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PubMedDate not supplied

Malathion and malaoxon environmental levels used for exposure assessment and risk characterization of aerial applications to residential areas of southern California, 1989-1990.

Between August 1989 and July 1990, California conducted a Mediterranean fruit fly eradication project in southern California which included repeated aerial applications of malathion bait to urban areas where approximately 1.6 million people resided. Concern about the safety of these applications prompted the California Department of Health Services to prepare a risk assessment. The current work presents the estimates of environmental levels of malathion and malaoxon, derived from mass deposition rates during application and monitoring of air. We estimated short and long-term malathion and malaoxon levels on outdoor surfaces, plants, and soils (0.1 and 1.0 cm mixing depth), using a simple first-order exponential decay model and literature half-life values ranging from three to nine days. Direct monitoring data were used to characterize short-term air levels. Average and upper-bound malathion levels immediately following an application were 0.091 microgram/m3 and 0.207 microgram/m3 in air; 22 and 52 mg/m2 on outdoor surfaces; 3.8 and 9.6 micrograms/g in plants; and 1.5 and 3.5 micrograms/g in soil (1 cm mixing depth). Malaoxon levels were 0.039 microgram/m3 and 0.110 microgram/m3 in air; 0.15 and 0.46 mg/m2, 0.03 and 0.09 microgram/g, and 0.01 and 0.03 microgram/g, respectively. Estimates of average and upper-bound levels over the duration of the eradication program were roughly one-third the immediate levels in all media. No field measurements were available for co-products other than malaoxon, for environmental persistence, or for concentrations on surfaces, soil, or plants after repeated applications. Because of limited monitoring data, and the likelihood that similar pest-eradication programs will be conducted, additional studies are warranted to more accurately characterize the environmental fate of malathion and human exposures after aerial application to residential communities.

Animals↗

PubMed1994

A new iridium applicator for vaginal vault irradiation.

A new disposable gynecologic applicator designed for postoperative vaginal vault brachytherapy is presented. The applicator is afterloading manually with iridium 192 wire. We have used this new applicator in more than thirty patients and recorded the following advantages: 1) There is no need to install expensive and complicated equipment; 2) Single use applicators are in sterile packages and are ready to use; 3) Applicator is easily and comfortably carried by patient; 4) There is no need for specific training to use the system; 5) There is no need for general anesthesia during application; 6) There is no need for patient immobilization during treatment; 7) There is no need for urinary catheterization during treatment; 8) Dose distribution is homogeneous; 9) Bladder and rectum doses are at acceptable levels; 10) Radioprotective measures needed to be taken are inexpensive. We believe that this new system could easily be used in every radiation oncology unit.

Brachytherapy↗

PubMed1994

Ultrastructural changes of the vestibular sensory organs after streptomycin application on the lateral canal.

Early changes in the vestibular sense organs resulting from the application of a streptomycin sulfate soaked Gelfoam pledget on the fenestra of the lateral semicircular canal were studied by transmission and scanning electron microscopy. Three days after the application, lesions were present in the central part of the lateral crista. The type I sensory cells were more affected than the type II cells. These sensory cells showed mitochondrial swelling, cytoplasm protrusion at the cell apex, inclusion of multiple vacuoles, fusion or loss of stereocilia, and pyknotic nuclei. Seven days after the drug application, the sensory cell damage extended to all three cristae and macula utriculi. The lesions were very extensive after ten days and the sensory cells had almost equally disappeared in all three cristae; the lesion in the macula utriculi was smaller and the macula sacculi was unaffected. At fourteen days, the lesions appeared less severe. Thus, a single application of a small amount of streptomycin on the lateral canal fenestra affected all vestibular sense organs, except the saccule, in a short time. The strong affinity of aminoglycosides for the cristae suggests possible entrapment of the drug at the ampullae. This local drug application technique to the canal will be useful in studying vestibular function in animals, and it is applicable to controlling severe vestibular symptoms in human patients.

Animals↗

PubMedDate not supplied

Mapping the future of hospital information systems: priorities for nursing applications.

The purpose of this study was to determine the value of computerized applications to nurse users in a large acute-care university-affiliated hospital. A hospital information system has been in place since 1983. A convenience sample of 77 staff nurses and 33 nurse managers from various clinical areas rated the benefits for decision making and patient care of approximately 19 existing automated applications, and prioritized for future acquisition, approximately 40 applications not currently available. Results of the study revealed that of the applications currently automated, respondents ranked the applications of results reporting, order entry, nursing station census, and message switching as most useful for decision making and patient care. Applications identified as high priorities for future acquisition were on-line charting, automated medication record, and enhanced results reporting.

Adult↗

PubMed1995

Constructing clinical applications: the GALEN approach.

A common problem for developers of clinical applications is coping with the diversity of medical language. Medical language as it is used all over the world varies widely, while the referents for these words stay essentially the same. Software developers must reconcile this diversity with the practical necessity of producing applications that are usable in a variety of hospitals, while ensuring that information can be shared between applications. Existing approaches center around coding and classification schemes, but these approaches must be supplemented by a range of sophisticated terminological services in order for the language barriers to be overcome. To address this, the GALEN project is developing an application called the Terminology Server to provide such a range of terminological services (e.g., conceptual and multilingual services). The software is built upon a re-usable core model of medical terminology. This paper reports on the development of a clinical application called the SCUI (Structured Clinical User Interface) which draws on these GALEN technologies and illustrates an innovative approach to the construction of future clinical applications. The SCUI was specifically developed and tested in the context of infectious diseases to satisfy the demands made by the medical intensive care unit on the Geneva Hospital's microbiology laboratory.

Clinical Laboratory Information Systems↗

PubMed1995

Collaborative social and medical service application.

Baylor College of Medicine has five Teen Health Clinics (THC) dispersed throughout Harris county. The population served by the clinics includes inner-city adolescent boys and girls 19 years of age and under. Patients receive services such as family planning, sexually transmitted disease screening and treatment, perinatal care, counseling, and support services. Adolescents may receive services at any one of the clinics at no cost to the adolescent or their dependents. Given the geographical distribution of the clinics and the reliance on paper-based records, client services cannot be provided efficiently or expeditiously. According to the statistics developed by Clinic staff, ineffective coordination of service needs and client schedules undermine the follow-up needed for effective care. For example, a counselor will often need to balance a school schedule, clinic visits, well baby follow-up, and the Best Friends Program for a new mother. In addition, the lack of ready access to patient information impairs the ability of clinical and social service staff to provide continuity of care. In fact, some cases of client dropout are attributable to these difficulties. We have developed the Collaborative Social and Medical Service Application (CSMSA) to facilitate the provision of social and medical services to this population. The CSMSA is a domain-specific application based on a robust infrastructure known as the Ambulatory Services Architecture (ASA). This system is designed to support integrated social and ambulatory care. The ASA is a Baylor developed application framework and architecture for the computerization of the patient medical record in the ambulatory care setting. The working environment for the CSMSA user is an integrated desktop which provides an operating environment for both third-party applications and the CSMSA, as well as a fundamental set of services. The integrated desktop services include a mechanism for object organization or grouping, a facility for the management of desktop objects including disposal and storage, and an embedded search utility to assist in the location of desktop objects as well as other application objects. The access control mechanism will provide the security for the desktop environment by requiring the user to log into and out of the environment. This security mechanism will also enable/disable CSMSA tools based on the user's role at the clinic. The CSMSA is designed to provide work process, functionality and data access appropriate to the responsibilities of the user, e.g., a THC clerk may have permission to view a patient's orders but does not have the facility to create an order. Patient context is defined through a patient browser containing the master patient index or a user defined patient list. Patient encounters are managed using forms based on the process for each encounter type (e.g., initial visit). Forms are used for data entry and for queries. Data entry forms are only committed to the patient database (i.e., making the patient data available to other users who have permission to access the data) when the user approves the data. The CSMSA provides a means to suspend an entry into a chart by saving incomplete or non-committed data entry forms as part of the desktop state which is restored when the user logs into the system. CSMSA was designed to provide a robust, expandable application capable of accommodating the changes in health care and social services delivery while encompassing evolving software standards and new technology. This goal was achieved using object-oriented methodologies and technologies, combined with an object-oriented database management system as the foundation of our server to facilitate the evolution of our data model.

Adolescent↗

PubMed1995

Number of applicants and examination frequency at the dental schools in Sweden 1968-1992.

The number of applicants to the dental schools in Sweden 1968-1987 has been documented. It was shown that there was a large number of applicants up to 1980. Then the number dropped dramatically. It was at its lowest in 1985 but increased slowly after this date. The number of applicants was related to other variables: the birth rate, education capacity, real wage and unemployment. A correlation and time series analysis shows that only real wage has an impact on the number of applicants. The number of applicants has also been related to the examination rate. The results show that the examination rate decreases when the application rate is going down.

Birth Rate↗

PubMed1996

Deposition of malathion and permethrin on sod grass after single, ultra-low volume applications in a suburban neighborhood in Michigan.

Deposition of malathion and permethrin onto grass surfaces, after ultra-low volume (ULV) application, was studied in a suburban neighborhood in Saginaw County, Michigan. Commercial concentrates of malathion (Cythion ULV) and permethrin (Biomist 4 + 12) were sprayed using a truck-mounted ULV aerosol generator. Sod-grass blocks (0.18 m2) were placed in the frontyard and backyard of homes in the neighborhood at 4 distances to 91.4 m from the road where applications were made. Grass samples were taken from the sod blocks before application and at 15 min, 12 h, 24 h, and 36 h after application. Samples were extracted with solvent, and extractions were subjected to gas-liquid chromatography for detection of malathion and permethrin. Ranges of detection for malathion were 0.0-16.6 mg/0.18 m2 and for permethrin were 0.0-25.9 mg/0.18 m2. Most detections were from samples taken nearest the road at 15 min after application. Detections declined as a logarithmic function of time after application and as an exponential function of distance from the road.

Malathion↗

PubMedDate not supplied

Influence of dentin primer application methods on dentin bond strength.

This study was carried out to determine the influence of dentin primer application methods on bond strength to human dentin. Two dentin bonding restorative systems, Imperva Bond/Lite-Fil II A (Shofu) and Scotchbond Multi-Purpose/Z-100 (3M) were employed. Human molars were mounted in self-cured resin and the buccal surfaces were prepared with #600-grit SiC paper. These surfaces were then conditioned according to each manufacturer's instructions. Two experiments were designed: (1) effect of the primer application procedures (inactive and active application), and (2) effect of the air drying time (0, 1, 5, 10, 20, and 30 seconds). The adhesives were applied and resin composites were bonded to the teeth. Ten samples per test group were stored in 37 degrees C deionized water for 24 hours, and shear tested with a circular knife edge at a crosshead speed of 1.0 mm/minute. A one-way ANOVA followed by the Newman-Keuls multiple comparison at P < 0.05 was done. For both restorative systems, the bond strengths for active application were higher than those for inactive application, but there was no significant difference between the two mean values. According to the air drying time, there appeared to be an optimal range of drying times, longer for Imperva Bond (10-30 seconds) than for Scotchbond MP (1-5 seconds). The data suggest that the bond strengths of employed dentin bonding systems were greatly influenced by the methods of the dentin primer application.

Air↗

PubMed1996

[Helical CT for lung-cancer screening: third report: fundamental study for ultralow-dose CT by application of small tube current and filter].

In order to develop ultra-low-dose helical CT for lung cancer screening, the effect of reduction of the tube current to 20mA and application of a 10mm thick aluminium filter upon radiation dose and image quality was evaluated with a phantom. Exposure dose at the center of a gantry and absorbed dose at the center of an acrylic phantom at 20mA with the filter were 15% and 29% of the dose at 50mA without the filter, respectively. For reduction of absorbed dose, reduction of the tube current was more useful than application of the filter. Image noise at 20mA with the filter was double that at 50mA without the filter. Neither reduction of the tube current nor application of the filter changed full width at half maximum on section sensitivity of the Z-axis. Although reduction of the tube current did not affect the difference in CT values between an acrylic sphere and styroform, application of the filter caused a reduction of 4.5% in the difference in CT values. Neither reduction of the tube current nor application of the filter affected the contrast resolution of the high-contrast phantom; however, that of the low-contrast phantom deteriorated. Although improvement of the filter and evaluation of clinical images are necessary, reduction of the tube current to 20mA and application of the aluminium filter appear to be a promising method for ultra-low-dose helical CT of the lung.

Filtration↗

PubMed1996

Dual application of dentin bonding agents: effect on bond strength.

PURPOSE: To evaluate the effect of a dual application of dentin bonding agents (DBA) on their shear bond strength on dentin with intermediate application of a provisional cement. MATERIALS AND METHODS: Freshly prepared flat dentin surfaces of human teeth were coated with a first layer of one of various dentin bonding agents (All-Bond 2, ART Bond, Syntac or an experimental DBA called P-Bond). After curing the DBA, a provisional cement (Temp Bond, Freegenol or Fermit, a soft provisional diacrylate) was applied to the bonded dentin surface. After 24 hours, the provisional cement was removed and the dentin surface scrubbed with pumice. A second application of the same DBA together with a composite cylinder followed. After curing and 1,500 thermal cycles with constant imitation of intrapulpal pressure, shear bond strengths were measured. RESULTS: Compared to a single application of dentin bonding agents following Temp Bond treatment (SBS in MPa: Syntac: 0.86 +/- 1.75, ART Bond: 0.26 +/- 0.47, P-Bond: 14.90 +/- 4.51) application of DBAs prior to use of Temp Bond as well as after its removal seems to be very beneficial to shear bond strength values (SBS in MPa: Syntac:13.36 +/- 4.70, ART Bond: 16.34 +/- 5.02, P-Bond: 19.04 +/- 2.01). Independent from the provisional cement, the values after serial application of P-Bond provided consistently high bond values which were not statistically different (Kruskal-Wallis, P > 0.05) from values of P-Bond on fresh dentin (18.19 +/- 2.29 MPa). The only exception from these findings in the present study was All-Bond 2. Regardless of the provisional materials used, the bond strength values of All-Bond 2 remained low (maximum SBS with Fermit as intermediate provisional cement: 4.63 +/- 2.91 MPa).

Cementation↗

PubMedDate not supplied

Shear bond strengths of one-bottle dentin adhesives using multiple applications.

This study evaluated the effect of multiple applications of the one-bottle adhesives Prime & Bond, One-Step, and Tenure Quik on the shear bond strength of composite to dentin. In addition, the study examined the effects of surface moisture and dual-cure composite on bond strengths of One-Step and Tenure Quik respectively. The adhesive systems were bonded to the occlusal dentin of extracted human teeth. Control group specimens received only two applications of adhesive, as recommended by the manufacturers. Two experimental groups of each system received a greater number of adhesive applications. Additional experimental groups using only two adhesive applications were made to test modifications in surface moisture and composite type for One-Step and Tenure Quik. Shear bond strengths were determined using an Instron Universal Testing Machine. The mean shear bond strength of the Prime & Bond control group was significantly greater than that of the other two control groups. Multiple applications of adhesive decreased the bond strength of each system, but the difference was significant only for four applications of One-Step. The method of moisture removal (compressed air or blotting) had no effect on shear bond strength of One-Step. The shear bond strength of Tenure Quik was not affected by the type of composite used. Prime & Bond had significantly higher shear bond strengths to dentin than either One-Step or Tenure Quik. Both Prime & Bond and One-Step had significantly higher bond strengths than Tenure Quik.

Analysis of Variance↗

PubMed1996

Prevalence of abnormal median nerve conduction in applicants for industrial jobs.

There has been much debate regarding the work relatedness of carpal tunnel syndrome (CTS) and whether workers diagnosed with CTS had pre-existing disease at the time they were hired. To elucidate the latter issue, we examined the prevalence of abnormal median nerve conduction within the carpal tunnel in applicants for industrial jobs. Nerve conduction studies (NCS) were performed on both hands of 1,021 applicants following a conditional offer of employment. Each applicant completed a self-administered symptom survey specific to the upper extremity. Applicants had worked previously for an average of 4.4 (range 0-33) years and had a mean age of 30.1 (S.D. 8.9) years. Nerve conduction studies were performed in a private medical clinic. Sensory palmar latencies were determined over an 8 cm segment for the median and ulnar nerves. The difference between the median and ulnar sensory latencies was the primary electrophysiologic measurement used to determine median neuropathy. Using a very conservative criterion for abnormal median nerve conduction, 17.5% of the applicants were classified with neuropathy in at least one hand. Despite the relatively high prevalence of median neuropathy, relatively few (10%) with positive NCS acknowledged symptoms associated with CTS. Males had a higher percentage of median neuropathy than did females. We conclude that a large percentage of industrial workers have objective evidence of abnormal median nerve conduction within the carpal tunnel when hired. The high prevalence of abnormal median nerve conduction without corresponding symptoms may suggest a subclinical entity associated with CTS.

Adolescent↗

PubMed2002

Selection fairness information and applicant reactions: a longitudinal field study.

Although laboratory studies have found that selection information can affect applicant perceptions, this has not been tested in the field. The authors followed 2 cohorts of police applicants (N = 274) in a longitudinal study to examine the relationship between information, applicant perceptions, and behavior (e.g., turnover). Information was related to perceived fairness measured at the time of testing and 1 month later when applicants received their results. Information moderated the relationship between outcome favorability and test-taking self-efficacy among African Americans but not among Whites. Information was not related to the behavioral measures. The discussion focuses on why certain findings from previous studies were not replicated and on the use of information when applicants have an investment in getting a job.

Adult↗

PubMed2005

Applicant attraction to organizations and job choice: a meta-analytic review of the correlates of recruiting outcomes.

Attracting high-performing applicants is a critical component of personnel selection and overall organizational success. In this study, the authors meta-analyzed 667 coefficients from 71 studies examining relationships between various predictors with job-organization attraction, job pursuit intentions, acceptance intentions, and job choice. The moderating effects of applicant gender, race, and applicant versus nonapplicant status were also examined. Results showed that applicant attraction outcomes were predicted by job-organization characteristics, recruiter behaviors, perceptions of the recruiting process, perceived fit, and hiring expectancies, but not recruiter demographics or perceived alternatives. Path analyses showed that applicant attitudes and intentions mediated the predictor-job choice relationships. The authors discuss the implications of these findings for recruiting theory, research, and practice.

Attitude↗

PubMed1999

The duty of care of the occupational physician in assessing job applicants.

Where an occupational physician carries out a medical assessment of a job applicant, he or she owes a duty to the employer but not to the applicant, unless actual physical harm is caused. If the applicant is unsuccessful as a result of an assessment which is alleged to be negligent, he or she cannot sue the physician. This is essentially because (i) the relationship between the physician and the applicant is insufficiently close, and (ii) the physician might be faced with a conflict of interest since differing duties might be owed to the employer and to the applicant.

Attitude of Health Personnel↗

PubMed2002

Scoring of orthopaedic residency applicants: is a scoring system reliable?

The purpose of the current study was to examine the interobserver reliability of a scoring system designed to objectify the screening of orthopaedic residency applications. Forty residency applications were selected randomly from those received in 1998 and were scored independently by six observers. The scoring system used included objective and subjective elements. Weights were assigned to individual data elements based on the results of a previous investigation. Interobserver reliability was calculated using an intraclass correlation coefficient. The overall reliability of the scoring system revealed an intraclass correlation coefficient of 0.80. The intraclass correlation coefficients for individual elements in the scoring system ranged from 0.28 to 0.98. The intraclass correlation coefficient was high for elements that were numeric, but was low for elements that were more subjective. Observers thought the scoring form was easy to complete but found some of the subjective data elements difficult to score. No benchmarks exist by which to define an acceptable intraclass correlation coefficient of a scoring model for resident applicants. Even with the use of careful definitions, raters had poor reliability in scoring elements such as letters of recommendation and personal statements. The results of the current study indicate that one score of objective data elements is adequate to screen a residency application for these elements. Programs screening applicants based on subjective elements, however, should be aware that great interobserver variability exists in the interpretation of those elements.

Humans↗

PubMed1995

Make an application for flexible (part time) training.

Part time training posts are advertised in the BMJ each year in August or September in an advertisement placed by the Department of Health. Although the advertisement is placed by the department and manpower approvals are allocated centrally, each region runs its own scheme, and the first person to approach is the regional postgraduate dean (most regions have an assistant dean responsible for flexible training). If an application is successful then part time trainees are interviewed by the same appointments committee as full time applicants and they are judged by the same criteria. Manpower approval is granted to applicants who reach the same standard as full time applicants, but there may be a waiting list if there are more suitable applicants than training places available. The next stage is to gain educational approval from the relevant higher training committee for the proposed training programme, followed by funding from the region.

Female↗