The interaction of Trypanosoma congolense and Haemonchus contortus infections in 2 breeds of goat. 2. Haematology.
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Camel haemonchosis is prevalent in the Sudan, especially during the rainy season, with a decrease in prevalence in the dry season possibly due to delayed maturation of the worms. The naturally occurring disease in Sudanese camels is characterized by emaciation, anaemia, oedema of the lower parts of the limbs, eosinophilia, hypoproteinaemia, hypoalbuminaemia, hyperglobulinaemia and eosinophilia, as well as elevated blood urea concentrations.
The pH, PO2 and the number of viable bacteria per ml of abomasal fluid were recorded before and after administering large doses of infective larvae of H. contortus to sheep. Highly significant increases were observed in the pH, in numbers of viable bacteria and in the proportion of oxygen-sensitive bacteria in the abomasal fluid during the first 10 to 14 days of infection. At the same time a decrease in the abomasal fluid PO2 was recorded. Subsequently a slow recovery of pH, PO2 and bacterial numbers to pre-infection values ensued. The microbiological and physiological changes occurring in the abomasum of sheep after infection with H. contortus are discussed with reference to these results.
Progressive post-mortem changes were observed, with fibre optic endoscopy, in the abomasum of uninfected sheep and sheep infected with H. contortus. Loss of epithelial cells was observed 14 to 16 min after death in the uninfected sheep. The loss exposed the underlying lamina propria. This loss became more widespread as the time after death increased. Epithelial cell loss was observed earlier (as early as 6 min after death) in the infected sheep. Three of the infected sheep also displayed dispersal of alkaline phosphatase activity 30 min after death. The present work shows that post-mortem changes can occur quite quickly in animals, especially infected animals, and emphasizes the importance of rapid removal of tissue from animals after death.
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A chronic infection was established in a group of twenty 18-month-old non-reproductive Merino ewes by oral administration of 3000 infective H. contortus larvae twice weekly for 12 weeks. Their live-weights and wool production were compared with those of 20 uninfected ewes grazing the same pasture. In the infected sheep, faecal egg counts increased over a period of 9 weeks to reach a mean of 5000 eggs per gram, accompanied by small, but significant effects on packed-cell volume and live-weight. The effects of infection on wool growth were also small, and not statistically significant, although there was evidence of a faster seasonal decline in wool growth in infected sheep. It was concluded that mortality induced by acute infection is the most important economic effect of this parasite.
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