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At least 973 records · Page 54Linked to original sources

PubMed2004

Antibodies specific for hypervariable regions 3 to 5 of the feline immunodeficiency virus envelope glycoprotein are not solely responsible for vaccine-induced acceleration of challenge infection in cats.

In a previous vaccination study in cats, the authors reported on accelerated feline immunodeficiency virus (FIV) replication upon challenge in animals vaccinated with a candidate envelope subunit vaccine. Plasma transfer studies as well as antibody profiles in vaccinated cats indicated a causative role for antibodies directed against the hypervariable regions HV3, HV4 and HV5 (HV3-5) of the envelope glycoprotein. The present study was designed to investigate further the contribution of antibodies in envelope vaccine-induced acceleration of FIV infection. To this end, regions HV3-5 of the envelope glycoprotein were deleted from the original vaccine, thus addressing the contributing role of antibodies directed against these hypervariable regions. Interestingly, this approach did not prevent acceleration of challenge infection. Analysis of the antibody responses in the respective groups suggested that removal of HV3-5 redirected the humoral immune response towards other regions of the envelope glycoprotein, indicating that these regions can also induce antibodies that accelerate virus replication.

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PubMed1999

Vacuum electron acceleration by coherent dipole radiation.

The validity of the concept of laser-driven vacuum acceleration has been questioned, based on an extrapolation of the well-known Lawson-Woodward theorem, which stipulates that plane electromagnetic waves cannot accelerate charged particles in vacuum. To formally demonstrate that electrons can indeed be accelerated in vacuum by focusing or diffracting electromagnetic waves, the interaction between a point charge and coherent dipole radiation is studied in detail. The corresponding four-potential exactly satisfies both Maxwell's equations and the Lorentz gauge condition everywhere, and is analytically tractable. It is found that in the far-field region, where the field distribution closely approximates that of a plane wave, we recover the Lawson-Woodward result, while net acceleration is obtained in the near-field region. The scaling of the energy gain with wave-front curvature and wave amplitude is studied systematically.

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PubMed2000

Simulations of a meter-long plasma wakefield accelerator.

Full-scale particle-in-cell simulations of a meter-long plasma wakefield accelerator (PWFA) are presented in two dimensions. The results support the design of a current PWFA experiment in the nonlinear blowout regime where analytic solutions are intractable. A relativistic electron bunch excites a plasma wake that accelerates trailing particles at rates of several hundred MeV/m. A comparison is made of various simulation codes, and a parallel object-oriented code OSIRIS is used to model a full meter of acceleration. Excellent agreement is obtained between the simulations and analytic expressions for the transverse betatron oscillations of the beam. The simulations are used to develop scaling laws for designing future multi-GeV accelerator experiments.

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PubMed2000

Laser-driven electron cyclotron autoresonance accelerator with production of an optically chopped electron beam.

Analysis is presented of the gyroresonant acceleration of electrons in a vacuum using a focused laser. Continuous and equal acceleration is shown for electrons injected at all optical phases over an interaction length of tens of centimeters. Beam stalling is avoided as beam energy increases. Acceleration from 50 to 178 MeV is predicted for a 4 TW, 10.6-microm laser focused to a waist radius of 1.0 mm; these parameters correspond to a planned experiment. A beam stop with an off-axis hole after acceleration is shown to create a train of optically chopped bunches with 3-fs bunch lengths and a 35-fs period.

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PubMed2001

Approaching classicality in quantum accelerator modes through decoherence.

We describe measurements of the mean energy of an ensemble of laser-cooled atoms in an atom optical system in which the cold atoms, falling freely under gravity, receive approximate delta-kicks from a pulsed standing wave of laser light. We call this system a "delta-kicked accelerator." Additionally, we can counteract the effect of gravity by appropriate shifting of the position of the standing wave, which restores the dynamics of the standard delta-kicked rotor. The presence of gravity (delta-kicked accelerator) yields quantum phenomena, quantum accelerator modes, which are markedly different from those in the case for which gravity is absent (delta-kicked rotor). Quantum accelerator modes result in a much higher rate of increase in the mean energy of the system than is found in its classical analog. When gravity is counteracted, the system exhibits the suppression of the momentum diffusion characteristic of dynamical localization. The effect of noise is examined and a comparison is made with simulations of both quantum-mechanical and classical versions of the system. We find that the introduction of noise results in the restoration of several signatures of classical behavior, although significant quantum features remain.

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PubMed2001

Fourier acceleration of Langevin molecular dynamics.

Fourier acceleration has been successfully applied to the simulation of lattice field theories for more than a decade. In this paper, we extend the method to the dynamics of discrete particles moving in a continuum. Although our method is based on a mapping of the particles' dynamics to a regular grid so that discrete Fourier transforms may be taken, it should be emphasized that the introduction of the grid is a purely algorithmic device and that no smoothing, coarse-graining, or mean-field approximations are made. The method thus can be applied to the equations of motion of molecular dynamics (MD) or its Langevin or Brownian variants. For example, in Langevin MD simulations our acceleration technique permits a straightforward spectral decomposition of forces so that the long-wavelength modes are integrated with a longer time step, thereby reducing the time required to reach equilibrium or to decorrelate the system in equilibrium. Speedup factors of up to 30 are observed relative to pure (unaccelerated) Langevin MD. As with acceleration of critical lattice models, even further gains relative to the unaccelerated method are expected for larger systems. Preliminary results for Fourier-accelerated molecular dynamics are presented in order to illustrate the basic concepts. Possible extensions of the method and further lines of research are discussed.

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PubMed2002

Quantum localization for a kicked rotor with accelerator mode islands.

Dynamical localization of classical superdiffusion for the quantum kicked rotor is studied in the semiclassical limit. Both classical and quantum dynamics of the system become more complicated under the conditions of mixed phase space with accelerator mode islands. Recently, long time quantum flights due to the accelerator mode islands have been found. By exploration of their dynamics, it is shown here that the classical-quantum duality of the flights leads to their localization. The classical mechanism of superdiffusion is due to accelerator mode dynamics, while quantum tunneling suppresses the superdiffusion and leads to localization of the wave function. Coupling of the regular type dynamics inside the accelerator mode island structures to dynamics in the chaotic sea proves increasing the localization length. A numerical procedure and an analytical method are developed to obtain an estimate of the localization length which, as it is shown, has exponentially large scaling with the dimensionless Planck's constant (tilde)h<<1 in the semiclassical limit. Conditions for the validity of the developed method are specified.

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PubMed2002

Improvements on the application of convergence accelerators for the evaluation of some three-electron atomic integrals.

Convergence accelerator methods are employed to analyze some of the most difficult three-electron integrals that arise in atomic calculations. These integrals have an explicit dependence on the interelectronic coordinates, and take the form integral r(i)(1)r(j)(2)r(k)(3)r(l)(23)r(m)(31)r(n)(12) exp((-alpha(r1)-beta(r2)-gamma(r3))dr(1)dr(2)dr(3). The focus of the present investigation are the most difficult cases of the parameter set [i, j, k, l, m, n]. Several convergence accelerator techniques are studied, and a comparison presenting the relative effectiveness of each technique is reported. When the convergence accelerator approach is combined with specialized numerical quadrature methods, we find that the overall technique yields high-precision results and is fairly efficient in terms of computational resources. Difficulties associated with the standard numerical precision loss of convergence accelerator techniques are circumvented.

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PubMed2002

Acceleration element for femtosecond electron pulse compression.

An acceleration element is proposed for compressing the electron pulse duration in a femtosecond photoelectron gun. The element is a compact metal cavity with curved-shaped walls. An external voltage is applied to the cavity where a special electric field forms in such a way that the slow electrons in the electron pulse front are accelerated more than the fast electrons, and consequently the electron pulse duration will be compressed. The distribution of the electric field inside the acceleration cavity is analyzed for the geometry of the cavity. The electron dynamics in this acceleration cavity is also investigated numerically. Numerical results show that the electron pulse front and pulse duration can be improved by compensating for the effects of space charge and the initial energy spread of photoelectrons with a Lambertian angular distribution. Depending on the design parameters and the shape of the electron pulse, for a femtosecond electron gun with an electron energy of 30 keV, 10(3) electrons per pulse, and an electron drift length of 40 cm, the electron pulse duration can be reduced from 550 to 200 fs when using a compensating cavity with an average radius of 1.7 and 5.6 cm in length. Electron pulses shorter than 200 fs can be achieved if the length of the drift region is reduced.

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PubMed2002

Trapping, compression, and acceleration of an electron bunch in the nonlinear laser wakefield.

A scheme of laser wakefield acceleration, when a relatively rare and long bunch of nonrelativistic or weakly relativistic electrons is initially in front of the laser pulse, is suggested and considered. The motion of test electrons is studied both in the one-dimensional (1D) case (1D wakefield) and in the case of three-dimensional laser wakefield excited in a plasma channel. It is shown that for definite parameters of the problem the bunch can be trapped, effectively compressed both in longitudinal and transverse directions, and accelerated to ultra-relativistic energies in the region of first accelerating maximum of the wakefield. The accelerated bunch has sizes much less than the plasma wavelength and relatively small energy spread.

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PubMed2003

Origin of protons accelerated by an intense laser and the dependence of their energy on the plasma density.

We study the high-energy (1-4 MeV) proton production from a slab plasma irradiated by a ultrashort high-power laser. In our 2.5-dimensional particle-in-cell simulations, a p-polarized laser beam of 1.6 x 10(19) W/cm(2), 300 fs, lambda(L)=1.053 microm, illuminates a slab plasma normally; the slab plasma consists of a hydrogen plasma, and the target plasma thickness and the laser spot size are 2.5lambda(L) and 5lambda(L), respectively. The simulation results show that an emitted proton energy depends on the slab plasma density, and three kinds of high-energy proton beams are generated at the target plasma surfaces: one kind of the proton beams is produced at the laser-illuminated target surface and accelerated to the same laser-incident side. The second is generated at the target surface opposite to the laser-illuminated target surface and is accelerated outward on the same side. The third is generated at the laser-illuminated target surface and accelerated to the opposite side while passing through the target plasma. The simulations also show a mechanism of proton accelerations. In an overdense plasma, laser energy goes to energies of hot electrons and magnetic fields in part; the electrons oscillate around the slab plasma so that a static electric field is generated and consequently protons are extracted. The magnetic field generated in the slab plasma exists longer and heats up the plasma electrons to sustain the static electric field even after the laser termination.

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PubMed2003

Direct electron acceleration by stochastic laser fields in the presence of self-generated magnetic fields.

A simple direct acceleration model is proposed, taking into account the stochastic phase disturbance of the coherent driving laser fields. A relativistic single particle simulation shows that plasma electrons are efficiently accelerated far above the ponderomotive energy. The energy and momentum distributions of the accelerated electrons are derived to examine the effects of the self-generated magnetic field on the characteristics of the electron beams. In addition to the beam collimation effect, the magnetic field is found to further enhance the electron acceleration, resulting in the generation of ultrahigh energy electrons.

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PubMed2004

Effect of self-injection on ultraintense laser wake-field acceleration.

The self-injection of plasma electrons which have been accelerated to relativistic energies by a laser pulse moving with a group velocity less than the speed of light with I lambda(2)>5 x 10(19) W microm(2)/cm(2) is found via particle-in-cell simulation to be efficient for laser wake-field acceleration. When the matching condition a(0)> or =(2(1/4)omega/omega(pl))(2/3) is met, the self-injection, along with wave breaking, dominates monoenergetic electron acceleration yielding up to 100 MeV energies by a 100 TW, 20 fs laser pulse. In contrast to the injection due to wave-breaking processes, self-injection allows suppression of production of a Maxwell distribution of accelerated particles and the extraction of a beam-quality bunch of energetic electrons.

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PubMed2004

Resonance acceleration of electrons in combined strong magnetic fields and intense laser fields.

The acceleration mechanism of electrons in combined strong axial magnetic fields and circularly polarized laser pulse fields is investigated by solving the dynamical equations for relativistic electrons both numerically and analytically. We find that the electron acceleration depends not only on the laser intensity, but also on the ratio between electron Larmor frequency and laser frequency. As the ratio approaches unity, a clear resonance peak is observed, corresponding to the laser-magnetic resonance acceleration. Away from the resonance regime, the strong magnetic fields still affect the electron acceleration dramatically. We derive an approximate analytical solution of the relativistic electron energy in adiabatic limit, which provides a full understanding of this phenomenon. Application of our theory to fast ignition of inertial confinement fusion is discussed.

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PubMed2005

Accelerating, hyperaccelerating, and decelerating networks.

Many growing networks possess accelerating statistics where the number of links added with each new node is an increasing function of network size so the total number of links increases faster than linearly with network size. In particular, biological networks can display a quadratic growth in regulator number with genome size even while remaining sparsely connected. These features are mutually incompatible in standard treatments of network theory which typically require that every new network node possesses at least one connection. To model sparsely connected networks, we generalize existing approaches and add each new node with a probabilistic number of links to generate either accelerating, hyperaccelerating, or even decelerating network statistics in different regimes. Under preferential attachment for example, slowly accelerating networks display stationary scale-free statistics relatively independent of network size while more rapidly accelerating networks display a transition from scale-free to exponential statistics with network growth. Such transitions explain, for instance, the evolutionary record of single-celled organisms which display strict size and complexity limits.

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PubMed2005

Demonstration of bulk acceleration of ions in ultraintense laser interactions with low-density foams.

Ion acceleration inside low-density foams irradiated by ultraintense laser pulses has been studied experimentally and theoretically. It is found that the ion generation is closely correlated with the suppressed hot electron transport inside the foams. Particle-in-cell simulations suggest that localized electrostatic fields with multi peaks around the surfaces of lamellar layers inside the foams are induced. These fields inhibit hot electron transport and meanwhile accelerate ions inside the foams, forming a bulk acceleration in contrast to the surface acceleration at the front and rear sides of a thin solid target.

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PubMed2006

Proton acceleration from microdroplet spray by weakly relativistic femtosecond laser pulses.

Angular distribution of protons is measured from ethanol droplet spray irradiated by linearly polarized 150 fs laser pulses at an intensity of 1.1 x 10(16)W/cm2. Fast protons (with energies >16 keV ) with an anisotropic distribution can be observed only in or near the polarization plane of the laser fields, while the slow protons (with energies <or=16 keV ) emit with nearly an isotropic distribution. Two-dimensional particle-in-cell simulations suggest that three groups of protons originate from different acceleration regimes in the laser-droplet interaction. The first group with the highest energies is accelerated backwards by the anisotropic charge-separation field near the front surface (laser-droplet interaction side) due to the resonance absorption; the second group (forward emission) is generated by the target-normal sheath acceleration mechanism; and the third group, with the lowest energies, is accelerated by the hydrodynamic expansion of the droplet plasmas.

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PubMed2000

Electron acceleration by a short relativistic laser pulse at the front of solid targets.

Acceleration of electrons in a low-density plasma in front of a solid target by a propagating short ultraintense laser pulse is studied. When the laser is reflected at the target surface the accelerated electrons, with energy scaling as the laser intensity, continue to move forward inertially and thus escape from the pulse. Electrons accelerated backwards by the reflected light can attain even higher energies due to their longer acceleration length and their high initial momentum from a relativistic return current.

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