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PubMed2000

[Leiomyosarcoma of the scrotum: a case report].

Leiomyosarcoma of the scrotum is a rare tumor. Up to 1999, only 29 cases have been reported in the literature worldwide. A 27-year-old man presented with a mass on the left side of the scrotum which had been painless and had gradually enlarged over the previous 10 years. During the following 3 months, however, it became painful and he was then referred to our hospital. Physical examination revealed a solid mass on the left side of the scrotum, measuring 7 cm in diameter, which was not adhering to the testis or to the vas deferens. The tumor was surgically resected. The histological examination confirmed the diagnosis of well differentiated leiomyosarcoma. Adjuvant therapy was considered unnecessary. The follow-up at 41 months revealed no local recurrence or distant metastasis.

Adult↗

PubMed2001

Primary cardiac leiomyosarcoma originating from the pulmonary valve. Case report and review of the literature.

Primary cardiac tumours are rare findings (incidence 0.02% according to a recent meta-analysis) with dismal prognosis. Approximately 25% are malignant, mostly represented by sarcomas. Among these, leiomyosarcomas are exceptional. Treatment for primary cardiac leiomyosarcomas consists of radical surgical resection followed by adjuvant radiation therapy and/or chemotherapy. The mean survival after surgery and adjuvant therapies is 6.8 months. We present a rare case of a 40- year-old male patient with a primary cardiac leiomysarcoma originating from the pulmonary valve. This patient died after surgery and implantation of a homograft of the pulmonary trunk. Furthermore, the literature has been reviewed.

Adult↗

PubMed2000

[Primary leiomyosarcoma of vascular origin in the groin causing lower extremity venous compression].

A soft tissue tumor causing left lower extremity swelling in a 43 years old female was detected in the left inguinal region and resection was performed at the Department of Cardiovascular Surgery of Semmelweis University of Medicine, Budapest. Histologic examination revealed primary leiomyosarcoma of vascular origin. On the base of this case attention is called to this rare disease, which has poor prognosis. Early diagnosis and complete resection plays key role in the treatment of leiomyosarcoma and may improve survival.

Adult↗

PubMed2000

Leiomyosarcoma of the mesocolon--a case report.

Retroperitoneal leiomyosarcomas including those arising from the mesentery are rare. These account for 5.8% of all soft tissue sarcomas. Most of these tumors present in late life with female preponderance. Diagnosing these tumors at an early stage is difficult due to their location. Hence, most of them attain large sizes with metastases to distant sites at the time of diagnosis. We report a case of leiomyosarcoma arising from the sigmoid mesocolon due to it's rarity and unusual clinical presentation.

Adult↗

PubMedDate not supplied

[Leiomyosarcoma of the inferior vena cava: a case report].

Leiomyosarcoma (LMS) of the inferior vena cava (IVC) is a rare vascular tumour, with about 200 cases reported since 1871. The Authors report a case of leiomyosarcoma of the suprarenal inferior vena cava preoperatively diagnosed by ultrasonography and computed tomography. A surgical resection and venous wall reconstruction was performed. Complete surgical resection with a tumour-free margin (1 cm) is the treatment of choice. Neoadjuvant therapy may be given to downsize the tumour and increase resectability rate. When complete resection is not possible, debulking combined with radiation therapy provides good palliation.

Humans↗

PubMed2001

[A case report of primary cardiac leiomyosarcoma].

A 26-year-old woman presenting symptoms of rapid progressive heart failure consulted with our hospital. Two-dimensional echocardiography showed a large mass in the left atrium (LA) and severe pulmonary hypertension. Emergent operation was performed because of hemodynamic reason and the risk of embolism. The tumor (7 x 6 x 3 cm) which was lobulated and had a smooth surface was arising from posterior wall of LA extending into the ostium of right lower pulmonary vein. The portion of tumor located was excised. The defect was reconstructed by bovine pericardium. Postoperative histopathological diagnosis was leiomyosarcoma. Hemodynamics recovered after surgical treatment and there were no problems for 5 months. However, tumor recurrence in LA and pulmonary metastasis was found 5.5 months after surgery. The patient died two weeks later by progressive heart failure. Primary cardiac leiomyosarcoma is extremely rare. The current world literature is reviewed with respect to this rare tumor.

Adult↗

PubMed2001

[MRI appearance of a primary leiomyosarcoma of bone with epiphyseal involvement].

Primary leiomyosarcoma of bone is a rarely reported tumor of elderly subjects. It usually shows an aggressive osteolytic pattern on plain radiographs and involves predominantly the metaphyses of long bones. We report a case of primary leiomyosarcoma of bone, which is atypical by its epiphyseal location, a non-aggressive pattern on plain radiographs and its MR imaging features.

Aged↗

PubMed2001

A case of leiomyosarcoma of the diaphragm.

A patient with a rare leiomyosarcoma of the diaphragm was encountered. A 74-year-old woman was admitted complaining of left shoulder pain and hypochondralgia. A mass was found on the left side of the diaphragm on imaging studies. Laparoscopic biopsy was performed and the diagnosis of leiomyosarcoma was established histopathologically. To improve her complaint, removal of the mass was attempted, which resulted in compromise resection.

Aged↗

PubMed1975

Primary hepatic leiomyosarcoma: A report of two cases.

Two cases of primary hepatic leiomyosarcoma are reported. Review of the literature reveals only seven previous reports. Cases presented predominantly with either hepatomegaly or ascites. Neither history nor physical and laboratory examination distinguished these patients with primary leiomyosarcomas from those with other hepatic tumors. Analysis of the cases reviewed suggests that aggressive hepatic surgery may improve prognosis.

Aged↗

PubMed2001

[Inferior vena cava leiomyosarcoma: report of a new case and review of the literature].

OBJECTIVE/METHODS: To present an additional case of leiomyosarcoma of the inferior vena cava and review the literature, with special reference to the etiology, diagnosis and treatment of this rare tumor. RESULTS: The patient was submitted to radical surgery and short course radiotherapy. Twelve months thereafter, the patient is asymptomatic and disease-free. CONCLUSIONS: Leiomyosarcoma of the inferior vena cava is a rare and aggressive tumor. Treatment is by aggressive and radical surgery.

Female↗

PubMed2001

Leiomyosarcoma of the duodenum. A successful reoperation after recurrency.

Leiomyosarcomas of the duodenum are rare tumours. Approximately 160 cases have been reported so far. Pain, bleeding and duodenal obstruction causing vomiting and weight loss are the leading symptoms. The mass may be palpable. If resected, prognosis is favorable in a majority of cases, much better then in carcinomas of the duodenum. Patients have to be followed up as eventual recurrencies are frequently suitable for resection. We present a 62 years old male who was submitted to cephalic duodenopancreatectomy for duodenal leiomyosarcoma (reported earlier) who developed recurrency 6 years after original surgery and in whom a successful reoperation was performed. Two years after second surgery the patient stayed disease free.

Duodenal Neoplasms↗

PubMed2002

[Large intraperitoneal leiomyosarcoma. Report of a case and review of the literature].

The leiomyosarcoma are rare tumors, accounting for only 0.1% to 3% of all gastrointestinal malignancies. 150 new cases are diagnosed annually in the United States. The spectacular character of leiomyosarcoma consists in its measurements, its size reaching 35 x 25 x 17 cm, its weight 5.5 kg, and in the asymptomatic character of the tumor. The final diagnosis, although suspect with preoperative diagnostic procedure, is obtained after histologic examination. Complete surgical excision is the best treatment, the role of radiation therapy and chemotherapy are not yet established.

Adult↗

PubMed2002

[Paratesticular leiomyosarcoma: report of a new case].

OBJECTIVE: To report an additional case of paratesticular leiomyosarcoma. METHODS: Herein we describe a 68-year-old male patient that presented with a growing, indolent, right inguinoscrotal lesion that he had noted several weeks earlier. Physical examination showed a mass involving the distal right spermatic cord and was confirmed by ultrasound and CT. Analyses were normal. Radical orchidectomy with high ligation of the right spermatic cord was performed. RESULTS: Histopathological and immunohistochemical studies demonstrated a well-differentiated paratesticular leiomyosarcoma. Local recurrence was observed at 3 1/2 years' follow-up. Complete excision of the tumorous tissue was performed with no other adjuvant therapy. Six months thereafter, there is no evidence of local recurrence or distant metastasis. CONCLUSIONS: This tumor type is uncommon. Like other authors, we believe that orchifuniculectomy is the treatment of choice. Furthermore, adjuvant radio or chemotherapy does not significantly influence survival in these patients.

Aged↗

PubMed2002

Vulvar leiomyosarcoma: a case report in a Nigerian woman.

Leiomyosarcoma of the vulva is a rare gynaecological malignancy. To date, only few cases have been reported in the literature, the majority of which are from Western countries. Although leiomyosarcoma is classically regarded as a malignant tumor, the generally favorable prognosis following surgical treatment, as well as its reduced propensity for widespread metastasis, makes it one of the most enigmatic malignancies in the medical literature. In addition, the tumor may attain enormous morphological proportions, a situation unusual in many malignant tumors.

Female↗

PubMed2002

[A case of primary leiomyosarcoma of the liver].

Primary hepatic leiomyosarcoma is a very rare malignant tumor of the liver and rather slowly progressing disease. When the tumor is solitary or even multiple but located in one lobe, the treatment of choice is an operation. We report a case of huge leiomyosarcoma in a 58-year old female patient treated by surgical resection.

Female↗

PubMed2002

[A case report of testicular leiomyosarcoma].

This report describes a case of primary leiomyosarcoma of the testis in a 70-year-old man. Treatment consisted in orchidectomy by the inguinal route with no adjuvant treatment. The patient developed pulmonary metastasis 14 months after surgical treatment. Few reports have been published on primary leiomyosarcoma of the testis. Most reported cases have been in small series in association with germ cell tumors. Surgical treatment is the most effective therapeutic modality. The standard surgical technique is orchidectomy by the inguinal route. Retroperitoneal lymph node dissection is not always performed. The prognosis of isolated testicular sarcoma is better than that of sarcoma associated with germ cell components.

Aged↗

PubMedDate not supplied

Estrogen and progesterone receptor expression in patients with uterine leiomyosarcoma and correlation with different clinicopathological parameters.

BACKGROUND: We examined the expression of estrogen and progesterone receptors in patients with uterine leiomyosarcoma (LMS) to determine their influence on prognosis (overall survival and disease-free survival) and to evaluate the association between the steroid receptor expression and various clinicopathological parameters. MATERIALS AND METHODS: Estrogen and progesterone receptor expression was investigated by immunohistochemistry from paraffin-embedded tissue in 21 patients with uterine LMS. The immunohistochemical findings were correlated with different clinicopathological parameters of the patients. RESULTS: Estrogen and progesterone receptors were expressed in 57% and 43%, respectively. The relationship between estrogen and progesterone receptor expression and clinical stage, age, vascular space involvement and recurrence of disease did not reach statistical significance (p > 0.05). Neither estrogen nor progesterone receptor expression significantly influenced overall survival and disease-free survival (p > 0.05). Early tumor stage (p = 0.0001), age at diagnosis < 50 years (p = 0.02) and the absence of vascular space involvement (p = 0.04) were prognostic factors associated with a lengthened overall survival. CONCLUSION: In conclusion, the present study observed that estrogen and progesterone receptors are frequently expressed in uterine leiomyosarcoma. However, their expression did not correlate with clinical stage, age, vascular space involvement and recurrence of disease and had no influence on overall and disease-free survival. Despite the lack of prognostic impact, further clinical studies with larger numbers of cases need to be performed to verify if estrogen and progesterone receptor-positive tumors can be treated by hormonal manipulation.

Adult↗

PubMed2003

Adrenal leiomyosarcoma: a case report and literature review.

Leiomyosarcoma of the adrenal gland is a very rare tumour. We report a case of this rare tumour and review the previous case reports. The patient, a 68-year-old woman, presented with a 1-week history of right loin pain and fever associated with loss of weight and appetite. Computerised tomography and ultrasound scans showed the presence of a right adrenal gland tumour, which was subsequently surgically removed. Histological examination of the 12.5-cm tumour revealed a leiomyosarcoma of the adrenal gland. The patient was alive and well with no evidence of recurrent disease 1 year later.

Adrenal Gland Neoplasms↗