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At least 955 records · Page 53Linked to original sources
PubMed1989

[Diabetic osteopathies. 1. Etiologic factors and theoretical prerequisites for the development of bone demineralization in diabetics].

The causes of impaired calcium, phosphorus and vitamin D metabolism in diabetic patients which in the long run lead to demineralization of bone can be summarized into several main groups. Above all disorders of calcium absorption from the small intestine are involved, associated with impaired absorption of vitamin D and its reduced conversion into active metabolites in the liver and kidneys. An increased elimination of calcium from the organism may also play a part (hypercalciuria, excretion in the faeces and sweat), hormonal changes (secondary hyperparathyroidism) and finally changes in the metabolism of the organic bone constituent--osteoid. Subsequent work will deal with the prevalence of osseous changes in diabetics, early diagnosis and rational treatment and possible prevention of these changes.

Bone Diseases, Metabolic↗
PubMed1989

[Pachydermoperiostosis--development of bone changes 25 years after disease onset].

Pachydermoperiostosis-hyperostosis generalisata cum pachydermia is considered a sex-linked hereditary pathological disposition of the mesenchyme with a favourable course of the dominant form; it is, however, progressively malignant in the recessive type of heredity. As a rule men affected. The author describes the case of a patient where the disease was diagnosed 25 years previously.

Adult↗
PubMed1988

[Natural history and development of bone metastasis. Apropos of 429 cases].

The records of 429 patients seen at the Centre Alexis-Vautrin in 1979 and 1980 with bony metastases were retrospectively reviewed to assess their natural history and survival. Breast was the location of primary lesion in 140 patients (32.6%), lung in 95 patients (22.1%) and prostate in 33 patients (7.7%). The primary tumor was of unknown origin in 42 cases (10.9%). The median survival from time of diagnosis was 5 months. Two and 5-year survival rates were 17.5 and 5.1% respectively. According to the nature of the primary tumor, 2 and 5-year survival periods for bony metastases were 36.4 and 7.9% in breast cancer, 33.3 and 15.2% in prostatic cancer, 4.3 and 2.1% in metastases of unknown origin, 2.1 and 0% in pulmonary carcinoma. Multivariate analysis revealed four factors to be of prognostic significance for survival: the nature of the primary tumor, the absence of local relapse, the disease-free interval and the absence of metastases in other sites. Patients with hormone-sensitive lesions or slowly-growing tumors had a better prognosis.

Adolescent↗
PubMed1988

[New developments in bone density measurement by quantitative computer tomography].

The standard procedure in bone mineral measurements of the lumbar spine with QCT is presented in detail and analyzed with respect to the steps that may influence the accuracy and precision of the measurement. As new technical and methodological approaches, we present an improved implementation of dual energy CT and algorithms for automated determination of the CT slice and the evaluation region of interest. Dual energy methods provide greater accuracy; the automated algorithms relieve the operator of a tedious task and ensure greater precision. With respect to the clinical requirement to determine changes in bone mineral density as reliably and as early as possible, the precision increasing measures are considered more important. They also constitute a new methodological concept in radiology. Dual energy CT is only recommended for basic studies at this time.

Adult↗