Medical journals and pharmaceutical companies: uneasy bedfellows.
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Helicobacter pylori infection and NSAID therapy are each closely associated with gastric and duodenal ulceration. The presence of both could have a major influence on the natural history of such disease or the efficacy of its treatment. Here we discuss the impact of eradicating H. pylori on the development and treatment of ulcers associated with NSAID therapy.
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In September 2002, the National Institute of Clinical Excellence (NICE) issued guidelines for England and Wales suggesting that ultrasound guidance should be used for all electives, and should be considered for most emergency, central venous catheterisations.1 These guidelines propose a major change of practice for most clinicians practising in UK Emergency Departments. There are also resource and training implications. In this paper we systematically review the literature to establish what evidence exists for the routine use of ultrasound guidance in the placement of central venous catheters in adult patients attending the Emergency Department, and provide an overview of the practical elements of this procedure.
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Yet another guideline on the prevention of infective endocarditis has been published, this time limiting prophylaxis to high-risk patients.
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