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[Urethral condyloma in the male: experience with 48 cases].

OBJECTIVES: To review our experience in the diagnosis and treatment of urethral condylomata. METHODS: From June, 1977 to November, 1994, 64 patients with condyloma acuminatum were treated at our institution. Forty-eight cases who had received no previous treatment were analyzed. The main reason for consultation was the appearance of an exophytic lesion in the meatus. Most of the condylomata were located in the navicular fossa. Treatment was by electrocoagulation in 24 patients, photocoagulation with the Nd:YAG laser in 21 and other treatment modalities were utilized in 3 patients. To determine the incidence of recurrence and response to therapy, we analyzed the data of 34 patients with a minimum follow up of 2 months and a mean of 16 months. RESULTS: 36% had associated cutaneous condylomata. Urethroscopy detected 14.2% of the lesions that were undetectable by eversion of the meatus. Recurrence was observed in 35.2%. There were no differences for recurrence or complications between patients submitted to electrocoagulation and those who were treated by laser photocoagulation. CONCLUSIONS: Condyloma acuminatum of the urethra is uncommon. Urethroscopy is useful in making the diagnosis and for post-treatment follow up control evaluation. Electrocoagulation and Nd:YAG laser photocoagulation are useful in the treatment of this condition. Recurrence is frequently observed in patients with extensive lesions.

Adolescent↗

Long-term outcome of flexible ureterorenoscopy in the diagnosis and treatment of lateralizing essential hematuria.

PURPOSE: We identified the long-term outcome of ureterorenoscopic diagnosis and treatment of patients with lateralizing essential hematuria. MATERIALS AND METHODS: We reviewed retrospectively 17 patients with lateralizing essential hematuria treated with flexible ureterorenoscopy (15) or flexible percutaneous nephroscopy (2) with or without biopsy and electrocoagulation. Followup was longer than 24 months (average 60, range 24 to 116) in all patients. RESULTS: At followup 9 of the 17 patients (59%) were cured and 7 (41%) had recurrent bleeding. Discrete lesions occurred in 11 patients (64%), who were treated with electrocoagulation with 9 (82%) cured. All 3 patients (18%) with diffuse lesions had recurrent bleeding as did 2 of 3 (66%, 18% overall) with negative examinations. CONCLUSIONS: Ureterorenoscopy is an effective means of diagnosis and treatment of lateralizing essential hematuria. The majority of patients with lateralizing hematuria will have a discrete lesion that will respond to ureterorenoscopic electrocoagulation in the long-term. However, if the lesions are diffuse or the diagnostic examination is unreliable recurrent bleeding is likely.

Adult↗

The bipolar needle for vasectomy. I. Experience with the first 1000 cases.

A battery-powered, bipolar electrocoagulator has been specifically developed for sealing the cut ends of the divided vas at vasectomy. With a minimum of electric power, the electrocoagulator destroys only the mucosa and one or two muscle cell layers of the vas, which leads to optimal fibrosis of the cut ends. This instrument has been used in more than 1000 vasectomies without a known failure and with a minimum of complications. An analysis of these cases is reported with emphasis upon the method's success in sealing the vas.

Adult↗

[Microscopic study of human fallopian tubes after laparoscopic sterilization (author's transl)].

Histological study was carried out on human fallopian tubes one hour and one month after various methods of laparoscopic sterilization (unipolar electrocoagulation, bipolar electrocoagulation, silicone ring and Hulka-Clemens clip). Microscopic lesions were observed. Ciliated cells were counted. Deciliation is proved at a distance from the site of sterilization. It has been possible to display the substance loss of the tubal tissues which have to be taken into consideration in case of surgical reanastomosis.

Cilia↗

Six-year recurrence free survival after intraluminal iridium-192 therapy of human bilobar biliary papillomatosis. A case report.

BACKGROUND: Biliary papillomatosis is rare and often fatal. Liver resection or transplantation is recommended but may be impossible due to tumor or patient factors; furthermore, it appears to the authors of this study that no follow-up results after transplantation have been reported in previous studies. METHODS: Bilobar but limited biliary papillomatosis in a man age 54 years was mapped by cholangiopancreatography, cholecystectomy, and operative cholangioscopy. After cholangioscopic electrocoagulation, iridium-192 wires were temporarily inserted into the affected bile ducts, giving a dose of 60 grays at a 3-mm distance. Another percutaneous cholangioscopic electrocoagulation was performed 3 weeks later. RESULTS: The patient has been free of tumor and in good health for 80 months, but he has a long term stenting of a nonneoplastic stricture at the confluence of the bile ducts. CONCLUSIONS: Mechanical tumor reduction and intraluminal brachytherapy could possibly replace transplantation (which up to now has been suggested but not reported) when this life-threatening disease is bilobar, and also possibly replace liver resection for limited tumors in patients who are too frail for surgery.

Bile Duct Neoplasms↗

Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10 ppm formaldehyde.

To study the significance of damage to the nasal mucosa for the induction of nasal tumours by formaldehyde in rats, a long-term inhalation study was conducted in which male rats with severely damaged or undamaged nose were exposed 6 h/day for 5 days/week to 0, 0.1, 1.0 or 10 ppm formaldehyde vapour for 28 months, or for 3 months followed by a 25-month observation period. The damage to the nasal mucosa was induced by bilateral intranasal electrocoagulation. The total number of rats used was 720, 480 with damaged and 240 with intact nose. Compound-related degenerative, inflammatory and hyperplastic changes of the nasal respiratory and olfactory mucosa were invariably observed when rats with intact nose were exposed to 10 ppm but not when exposed to 1.0 or 0.1 ppm formaldehyde. Nasal electrocoagulation increased the incidences of formaldehyde-induced rhinitis, hyper- and metaplasia of the respiratory epithelium, and degeneration and hyper- and metaplasia of the olfactory epithelium. In addition, exposure to 10 ppm formaldehyde for 28 months produced nasal squamous cell carcinomas in rats with damaged nose (15/58) but not in rats with intact nose. Three months of exposure to 10 ppm formaldehyde or exposure to 0.1 or 1.0 ppm formaldehyde for 28 months had no such effect. It was concluded that severe damage to the nasal mucosa may contribute to the induction of nasal tumours by formaldehyde.

Animals↗

Argon coagulation in laparoscopic cholecystectomy.

BACKGROUND: The purpose of this study is to compare argon coagulation with standard electrocoagulation. METHODS: Twenty-four consecutive patients submitted to laparoscopic cholecystectomy (LC) were divided randomly into two equal groups. Group 1 used standard electrocoagulation and group 2 argon coagulation. The operative time and amount of blood loss were measured. RESULTS: Operative time (minutes): Group 1 65.33 +/- 4.07 SE. Group 2 55.83 +/- 2.82 SE (P < 0.10). Amount of blood loss (ml): Group 1 105.58 +/- 6.37 SE. Group 2 62.92 +/- 5.82 SE (p < 0.001). CONCLUSIONS: Preliminary results support our opinion that argon coagulation is to be favored over standard coagulation.

Blood Loss, Surgical↗

Hypofractionation radiotherapy for a locally recurrent rectal carcinoma as a treatment for an elderly patient.

A very old patient, who had been suffering from rectal carcinoma for many years without achieving a complete response to electrocoagulations, was given palliative radiotherapy by hypofractionation with a total dose of 30 Gy in 3 weeks, 1 fraction a week. A complete response was achieved. No special therapy-related morbidity was noted. After the radiotherapy, an acceptable quality of life was maintained for 12 months without a local recurrence. It is concluded that radiotherapy may be a simple and efficient method of palliation without distressing morbidity compared with electrocoagulation.

Adenocarcinoma↗

Angiodysplasia. Natural history and efficacy of therapeutic interventions.

Angiodysplasia, a disease for which the optimal treatment is uncertain, is a frequent cause of lower intestinal bleeding among older patients. To study the natural history of angiodysplasia and compare the efficacy of medical therapy, endoscopic electrocoagulation, and surgery, the course of 101 patients evaluated from 1974 through 1983 at the Massachusetts General Hospital was reviewed. Angiodysplasia caused bleeding that ranged from occult blood in stools to massive hemorrhage and was also observed incidentally in nonbleeding patients. Patients were followed for up to 10 years (mean of 22 months). Rebleeding was defined as evidence of hemorrhage requiring hospital admission, transfusion, or surgery. Thirty-one patients were treated surgically, 19 patients were treated endoscopically, and 36 patients were treated medically. Using life table analysis we observed similar rebleeding rates among medically and endoscopically treated groups. The surgically treated group had a frequency of rebleeding less than half that of the other groups (P = 0.15). A multivariate regression analysis failed to identify any factors other than coagulopathy to explain the different incidence of rebleeding in the patients treated by endoscopic electrocoagulation and surgery.

Diverticulum↗

The 980-nm diode laser for brain surgery: histopathology and recovery period.

The 980-nm diode laser has been under investigation for neurosurgery because of a local peak in the absorption spectra of water around this wavelength. This work was carried out to examine the extent of thermal changes and the recovery process of laser-induced brain lesions. In order to study the quality of the lesions, a conventional monopolar electrocoagulation technique was applied comparatively. An in vivo stereotaxic neurosurgical procedure was performed on Wistar rats. Bilateral brain lesions of the same size (2-3 mm diameter) were created with a diode laser and via electrocoagulation. Subjects were sacrificed 0, 2 and 7 days after surgery in order to observe the healing process of the necrotic tissue. The surgical after-effects of both types of lesions were identified through immunohistochemical staining with CD68 macrophage marker and haematoxylin eosin (H&E). CD68 was found to be more efficient than H&E in determining the thermally altered areas. Histological examinations showed that the 980-nm diode laser system has a remarkable ablating ability with minimal thermal damage of nearby tissue.

Animals↗

An epidemiologic study of risk factors associated with pregnancy following female sterilization.

Data on 14,700 female sterilization patients were collected by the International Fertility Research Program (IFRP) from 1972 to 1978 and analyzed to determine risk factors associated with the incidence of pregnancy following sterilization. With a case-control approach, it was found that younger patients (less than or equal to 34 years old) and those who did not lactate after sterilization had a higher risk of becoming pregnant. Patients who were sterilized in the early phases of a service program had a higher risk of pregnancy than those sterilized later. In the laparoscopic series, the relative risk of pregnancy was four times greater in patients who had the prototype spring clip than in patients who had the Falope ring. The relative risk increased to 7.0 when patients who had the prototype spring clip were compared to those who had the Falope ring, electrocoagulation, or the Rocket clip. Patients sterilized by electrocoagulation had a low pregnancy risk, but the risk of an ectopic pregnancy was significantly higher than for those sterilized with mechanical devices. In the culdoscopic series, the tantalum clip had an unacceptable pregnancy risk.

Adult↗

Specificity of dopaminergic neuronal degeneration induced by intracerebral injection of 6-hydroxydopamine in the nigrostriatal dopamine system.

The neurotoxic specificity of injections of 6-hydroxydopamine (6-OHDA) into areas containing either dopamine (DA) cell bodies (substantia nigra) or DA axon terminals (striatum) was studied. This selective effect was compared to the unspecific effects of copper sulfate (CuSO4) injection and electrocoagulation. One to two days after unilateral nigral injection of 2 mug of either 6-OHDA or CuSO4 into the nigra the volume of the unspecific lesions around the tip of the cannula was very similar. Only the 6-OHDA-induced lesions were associated with elective degeneration of the nigral DA neurons. Ten days after the administration of the same compounds the gliosis in the substantia nigra was much more extensive in CuSO4-than in 6-OHDA-treated rats; however, the reduction of DA concentrations in the ipsilateral striatum was only noticeable after 6-OHDA (-62%). A somewhat similar decrease of striatal DA levels (-52%) was observed after large electrocoagulation of the substantia nigra. Ten days after 6-OHDA (8mug) or electrolytic lesion of the striatum the Km for DA, serotonin and choline uptakes were similar in the striata of both sides, suggesting that the uptake process in the non-damaged neurons of the lesioned side was functionally normal. Following electrolytic lesion of the striatum, serotonin and choline Vmax values were decreased to about the same extent as the striatal reduction in weight and DA levels. When directly administered into the striatum 6-OHDA also produced a decline in DA concentration and Vmax but in contrast did not affect serotonin and choline uptake (Vmax), suggesting that the drug specifically destroyed dopaminergic neurons. The present data confirm that selective DA denervation can be achieved when appropriate amounts of the drug are injected into brain tissue in order to limit the unspecific lesion.

Animals↗

Changes in the circulating levels of hemoglobin, hematocrit, serum iron and total iron binding capacity after four methods of surgical tubal sterilization.

One-hundred women requesting voluntary surgical sterilization were included and enrolled into four groups (each n = 25). Four sterilization modalities were used namely: Falope ring, electrocoagulation, clip and Pomeroy ligation. The circulating levels of hemoglobin, hematocrit, serum iron and total iron binding capacity were studied before sterilization and at 3, 6 and 12 months thereafter. No significant changes were observed at 3 and 6 months post-sterilization. At 12 months a significant increase in the hemoglobin and serum iron was observed with a significant decrease in total iron binding capacity. Falope ring, clip and Pomeroy ligation were of a higher rank in this context versus electrocoagulation.

Adult↗

Immunocytochemical localization of tubulin and the high molecular weight microtubule-associated protein 2 in Purkinje cell dendrites deprived of climbing fibers.

The modifications in the localization of tubulin and the high molecular weight microtubule-associated protein 2 were studied in the cerebellum after partial denervation. Both proteins were localized in 40 micron sections using monoclonal antibodies against beta-tubulin (clones Tu9B and Tu12) or microtubule-associated protein 2 (clones AP9 and AP13), and polyclonal antisera against alpha- and beta-tubulin or microtubule-associated protein 2, visualized with the immunoperoxidase method of Sternberger [Sternberger (1979) Immunocytochemistry; Sternberger and Sternberger (1983) Proc. natn. Acad. Sci. U.S.A. 80 6126-6130] or a biotin-avidin system. The destruction of the inferior olive was performed in adult male rats by electrocoagulation or by intraperitoneal administration of 3-acetylpyridine. One day after chemical destruction of the inferior olive, anti-microtubule-associated protein 2 staining with either of the monoclonal antibodies or with the polyclonal antiserum was almost identical to that observed in the cerebellum of non-denervated animals. Specific staining was intense in the cell somata and dendrites and absent in myelinated tracts and in parallel fibers. However, 3 days after the lesion anti-microtubule-associated protein 2 staining showed a clear decrease, both in the proximal and the distal portions of thick secondary and tertiary dendritic trunks of the Purkinje cell. The intensity of the staining was also considerably reduced in the fine dendritic ramifications. By 8 days post-lesion, microtubule-associated protein 2 immunoreactivity began to increase, but only in the portions of the dendrites deprived of the climbing fibre; on the contrary, low immunoreactivity was found in the fine dendritic ramifications which are contacted by normal parallel fibers; microtubule-associated protein 2 immunoreactivity increased considerably by 11 days post-lesion, giving a pattern quite similar to that of non-denervated Purkinje cells. The alterations in microtubule-associated protein 2 immunoreactivity were also accompanied by a dramatic decrease in the immunostaining for tubulin, beginning on day-3 post-lesion and lasting until day-15 post-lesion. These changes were observed with either the monoclonal antibodies against beta-tubulin or with the polyclonal antiserum against alpha- and beta-tubulin. The changes in both molecules were also observed in animals in which the inferior olive was destroyed by electrocoagulation, ruling out the possibility of a direct action of 3-acetylpyridine on dendritic microtubular proteins.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

Changes in menstrual pattern and ovarian function following bipolar electrocauterization of the fallopian tubes for voluntary surgical contraception.

OBJECTIVE: Our aim was to investigate the changes in menstrual pattern, ovarian reserve and presence of dysmenorrhea and ovulation after tubal ligation via bipolar electrocautery. METHODS: Sixty patients requesting voluntary tubal ligation were recruited in the study. Laparoscopic tubal sterilization via bipolar electrocoagulation was performed in all patients in the early follicular phase. Blood samples were collected on day 3, one cycle before the procedure, in the same cycle when the procedure was carried out and on the third cycle following the procedure for determination of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E(2)), and on day 21 for progesterone (P) levels. All patients were followed for 3 months, and changes in menstrual pattern, presence or absence of dysmenorrhea and ovulation were noted. RESULTS: Menstrual changes occurred in six patients (10%), although only one patient had mild dysmenorrhea (1.6%) after the procedure. The incidence of ovulation was 33% preoperatively, rising to 40% in the cycle when surgery was performed and maintained a constant level at 40% 3 months after tubal ligation. There was no statistically significant difference in the serum FSH, LH and estradiol levels in preoperative and postoperative assessments (p > .05). CONCLUSION: Tubal ligation has been blamed for causing luteal phase defect as a result of an effect on ovarian circulation. In our study, the rate of ovulation was slightly improved after the procedure, and ovarian reserve was not negatively affected. Bipolar electrocoagulation of the fallopian tubes did not alter the ovarian reserve and function.

Adult↗

[Cochlear implants using the Ultracision harmonic scalpel].

We have evaluated the utility, indications and disadvantages of the Ultracision harmonic scalpel, in the cochlear implants, and his advantages compare to other electrocoagulation's systems. These aspects were evaluated in 50 cases of cochlear implants, made along the last years. We concluded that the Ultracision harmonic scalpel is indicated, mainly, in the otology field, in these situations in wich the cochlear implant is in the cochlea, and is mandatory the use of an electrocoagulation system. In this situation, the Ultracision harmonic scalpel was quick, safe and sure, and with many advantages, over the traditional scalpel and the bipolar diathermy.

Cochlear Implantation↗

Endoscopic therapy for upper-GI vascular ectasias.

BACKGROUND: Upper-GI vascular ectasias, including angiodysplasia and gastric antral vascular ectasia may present with either acute or chronic bleeding. Endoscopic thermal modalities have been used to control acute bleeding and reduce transfusion requirements. METHODS: Endoscopic experience was reviewed for a 6-year period during which 32 patients requiring blood transfusions for upper-GI angiodysplasia or gastric antral vascular ectasia were evaluated. Patients seen during the first 5 years were treated with either Nd:YAG laser photocoagulation or multipolar electrocoagulation. During the most recent 12 months, all patients were treated by argon plasma coagulation. Response to therapy was assessed by change in mean Hb and transfusion requirements. RESULTS: Overall, 16 patients were treated by laser photoablation alone; 9, argon plasma coagulation with or without laser; and 7, multipolar electrocoagulation with or without laser. Mean follow-up for all patients was 19 months. After therapy, mean Hb concentration rose from 76 to 114 g/L for patients with gastric antral vascular ectasia and from 85 to 118 g/L for those with angiodysplasia. Endoscopic therapy abolished or reduced transfusion requirements in 93% of patients with gastric antral vascular ectasia and 76% with angiodysplasia. Patients with gastric antral vascular ectasia required a mean of 6 treatment sessions, while those with angiodysplasia required one to two sessions. CONCLUSIONS: Endoscopic thermal ablation effectively controls acute bleeding and reduces transfusion requirements in most patients with upper-GI vascular ectasias. Patients with gastric antral vascular ectasia require significantly more treatment sessions to achieve this effect.

Aged↗

Complications of the hot biopsy forceps technique.

Hot biopsy forceps technique involves the use of insulated monopolar electrocoagulating forceps to simultaneously biopsy and electrocoagulate tissue. It has been recommended for removal of diminutive polyps and treatment of vascular ectasias of the gastrointestinal tract. The extent of its use and associated complications have not been delineated. This study evaluated the practice of 517 endoscopists. Seventy-one percent (369 endoscopists) used hot biopsy forceps and reported 117 complications, including 85 episodes of bleeding, 19 perforations, and one death. While the overall complication rate was less than that previously reported for colonoscopic polypectomy, 87% of colon perforations occurred on the right side. Factors that may have been important in the development of complications included the degree and length of current application. Adherence to suggested limitations in current application and use of proper technique should result in fewer complications.

Biopsy↗