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At least 973 records · Page 54Linked to original sources
PubMed1978

Congenital ocular toxoplasmosis. Possible occurrence in siblings.

In two siblings, we saw bilateral macular lesions that were consistent with the diagnosis of congenital toxoplasmosis. Although the congenital nature of this type of infection cannot be proven conclusively, there is considerable evidence that the lesions in our young patients were scars from congenital toxoplasmic retinochoroiditis. To our knowledge, congenital ocular toxoplasmosis in siblings has not previously been reported.

Adolescent↗
PubMed1995

Cost-benefit analysis of screening for toxoplasmosis during pregnancy.

Congenital toxoplasmosis is a risk for fetus both in 'low' and 'high risk' areas. A cost-benefit analysis based on data from a Finnish prospective study (20.3% seropositivity of pregnant mothers and incidence of 2.4/1,000 seronegative pregnancies) and on Finnish cost data was performed to compare the no-screening and screening alternatives for primary toxoplasma infections during pregnancy. A maternal-feto transmission risk of 40%, effectiveness of treatment of 50%, and discount rate of 4% were used as other baseline probabilities. The calculations were carried out by decision analysis combined with sensitivity analysis. The total annual costs of congenital toxoplasmosis without screening amount to US$ 128/pregnancy/year, and with systematic serological screening, US$ 95/pregnancy. Thus screening reduces the costs by 25%. The present value of net savings in Finland would be US$ 2.1 million every year. A one-way sensitivity analysis showed that screening together with health education is preferable to health education without screening if the incidence of maternal primary infections exceeds 1.1/1,000 and effectiveness of treatment is better than 22.1%. Screening for toxoplasma infections during pregnancy is economically worthwhile even in a country with a low incidence. A scheme of systematic screening for maternal primary toxoplasma infections combined with health education should be considered.

Cost-Benefit Analysis↗
PubMed1976

Some remarks on the immunopathology of toxoplasmic uveitis.

Data obtained from prospective studies of congenital toxoplasmosis and from serological examination of patients with uveitis suggest that ocular toxoplasmosis is mostly congenital in origin. It is mainly related to the immunological clearance of residual cysts persisting after a subclinical congenital toxoplasmosis.

Adolescent↗
PubMed1984

Encephalitis in mice with congenital ocular toxoplasmosis.

The brains of mice with congenital ocular toxoplasmosis were examined histologically. Toxoplasma tissue cysts and a subacute/chronic meningo-encephalitis were present in the brains of all infected mice. The findings were very similar to those seen in human congenital toxoplasmosis. The murine model of congenital toxoplasmic encephalitis described in this paper will be valuable in the study of the pathogenesis, natural history and treatment of this condition.

Animals↗
PubMed1980

Computed tomography in the evaluation of congenital cerebral toxoplasmosis.

This report deals with the contribution of computed tomography (CT) to the diagnosis of congenital toxoplasmosis in two infants. Computed tomography revealed diffuse hydrocephalus and confirmed the periventricular nature of the brain calcifications. The clinical, radiographic, and CT findings are discussed.

Brain Diseases↗
PubMed1981

[Congenital ocular toxoplasmosis and late recurrences (author's transl)].

Congenital toxoplasmosis is essentially characterized on the ophthalmological point view by a pathognomonic focus of necrotic chorioretinitis in the cicatricial stage and taking the aspect of a rose-window, which is seen in more than 50% of the cases. The late recurrences of this ocular toxoplasmosis are not rare and may be seen in nearly one third of the cases. They may be due to a congenital toxoplasmic cyst, which may exist in a healthy retina in the absence of any old cicatricial focus.

Adolescent↗
PubMed1985

The role of toxoplasmosis in congenital disease in Malaysia.

Toxoplasmosis was found not to be an important cause of intrauterine infection in Malaysia as the rate of toxoplasma-specific IgM in 1,060 congenitally defective Malaysian children, 0 to 4 months old (0.4%) was lower than that in 405 normal children of the same age group (2.0%). A total of 8.2 intra-uterine toxoplasmic infections per 1,000 live births was detected of which one-third (2.7 per 1,000 live births) was overt, manifesting symptoms more of liver damage, than eye or brain damage. A comparison was made with the rates in U.S.A. and Europe. The role of toxoplasmosis in abortion needs to be studied.

Hepatomegaly↗
PubMed2005

[Congenital ocular toxoplasmosis--ocular manifestations and prognosis after early diagnosis of infection].

BACKGROUND: Congenital toxoplasmosis (CT) is the most frequently encountered congenital infection. The aim of the present review is to report about the long-term outcome of functional and morphological manifestations after an early confirmation of the diagnosis. PATIENTS AND METHODS: We report on a cohort of patients with serologically confirmed CT, born between 1988 and 2001, who were followed up prospectively at a single centre (Institute of Parasitology, Hôpital de la Croix Rousse, University of Lyon). All patients underwent regular ophthalmological, parasitological and paediatric controls on a half-yearly or annual basis. Ocular manifestations were documented and visual acuity was assessed as far as was possible. RESULTS: 1,506 seroconversions were diagnosed during pregnancy, and 327 of the live-born offspring were seropositive for CT. At the end of the study period, ocular manifestations occurred in 79 of the children (24 %), and in 7 cases (9 %) they were discovered during the first month of life. In 72 of the patients (91 %), the ocular manifestations developed between 1 and 151 months (median follow-up time: 6.3 +/- 3.7 years; range: 0.5 - 14 years) under medical treatment for the first year of life. At the end of the study period, information regarding visual acuity was available for 66 patients. In 55 of these (83 %), visual acuity was normal in both eyes, and in 11 (17 %), it was reduced below 0.5. In 1 child, both eyes were functionally affected, one severely. CONCLUSION: CT may not become manifest ocularly until after a decade, which underlines the necessity for long-term ophthalmological monitoring of the infected individuals. In our patients, the prognostic outcome after therapy for the first year of life was better than that reported in the literature. This favourable outcome may serve as a basis for patient counselling.

Adolescent↗
PubMed1986

[Serological tests for the diagnosis of toxoplasmosis].

There are number of tests that can be used in diagnosis of Toxoplasmosis. The clinical findings should always be supported by serological tests for a definitive diagnosis. A four fold use in the titre, or a titre of over 1:32 for IgM should be sought for the diagnosis of acute toxoplasmosis. In this article the validity of the IgG and IgM antibody titres in diagnosis of acute toxoplasmosis and congenital toxoplasmosis are discussed.

Acute Disease↗
PubMed1985

[Acquired toxoplasmic chorioretinitis with a late onset].

Maternal toxoplasma infection was responsible for congenital toxoplasmosis with ocular and cerebral manifestations in the infant. The acquired character of the toxoplasmosis in the 5th month of pregnancy was confirmed by serologic data and isolation of the parasite from the placenta. Five years later, an evolutive chorioretinitis was found in the mother. The toxoplasma origin of the ocular injury was proven by the study of aqueous humor. This case report is compared with the rare similar cases in the literature. The late discovery of ocular impairment is discussed.

Adult↗