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Fall and rise of Lyme disease and other Ixodes tick-borne infections in North America and Europe.

Lyme disease is a spirochaetal infection with acute and chronic manifestations. Lyme disease and other infections transmitted by Ixodes species ticks are increasing in temperate and Holarctic regions of the Northern hemisphere. These zoonotic infections are most commonly acquired in suburban residential areas and outdoor recreation areas close to cities. Different enzootic cycles, which include a variety of large and small mammals as well as migratory birds, maintain and distribute in nature the Borrelia species that cause Lyme disease. The rise in cases of Lyme disease and the other Ixodes tick-borne infections is, in part, the consequence of reforestation and the increase in deer populations in developed countries.

Europe↗

Mitochondrial DNA "clock" for the Amerinds and its implications for timing their entry into North America.

Students of the time of entry of the ancestors of the Amerinds into the New World are divided into two camps, one favoring an "early" entry [more than approximately 30,000 years before the present (YBP)], the other favoring a "late" entry (less than approximately 13,000 YBP). An "intermediate" date is unlikely for geological reasons. The correlation of the appropriate data on mtDNA variation in Amerinds with linguistic, archaeological, and genetic data offers the possibility of establishing a time frame for mtDNA evolution in Amerinds. In this paper, we estimate that the separation of the Chibcha-speaking tribes of Central America from other linguistic groups/nascent tribes began approximately 8000-10,000 YBP. Characterization of the mtDNA of 110 Chibcha speakers with 14 restriction enzymes leads on the basis of their time depth to an estimated mtDNA nucleotide substitution rate for Amerinds of 0.022-0.029% per 10,000 years. As a first application of this rate, we consider the mtDNA variation observed in 18 Amerind tribes widely dispersed throughout the Americas and studied by ourselves with the same techniques, and we estimate that if the Amerinds entered the New World as a single group, that entry occurred approximately 22,000-29,000 YBP. This estimate carries a large but indeterminate error. The mtDNA data are thus at present equivocal with respect to the most likely times of entry of the Amerind into the New World mentioned above but favor the "early" entry hypothesis.

Anthropology↗

Scope of the COPD problem in North America: early studies of prevalence and NHANES III data: basis for early identification and intervention.

COPD is a common disease that is often not diagnosed in the primary-care setting. This review highlights the findings of studies ranging from the early 1960s to the third National Health and Nutrition Examination Survey (NHANES III) study, undertaken to try and accurately estimate the prevalence of COPD in the US population. Results of the NHANES III indicate that COPD remains frequently underdiagnosed, and that spirometry should be more widely used in the primary-care setting to identify asymptomatic disease. Early intervention, in particular smoking cessation, could alter the course and outcome of disease in patients with COPD.

Health Surveys↗

Trauma system development in North America.

The concepts of organized trauma care, many of which originated in military medicine, have been proven effective in the civilian sector. A formal trauma system includes all phases of care from prehospital through rehabilitation. Although trauma centers assume the leadership role, in a truly inclusive system, all healthcare providers (prehospital providers, community hospitals, and trauma centers) have a defined role in providing care to patients with trauma. As a result, patients receive treatment at the appropriate institution, resources are allocated appropriately, and the clinical outcome is optimized. Such a system ideally is suited to the unique needs of the mass casualty scenario.

Continuity of Patient Care↗

Human resources for maternity care: the present system in Brazil, Japan, North America, Western Europe and New Zealand.

This article describes the nature of the humanization of birth and the overlapping but distinct role of professionals within the maternity services with an emphasis on the role of the midwife. It describes the status of midwives in different parts of the world, and the common characteristics of work undertaken to restore the role of the midwife. Midwifery is seen as an essential component of effective maternity services. In addition it is important to recognize the important role that traditional birth attendants play in many parts of the world. An appropriate structure including primary and secondary and tertiary care services are important for professionals to play their full part.

Brazil↗

Control of Aedes albopictus from the perspective of North America.

Aedes albopictus is a serious nuisance species and a potential vector of domestic arboviruses in the U.S. Public health and mosquito control agencies have taken numerous actions to address the problems posed by this species. Federally mandated programs of disinsection and inspection of tire casings imported into the U.S. are aimed at preventing additional introductions of this and other exotic mosquito species. Control programs, including the use of traditional chemical larvicides and adulticides, as well as the introduction of predatory copepods into larval habitats, have been developed and tested for population management. A few of the established populations in the northern areas of Ae. albopictus distribution in the continental U.S. have been successfully eradicated through source reduction and insecticide application.

Aedes↗

Injection drug use in North America.

Injection drug use of psychotropic agents for nontherapeutic purposes is associated with some of the most pernicious infectious diseases seen in the United States. There is an inextricable link between infection, injection drug use (IDU) and other risk behaviors, especially those related to sexual activity. A number of national surveys now provide excellent databases to track the breadth, scope and impact of IDU across the United States. The prevalence of heroin use has increased over the past decade with larger numbers of users presenting for treatment of drug use disorders. A host of serious infections can result from IDU. Prevention and early intervention with evidence-based harm-reduction strategies are crucial to reducing and eliminating these odious consequences.

Communicable Diseases↗

Report from the International Bone Marrow Transplant Registry and Autologous Blood and Marrow Transplant Registry - North America.

Allogeneic and autologous bone marrow and blood cell transplants are increasingly used treatments for cancer and disorders of bone marrow and immune function. This is largely due to use of autotransplants to treat common diseases such as breast cancer. The use of blood cells alone for autotransplants was also a significant change in the past 5 years. The IBMTR and ABMTR continue to provide a unique resource for studying outcomes and trends in allogeneic and autologous bone marrow and blood cell transplants.

Adolescent↗

Pharmacogenetics and public policy: expert views in Europe and North America.

The new genetics is stimulating the development of genetic testing of patients to help choose the best drug, adjust doses and avoid side effects. Proponents say that this personalized medicine will revolutionize drug development and healthcare. In a series of group meetings, 48 leading experts from regulatory agencies, industry, academia and consumer interests gave their opinions on the public policy priorities. Most believed that pharmacogenetics would have a clear impact on care within 15 years and that a public policy response was needed. The establishment of a good clinical evidence base should be a priority, together with addressing the needs of drug response gene minorities. A total of 72% also believed that postmarketing surveillance systems should be collecting DNA from patients experiencing moderate or severe adverse events.

Europe↗

Cultural identification and substance use in North America--an annotated bibliography.

Level of identification with one's culture has long been thought to be a predictor of substance use among ethnic minority populations. However, cultural identification is a complex construct that has been difficult to capture in a coherent theoretical way. Additionally, the various theoretical approaches have led to numerous and divergent methods of measurement. Although measurement is becoming more sophisticated, the evidence for a link between cultural identification and drug use remains elusive. There is evidence that immigrants to a new culture do change their pattern of substance use to match that of the host culture, but the mechanism of that change is not well understood. That culture impacts behavior is without question although how culture operates specifically with respect to substance use will require further effort.

Acculturation↗

The Chinese palliative patient and family in North America: a cultural perspective.

Professionals may become frustrated when caring for the Chinese palliative patient and family, as we may expect them to behave or act like us. This paper discusses two distinctive characteristics which may be unfamiliar to Western caregivers. The first pertains to the concept of family-based popular health care, where the family assumes the major role of decision-maker on behalf of the patient. The second relates to the Eastern belief of silence surrounding the discussion of dying and the impending death, versus our Western orientation, which advocates openness and honesty. By gaining a greater understanding of these cultural traditions and practices, we can deliver more culturally sensitive health care to the Chinese patient and family.

Attitude to Death↗

Tick toxicosis in North America.

This is a case presentation and review of an uncommon disorder, tick toxicosis. The history, epidemiology, pathophysiology, and treatment are discussed. This disorder was mentioned in diaries from the early 1800s and has been reported in 18 states and the District of Columbia. A review of 70 cases reveals that the typical patient is a female child who develops leg weakness, irritability, or clumsiness. The exact site at which the toxin induces the paralysis is unknown. Removal of the tick usually reverses the paralysis within hours. Confusing tick toxicosis with other disorders may occur, and death has resulted. This article will remind physicians to consider tick toxicosis when seeing patients with acute ataxia or ascending paralysis and to, perhaps, prevent death from an easily treatable disorder.

Adolescent↗

Field use of a vaccinia-rabies recombinant vaccine for the control of sylvatic rabies in Europe and North America.

During recent years, most research on the control of sylvatic rabies has concentrated on developing methods of oral vaccination of wild rabies vectors. To improve both the safety and the stability of the vaccine used, a recombinant vaccinia virus, which expresses the immunising glycoprotein of rabies virus (VRG), has been developed and tested extensively in the laboratory as well as in the field. From 1989 to 1995, approximately 8.5 million VRG vaccine doses were dispersed in Western Europe to vaccinate red foxes (Vulpes vulpes), and in the United States of America (USA) to vaccinate raccoons (Procyon lotor) and coyotes (Canis latrans). In Europe, the use of VRG has led to the elimination of sylvatic rabies from large areas of land, which have consequently been freed from the need for vaccination. Nevertheless, despite very good examples of cross-border cooperation, reinfections have occurred in some regions, due to the difficulty of co-ordinating vaccination plans among neighbouring countries. In the USA, preliminary data from field trails indicate a significant reduction in the incidence of rabies in vaccinated areas.

Animals↗

Stories of success: the use of donor milk is increasing in North America.

Donor milk has been used to successfully treat a number of medical conditions in infants. This article highlights 3 such success stories describing the use of human milk in cases of velocardiofacial syndrome, very-low-birth weight, and failure to thrive. In 2002, more than 300 infants and young children and 15 adults received donor milk from 6 milk banks in the United States and I milk bank in Canada. Donor milk is often used to ensure optimal outcomes in full term or preterm infants until their own mother's milk volume is sufficient to meet their needs. However, human milk may be a lifesaving therapy for infants and young children with unusual medical conditions.

Female↗

Current patterns of intraocular gas use in North America.

A 1987 survey of 365 members of the Retina and Vitreous societies revealed that use of long-acting intraocular gases was both widespread and frequent. However, despite the expanded use of intravitreal gases and the stated intention of the Food and Drug Administration to approve premarket applications for use of sulfur hexafluoride and perfluoropropane, there are still limitations in the ready availability of these substances. Therefore, we conducted another survey to determine current patterns of intraocular gas use. The results indicate that more surgeons are using long-acting gases. The data also demonstrate the selective use of pneumatic retinopexy with geographic pockets of increased retinopexy use in California and Florida. Finally, 100% of respondents now indicate that they consider the use of sulfur hexafluoride and perfluoropropane to be a standard of care.

Air↗

The development and implementation of case management for substance use disorders in North America and Europe.

Because of the multifaceted, chronic, and relapsing nature of substance use disorders, case management has been adapted to work with persons who have these disorders. Deliberate implementation has been identified as a powerful determinant of successful case management. This article focuses on six key questions about implementation of case management services on the basis of a comparison of experiences from the United States, the Netherlands, and Belgium. It was found that case management has been applied in various populations with substance use disorders, and distinct models have been associated with positive effects, such as increased treatment participation and retention, greater use of services, and beneficial drug-related outcomes. Program fidelity, robust implementation, extensive training and supervision, administrative support, a team approach, integration in a comprehensive network of services, and minimal continuity have all been linked to successful implementation.

Case Management↗

Concomitant positive patch test results with standard screening tray in North America 1985-1989.

Responses to patch test substances may occur contemporaneously. Such simultaneous reactions may reflect concomitant sensitization to 2 dissimilar allergens to which concurrent exposure has taken place (e.g., ethylenediamine dihydrochloride and neomycin). It may occur when the individual has been exposed to only 1 of the substances and exhibits a response to other substances of similar chemical structure (i.e., cross-sensitization such as between para-phenylenediamine and benzocaine). Such simultaneous responses may also be chance occurrences, reflecting multiple sensitization or the result of altered response due to the "angry back syndrome". This investigation established that such concurrence of response is not uncommon and adds further documentation to the literature of these associations in patch test responses.

Adult↗

Evidence of probable scurvy in subadults from archeological sites in North America.

The authors surveyed subadult human skeletons from Native American archeological sites in the United States for evidence of skeletal lesions associated with scurvy. Geographic regions surveyed include the Midatlantic area, the Southeast (Florida), the Southwest, and the Plains. The prevalence of probable subadult scurvy ranged from zero in the Plains samples to 38% in a small sample from Florida. These data indicate the likelihood that scurvy was a significant childhood disease in many Native American groups. Reasons for variation in prevalence remain speculative but include regional and seasonal variation in food types and abundance, cultural patterns of storage and utilization, periodic food shortages, and the relative importance of corn in the diet. These factors are part of a nutritional complex that is related to disease prevalence which can be studied through evidence seen in archeological human remains.

Adolescent↗