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Results for “VASCULAR DISEASES PERIPHERAL”

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At least 973 records · Page 54Linked to original sources
PubMed1978

A new noninvasive approach to peripheral vascular disease: thallium-201 leg scans.

A new noninvasive technique to evaluate blood flow distribution to the legs is described. Intravenous thallium-201 is used during rest and exercise followed by scanning and point counting of the lower extremities. The normal blood flow distribution recorded in 30 patients with no known peripheral vascular disease was primarily proportional to muscle mass. Using both scans and point counting, normal intra- and interextremity ratios were qualitatively and quantitatively defined, and significant increases in muscular to nonmuscular perfusion with exercise were documented. The symmetry in perfusion in the contralateral muscle groups was verified for the first time.

Arterial Occlusive Diseases↗
PubMed1993

A comparison of different methods of assessing free radical activity in type 2 diabetes and peripheral vascular disease.

Increased free radical activity in diabetes mellitus may contribute to the higher prevalence and mortality from macrovascular disease in diabetic patients. To investigate this, levels of plasma antioxidants (superoxide dismutase, caeruloplasmin, plasma, and lysate thiol), diene conjugates, lipid peroxides, and chemiluminescence were measured in diabetic and non-diabetic patients with peripheral vascular disease compared with healthy control subjects. Caeruloplasmin, diene conjugate ratio, and lipid peroxides were significantly increased in patients with vascular disease but there was no difference between diabetic and non-diabetic patients. Conjugated diene ratio correlated with caeruloplasmin (r = 0.40, p < 0.02) and inversely with superoxide dismutase level (r = 0.36, p < 0.05) but there was no significant correlation between other antioxidants and diene conjugates, lipid peroxides or chemiluminescence. The relationship between different indirect measurements of free radical activity is variable but there appears to be no additive effect of diabetes on the increased free radical activity associated with vascular disease.

Aged↗
PubMed1984

The value of digital subtraction angiography in peripheral vascular diseases.

The iliac and subclavian arteries and their distal branches were studied by digital subtraction angiography (DSA) in 79 patients and the results compared with conventional angiograms for 35 patients. Techniques, results, advantages and disadvantages are described. DSA (both intravenous and intra-arterial) looks very promising in the diagnosis of peripheral vascular disease.

Adult↗
PubMedDate not supplied

Free radical production in peripheral vascular disease. A risk for critical ischaemia?

Malondialdehyde (MDA) plasma concentrations (marker of lipid free radical peroxidation) and the unfractionated leucocyte and erythrocyte filterability rates (through 5 micron Nuclepore filters in a positive pressure filtration system) were determined during a partial ischaemia induced by two consecutive treadmill tests in 64 stage II peripheral vascular disease (PVD) patients and in 32 matched controls. Transcutaneous oxygen pressure (tcPO2) was monitored constantly throughout the walking tests and recovery periods. In the PVD patients impairments in the flow properties of leucocytes and erythrocytes were associated with increases in MDA plasma concentrations which correlated significantly with a lengthening of the tcPO2 half recovery times--index of the worsening of ischaemia. Patients could be divided into two sub-groups on the basis of these impairments and their half recovery times, suggesting this experimental model may provide a means to identify those stage II PVD patients most likely to develop critical limb ischaemia.

Aged↗
PubMed1984

The assessment of skin blood flow in peripheral vascular disease by laser Doppler velocimetry.

The helium-neon laser Doppler (LD) is designed to measure skin blood flow velocity (SBFV). Flow velocity and pulse wave amplitude are expressed in millivolts (mv) relative to a zero-flow reference. The authors have reviewed their initial experience in ten persons (20 limbs) without peripheral vascular disease (PVD, group I) and nine patients (12 limbs) with severe PVD (group II). The finger, palm, great toe, and forehead had a significantly (P less than 0.05) greater flow velocity than the plantar and dorsal foot, distal and proximal leg, thigh, chest, arm, and forearm. Baseline and hyperemic SBFV, measured at the great toe, were compared in groups I and II. In group I, the baseline SBFV (mv, mean +/- standard error of the mean (SEM] in the great toe was 197 +/- 38 compared with 67 +/- 12 in group-II patients (P less than 0.05). The pulse wave amplitude (mv, mean +/- SEM) was 77 +/- 14 in group I and 5.4 +/- 1.1 in group II (P less than 0.05). The time to maximal hyperemic response (seconds, mean +/- SEM) in group I was 18 +/- 1.5 compared with 150 +/- 14 in group II (P less than 0.05). LD is a sensitive indicator of changes in SBFV, allowing differentiation between normal persons and patients with PVD. The LD tracing in patients with PVD is characterized by a baseline SBFV that is significantly less than normal and also by the attenuation or absence of pulse waves. The diagnostic accuracy is enhanced by the use of reactive hyperemia.

Adult↗
PubMed1997

Peripheral vascular disease and its evaluation.

The occurrence of arterial vascular disease is increasing because of the increasing age of the population. The at-risk population includes diabetics, smokers, patients with heart disease, and those with a family history of heart disease. History and physical examination help delineate two classes of patients: symptomatic and asymptomatic.

Angiography↗
PubMed2005

Plantar pressure distribution in Type 2 diabetic patients without peripheral neuropathy and peripheral vascular disease.

AIMS: To evaluate the distribution of plantar pressure during walking on a level gradient in patients with Type 2 diabetes mellitus without any microvascular and macrovascular complications and to compare them with non-diabetic control subjects. METHODS: A group of 15 patients with Type 2 diabetes mellitus without either peripheral neuropathy or peripheral vascular disease (PVD), as well as without both diabetic retinopathy and nephropathy, was compared with a group of 15 non-diabetic subjects matched for age, sex, body weight and height. The plantar pressure and duration of plantar pressure were measured on big toe, 1st, 3rd and 5th metatarsal heads, and on the heel of both feet by Force Sensing Resistors sensors. The static contact plantar surface was measured by method of Harris footprints. RESULTS: The diabetic group showed a significant increase in peak plantar pressure at the level of the big toe [right foot 205 +/- 94 vs. 101 +/- 39 kPa (mean +/- SD), P = 0.01; left foot 165 +/- 61 vs. 104 +/- 43 kPa, P = 0.05] and 5th metatarsal head (right foot 160 +/- 68 vs. 97 +/- 32 kPa, P = 0.05; left foot 174 +/- 65 vs. 91 +/- 42 kPa, P = 0.02) with a significantly prolonged duration of plantar pressure at each step. Under the heel, the peak plantar pressure was significantly lower in the diabetic group (right foot 187 +/- 54 vs. 321 +/- 91 kPa, P = 0.05; left foot 184 +/- 63 vs. 298 +/- 110 kPa, P = 0.05). No significant differences were noted under 1st and 3rd metatarsal heads. The contact plantar surface was significantly reduced in the diabetic group compared with control subjects (right foot 118.2 +/- 10.8 vs. 141.5 +/- 12.7 cm2, P = 0.05; left foot 127.5 +/- 8.7 vs. 140.0 +/- 11.1 cm2, P = 0.05). CONCLUSIONS: We observed an anterior displacement of weight-bearing during walking on a level gradient as well as a reduced static contact plantar surface in diabetic patients without evidence of any complications compared with the non-diabetic control group. This could be a premature sign of peripheral neuropathy, which is not evaluated on clinical examination or quantitative sensory testing used in clinics.

Adult↗
PubMed1988

Evaluation of a computerised test for the assessment of peripheral vascular disease.

This paper reports a study carried out in 200 patients to assess the effectiveness of a clinical vascular laboratory in the routine assessment of peripheral vascular disease (PVD) of the lower limb. Laboratory assessments involved a computer based hierarchical testing system incorporating pedal pressure indices, maximum walking distances and principal component analysis of the common femoral artery blood velocity waveform. The study fell into two parts. In the first, the laboratory assessments of 100 patients referred six years ago were compared retrospectively with their eventual clinical outcome. In this comparison, the laboratory provided a "diagnosis" which was 79% correct. In the second, a double blind prospective study was carried out in 100 patients to compare the vascular laboratory "diagnosis" with the diagnosis and prognosis of a skilled clinician, the outcome being compared one year after the initial assessment. In this study the laboratory proved to be correct in 78% of cases, the clinician in 70%. With a slightly modified computer protocol for the non vascular diagnosis, the computer would have been correct in 85% of cases. This test provides a quantitative and objective assessment of PVD which can assist in the patient's clinical diagnosis and management.

Diabetic Angiopathies↗