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Economic evaluation of different systems for cataract surgery and anesthesia.

Economic evaluation is an increasingly important component of health and medical care policy making although it continues to be met with some resistance. Many fields of medical care services and public health have extensive economic evaluation literatures. In ophthalmology, the literature is less well developed and there is an ongoing discussion of the most appropriate methods. This article outlines different types of economic evaluations providing examples on their potential use in ophthalmic care decision making, reviews three articles in the brief recent literature on the cost-effectiveness of ophthalmic anesthesia and cataract surgery in the United States with a focus on explaining methods that were used, and discusses ways in which research in this area might be moved forward.

Anesthesia↗

Transforming health care from the inside out: advancing evidence-based practice in the 21st century.

Health care is in need of change. Major professional and health care organizations as well as federal agencies and policy-making bodies are emphasizing the importance of evidence-based practice (EBP). Using this problem solving approach to clinical care that incorporates the conscientious use of current best evidence from well designed studies, a clinician's expertise, and patient values and preferences, nurses and other health care providers can provide care that goes beyond the status quo. Health care that is evidence-based and conducted in a caring context leads to better clinical decisions and patient outcomes. Gaining knowledge and skills in the EBP process provides nurses and other clinicians the tools needed to take ownership of their practices and transform health care. Key elements of a best practice culture are EBP mentors, partnerships between academic and clinical settings, EBP champions, clearly written research, time and resources, and administrative support. This article provides an overview of EBP and offers recommendations for accelerating the adoption of EBP as a culture in education, practice and research.

Benchmarking↗

Capacity strengthening in malaria research: the Gates Malaria Partnership.

The Gates Malaria Partnership (GMP) includes five African and four European partner institutions. Its research programme has five priority areas involving an extensive range of field-based studies. GMP research has contributed significantly to the development of new research consortia investigating strategies for improving means of malaria control, and has already had an impact on policy and practice. A substantial investment in innovative training activities in malaria has enhanced knowledge and practice of malaria control at all levels from policy making to local community involvement. Capacity development, notably through a PhD programme, has been an underlying feature of all aspects of the programme.

Africa↗

Measuring the burden of premature mortality in Pakistan: use of sentinel surveillance systems.

INTRODUCTION: In developing countries, finding valid and reliable data is a great challenge. The Federal Bureau of Statistics in Pakistan maintains a surveillance system that records vital events. Results are reported as the Pakistan Demographic Survey (PDS). METHODS: The adjusted mortality data from PDS-1997 was used to estimate the burden of premature mortality using the healthy life year (HeaLY) methodology. RESULTS: The burden of premature mortality for Pakistan was 367 HeaLYs lost per 1000 population. More than half of the HeaLYs are being lost due to infection, maternal and perinatal conditions, and malnutrition. CONCLUSION: In the absence of a system maintaining reliable information regarding vital events, PDS provides a good alternate source of such information that can be used to aid policy making for health care and future research.

Adolescent↗

Using economic valuation techniques to inform water resources management: a survey and critical appraisal of available techniques and an application.

The need for economic analysis for the design and implementation of efficient water resources management policies is well documented in the economics literature. This need is also emphasised in the European Union's recent Water Framework Directive (2000/60/EC), and is relevant to the objectives of Euro-limpacs, an EU funded project which inter alia, aims to provide a decision-support system for valuing the effects of future global change on Europe's freshwater ecosystems. The purpose of this paper is to define the role of economic valuation techniques in assisting in the design of efficient, equitable and sustainable policies for water resources management in the face of environmental problems such as pollution, intensive land use in agriculture and climate change. The paper begins with a discussion of the conceptual economic framework that can be used to inform water policy-making. An inventory of the available economic valuation methods is presented and the scope and suitability of each for studying various aspects of water resources are critically discussed. Recent studies that apply these methods to water resources are reviewed. Finally, an application of one of the economic valuation methods, namely the contingent valuation method, is presented using a case study of the Cheimaditida wetland in Greece.

Agriculture↗

Evaluating alternative river management options in the tidal Ouse using the QUESTS1D model.

The tidal Ouse forms a significant part of the Humber river system in Eastern England, which provides the largest UK fresh water source to the North Sea and a valuable habitat for fish. However it suffers from dissolved oxygen (DO) sag in summer, exacerbated by the industrial effluent discharged at Selby. A one-dimensional water quality model, QUESTS1D, as utilized by the Environment Agency (EA) has been used to evaluate the effectiveness of management options based on exploiting spatial distribution of the assimilative capacity of the river as an alternative to implementing more stringent effluent consents. Significant improvements in water quality of the tidal Ouse are predicted compared to the effects of tightening effluent consents. A system of water quality functions is derived in this paper for quicker and more direct predictions of water quality, which will be useful in future research when combined with other analyses. Taking account the assimilative capacity in policy making, this paper suggests that a combined water management framework should be applied to ensure the required water quality.

England↗

Potential access and revealed access to pain management medications.

The area configuration of healthcare resources, such as the number of hospitals per hundred thousand population, has often been used in healthcare planning and policy making to estimate the global access (potential access) of health services to a local population. However, the actual utilization of the "available" healthcare resources (revealed access) is usually much more limited. The objectives of this study were to examine the availability of healthcare resources by measuring the potential access and the revealed access for outpatients who need to access pharmacies to fill prescriptions of Schedule II (CII) opioids for pain management, and to explore the difference between rural and urban residents in these two types of access. About 191,700 prescriptions for CII opioids dispensed in 1997 in the state of Michigan, USA were analyzed. Revealed accessibility was measured by the distance between the paired zip codes of the pharmacy and the patient listed on each prescription. Potential accessibility was measured by the distance from a patient's zip code to that of the nearest community pharmacy that could dispense the opioid prescriptions. The analyses on revealed access showed that 50% of the CII prescriptions were dispensed by pharmacies located within a 5-mile radius of patients' residences, 75% of prescriptions were dispensed within about a 10-mile radius, and 90% were within 20 miles. If patients were free to access the nearest pharmacy for dispensing (a hypothetical situation under potential access), the median, 75th percentile, and 90th percentile distances could reduce to 2, 3, and 5 miles, respectively. Similar differences between revealed and potential access were observed in both rural and urban areas and for every major opioid drug group. We conclude that policymakers should recognize the discrepancy between potential and revealed accessibility and move beyond only considering area configuration of healthcare resources to evaluating and improving access to care.

Analgesics, Opioid↗

Health, wealth and fairness based on gender: the support for ethical principles.

Sex differences in health, and the reality of a gender system, are well-known, but we know little about how this connects to opinions on fairness and desired change. This study aims to explore two principal questions: how to compare the position of women and men within-state and how to choose between-states, where a state is defined as a situation in which individuals have a particular set of resources, rights and duties, and if components in the set are altered, a new state for the same individuals appears. Based on various normative rules (monistic view or separate spheres, equity as choice or ethics of care, equity by attainment or shortfall; variants of welfarism, feminism and conservatism), a survey among Swedish public health workers was carried out. The results demonstrate a major rejection of the idea of compensation between health, power, influence and resources, and of considering past processes when judging fairness as to women and men. Moreover, most respondents believe that a biologically based difference in health is fair and reject health maximization as a guiding principle. The support for gender equality is strong when contrasted with the conservative goal, and subsists when contrasted against the Pareto criterion and trading-off health/income as well. Results that call for additional research and exchange of views include that common notions in research and policy-making are rejected by a majority, and that females and males differ considerably when judging change from a societal perspective.

Data Collection↗

The myth of the biotech revolution.

The existence of a medicinal 'biotech revolution' has been widely accepted and promoted by academics, consultants, industry and government. This has generated expectations about significant improvements in the drug discovery process, healthcare and economic development that influence a considerable amount of policy-making. Here we present empirical evidence, from a variety of indicators, that shows that a range of outputs have failed to keep pace with increased research and development spending. Rather than producing revolutionary changes, medicinal biotechnology is following a well-established pattern of slow and incremental technology diffusion. Consequently, many expectations are wildly optimistic and over-estimate the speed and extent of the impact of biotechnology, suggesting that the assumptions underpinning much contemporary policymaking need to be rethought.

Attitude to Health↗

The history of the SIMD: from small molecules to metabolomics.

The Society for Inherited Metabolic Disorders (SIMD) recently completed its 28th annual meeting and requested that its birth and development be documented. Accordingly, this communication reviews the origins of the SIMD and considers its development over the past three decades. Each decade had growth and differentiation regarding policy making, international connections, highlights and tragedies. Past contributions are defined and future directions for the SIMD are subjected to prophesy.

History, 20th Century↗

Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa.

Health policy making in developing countries requires estimates of the (global) burden of disease. At present, most of the available data on schistosomiasis is limited to numbers of individuals harbouring the infection. We explored the relationship between the presence of schistosome infection and clinical morbidity, in order to estimate numbers of individuals with disease-specific morbidity for Schistosoma haematobium and Schistosoma mansoni infection in sub-Saharan Africa. We searched the literature for cross-sectional data from field studies reporting both schistosome infection and morbidity. This was used to derive a functional relationship between morbidity and infection. After standardisation for diagnostic method, the number of individuals with specific types of clinical morbidity or pathology was predicted. As only aggregated prevalences of infection were available for countries or areas, we adjusted for heterogeneity in infection levels within communities in those countries. In total, 70 million individuals out of 682 million (2000 estimate) in sub-Saharan Africa were estimated to experience haematuria in the last 2 weeks associated with S. haematobium infection, and 32 million dysuria. Ultrasound detected serious consequences of S. haematobium, major bladder wall pathology and major hydronephrosis, were predicted at 18 and 10 million, respectively. Infection with S. mansoni was estimated to cause diarrhoea in 0.78 million individuals, blood in stool in 4.4 million and hepatomegaly in 8.5 million. As the associations between prevalence of S. mansoni infection and prevalence of diarrhoea and blood in stool were not very clear, the resulting estimates may be underestimations. Using the very limited data available, we estimated the mortality rates due to non-functioning kidney (from S. haematobium) and haematemesis (from S. mansoni) at 150000 and 130000 per year. Given the overall high number of cases with schistosomiasis-related disease and associated death, we conclude that schistosomiasis remains an important public health problem in sub-Saharan Africa.

Africa South of the Sahara↗

Improving the health and well-being of adolescent boys.

Adolescent men are at risk of having significant unmet health care needs. Like adolescent girls, they have complex health care needs and are more likely than younger children to be to be uninsured. They are less likely than women and other age groups to seek medical attention from traditional sources of care. Because of inadequate youth-oriented services, as well as teens' developmental stage, they have a tendency to receive care that is brief and problem oriented [20]. Such care is not likely to address complex problems that may be related to risk behaviors. Adolescent boys are also more concerned with the skills of the provider offering services than with the system in which the provider functions. Opportunities for outreach to adolescent men exist within many institutions. Nurses as advocates, educators, counselors, and providers of preventive health care have a creative opportunity for enhancing services to the teenage boy. The school is a natural place to begin as adolescents spend a significant part of each day there. Family planning and STI clinics are a source of care that are not well used by adolescent males, but when they do attend it is an opportunity to identify problems, provide counseling and referrals, and offer continuity. These health care institutions are not often welcoming or comfortable for the male youth. Use of these clinics will be enhanced by providers demonstrating increased acceptance of the adolescent when he attends as well as actively requesting that he attend with his partner. The most unusual but sorely needed outreach must be made to incarcerated and delinquent adolescent male. Residential facilities for delinquent youth need to be encouraged to provide a multidisciplinary comprehensive medical, mental health, and social services model. This approach will not only benefit the adolescent but the youth's community as well. Emergency rooms represent another crucial, missed opportunity to connect with young men. With some forethought and follow-up, emergency departments must become connected to appropriate and accessible adolescent primary care resources in the community. Finally, adolescent men are an underinsured population. Nurses can be important advocates of available state insurance funds, sliding scale or free services to youth, and must be a voice in youth policy-making.

Adolescent↗

Screening interval and risk of invasive squamous cell cervical cancer.

To compare the risks of developing invasive squamous cell cervical cancer associated with screening intervals of 1, 2, and 3 years after a negative cervical smear. We conducted a matched case-control study of invasive squamous cell cervical cancer patients (n = 482) diagnosed between 1983 and 1995 among long-term members of a large health maintenance organization. Controls were matched for age, length of membership, and race (n = 934). Screening interval was time between the last negative cervical smear and the case diagnosis date. The main outcome measure was the relative odds of invasive disease associated with 1-year, 2-year, and 3-year intervals. The odds ratio for a 2-year versus a 1-year interval was 1.72 (95% confidence interval 1.12, 2.64, P =.013) and for a 3-year versus a 1-year interval was 2.06 (95% confidence interval 1.21, 3.50, P =.007). The odds ratio for a 3-year versus a 2-year interval was 1.20 (95% confidence interval 0.65, 2.21, P =.561). Controlling for ever having had an abnormal cervical smear or a previous consecutive negative smear did not substantially change these results. In this large health plan, the relative risks of invasive squamous cell cervical cancer were significantly greater for 2-year and 3-year cervical cancer screening intervals compared with a 1-year interval, but not for a 3-year interval compared with a 2-year interval. Our findings need to be placed in the context of the low absolute risks of developing invasive cervical cancer during the first 3 years after a negative cervical smear before making policy recommendation.

Adult↗

Screening strategies for colorectal cancer.

The efficacy of screening for colorectal cancer has not been established. Policy-making organizations differ in recommendations for asymptomatic and high-risk groups because of the inadequacy of current evidence. A critical appraisal of the current evidence for screening for colorectal cancer and a discussion of the aims and pitfalls of screening programs are presented.

Colonoscopy↗

Eutrophication research of West Lake, Hangzhou, China: modeling under uncertainty.

The models such as the eutrophication ecosystem model of West Lake, Hangzhou (EEM), are always used to make policy decisions for eutrophication management. Thus it is important to know the uncertainty in the model predictions due to the combined effects of uncertainty in the full set of input variables, and the individual input parameters whose variations have the greatest effect on variations in model predictions. In this study, randomized methods based on Monte Carlo technique have been developed and applied to the model (EEM). The technique consists of parameter sensitivity analysis, randomly sampling from underlying probability distributions and multivariate regression analysis. With this technique, model uncertainties during modeling are clarified and their propagation evaluated. Results show that among the five input parameters selected for uncertainty analysis, the settling rate of algae SVS and water temperature TEM have the largest contribution to model prediction uncertainty of the model outputs (PC, PS and PHYT).

China↗

Workplace expansion, long-term sickness absence, and hospital admission.

BACKGROUND: Downsizing has in previous studies, as well as in public debate, been associated with increased sickness absence. No studies have, however, looked at the long-term relation between workplace expansion and morbidity. METHODS: We investigated exposure to personnel change during 1991-96 in relation to long-term (90 days or longer) medically certified sickness absence and hospital admission for specified diagnoses during 1997-99 in 24?036 participants with a complete employment record in the biennial national Swedish Work Environment Surveys from 1989 to the end of 1999. FINDINGS: Accumulated exposure to large expansion (> or =18% per year) was related to an increased risk of long-term sickness absence (odds ratio 1.07 [95% CI 1.01-1.13], p=0.013) and hospital admission (1.09 [1.02-1.16], p=0.017). In this context, odds ratio signifies the change in odds for each additional year of exposure, varying from 0 to 6. Moderate expansion (> or =8% and <18% per year), was associated with a decreased risk of admission (0.91 [0.84-0.98], p=0.012). Moderate downsizing (> or =8% and <18% per year) was associated with an increased risk of sickness absence (1.07 [1.02-1.12], p=0.003). The strongest association between large expansion and sickness absence was in women in the public sector (1.18 [1.08-1.30], p=0.0002), corresponding to an odds ratio of 2.77 [1.62-4.74] between full exposure (all 6 years) and no exposure. INTERPRETATION: This study confirms earlier findings that downsizing is associated with health risks. It also shows that repeated exposure to rapid personnel expansion, possibly connected with centralisation of functions, statistically predicts long-term sickness absence and hospital admission. Although no conclusions about causal pathways can be drawn from our results, this exposure should be considered in future studies, policy making, and occupational health care practice.

Adult↗

Status of clinical and academic emergency medicine at 111 Veterans Affairs medical centers.

STUDY OBJECTIVES: To assess the current state of clinical and academic emergency medicine at Veterans Affairs medical centers in the nation's largest health care system. DESIGN AND INTERVENTIONS: Written survey mailed to 111 Veterans Affairs medical centers. SETTING: One hundred eleven Veterans Affairs medical centers affiliated with medical schools and designated as providing acute medical care. PARTICIPANTS: Veterans Affairs physicians and administrative managers responsible for Veterans Affairs medical center emergency departments. MEASUREMENTS AND MAIN RESULTS: All 111 Veterans Affairs medical centers surveyed were included in the results. All provide emergency patient care; all but one of these Veterans Affairs EDs (99%) are open 24 hours a day, seven days a week. The mean ED census is 55 patients per day (or slightly more than 20,000 patients annually). The mean percentage of admitted patients is 26%, 31% of whom are admitted to ICUs. Acute, unscheduled ambulance patients are transported from home to 106 (96%) Veterans Affairs medical centers, and 105 (95%) accept patient transfers directly from other hospitals' EDs. House staff rotate through 60 (55%) of these EDs as part of their training; emergency medicine house staff rotate through four (7%) of these EDs. There are emergency medicine residency-trained and/or emergency medicine board-certified physicians in 21 (19%) of these Veterans Affairs EDs. At the time of the survey, 29 (26%) of the respondents were either actively recruiting (12) or planning to recruit (17) emergency medicine staff physicians, including 13 seeking an ED director. In five cases, an independent emergency medicine service/section is responsible for their ED, three of which are affiliated with a division/department of emergency medicine at their medical school. CONCLUSION: In many EDs at Veterans Affairs medical centers, nonemergency medicine staff physicians and house staff unsupervised by emergency physicians care for patients seeking emergency medical care. In addition, there is a growing need for more emergency medicine staff physicians and emergency medicine house staff in the Veterans Affairs system. Organized emergency medicine should initiate efforts to inform administrators and legislators responsible for Veterans Affairs policy making and funding.

Academic Medical Centers↗

Evaluation of EMS management training offered during emergency medicine residency training.

Physician involvement in the provision of both direct and indirect medical control to emergency medical providers is critical to the effective operation of an emergency medical services (EMS) system. We conducted a survey of all accredited emergency medicine residency programs in the United States to determine the content of EMS instruction provided to these physicians-in-training. The majority of programs provide an introduction to direct medical control, to EMS organizational structure, and the opportunity to participate in EMS-related research. Less than 65%, however, provide formal instruction in EMS risk management or quality assurance or the opportunity to observe policy-making bodies related to EMS. The importance placed on EMS during residency training is variable. EMS is the domain of emergency medicine, and adequate training of residents for these responsibilities is imperative.

Curriculum↗