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PubMed1990

The effect of stannous and sodium fluoride on coronal caries, root caries and bone loss in rice rats.

Sixty rice rats (Oryzomys palustris) were divided by littermate into 3 groups of 20 each. The 3 groups received either SnF2 (1000 parts/10(6) F), NaF (1000 parts/10(6] or double-distilled water (control). Test solutions were topically applied to molar teeth, twice daily, for 7 days. All rats were also provided with double-distilled drinking water and diet 2000 ad libitum. Experiments ended after 9 weeks. Alveolar bone loss, root and coronal caries were recorded and scored. SnF2 significantly reduced bone loss (p less than 0.05), but NaF did not. Root caries was significantly different in all 3 groups (p less than 0.05). SnF2 and NaF both reduced coronal caries significantly (p less than 0.05) in comparison to the control. However, the fluoride groups were not significantly different from each other. SnF2 may influence root caries via remineralization and an antimicrobial effect of the stannous ion.

Animals↗
PubMed1984

Mineral flux of surface enamel and root surfaces in acidified gelatin gels.

Gels of crude gelatin were dialyzed to eliminate fluoride, and then acidified with 75 mM lactic and 25 mM acetic acid at pH 4.2 and interfaced with enamel and root surfaces in gel-surface ratio of 0.2 ml/0.15 cm2. Enamel and root surface to gel mineral flux was reduced by initial inclusion of 0.5 and 1.0 mM fluoride with 2.5 mM calcium and 1.5 mM phosphate in gels at pH 4.2. Inclusion of 0.25 mM fluoride in the gels without added mineral ions had no effect in the first 22-day interface. The 0.25, 0.5 and 1.0 mM fluoride remarkably increased remineralization in a second 12-day interface. This indicated that the first fluoride exposure initiated formation of fluorapatites in the enamel which required a lower degree of gel saturation for enhanced remineralization in the second acid exposure. Fluoride had the same effect, but greater effectiveness on enamel than root-surface remineralization. Gels of crude gelatin may contain sufficient mineral ions to alter remineralization-demineralization of enamel and root surface.

Acetates↗
PubMed1987

The ultrastructure of human dental enamel heat-treated in the temperature range 200 degrees C to 600 degrees C.

Heating enamel in the temperature range 200 degrees C to 600 degrees C resulted in poor crystal packing due to void formation, permanent change in the sign of its birefringence (from negative to positive) in some areas, and an altered crystal morphology. Transmission electron microscopy of enamel heated in the temperature range 200 degrees C to 400 degrees C revealed that the distinction between the positively birefringent regions and the negatively birefringent regions (which were present up to 350 degrees C and occasionally up to 400 degrees C) at the tooth's surface was due to the greater volume of intra- and inter-crystalline voids within the positively birefringent regions. There was a significant increase in void volume at 400 degrees C, and above this all of the enamel was positively birefringent and opaque. Large remineralized crystals of beta-tricalcium phosphate (beta-TCP) phase (whitlockite) were initially formed at 400 degrees C, and their size and number increased at 500 degrees C and above. Both the greater solubility of beta-TCP crystals and the increased surface area due to the presence of voids would increase the rate of demineralization of heat-treated enamel.

Crystallography↗
PubMed1986

Superficial fluoride levels and response to in-vitro caries-like lesion induction of enamel from Bristol (U.K.) and Birmingham (U.K.) human deciduous teeth.

Surface enamel fluoride levels were measured in deciduous canine teeth from Bristol, with non-fluoridated water supplies, and Birmingham, with fluoridated water supplies. Three populations studied were from Bristol (teeth shed before 1960), Bristol (after 1975) and Birmingham (after 1975). Up to 75 micron from the enamel surface, fluoride concentrations of post-1975 Bristol and Birmingham teeth were, respectively, X 1.3 and 3.4 greater than those of pre-1960 Bristol teeth. The increase in the Bristol teeth is presumably due mainly to the increased use of fluoride-containing toothpastes, that in Birmingham to fluoridated water plus the use of fluoride toothpastes. No difference in the rates of penetration into enamel of acid-gel induced, caries-like lesions were found between the two Bristol populations; Birmingham teeth showed a reduction of 10 per cent in penetration rate. It is suggested that raised fluoride levels in surface enamel do not reduce solubility sufficiently to account, by themselves, for the recent nationwide marked reduction in caries in children. Possibly, the raising of plaque fluoride levels is a more important factor, affecting demineralization, remineralization and bacterial activity.

Acid Etching, Dental↗
PubMed1984

Microradiography of in vivo remineralized lesions in human enamel. II.

The purpose of this work was to investigate mineral deposition and redistribution in subsurface human artificial enamel lesions during in vivo remineralization period of 3 months. The enamel lesions were placed in lower prostheses of 30 patients, divided in 3 groups. Group A brushed daily with H2O; group B brushed with H2O and rinsed with a neutral 50 ppm F solution and group C brushed with a neutral 1500 ppm F toothpaste. The technique employed was microradiography. Initially the average vol % of mineral in the lesion body was 47%. After 3 months remineralization in vivo the vol % of mineral in the lesion body was for group A, B and C: 50.7, 48.7 and 53.1 vol %, respectively. The average lesion depth decreased for groups A, B and C 18, 13 and 25 microns respectively over 3 months. The original lesion depth was +/- 100 microns. The microradiographic data show conclusively that mineral is deposited "de novo" inside subsurface lesions. The remineralization percentages are for the control, rinse and brush group 20%, 15% and 31%, respectively.

Dental Caries↗
PubMed1993

The functional equivalence of demineralized bone and tooth matrices in ectopic bone induction.

The objective of this study was to determine whether demineralized rat incisor matrices were a more potent inducer of ectopic endochondral bone formation than demineralized diaphyseal bone matrices derived from the same donors. Twenty-five-milligram disks of demineralized bone or tooth matrix obtained from adolescent Long-Evans rats were implanted in a standardized ectopic site. Biochemical and histometric measurements of bone formation revealed that the two matrices were functionally equivalent inducers of endochondral bone formation. The induced pellicle of bone reached a maturation point 18 days after implantation. Dentin matrix implants generated a significantly greater amount of mineralized tissue than did bone matrix implants. This difference could be explained on the basis of remineralization of the dentin particles to a greater degree than the bone matrix particles. Initial observations suggesting a more robust osteoinductive activity in demineralized incisor matrix can be attributed to the decreasing activity of bone matrix from older donors when compared to younger donors. The extent of osteoinduction by the two substrata was equivalent when the matrices were matched for age.

Acid Phosphatase↗
PubMed2003

Fluoride-releasing restorative materials and secondary caries.

Secondary caries is responsible for 60 percent of all replacement restorations in the typical dental practice. Risk factors for secondary caries are similar to those for primary caries development. Unfortunately, it is not possible to accurately predict which patients are at risk for restoration failure. During the past several decades, fluoride-releasing dental materials have become a part of the dentist's armamentarium. Considerable fluoride is released during the setting reaction and for periods up to eight years following restoration placement. This released fluoride is readily taken up by the cavosurface tooth structure, as well as the enamel and root surfaces adjacent to the restoration. Resistance against caries along the cavosurface and the adjacent smooth surface has been shown in both in vitro and in vivo studies. Fluoride-releasing dental materials provide for improved resistance against primary and secondary caries in coronal and root surfaces. Plaque and salivary fluoride levels are elevated to a level that facilitates remineralization. In addition, the fluoride released to dental plaque adversely affects the growth of lactobacilli and mutans streptococci by interference with bacterial enzyme systems. Fluoride recharging of these dental materials is readily achieved with fluoridated toothpastes, fluoride mouthrinses, and other sources of topical fluoride. This allows fluoride-releasing dental materials to act as intraoral fluoride reservoirs. The improvement in the properties of dental materials with the ability to release fluoride has improved dramatically in the past decade, and it is anticipated that in the near future the vast majority of restorative procedures will employ fluoride-releasing dental materials as bonding agents, cavity liners, luting agents, adhesives for orthodontic brackets, and definitive restoratives.

Adolescent↗
PubMed2000

The science and practice of caries prevention.

BACKGROUND AND OVERVIEW: Dental caries is a bacterially based disease. When it progresses, acid produced by bacterial action on dietary fermentable carbohydrates diffuses into the tooth and dissolves the carbonated hydroxyapatite mineral--a process called demineralization. Pathological factors including acidogenic bacteria (mutans streptococci and lactobacilli), salivary dysfunction, and dietary carbohydrates are related to caries progression. Protective factors--which include salivary calcium, phosphate and proteins, salivary flow, fluoride in saliva, and antibacterial components or agents--can balance, prevent or reverse dental caries. CONCLUSIONS: Caries progression or reversal is determined by the balance between protective and pathological factors. Fluoride, the key agent in battling caries, works primarily via topical mechanisms: inhibition of demineralization, enhancement of remineralization and inhibition of bacterial enzymes. CLINICAL IMPLICATIONS: Fluoride in drinking water and in fluoride-containing products reduces caries via these topical mechanisms. Antibacterial therapy must be used to combat a high bacterial challenge. For practical caries management and prevention or reversal of dental caries, the sum of the preventive factors must outweigh the pathological factors.

Adolescent↗
PubMed1981

In vitro studies on susceptibility of enamel to caries attack after orthodontic bonding procedures.

Oral hygiene plays an important role in the prevention of caries. Therefore, when one is investigating the possible effects of acid etching on caries susceptibility, oral hygiene aspects and the supplementation of fluoride have to be considered. The objective of this investigation was to study the caries susceptibility of etched enamel surfaces in vitro. To simulate the in vivo situation, much attention was given to the influence of remineralization of saliva and fluorides. It was shown that etching and subsequently fluoridating and remineralization increases resistance of enamel against a caries attack.

Acid Etching, Dental↗
PubMed2004

NMR studies of a novel calcium, phosphate and fluoride delivery vehicle-alpha(S1)-casein(59-79) by stabilized amorphous calcium fluoride phosphate nanocomplexes.

The repair of early tooth enamel lesions has been recently demonstrated by tryptic phosphopeptides derived from milk caseins that associate with amorphous calcium phosphate (ACP) forming stable complexes. These casein phosphopeptides (CPP), containing the cluster sequence-Ser(P)-Ser(P)-Ser(P)-Glu-Glu-, form calcium phosphate delivery vehicles that retard enamel demineralization and promote remineralization. Recently, we have shown that these peptides also stabilize calcium fluoride phosphate as soluble complexes. These complexes designated CPP-ACFP, have the potential to provide superior clinical efficacy in preventing dental caries and treating and repairing early stages of disease. In an approach to determine the ultrastructure of the casein phosphopeptide-amorphous calcium fluoride phosphate complexes, we have studied the structure of the predominant peptide alpha(S1)-CN(59-79) bound to ACFP using nuclear magnetic resonance (NMR) spectroscopy and X-ray diffraction. The alpha(S1)-CN(59-79) peptide stabilized calcium fluoride phosphate as amorphous nanocomplexes with a hydrodynamic radius of 2.12+/-0.26 nm. The nanocomplexes exhibited stoichiometry of one peptide to 15 calcium, nine phosphate and three fluoride ions. Sequence-specific resonance assignments were determined for the peptide alpha(S1)-CN(59-79) complexed to the ACFP. The secondary structure of the peptide alpha(S1)-CN(59-79) was characterized by sequential (i, i+1), medium-range (i, i+2) nOes and H alpha chemical shifts. The spectral data were compared with that of the peptide alpha(S1)-CN(59-79) bound to calcium ions, revealing that the structurally significant secondary NH and alpha-chemical shifts were similar.

Amino Acid Motifs↗
PubMedDate not supplied

Early detection of secondary caries using quantitative, light-induced fluorescence.

The authors hypothesize that the arrestment and remineralization of these lesions could be improved if secondary caries could be detected and monitored at earlier stages. Traditional diagnostic techniques detect secondary caries when it is relatively advanced and when significant tissue has been lost. This in vitro study evaluated the Quantitative Light-induced Fluorescence (QLF) system for detecting and monitoring demineralization surrounding tooth-colored restorations. This investigation was divided into three studies. The first study evaluated QLF for the detection and measurement of chemically induced lesions surrounding resin composite restorations. The second study evaluated QLF for the detection of demineralization around different tooth-colored restorations (glass ionomer, resin composite, compomer and smart material) created in a microbial caries model. Finally, the third study tested whether QLF was effective at detecting early wall lesions adjacent to resin composite restorations. Data from Study 1 demonstrated the potential for QLF to detect very early secondary caries and to distinguish between the different stages of early demineralization. Study 2 confirmed the potential for QLF to detect early secondary caries created by cariogenic bacteria and concluded that the four types of materials differed in their ability to prevent secondary caries in this model, with the glass ionomer being the most effective and the non-fluoride releasing composite performing the worst, which allowed for the development of larger lesions. The results of Study 3 suggest a potential application of the QLF system to detect early wall lesions. Data from this investigation strongly suggest that QLF is a potentially viable technology to detect and monitor early secondary caries.

Analysis of Variance↗