PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “SOCIAL ISOLATION”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 973 records · Page 54Linked to original sources

Effects of alprazolam on the free-choice ethanol consumption induced by isolation stress in aged rats.

Late-onset drinking is a common problem in elderly people related to stress induced by social isolation. Experiments were performed in order to evaluate the effects of alprazolam, a benzodiazepine agonist anxiolytic, on the free-choice ethanol consumption in aged rats subjected to isolation stress. The animals we offered a two-bottle choice consumption (one of 0.2% saccharin and the other with 10% ethanol/0.2% saccharin) and then exposed to 4 days of isolation stress on an irregular, unpredictable schedule. Stress resulted in significant increase in ethanol consumption. Treatment with alprazolam (1 mg/Kg) partially reversed this adverse effect of stress.

Aging↗

Social specificity: interaction with own species is necessary to foster species-specific maternal preference in ducklings.

Previous studies have shown that if domestic mallard ducklings are allowed social interaction with broodmates after their initial exposure to a stuffed mallard (Anas platyrhynchos) hen, they later show a visual preference for the familiar mallard over an unfamiliar redhead (Aythya americana) hen. Birds kept in social isolation do not make this difficult discrimination. In the present study, we examined whether this social enhancement of imprintability to a natural maternal model is merely the result of social stimulation in its most general sense, or if its effects are specific to social interaction for 30 min (training). This experience resulted in visual preference for the familiar mallard hen over the unfamiliar redhead hen in simultaneous choices tests at 48 hr and 72 hr after hatching only if the birds were allowed social experience with a group of same-age undomesticated mallard hatchings. No visual preference for the familiar mallard hen was found if the ducklings were permitted social experience with a group of same-age chick (Gallus domesticus) hatchlings or muscovy (Cairina moschata) ducklings. Thus, it appears that for ducklings to show a visually imprinted preference for a natural maternal model, they must be allowed social interaction with broodmates of their own species. Social rearing with other precocial bird hatchlings, even other ducklings, is without apparent effect. These results provide further evidence of the importance of nonobvious experimental factors in the development of species-typical behavior. They also suggest that in the evolution of the species-specific learning underlying early species identification, natural selection has operated on the entire (organism-environment) developmental manifold and not merely on genetic, organic, or organismic aspects of that system.

Animals↗

[Social-political aspects of psychological stress].

Emotional stress is often based on defective social conditions like social isolation or the urge for maximal efficiency in production and consumption. The improvement of these social conditions and the elimination of the resulting pathogenic stress is a political task. There is a curious and unrealistic separation of responsibilities which is justified by tradition only: the social part of the therapy is abandoned to political institutions and groups whereas the psychiatrist whose therapy should be comprehensive concerns himself with individual problems only. As he neglects the noxious social circumstances and aims entirely at the social adaptation of the patient the psychiatrist denies the defectiveness of the social conditions as they are and corroborates a system which is the true cause of numerous psychiatric disturbances.

Humans↗

Effects of 28-day isolation (ESA-ISEMSI'90) on blood pressure and blood volume regulating hormones.

The aim of this study was to determine what effects social isolation and confinement stress had on the volume regulating hormones. In six healthy male subjects, during a 28-d isolation and confinement study (ESA-ISEMSI'90), hematocrit, blood pressure and resting heart rate, plasma cortisol, renin, aldosterone, arginine vasopressin levels besides the electrolyte (Na+, K+) balance and plasma creatinine were measured. During the confinement, an elevated systolic blood pressure (p < 0.01) was observed together with an increase in MHPG corresponding to an elevated mental work load. The pattern displayed by volume regulating hormones (increased values for renin, aldosterone (p < 0.05) and arginine vasopressin) was not only characteristic of confinement stress but also reflected changes in the water and electrolyte metabolism. The increased creatinine levels seen throughout the study were regarded as consequences of hypohydration, and an enhanced muscular catabolism due to reduced physical activity. A similar pattern of hormone modifications was obtained in a head down tilt of the same duration, indicating that some of the described modifications are probably related to isolation and confinement stress.

Adult↗

Development of sound production in normal, isolated, and deafened kittens during the first postnatal months.

The development of calls (quantified by a series of acoustic parameters) of (a) normal, (b) socially isolated, and (c) deafened kittens that were released in four different situations has been studied from birth to 170 days of age. All call parameters studied except noise components show developmental changes that can be related to the development of (a) the vocal tract (fundamental frequency, harmonic with maximum intensity, upper-frequency limit and frequency range, occurrence of frequency, and intensity modulations), (b) feedback control through the auditory system (sound-pressure level, harmonic with maximum intensity, call-variability), and (c) motivational valuation of the releasing situations (duration). Isolated and deafened kittens displayed quantitative differences in certain call parameters compared with normal animals. Calls of deafened animals are, on the average, louder, more tonal and uniform, and differentially pitched compared with those of normal, hearing animals.

Aging↗

Prevalence and correlates of HIV risk behaviors among drug users in China.

This study examined the prevalence and correlates of HIV risk behaviors among 1,153 current drug users in China. Chi-squared tests of differences were used to test if drug users differed from non-users; logistic regression was used to identify behavior-specific risk factors. Results indicate that 60% of drug users injected drugs and more than one third shared needles. Compared to non-users, drug users had higher rates of risky sexual behavior and HIV/STDs. Among drug users, ethnic minorities and migrants were most vulnerable to unprotected casual sex and needle sharing. Drug users who experienced social isolation were associated with lower odds of risk behaviors; those who had experiences of anti-social behaviors and commercial sex, poor HIV knowledge, and perceived greater vulnerability were more prone to unprotected casual sex and needle sharing. Additional correlates of unprotected casual sex included being single, depression, and taking drugs/alcohol during sex. Additional risk factors of needle sharing included education and initiated drug use at younger ages. It is imperative that HIV interventions in China target drug users and address behavior-specific risk factors.

Adolescent↗

Impaired interns and residents.

In 1981 a study was undertaken to determine intern and resident psychological well-being and identify those house staff who were psychologically impaired. Fourteen percent of house staff were found to be impaired. Single females and house staff who were chronically fatigued or socially isolated were at highest risk for impairment. Impairment arose out of the interaction between sleep and social deprivation and individual vulnerability. Minor tranquilizers, but not alcohol, were used as a coping response to impairment.

British Columbia↗

Structural and functional abnormalities of the hippocampal formation in rats with environmentally induced reductions in prepulse inhibition of acoustic startle.

The effects of social isolation on prepulse inhibition of acoustic startle (PPI), electrophysiology and morphology of subicular pyramidal neurons and the densities of interneuronal sub-types in the hippocampal formation were examined. Wistar rats (male weanlings) were housed socially (socials, n=8) or individually (isolates, n=7). When tested eight weeks later, PPI was lower in isolates. Rats then received terminal anaesthesia before slices of hippocampal formation were made in which the electrophysiological properties of a total of 108 subicular neurons were characterized. There were no differences in neuronal sub-types recorded in socials compared with isolates. Intrinsically burst-firing and regular spiking pyramidal neurons were examined in detail. There were no differences in resting membrane potential or input resistance in isolates compared with socials but action potential height was reduced and action potential threshold raised in isolates. A limited morphological examination of Neurobiotin-filled intrinsically burst-firing neurons did not reveal differences in cell-body area or in number of primary dendrites. Sections from the contralateral hemispheres of the same rats were stained with antibodies to calretinin, parvalbumin and the neuronal isoform of nitric oxide synthase (nNOS). In isolates, the density of calretinin positive neurons was increased in the dentate gyrus but unchanged in areas CA3, CA1 and subiculum. Parvalbumin and nNOS positive neuronal densities were unchanged. Hence in rats with environmentally induced reductions in PPI there are structural and functional abnormalities in the hippocampal formation. If the reduction in PPI stems from these abnormalities, and reduced PPI in rats is relevant to schizophrenia, then drugs that correct the reported electrophysiological changes might have antipsychotic effects.

Acoustic Stimulation↗

Anxiolytic-like profile in Wistar, but not Sprague-Dawley rats in the social interaction test.

RATIONALE: The social interaction test is a valuable behavioural model for testing anxiolytic drugs in rodents, quantifying the level of social behaviour between pairs of rats. OBJECTIVE: The aim of the present study was to assess the appropriateness of the social interaction test for use with a Sprague-Dawley rat line, because of increasing use of this strain in targeted mutagenesis research. METHODS: Sprague-Dawley and Wistar rats received either diazepam or mCPP or were exposed to different environmental conditions (lighting, social isolation prior testing, habituation, testing-time). General anxiety-related parameters measured were: duration of active social contact, frequency of active social contact, latency to first contact. Different forms of active social contact were recorded: number of crawls, follows and sniffs. Secondly, aversion-induced hippocampal serotonin release and serotonin content in brain regions were measured. RESULTS: In Wistar rats habituation to the test substantially increased the time of social contact, an effect comparable with treatment with diazepam (1 mg/kg), whereas changes in the lighting level had less impact. Latency to the first contact increased under "anxiety-reducing" conditions, the frequency of contacts did not change consistently. Sprague-Dawley rats behaviour did not change under varying environmental conditions, and treatment with diazepam had only sedating effects at higher doses (5 mg/kg). Anxiogenic doses of mCPP caused reduced social interaction in both strains. Serotonin release and serotonin content were higher in the anxious Wistar rats. CONCLUSIONS: Different rat strains as well as differing test conditions have a major impact on the outcome of this animal test for anxiety.

Animals↗

An ethnographic study of a day care center for Iranian immigrant seniors.

Late-in-life immigrants are often at risk for psychological stress and social isolation because of language problems, small social networks, and cultural differences from the host society. Community intervention programs can reduce such stress and isolation. In this article, the authors describe a Swedish municipality's culturally appropriate intervention program for elderly Iranian immigrants based on ethnographic data gathered during a 12 month period. The description includes the activities provided by the program and the experiences of the elderly Iranian immigrants who participate regularly in these activities. The findings document the positive impact of regular participation in the center's activities on the elders' well-being and health.

Aged↗

Toward a model of social course in chronic illness: the example of chronic fatigue syndrome.

Retrospective, narrative accounts of illness experience in chronic fatigue syndrome provide the empirical basis for a preliminary conceptual model of social course in chronic illness. Qualities of distress interact with culturally specific expectations for social life and personal conduct to trigger microsocial processes of marginalization: role constriction, delegitimation, impoverishment, and social isolation. Marginalizing processes are opposed by acts of resistance initiated by ill individuals and directed toward integration in social worlds. Social distance from the perceived centers of CFS sufferers' interpersonal worlds expands and contracts with the changing predominance of marginalizing and resisting influences over time. Social course thus consists of successive, bi-directional movements along a 'continuum of marginality' by persons living lives with chronic illness.

Adaptation, Psychological↗

Individual social skills training and co-worker training for supported employees with dual sensory impairment. Two case examples.

Two case studies examined the efficacy of two social enhancement procedures--individual social skills training (SST) and co-worker intervention for two employees with dual sensory impairment who were working in competitive employment settings but who were socially isolated from contact with their nondisabled co-workers. A variety of measures, including direct behavioral observations and social validation ratings, examined social interaction and the formation of social networks in the workplace. Results showed that the number and duration of social interactions improved with each of the social enhancement programs. Social validation data and anecdotal reports indicated that the employees with disabilities became more socially competent, interactive, and included in the social network of the workplace. Interestingly, SST followed by co-worker training resulted in greater increases in social responding as compared to co-worker training followed by SST.

Adult↗

["Current city district-oriented counseling of the elderly"--forms of approach and intervention patterns].

The Federal Ministry for Youth, Family, Women and Health in the Federal Republic of Germany supported a research project on counselling processes with the elderly. The overruling aim is to enable them to live at home as long as possible. A model of preventative intervention was developed and tested by a group of gerontologists and social workers in Kassel. Every fifth inhabitant aged 60 and over in a working class district of Kassel was interviewed (n = 106) with respect to his/her living conditions and need for care. As a second step, all aged persons at risk (i.e. with low income, in social isolation, with health handicaps - as well as those of a very old age) were selected (n = 53). Two social workers contacted them at home and attempted to build up a relation of confidence with a view to active counselling measures. This paper reports some important statistical results and specifies the concepts of counselling procedures developed. They are basically biographically and help oriented, encompassing intervention in acute situations of need as well as counselling in the more restricted, traditional sense of the term.

Activities of Daily Living↗

Correlations between sleep and wake in internally synchronized and desynchronized circadian rhythms in humans under prolonged isolation.

The authors report the results of their experiments performed on the sleep-wake and rectal temperature rhythms of human subjects, who were held in prolonged social isolation for periods of 15-43 days in a specially constructed facility. Of 13 experiments performed with 11 subjects, the sleep-wake and rectal temperature rhythms free ran with circadian periods, remaining internally synchronized for the entire duration of the experiments in 9 subjects. The relationship between sleep and wake that is highlighted in this article is a trend that clearly and significantly expresses itself in four long-term experiments performed on a male subject and a female subject in separate experiments. There was clear-cut positive correlation between episodes of sleep and preceding episodes of wake. In all four experiments, the circabidian sleep-wake cycle and circadian rectal temperature rhythms, were in a state of internal desynchronization. The authors therefore attribute the differences reported in the literature and this article in the quality of correlation between sleep and wake to the phenomenon of internal desynchronization. However, they do not find significant correlation between sleep and wake episodes in 8 of their 9 subjects; in 1 35-year-female, there is a strong negative correlation between sleep and (preceding or following) wake episodes. It is of much physiological significance that the phenomenon of internal desynchronization should so radically alter the "quality of correlation" between sleep and wake and may be of interest for models of sleep regulation.

Adult↗

Support for carers of people with Alzheimer's type dementia.

BACKGROUND: Research has highlighted the problems for carers of people with dementia. These include the effective loss of companionship and support of a life partner, social isolation and complex financial, legal and social decision making. The burden of caring is financially, emotionally and physically significant. Studies of the effects of ways of supporting carers and reducing the burden of caring often examine a range of outcomes. Probably because of these characteristics, no formal overview of this area of service provision has been undertaken. Moreover, the term 'intervention' in relation to caregivers of people with Alzheimer's disease is open to wide variations in interpretation at the level of service provision. Interventions range from the application of 'hi-tech' computer technology for socialy isolated carers, to the formation of specialist support groups and respite services. OBJECTIVES: The objective of this review is to provide an assessment of the effectiveness of health and/or social interventions designed to help support the carers of people with Alzheimer's-type dementias. SEARCH STRATEGY: The Cochrane Controlled Trials Register was searched using the terms 'carer*' and 'caregiv*'. See the Cochrane Dementia & Cognitive Impairment group's details for the full search strategy. SELECTION CRITERIA: All randomised trials in which primary carers of people with Alzheimer's disease are allocated to either intervention or non-intervention/control groups and where the intervention was provided by healthcare and/or social services. DATA COLLECTION AND ANALYSIS: Data was extracted by both reviewers and was found to be unsuitable for quantitative synthesis. A qualitative overview is presented and structured according to the comparisons used in the review. Weighted Mean Differences (weighted by sample size) for each outcome and its subcategories are also presented. MAIN RESULTS: The results of the review are inconclusive. No evidence was found for the following comparison interventions: 1) individualised service assessment and planning versus conventional support 2) technology-based carer networking (via computers or telephones) versus conventional support 3) carer-education/training versus conventional support 4) multi-faceted/dimensional strategies (such as specialised carer assessment and training) versus conventional support Whilst the overview suggests little or no evidence that interventions to support caregivers of people with Alzheimer's disease are of quantifiable benefit, the poor quality and small sample sizes of the studies, as well as the diversity of interventions examined and outcomes reported, mean that this conclusion cannot be put forward without the need for caution, particularly as some of the studies put forward qualitative evidence which contradicts this conclusion. REVIEWER'S CONCLUSIONS: With the limited nature of the research evidence in mind, it is not possible to recommend either wholesale investment in caregiver support programmes or withdrawal of the same. With the addition of further studies in future updates of this review, expected in early 1999, this presently inconclusive picture may become clearer. A number of conclusions relating to future areas of research can be put forward with more conviction. Specifically, 1) Future trials need to examine interventions included in the existing knowledge base on Alzheimer's carer-supportive interventions. 2) Outcome measures used should mirror those in similar studies. 3) Outcome measures need to be clinically and 'lay' relevant. 4) Trials need to be of longer duration given the 7-10 years median life expectancy of people with Alzheimer's Disease. 5) Sample sizes need to be increased and calculated properly given the likelihood of a moderate intervention effect (if any). 7) Blinding at the outcome assessment stage needs to be a part of future basic trial designs if bias is to be avoided. 8) If reviews are to have their power increased then quality o

Alzheimer Disease↗

Effectiveness of knee replacement surgery in arthritis.

This study examined the effectiveness of knee replacement surgery in an elderly population suffering from arthritis. Four questionnaires which measured pain, mobility, anxiety, depression and social isolation were completed by the study group before and after surgery to assess changes in physical function, psychological state, social interaction and somatic sensation. A statistically significant difference was found in pain which was reduced from a median score of 3 before the operation to 0 afterwards on an intensity scale of 0-5. Statistically significant improvements were also found in the mobility/dependency scores and in the level of anxiety and depression following the operation. It was concluded that knee replacement is a highly effective treatment for arthritis of the knee, reducing pain, increasing mobility and improving the persons emotional state, thus improving the quality of life of the recipient. The use of separate questionnaires to measure single dimensions of quality of life as opposed to a single health profile is also discussed.

Activities of Daily Living↗

Adolescent self-reports of social activity: assessment of stability and relations to social adjustment.

Adolescents' self-reports of peer social activity were examined with regard to short-term stability and in relation to social adjustment. Two separate periods of data collection are reported; year 1 with 74 grade nine students and year 2 with 76 grade nine students. On both occasions, four administrations of a self-report questionnaire were undertaken. As well, in year 2, social adjustment ratings, indices of perceived competence and self-efficacy, and IQ were collected. The analyses of the measure's consistency indicated acceptable stability of the self reports across two weeks and high internal consistency. These findings indicate the potential utility of this methodology for studying peer activity. Zero-order and multiple correlation analyses between social activity, self-evaluations and social adjustment were computed. The analyses suggest that peer social activity is correlated with social self-esteem, enhanced social self-efficacy and teacher's ratings of social engagement. Social isolation appeared to be an independent dimension and was related to lowered self-esteem and teacher ratings of social withdrawal. Overall, the results of the study add to our understanding of the components of social adjustment in adolescence.

Adolescent↗

The influence of patterns of welfare receipt during the child-rearing years on later physical and psychological health.

This study examined interrelations among welfare receipt, social integration, and later physical and mental health in a cohort of African American mothers from the Woodlawn neighborhood on the south side of Chicago. These women (N = 681) have been followed prospectively from 1966-67 to 1997-98. Findings indicate that receiving welfare during the child-rearing stage of life is related to both social integration and later health, with those who had received welfare in young to middle adulthood being more socially isolated and having more health problems twenty to thirty years later. Findings provided no support for the hypothesis that social integration mediated the relationship between welfare receipt and later physical and psychological health problems. Welfare receipt had a direct detrimental effect on later health outcomes. Attending church regularly was protective for later physical and psychological health. The relationship between early welfare and later health remained even when the women's current poverty was added to the model.

Adult↗