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At least 973 records · Page 54Linked to original sources
PubMed1989

[Calcium hydroxide cements in an in vivo study].

Great caution is required when choosing materials coming into direct contact with pulpal tissue. The aim of this study was to assess the connective tissue tolerance to Cap-cap and Cinacal, clinically used for pulp capping, in experimental animals. On the basis of tissue reactions around implanted material specimens at intervals of 2, 14 and 28 days after application, the two materials were found to belong to a group of biocompatible materials. Marked infiltration with inflammatory cells around Cap-cap specimens during the first few days after injection pointed to irritative feature of the material as compared to Cinacal, possibly attributable to eugenol, a Cap-cap constitutive component.

Animals↗
PubMed2005

Effect of ProRoot MTA on pulp cell apoptosis and proliferation in vitro.

ProRoot Mineral Trioxide Aggregate (MTA) has been indicated as a pulp capping material. The purpose of this study was to evaluate the effect of tooth-colored (white) MTA on pulp cell apoptosis and cell cycle. Mouse odontoblast-like cells (MDPC-23) and undifferentiated pulp cells (OD-21) were exposed to 0 to 100 mg MTA for 24 h. Propidium iodide staining followed by flow cytometry demonstrated that MTA did not induce apoptosis of MDPC-23 or OD-21 (p > 0.05). Cell cycle analysis showed that MTA induced a modest (but significant) increase in the percentage of MDPC-23 in the S and G2 phases, and OD-21 in the S phase of cell cycle, as compared to untreated controls (p </= 0.05). In conclusion, MTA induced proliferation, and not apoptosis, of pulp cells in vitro. These findings suggest a potential mechanism to explain the regenerative effect observed in the dentin-pulp complex when MTA was used for direct pulp capping.

Aluminum Compounds↗
PubMed2002

The dentinogenic effect of mineral trioxide aggregate (MTA) in short-term capping experiments.

AIM: The objective of the present experiment was to study the early pulpal cell response and the onset of reparative dentine formation after capping application of MTA in mechanically exposed pulps. METHODOLOGY: Thirty-three teeth from three dogs, 12-18 months of age were mechanically exposed via class V cavities. Light pressure was applied to control haemorrhage. ProRoot MTA (Dentsply Simfra, Paris) was placed at the exposure site and light pressure was applied with a wet cotton pellet. The cavities were restored with amalgam and the pulpal tissue reactions were assessed by light and electron microscopy (transmission and scanning) after healing intervals of 1, 2 or 3 weeks. RESULTS: A homogenous zone of crystalline structures was initially found along the pulp-MTA interface, whilst pulpal cells showing changes in their cytological and functional state were arranged in close proximity to the crystals. Deposition of hard tissue of osteotypic form was found in all teeth in direct contact with the capping material and the associated crystalline structures. Formation of reparative dentine (tubular matrix formation in a polar predentine-like pattern by elongated polarized cells) was consistently related to a firm osteodentinal zone. CONCLUSIONS: The present experiments indicate that MTA is an effective pulp-capping material, able to stimulate reparative dentine formation by the stereotypic defensive mechanism of early pulpal wound healing.

Aluminum Compounds↗
PubMed2006

The incidence of pulp healing defects with direct capping materials.

PURPOSE: To (1) study the injury and healing activity of the pulp tissue to calcium hydroxide [Ca(OH)2], resin composite (RC) and resin-modified glass-ionomer (RMGI) materials when used as direct pulp capping agents, and (2) compare the incidence of healing defects between these materials. METHODS: 135 Class V pulp exposed cavities were prepared in non-human primate teeth. Direct pulp capping was conducted over 6 to 730 days with hard set Ca(OH)2, RMGI and CR materials. Healing defects recorded were: (1) bacterial leakage with McKays stain; (2) operative debris including dentin fragments and particles of capping material; (3) pulpal inflammatory activity according to FDI standards; (4) area and absence of dentin bridge formation; and (5) presence of tunnel defects in bridge. Statistical analysis was evaluated using ANOVA. RESULTS: The capping materials were associated with varying levels of pulp healing defects, including tunnel defects (P= 0.0001); operative debris (P= 0.0001); pulpal inflammatory cell activity (P= 0.0073) and bacterial leakage (P= 0.0260). Other healing defects, and the area of dentin bridge were not influenced by capping materials (P> 0.05).

Analysis of Variance↗
PubMed2006

Influence of rubber dam isolation on human pulp responses after capping with calcium hydroxide and an adhesive system.

OBJECTIVE: The objective was to evaluate the influence of rubber dam isolation on the response of human pulps capped with calcium hydroxide and an adhesive system. METHODS AND MATERIALS: Direct pulp capping was performed in 40 caries-free human premolars scheduled for extraction as part of orthodontic treatment. The teeth were randomly divided into 8 groups (n = 5) according to the combination of treatment factors: capping agent (adhesive resin or calcium hydroxide), isolation (rubber dam or cotton pellets only), and period of evaluation (30 or 60 days). Class 2 cavities were prepared, and pulp exposures were created on the occlusal floor. After capping, all teeth were restored with Z-100 placed incrementally. After 30 or 60 days, patients were asked about their symptoms, teeth were extracted, and serial sections were evaluated. The data were subjected to a nonparametric test. RESULTS: Overall, the histologic features showed that the pulp response was worse for groups capped with adhesive. For adhesive-capped groups, the pulp response varied from pulp necrosis to acute inflammatory cell infiltrate, and most of the pulps capped without rubber dam isolation showed severe inflammatory cell infiltrate involving the coronal pulp with chronic abscesses. For the calcium hydroxide groups, all specimens showed dentin bridge formation, regardless of the type of isolation used. CONCLUSION: Calcium hydroxide should be used as the material of choice for pulp capping with or without rubber dam isolation. The use of adhesive systems in vital pulp capping is contraindicated, especially if rubber dam isolation is not implemented.

Adhesives↗
PubMed1984

In vivo fixative effect of formocresol on pulpotomized deciduous teeth of dogs.

Formocresol was checked with respect to its in vivo fixative effect after pulpotomy, through observation of tissue resistance to necrosis. The root pulps were freed from their hard-tissue wrapping and processed for 48 hours, followed or not by capping (15 days) with zinc oxide-eugenol or with zinc oxide-eugenol-formocresol. The effect of only capping with zinc oxide-eugenol, with or without formocresol, was also recorded.

Animals↗
PubMed1990

An ultrastructural study of the process of hard tissue formation in amputated dental pulp dressed with alpha-tricalcium phosphate.

This study was undertaken to determine the reaction of amputated dental pulp to the capping agent, alpha-tricalcium phosphate (alpha TCP), and to reveal the exact nature of the processes involved in both the healing of, and new hard tissue formation in the pulp when dressed with alpha TCP. The dental pulps of the anterior teeth of Macaca fuscata were dressed with alpha TCP ceramic 4-10 microns in diameter. The teeth were fixed by perfusion, then observed with light and electron microscopes. At 10 and 14 days postoperatively, the phagocytosis of the alpha TCP layer by the many macrophages and multinucleated giant cells, both of which had emerged beneath it, was seen. The synthesis of collagenous matrix underlying the alpha TCP layer began at 14 or 21 days, the cells involved exhibiting morphologic characteristics similar to those seen in osteoblasts. By the 90th day, only a bone-like hard tissue remained. No inflammation was observed in the residual dental pulp at any time during the experimental period. At 14 days, needle-like crystals were seen to have formed on the surface of alpha TCP particles, and by the 21st day, these crystals had extended to the newly synthesized matrix, with the result that calcification of the matrix was initiated, a calcified layer being superficially produced in the matrix. In the region of the matrix adjacent to the superficial calcified layer, a number of matrix vesicles were also found to function as another mechanism of matrix mineralization. Thus, it was concluded that the bone-like hard tissue was induced in the pulp capped with alpha TCP, and its potential for clinical application to exposed dental pulp was confirmed.

Animals↗
PubMed1978

Direct pulp capping treatment: a long-term follow-up.

In reviewing 356 instances of pulp capping during the past 25 years, 149 cases were recalled with posttreatment intervals greater than five years. One hundred thirty teeth (87.3%) were still vital and functioning with an average posttreatment interval of 11.7 years. The criteria for pulp capping procedures are in need of revision. Restrictions based on tooth size and age of the patient are unfounded.

Adolescent↗
PubMed2003

Biocompatibility of resin-based materials used as pulp-capping agents.

AIM: To evaluate and compare the response of pulps of rats capped with resin-modified glass-ionomer cement (RMGIC) or self-etching adhesive system. METHODOLOGY: Class I cavities were prepared on the occlusal surface of 54 maxillary first molars of 27 rats. Pulp exposure was performed on the cavity floor. The following resin-based materials were applied as pulp-capping agents: G1, Clearfil Liner Bond 2V (CLB 2V; Kuraray Co., Japan); G2, Vitrebond (VIT; 3M/ESPE, USA). In group 3 (control group), a calcium hydroxide/saline paste (CH; Labsynth, Brazil) was used. The cavities were restored with amalgam. After 7, 30 and 60 days, the animals were sacrificed and the jaws were processed for microscopic evaluation. RESULTS: Despite the inflammatory response caused by the experimental and the control materials at 7 days, pulpal healing associated with calcified barrier formation was observed at 60 days following the pulp therapy. Both resin-based materials promoted a large zone of cell-rich fibrodentine matrix deposition on the pulp horn related to the pulp exposure site, which was larger to VIT than to CLB 2V specimens. Tertiary dentine underneath the fibrodentine matrix was deposited by a layer of elongated pulpal cells. The remaining pulpal tissue exhibited normal histological characteristics. In the control group, healing and dentine-bridge formation was observed at 30 days. Pulpal breakdown occurred only when bacterial infection occurred. CONCLUSION: Both experimental pulp-capping agents allowed pulpal healing characterized by cell-rich fibrodentine and tertiary dentine deposition as well as calcified barrier formation.

Animals↗