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At least 955 records · Page 53Linked to original sources
PubMed2000

On pins and needles? Pediatric pain patients' experience with acupuncture.

INTRODUCTION: Despite its increasing use as a complementary therapy to treat pain, acupuncture is rarely considered by pediatricians, in part due to perceptions that it will not be acceptable to pediatric patients. We wished to describe pediatric pain patients' experience with acupuncture treatment for chronic pain. DESIGN: Retrospective case series. METHODS: Subjects were pediatric pain patients referred by the Pain Treatment Service at Children's Hospital in Boston, who went to a pediatric acupuncturist. A research assistant not involved in the patient's care conducted the survey by telephone. Data were analyzed qualitatively and descriptively. RESULTS: Of 50 eligible patients, 47 families were reached by telephone; all agreed to be interviewed. Patients had a median age of 16 years at the time of referral, 79% were female, and 96% were white. The most common three diagnoses were migraine headache (n = 7), endometriosis (n = 6), and reflex sympathetic dystrophy (n = 5). Patients had a median of 8 treatments (range: 0-60) within 3 months (range: 0-48 months); 85% of families paid out-of-pocket. Acupuncture therapies included needle insertion (98%), heat/moxa (85%), magnets (26%), and cupping (26%). Most patients and parents rated the therapy as pleasant (67% children/60% parents), and most (70% children/59% parents) felt the treatment had helped their symptoms; only 1 said that treatment made symptoms worse. CONCLUSION: Pediatric patients with chronic, severe pain found acupuncture treatment pleasant and helpful. Additional, prospective studies are needed to quantify the costs and effectiveness of acupuncture treatment for pediatric pain.

Acupuncture Therapy↗
PubMed2003

Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.

Mirror-image allodynia is a mysterious phenomenon that occurs in association with many clinical pain syndromes. Allodynia refers to pain in response to light touch/pressure stimuli, which normally are perceived as innocuous. Mirror-image allodynia arises from the healthy body region contralateral to the actual site of trauma/inflammation. Virtually nothing is known about the mechanisms underlying such pain. A recently developed animal model of inflammatory neuropathy reliably produces mirror-image allodynia, thus allowing this pain phenomenon to be analyzed. In this sciatic inflammatory neuropathy (SIN) model, decreased response threshold to tactile stimuli (mechanical allodynia) develops in rats after microinjection of immune activators around one healthy sciatic nerve at mid-thigh level. Low level immune activation produces unilateral allodynia ipsilateral to the site of sciatic inflammation; more intense immune activation produces bilateral (ipsilateral + mirror image) allodynia. The present studies demonstrate that both ipsilateral and mirror-image SIN-induced allodynias are (1) reversed by intrathecal (peri-spinal) delivery of fluorocitrate, a glial metabolic inhibitor; (2) prevented and reversed by intrathecal CNI-1493, an inhibitor of p38 mitogen-activated kinases implicated in proinflammatory cytokine production and signaling; and (3) prevented or reversed by intrathecal proinflammatory cytokine antagonists specific for interleukin-1, tumor necrosis factor, or interleukin-6. Reversal of ipsilateral and mirror-image allodynias was rapid and complete even when SIN was maintained constantly for 2 weeks before proinflammatory cytokine antagonist administration. These results provide the first evidence that ipsilateral and mirror-image inflammatory neuropathy pain are created both acutely and chronically through glial and proinflammatory cytokine actions.

Aconitate Hydratase↗
PubMed1980

[Experiences on stereotaxic hypophysectomy for recurrent breast carcinoma; with particular reference to its pain relief (author's transl)].

Stereotaxic hypophysectomy was performed in nine patients with advanced breast carcinoma. Only one patient showed an objective remission in the form of decreased size of the chest wall ulcer after the operation. However, all but one patient did get relief of pain lasting for months. In one of these cases, where hypophyseal ablation was carried out under local anesthesia, pain relief was ascertained immediately after the ablation, i.e., during the operation. Such an instantaneous pain relief, which to the author's knowledge has never been described elsewhere, was considered to be the result of an influence on the hypothalamus rather than the pituitary itself. Mechanism of lasting pain relief was ascribed to endorphins which have recently attracted attention as endogenous peptides with opiate-like activities. Pituitary ablation of the present authors were noted to be incomplete either seen from hormonal assessment or from morphological evaluation. It was stressed that significant pain relief could be gained by the apparently incomplete hypophyseal ablation, whereas complete destruction does not necessarily guarantee a hundred percent relief of pain. A deduction was made that although endorphins may play an important role in alleviating pain, integrity of its productive system and/or its receptors could also be important as well. Stereotaxic hypophyseal ablation might be the procedure of choice in certain patients with advanced breast carcinoma suffering from excruciating pain.

Breast Neoplasms↗