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At least 973 records · Page 54Linked to original sources
PubMed1993

[Macrophage scavenger receptors and the maintenance of blood vessels].

Recent molecular cloning of cDNAs for Macrophage Scavenger Receptors (MSR) reveal several unexpected features of these receptors. These MSRs mediate wide range of ligands, especially negatively charged macromolecules. Expression of MSRs are highly specific to macrophages. The intracellular pathways for endocytosis and recycling of MSRs are efficient only in macrophages. Immunocytochemical study of MSRs show that all of the tissue macrophages, including brain scavenger cells (FGP cells) are MSR positive. Under some pathological conditions, such as atherosclerotic lesions, macrophages infiltrating into these lesions, which are derived from monocytes, are also positive for MSR. Macrophages expressing MSR are thought to play an important role in the clearance and maintenance of blood vessels. Brain scavenger cells may play a role in the maintenance of small blood vessels in the brain.

Animals↗
PubMedDate not supplied

[Changes in the central and cerebral blood flows of patients with arteriosclerosis obliterans of the arteries of the lower extremities after different types of anesthesia].

A comparative analysis of changes in central hemodynamics and cerebral circulation depending on the technique of anesthesia used has been performed in 63 patients after reconstructive surgery on aorto-ileo-femoral segment. Signs of ischemic heart disease have been revealed preoperatively in 40 patients. The majority of them (88%) showed hypokinetic type of hemodynamics. Signs of cerebral atherosclerosis were found in 90% of patients. Rheoencephalographic index in them was lowered by 42%. A statistically significant deterioration in central hemodynamic and cerebral circulation parameters has been recorded immediately after the operation in patients with concomitant ischemic heart disease operated on under general endotracheal anesthesia. An improvement in central hemodynamic parameters after surgery has been observed in the group of patients operated on under epidural anesthesia.

Anesthesia, Epidural↗
PubMed1975

Frequency of Alzheimer's neurofibrillary tangles in the basal ganglia and brain-stem in Alzheimer's disease, senile dementia and the aged.

The authors studied the frequency of neurofibrillary tangles in the basal ganglia and brain-stem of two cases with Alzheimer's disease (average 55 years of age), six cases with senile dementia (average 82 years) and ten cases with cerebral softening and arteriosclerosis in old age (average 79 years). The distribution pattern of ANC was almost the same in Alzheimer's disease and senile dementia, i.e. plenty of ANC were found in the nucl. dorsalis raphe, nucl. centralis superior, nucl. mamilloinfundibularis and nucl. basilaris, but in senile dementia ANC were much fewer in the thalamus and lenticular nuclei. In the aged with cerebral softening and arteriosclerosis, a negligible number of ANC in the brain-stem made a marked contrast to a large quantity of ANC in the cases with senile dementia. Hence, as far as ANC in the brain-stem is concerned, no continuum seems to exist between normal senility and senile dementia.

Aged↗