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At least 955 records · Page 53Linked to original sources
PubMed2005

Cytotoxicity of a dentine bonding agent on four different cell-lines.

UNLABELLED: The aim of this study was to compare the cytotoxicity of a recently available dentine bonding agent on four different cell-lines (three human dental pulp fibroblast cell-lines and one mouse 3T3 fibroblast cell-line). METHODOLOGY: Three human dental pulp cell-lines from 3 different donors and one established 3T3 mouse cell-line were grown and sub-cultured. Cell viability following exposure to Scothbond was then compared to a similar number of controls using the MTT assay. RESULTS: Scotchbond 1 was cytotoxic to all four cell-lines. 3T3 cells showed a survival rate of about 60% as compared to two of the human dental pulp cells which showed a significantly lower survival rate (p<0.05, Kruskal-Wallis Multiple-Comparison Test). CONCLUSION: These findings indicated that is cytotoxic to both human pulp and 3T3 cell-lines. In general, the human pulp cell-lines showed higher sensitivity than the 3T3 cell-lines. CLINICAL SIGNIFICANCE: Scotchbond 1 cannot be recommended for direct pulp capping techniques and care should be taken when using this dentine bonding agent in cavities where the remaining dentine layer is minimal.

3T3 Cells↗
PubMed1995

Providing an environment for reparative dentine induction in amputated rat molar pulp by high molecular-weight hyaluronic acid.

To study provision of this environment, wound healing was examined by light and electron microscopy following pulp amputation and direct capping with hyaluronic acid. Molar pulps of female Sprague-Dawley rats were mechanically exposed and directly capped; the cavities were then restored with glass-ionomer cement. As an experimental control. Calvital (a commercial preparation of calcium hydroxide paste) was used as the direct pulp-capping agent in other rats, and its effect on pulp healing was compared with that of hyaluronic acid. In hyaluronic acid-treated pulps, at 2 days after amputation, wound surfaces were covered with blood and fibrin clots and inflammatory cells such as neutrophils and macrophages. At 1 week, differentiation of fibroblastic and odontoblast-like cells was observed beneath the wound layer; and odontoblast-like cells produced globular calcified nodules along the existing dentine walls. At 2 weeks, a layer of reparative dentine had been formed by odontoblast-like cells over the dentine walls. Between 30 and 60 days, the formation of reparative dentine had extended throughout the pulp chamber. The healing observed after direct capping with hyaluronic acid was, except for the formation of dentine bridges, similar to that seen after Calvital capping. These results suggest that high molecular-weight hyaluronic acid can provide an environment suitable for reparative dentine formation through mesenchymal cell differentiation during healing of the amputated dental pulp.

Animals↗
PubMed1989

pH values of pulp-capping agents.

Calcium hydroxide has been used extensively in dentistry. Few investigators have reported the pH values of pulp-capping agents containing calcium hydroxide. The purpose of this study was to evaluate pH levels of eight pulp capping agents containing calcium hydroxide. The results indicate that the pH values of five capping agents tested are neutralized by the dentin wall, but that three of these capping agents are not neutralized.

Animals↗
PubMed1999

Newly developed resinous direct pulp capping agent containing calcium hydroxide (MTYA1-Ca).

AIM: The aim of this study was to evaluate a newly developed resin (MTYA1-Ca) for direct pulp capping. METHODOLOGY: The powder of MTY1-Ca is composed of 89.0% microfiller, 10.0% calcium hydroxide and 1.0% benzoyl peroxide and was mixed with liquid (67.5% triethyleneglycol dimethacrylate, 30.0% glyceryl methacrylate, 1.0% o-methacryloyl tyrosine amide, 1.0% dimethylaminoethylmethacrylate, and 0.5% camphorquinone). The shear bond, diametral tensile, bending and compressive strengths were measured. The alkaline activity of the elute dissolved from MTYA1-Ca was calculated. Cell viability by MTT assay and alkaline phosphatase (ALPase) activity were evaluated from dental pulp fibroblast reaction to the eluate dissolved from MTYA1-Ca. Histopathological studies of the response to exposed dental pulp of beagle dogs were completed with Dycal as a control. RESULTS: The physical properties of MTYA1-Ca were significantly superior to those of Dycal. It was impossible to measure these properties with Dycal because of poor physical properties. Both MTYA1-Ca and Dycal maintained high levels of alkaline activity (pH 10.96-12.20) over the 168-h duration of the study. Cell viability by MTT assay in the intact eluate of MTYA1-Ca was significantly higher than that of Dycal, whilst ALPase showed no difference between MTYA1-Ca and Dycal. A dentine bridge formed more slowly under MTYA1-Ca than under Dycal, but similar amounts had formed at 90 days. CONCLUSIONS: MTYA1-Ca has the potential to be used as a direct pulp capping material.

Analysis of Variance↗
PubMed1990

[Experimental study of the effect of a photopolymerizable glass ionomer cavity liner on pulp pressure and temperature].

The biocompatibility of a light curing glass ionomer cement was studied for its pulpal effect when used as a capping agent in a dentin cavity. Pulpal pressure and temperature were recorded in 14 dog canines after placement of the glass ionomer cement. No increase was observed in 12 specimens on 14 samples. These results indicate that no pulpal effect can be demonstrated when using Vitrabond as a dentin capping agent.

Animals↗
PubMed1995

Histologic study of pulp capping using chlorhexidine in dogs.

This histological study was conducted to compare the pulp reactions to chlorhexidine and calcium hydroxide. Twenty permanent premolar teeth of beagle dogs were mechanically exposed under aseptic conditions. The pulp was then capped with one of the following: chlorhexidine 0.2% on the left side and calcium hydroxide (dycal) on the right side of the same dog. Maxillary second premolars were extracted from each dog three weeks after the pulp capping procedure. Maxillary third premolars and mandibular first premolars were extracted at 6 weeks and 9 weeks respectively. The mandibular second premolars were extracted three months after the pulp capping procedure. The specimens were fixed in 10% formalin and decalcified in 5% formic acid. Serial sections, 7 microns thick, were prepared and stained with hematoxylin and eosin. Teeth treated with chlorhexidine or with calcium hydroxide were well tolerated by the dental pulp at 3 and 6-week intervals. Pulps treated showed satisfactory pulp reaction and the odontoblastic layer appeared to be normal and in its configuration. Inflammatory response was not present at the 6-week time interval. At nine weeks, the inflammatory response was severe in those teeth treated with calcium hydroxide. There were no remarkable histological differences among the treatment groups at 12 and 15 weeks. These specimens showed complete loss of pulpal architecture. Regressive changes were seen and microscopic specimens revealed presence of spaces and intertwining bundles of films in the pulp.

Animals↗
PubMedDate not supplied

A comparison of two calcium hydroxide agents in direct pulp capping of primary teeth.

Twenty-two pairs of bilateral primary canines, indicated for extraction due to excessive crowding, were chosen to study pulpal response to direct pulp capping with two calcium hydroxide medicaments (Life and Dycal). Following mechanical exposure of the pulp and direct pulp capping with calcium hydroxide, the teeth were extracted after either seven or sixty-three days to determine both the immediate and long-term pulpal response to the medicaments. The results indicate no statistical difference between the two materials in terms of biological response. Favorable results as to degree of pulpal inflammation and matrix formation indicate direct pulp capping using calcium hydroxide in primary teeth with no pulpal inflammation may be a viable procedure.

Calcium Hydroxide↗
PubMed2006

Formation of a hard tissue barrier after pulp cappings in humans. A systematic review.

AIM: To evaluate the evidence on the formation of a hard tissue barrier after pulp capping in humans. METHODOLOGY: A PubMed and CENTRAL literature search with specific indexing terms and a hand search were made. The authors assessed the level of evidence of each publication as high, moderate or low. Based on this, the evidence grade of the conclusions was rated as strong, moderately strong, limited or insufficient. RESULTS: The initial search process resulted in a total of 171 publications. After reading the abstracts and hand searching the reference lists of the retrieved publications, 107 studies were retrieved in full-text and interpreted. After the interpretation, 21 studies remained and were included in the systematic review and given a level of evidence. No study had a high level of evidence, one study had moderate and 20 studies had a low level of evidence. There was heterogeneity between the studies; therefore, no meta-analysis was performed. The majority of studies on pulp capping using calcium hydroxide based materials reported formation of hard tissue bridging, studies on other pulp capping materials such as bonding agents presented inferior results. The evidence grade was insufficient. CONCLUSIONS: Insufficient evidence grade does not necessarily imply that there is no effect of a pulp capping procedure or that it should not be used. Rather, the insufficient evidence underpins the need for high-quality studies.

Calcium Hydroxide↗
PubMed1991

Pulp capping of immature teeth with anatomic anomalies.

This case report describes the treatment of two immature teeth with anatomic anomalies which created plaque retentive areas and in one case occlusal disturbance. Periodontal and pulpal consequences were inevitable. Reshaping of the teeth was carried out which as expected led to exposure of the pulp in both instances. Pulp capping was then performed under aseptic conditions. The vitality of the teeth was maintained and continued root development was observed.

Adolescent↗