DEFECOGRAPHY OR ANORECTAL STUDIES IN CHILDREN INCLUDING CINEFLUOROGRAPHIC OBSERVATIONS.
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To reveal a major cause of postnatal lethality in F1 Dh/+ male mice from DDD x DH (Dh/+) mating, the current study was performed. Dh/+ males with retarded growth appeared within a few days after birth. The unusual junction between the rectum and the urinary bladder (rectovesical fistula) was found in nine of 22 Dh/+ male mice, and the bladder contained unusual substances derived from the intestines. When the fistula was recognized, the urine was always gelatinous, and the anus was imperforate in eight cases, suggesting that an affected individual would have trouble in urination and evacuation. From these observations we conclude that the rectovesical fistula is a major cause of postnatal death in the F1 Dh/+ male.
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A 10-day old male calf exhibited multiple congenital anomalies of the urinary and gastrointestinal tracts, including renal fusion (horseshoe kidney), ureteral fusion, rectovesicular fistula, and atresia ani. In horseshoe kidney, the organs were fused together at the caudal poles. The left kidney and cranial half of right kidney were shrunken, while the remaining lobules were hypertrophic. Ureters were fused cranially and bifurcated caudally. The terminal rectum was narrowed and connected with the bladder. The anus was imperforate. The cause of these anomalies could not be determined.
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