jacket until consolidation, and early mobilization was the treatment. Distraction rods were used in twelve patients and compression rods, in four. Nine patients with incomplete paraplegia showed marked neurological recovery, while five with complete paraplegia regained only some sensation. Two patients had no neurological involvement. Solid fusion was achieved in fifteen patients after a minimum of three months of plaster-cast immobilization. In one patient stabilization failed. There was a loss of 5 degrees on average (range, 2 to 23 degrees) in the correction of the kyphosis. Lateral angulation after surgery did not occur. The treatment allowed easier postoperative nursing and early mobilization of the patient.

Adolescent↗