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PubMed2006

High and low temperatures have unequal reinforcing properties in Drosophila spatial learning.

Small insects regulate their body temperature solely through behavior. Thus, sensing environmental temperature and implementing an appropriate behavioral strategy can be critical for survival. The fly Drosophila melanogaster prefers 24 degrees C, avoiding higher and lower temperatures when tested on a temperature gradient. Furthermore, temperatures above 24 degrees C have negative reinforcing properties. In contrast, we found that flies have a preference in operant learning experiments for a low-temperature-associated position rather than the 24 degrees C alternative in the heat-box. Two additional differences between high- and low-temperature reinforcement, i.e., temperatures above and below 24 degrees C, were found. Temperatures equally above and below 24 degrees C did not reinforce equally and only high temperatures supported increased memory performance with reversal conditioning. Finally, low- and high-temperature reinforced memories are similarly sensitive to two genetic mutations. Together these results indicate the qualitative meaning of temperatures below 24 degrees C depends on the dynamics of the temperatures encountered and that the reinforcing effects of these temperatures depend on at least some common genetic components. Conceptualizing these results using the Wolf-Heisenberg model of operant conditioning, we propose the maximum difference in experienced temperatures determines the magnitude of the reinforcement input to a conditioning circuit.

Adenylyl Cyclases↗

PubMed1990

Neonatal Section of the Optic Chiasm Changes the Interhemispheric Transfer of Visual Information in Cats.

Recent studies in adult split-chiasm cats show that the contrast gain of the visual callosal pathway is considerably lower than the gain of the direct geniculocortical system and that high spatial and temporal frequencies are strongly attenuated in the process of callosal transfer. We recorded visual evoked potentials (VEPs) and single unit activities from visual cortical areas 17 and 18 in cats which had the optic chiasm sectioned at 3 weeks of age. Our results show that, unlike the animals sectioned as adults, the contrast gain and the spatial and temporal acuities of the callosal pathway of young split-chiasm cats were as good as the direct retinogeniculocortical pathway. Thus, under the present experimental conditions all the spatial and temporal information processed in areas 17 and 18 of one hemicortex is transferred to the other hemicortex via the callosal connections. These animals have also been tested behaviourally for the interocular (interhemispheric) transfer of learning of patterns of high spatial frequency and low contrast. In agreement with the electrophysiological results, we find a complete interocular transfer for this behavioural task. We conclude that the functional development of the interhemispheric connections can be modified by an early section of the optic chiasm and therefore the loss in binocular convergence can be partially compensated.

Journal Article↗

PubMed1988

Electrolytic but not ibotenic acid lesions of the posterior cingulate cortex produce transitory facilitation of learning in mice.

The rate of acquisition of 12 Hebb-Williams mazes was studied after restricted bilateral lesions of the anterior (ANT) or posterior (POST) cingulate cortex in BALB/c mice. In a first experiment, animals with electrolytic lesions were tested with the different mazes at 3 time intervals between 19 and 48 days after surgery. The rate of acquisition in POST-lesioned mice was observed to be facilitated at the 2 first time intervals (between days 19-22 and 32-35), but this effect was reversed (impairment) when the test was carried out between 45-48 days postsurgery; no significant effects were observed in ANT-lesioned mice. In a second experiment, the same behavioral paradigm was used in mice with restricted ibotenic acid lesions of the POST cingulate cortex. These lesions had no significant effects on the acquisition of the mazes. A third experiment was carried out to test if the postoperative delay itself contributed to the long latency of the impairment observed in Expt. I. No impairment of acquisition was observed when POST cingulate lesioned animals underwent their first learning session between 45-48 days after surgery; in contrast, a significant facilitation of the performance was observed at this time. These results suggest an involvement of the posterior cingulate cortex, and in particular the cingulum bundle, both in acquisition and long-term memory processes.

Animals↗

PubMed1993

Pattern recognition in the neocognitron is improved by neuronal adaptation.

We demonstrate that equipping the neurons of Fukushima's neocognitron with the phenomenon that a neuron decreases its activity when repeatedly stimulated (adaptation) markedly improves the pattern discriminatory power of the network. By means of adaptation, circuits for extracting discriminating features develop preferentially. In the original neocognitron, in contrast, features shared by different patterns are preferentially learned, as connections required for extracting them are more frequently reinforced.

Adaptation, Physiological↗

PubMedDate not supplied

Perceptual brightness space in the carp (Cyprinus carpio L.).

An instrumental differentiation method was used to study the discrimination of the intensities of black/white (over the range 0.0082-0.214 W/m2; coordinates in the CIE-31 system: X = 0.340, Y = 0.354) and red (over the range 0.0035-0.106 W/m2; coordinates in the CIE-31 system: X = 0.641, Y = 0.342) stimuli in two carp fish (cyprinus carpio L.). Confusion matrices were constructed using the probabilities of instrumental responses (bead seizing) on selection from a pair of stimuli (a conditioned stimulus and one of nine differentiating stimuli) in six series using a conditioned stimulus of defined brightness. Matrices of correlations between vectors (the stimuli used for the confusion matrices) were subjected to factor analysis to identify their intrinsic vectors. The perceptual brightness spaces for both black/white (two fish) and red (one fish) stimuli were found to be spherical in structure, resembling the major features of the human brightness space. The coordinate axes of this space were interpreted as representing excitation of two channels encoding intensity as brightness and darkness.

Animals↗

PubMed2002

Visual responses in the temporal cortex to moving objects with invariant contours.

We were interested in how the visual attributes of motion and shape are integrated in the temporal cortex of monkeys. We recorded neural activity in the middle portion of the superior temporal sulcus (STS) of monkeys during a sequential visual discrimination task while the animals maintained fixation. We used images of objects with invariant outlines rotating in 3D space either clockwise or counterclockwise as visual stimuli. In the sequential discrimination task, after the fixation pattern was presented for 1.0 s, the sample stimulus (S1) appeared at the center of the monitor screen for 0.8 s. After a delay period of 0.5-2.0 s, the same stimulus or a new response stimulus appeared on the screen for 0.8 s. In each block, the response stimulus was either a new direction of rotation or a new shape. Of 425 responding neurons isolated in the STS, 202 (48%) showed significant activity when S1 stimuli were presented. Of these visual neurons, 27 (13%) were categorized as motion and shape selective (MS), 69 (34%) as shape selective (S), and 6 (3%) as motion selective (M). Briefer than for MS or S neurons, the latency of the remaining non-selective neurons was 80 ms. Latencies of visual response (110 ms) of both MS and S neurons were similar. On the other hand, MS neurons started responding later (180 ms) to changes in direction. Our findings show that neurons in the STS, responding selectively to changes in shape, do respond to relatively simple motion and that variable contouring is not essential to elicit motion response. The results may also suggest the functional segregation of selective versus non-selective neurons and the later arrival of directional response to MS neurons in the STS.

Action Potentials↗

PubMed1991

Tolerance to anticonvulsant effects of the partial benzodiazepine receptor agonist abecarnil in kindled rats involves learning.

The effects of chronic treatment with the beta-carboline, abecarnil, a novel partial and/or subtype-specific agonist at central benzodiazepine receptors, were studied on fully kindled amygdaloid seizures in rats. Two different experimental protocols were used to differentiate between "pharmacologic tolerance', i.e. tolerance as a function of drug exposure, and "contingent tolerance, i.e. tolerance contingent upon the repeated occurrence of the criterion effect, i.e. the anticonvulsant effect. When kindled seizures were repeatedly initiated during chronic treatment of rats with abecarnil (5 mg/kg i.p. three times daily), marked tolerance developed to its anticonvulsant effect, although plasma levels of abecarnil even increased during the 2 weeks of treatment. When the same treatment protocol was used, but seizures were initiated only at the start and end of the treatment period, almost no tolerance to the anticonvulsant effect of abecarnil was measured, indicating an important role of learning processes for the development of tolerance. In contrast to the differences in anticonvulsant tolerance between the two protocols, the motor impairment induced by abecarnil was similarly attenuated during chronic treatment according to both protocols. The data indicate that, because of the response contingency in abecarnil tolerance, development of tolerance to anticonvulsant effects of this compound depends critically on seizure frequency during drug administration, while adverse effects of this compound are reduced independently of seizure frequency.

Animals↗

PubMed2006

Facilitated cognitive disengagement in depression.

The present study was conducted to test predictions derived from the hypothesis that depression may serve the purpose of adaptively facilitating disengagement from obsolete cognitive plans. Groups of students with either low or high depression scores were contrasted using a procedure that featured an initial learning phase, within which participants learned to perform a task, followed by a relearning phase within which they needed to disengage from initial learning in order to relearn to perform an altered task. It was assumed that performance in the relearning phase would be affected by the degree to which participants could readily disengage from their initial learning. As predicted, participants in the high depression group, relative to those in the low depression group, demonstrated superior performance in the relearning phase alone. The theoretical and applied implications of this finding are discussed.

Adaptation, Psychological↗

PubMed2004

A comparison of the effects of ageing upon vernier and bisection acuity.

While most positional acuity tasks exhibit an age-related decline in performance, the effect of ageing upon vernier acuity continues to be the subject of some debate. In the present study we employed a stimulus design that enabled the simultaneous determination of bisection and vernier acuities in 36 subjects, aged between 22 and 84 years. This approach provided a means for directly testing the hypothesis that ageing affects bisection acuity but not vernier acuity by ensuring that differences in stimulus configuration and in the subject's task were kept to an absolute minimum. Optimum thresholds increased as a function of age for both bisection and vernier tasks. Inter-subject threshold variability also increased with age. Issues surrounding the comparison of absolute vernier thresholds across different studies are discussed and two important methodological factors are identified: the precise statistical method used to estimate thresholds, and the magnitude, in angular terms, of the smallest spatial offset of the elements of the vernier stimulus which can be displayed. Comparison with previously published data indicates that the discrepancy between this study and most previous investigations with respect to the effect of age upon vernier performance can be at least partly accounted for by differences in the minimum displayable vernier offset. Vernier thresholds do increase with age. The increased variability of vernier thresholds in older subjects would appear to limit the diagnostic value of the test as a means of enabling normal ageing to be distinguished from visual loss due to pathology of the eye or visual system.

Adult↗

PubMed2000

Is the avian hippocampus a functional homologue of the mammalian hippocampus?

The effects of hippocampal lesions on the processing and retention of visual and spatial information in birds and mammals is reviewed. Both birds and mammals with damage to the hippocampus are severely impaired on a variety of spatial tasks, such as navigation, maze learning, and the retention of spatial information. In contrast, both birds and mammals with damage to the hippocampus are not impaired on a variety of visual tasks, such as delayed matching-to-sample, concurrent discrimination, or retention of a visual discrimination. In addition, both birds and mammals with hippocampal damage display impairments in the acquisition of an autoshaped response, as well as alterations in response suppression. These findings suggest that the avian hippocampus is a functional homologue of the mammalian hippocampus, and that in both birds and mammals the hippocampus is important for the processing and retention of spatial, rather than purely visual information.

Animals↗

PubMed1993

Issues in the acquisition of the Sesotho tonal system.

This paper examines the acquisition of the grammatical tone system of Sesotho, a southern Bantu language where tone sandhi is rich, and where surface and underlying representations are often quite distinct. Results of the longitudinal case study show that rule-assigned tone on subject markers is generally marked appropriately by age two. In contrast, underlying tonal representations on verb roots are learned gradually over time, showing an early Default High tone pattern. The study also finds that, while some tone sandhi rules are in the process of being acquired between 2;6 and 3;0, problems in the mapping between tonal representations and segments persist. The paper raises methodological and theoretical issues not only for the acquisition of tonal systems, but for the acquisition of phonology in general.

Acoustic Stimulation↗

PubMed1996

Mechanisms of visual-spatial attention: resource allocation or uncertainty reduction?

Many studies have found that stimuli can be discriminated more accurately at attended locations than at unattended locations, and such results have typically been taken as evidence for the hypothesis that attention operates by allocating limited perceptual processing resources to attended locations. An alternative proposal, however, is that attention acts to reduce uncertainty about target location, thereby increasing accuracy by decreasing the number of noise sources. To distinguish between these alternatives, we conducted 6 spatial cuing experiments in which target location uncertainty was eliminated. Despite the absence of uncertainty, target discriminations were more accurate at the attended location, consistent with resource allocation models. These cue validity effects were observed under a broad range of conditions, including central and peripheral cuing, but were absent at very short cue-target delay intervals.

Attention↗

PubMed2006

Resistance to extinction in evaluative conditioning.

A well-demonstrated phenomenon in traditional Pavlovian conditioning research with humans is that of experimental extinction. In contrast, human evaluative conditioning research suggests that evaluative learning shows marked resistance to extinction. Here, the authors replicate both findings concurrently. Two differential fear conditioning experiments with an electrocutaneous stimulus as the unconditioned stimulus evidenced (a) sensitivity to extinction using an autonomic skin-conductance measure and (b) complete resistance to extinction using an affective-priming measure. The results corroborate the idea that evaluative conditioning is more resistant to extinction than is expectancy learning (F. Baeyens, P. Eelen, & G. Crombez, 1995).

Adolescent↗

PubMed1981

Meridional variation in visual acuity of hooded rats reared in a carpentered environment.

Resolution acuity in people is frequently better for horizontal and vertical gratings than for obliques. An animal model of this oblique effect might be of help in elucidating its underlying neural mechanisms. Rats were chosen because laboratory rats area reared in a 'carpentered environment' apparently similar to those proposed to cause the oblique effect in people, and because electrophysiological experiments suggest that orientation selective units in rats' visual cortex may prefer horizontal and vertical stimuli. The acuity of eight laboratory-reared hooded rats was measured with high-contrast horizontal, vertical, and oblique gratings. The animals learned to detect low-frequency square-wave gratings with slightly fewer errors if they were horizontal or vertical than if they were oblique, but the effects of grating orientation on acuity were not significant. Refraction of the rats' eyes gave no evidence of astigmatism. These results suggest that the rat may not be a good animal model for studying the mechanisms that underlie meridional variations in acuity in people, and raise questions concerning both the neural bases of resolution acuity, and the validity of the 'carpentered environment' hypothesis.

Animals↗

PubMed1995

Integration of stereo, texture, and outline cues during pinhole viewing of real ridge-shaped objects and stereograms of ridges.

Three experiments are reported in which the possible role of blur cues as a factor needing to be taken into account in cue-integration studies involving conflicts between stereo and texture/outline cues was investigated. The earlier suggestion was tested that uncontrolled blur cues might have caused the quite different patterns of cue integration reported for real ridge-shaped objects oriented vertically and for stereograms depicting similar surfaces. Blur cues were manipulated by pinhole viewing intended to render accommodation open loop. The results for real ridges were as predicted by the blur-cue hypothesis: pinhole viewing strengthened texture/outline cues in vertically oriented ridges, thereby diminishing the pattern of stereo dominance hitherto observed for these stimuli (and as observed here in non-pinhole-viewing control conditions and in horizontally oriented ridges). The results for the stereograms did not conform to predictions: pinhole viewing, assumed to remove blur cues from the cue-integration process, still produced the pattern observed in control conditions in which a texture/outline cue for a shallow ridge overwhelmed stereo cues for a steep ridge. This result is against the hypothesis that perhaps blur cues for the stereogram projection surface differentially favoured the shallow texture/outline cues. A new variant of the blur-cue hypothesis is offered to account for this result. The main conclusion from the study is: beware drawing firm conclusions from stereograms about the pattern of cue integration that can be expected when real objects are being viewed. The two situations can produce very different results as far as cue integration is concerned. This is a conclusion with serious implications for the use of stereograms for studying the integration of stereo with other cues.

Adolescent↗

PubMed2006

Does the use of natural stimuli facilitate amodal completion in pigeons?

Three experiments were carried out to investigate whether amodal completion in pigeons can be facilitated by the use of colour photographs instead of highly artificial stimuli such as geometrical shapes. Ten pigeons were trained in a go/no-go procedure to discriminate between photographs of complete and of incomplete pigeon figures. In the subsequent test, the birds classified pictures of partly occluded pigeons as though they were complete (experiment 1). However, we found evidence that classification was based on spurious stimulus features that paralleled the intended class rule of figural completeness versus incompleteness. In particular, classification was shown to be guided by white background gaps that separated the parts of the fragmented pigeon figures (experiment 2), as well as by cues related to overall Gestalt (experiment 3). In summary, the present results indicate that the use of more natural stimuli such as photographs instead of geometrical shapes is insufficient for providing amodal completion in pigeons. It is suggested that a combination of various cues, including, eg, 3-D information and common motion in addition to surface and contour properties, may be required to induce a perceptual bias favouring visual completion of occluded portions.

Animals↗

PubMedDate not supplied

Case-based teaching and learning experiences.

Case-based teaching and learning strategies can be utilized to assist advanced practice psychiatric nursing students in both obtaining requisite knowledge and enhancing clinical reasoning skills. We discuss the benefits of case-based learning in terms of how it (1) contributes to students' appropriate organization of information to be recalled later for use in clinical reasoning situations; (2) generates experiences that students would not otherwise have; (3) increases the visibility of students' clinical reasoning processes; and (4) enhances students' confidence. This article also explores three examples of case-based teaching and learning: use of written cases in a seminar; use of standardized patients in an assessment course; and utilization of web-based cases for learning assessment and intervention skills. Finally, we compare and contrast each of these methods in terms of their relative effectiveness in achieving each of the benefits.

Computer-Assisted Instruction↗

PubMed2001

Focal autobiographical amnesia in association with transient epileptic amnesia.

Although problems with remembering significant events from the past (e.g. holidays, weddings, etc.) have been reported previously in patients with transient epileptic amnesia (TEA), to date there have been no detailed studies of autobiographical memory in patients with this disorder. To investigate this issue, a 68-year-old right-handed man (R.G.) who suffered from TEA and reported significant autobiographical memory problems was tested on a battery of neuropsychological tests of anterograde and remote memory. Tests of autobiographical memory revealed that R.G. was unable to evoke detailed autobiographical recollections from a substantial part of his life. By contrast, he performed well on tests of new learning and general knowledge and possessed good personal semantic information about his past. In summary, a distinct form of autobiographical amnesia, which is characterized by loss of experiential remembering of significant events, may be associated with TEA. It is proposed that the autobiographical memory deficit seen in the disorder may result from the progressive erasure of cortically based memory representations. This case adds to growing evidence for a dissociation between mechanisms subserving anterograde memory and those required to evoke remote episodic memories.

Aged↗