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PubMed1981

The effects of propylthiouracil and other drugs on the uptake of 75Se-selenomethionine by the pancreas.

The influence of pre-treatment with a variety of agents on the uptake of 75Se-selenomethionine by the rat pancreas has been studied. The agents ranged from thyroid hormones to protein synthesis inhibitors but out of 16 tested, only propylthiouracyl (50 mg/kg i.p. administered for 3 days prior to 75Se-methionine injection) resulted in a significant increase in the pancreatic uptake (17%) and in the pancreas liver concentration ratio (25%). Seven of the agents resulted in significant reductions in the pancreas/liver concentration ratios. No significant effects were produced by the addition of carrier methionine or selenomethionine (in the range 10-250 micrograms/kg body weight) to the injected radiopharmaceutical. It was concluded that many factors may influence the uptake, but that the interrelationship of hypothalamus, pituitary and pancreas is of particular interest.

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