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Dependency in Parkinson's disease: a population-based survey in nondemented elderly subjects.

Little epidemiological data are available on the dependency status of elderly patients with Parkinson's disease (PD) living in the community. This study assessed the activities of daily living (ADL), the instrumental activities of daily living (IADL), and mobility in a representative sample of elderly nondemented PD subjects (n = 20), compared to a control population (n = 2,697). We found a significantly higher level of dependency in the PD sample based on ADL, IADL, and mobility scales. Half of the PD subjects were dependent for ADL (versus 13.2% for controls), 80% were dependent for IADL (versus 28% for controls), and 20% had their mobility restricted to their home (versus 1.5% for controls). The proportion of PD patients tended to be higher in those more depressed or with more severe motor symptoms. PD patients were not found to be more isolated socially or from family than was the control group and, in any case, dependency seemed not to be associated with isolation. When adjusting for age, sex, depressive symptoms, Mini Mental Status examination score, and dyspnea, PD remained significantly associated with dependency. PD thus constitutes a significant factor of dependency in elderly subjects living at home. Institutionalization occurred over four times more frequently in the PD group than in the general population, but no specific factor of institutionalization was noted.

Activities of Daily Living↗

Ultrasonic vocalizations by infant laboratory mice: a preliminary spectrographic characterization under different conditions.

During the first 2 to 3 weeks of life, isolated neonatal mice emit ultrasonic vocalizations, with various conditions such as hypothermia or olfactory or tactile stimulation eliciting this behavior. Although it is known that pup vocalizations stimulate prompt expression of maternal behavior, the communicative role of infant ultrasonic calls is still a matter of investigation. A fine-grained spectrographic analysis of ultrasonic calls emitted by pups exposed to different conditions was performed. Forty 8-day-old outbred CD-1 mice (Mus musculus) were isolated from their mothers and littermates and randomly exposed to one of the following conditions: (a) odor from the nest, (b) social isolation, (c) low temperature-isolation, (d) tactile stimulation, or (e) odor from a conspecific adult male. Upon consideration of the spectrogram typology and emission frequency interval, it appears that the conditions under which vocalizations are emitted influence the sound characteristics of call production.

Analysis of Variance↗

Short communication: effects of isolation stress on mammary tight junctions in lactating dairy cows.

Eighteen cows had been selected for their responsiveness to psychological stress during the first lactation and were classified as having low (n = 10) or high (n = 8) cortisol concentrations in response to isolation-induced stress. In the present study these cows, now in their second lactation, were used to determine the effect of social isolation stress on the permeability of mammary tight junctions. During the experiment, each cow was isolated from the rest of the herd for 55 h. After the 1st h of isolation, each cow received a bolus infusion of endotoxin in one hind quarter in order to challenge tight junctions. Blood samples were taken throughout to measure lactose, which was used as an indicator of tight-junction leakiness. After 1 h of isolation, stress caused an increase in tight junction permeability in both groups, which was further enhanced by the endotoxin treatment. Although the permeability did not differ significantly between the two groups, it was consistently higher in the high-cortisol group, which was also the most stress-responsive group. Thus, psychological stress may adversely affect milk quality by allowing serum components to leak into milk.

Animals↗

Changes in 5-HT1 receptors in different brain structures of rats with isolation syndrome.

1. Prolonged (3 month) individual housing of Wistar rats produced aggressive muricidal behavior in 28% of the animals. 2. Binding studies with [3H]5-HT showed that the affinity (Kd) of 5-HT1 receptors in the frontal cortex, striatum, hippocampus and hypothalamus of isolated aggressive rats was significantly decreased as compared to that in grouped rats. 3. The affinity of 5-HT1 receptors was also significantly decreased in the striatum, hippocampus and hypothalamus of isolated nonaggressive rats. 4. The number (Bmax) of 5-HT1 receptors was significantly decreased in the hippocampus and hypothalamus of isolated aggressive rats and in isolated nonaggressive rats it was decreased only in the hypothalamus. 5. The data suggest that aggressive muricidal behavior in rats with syndrome of social isolation is connected with the decreased activity of brain 5-HT1 receptors.

Aggression↗

Nocturnal sleep in isolation-reared monkeys: evidence for enviromental independence.

Thirteen all-night recordings were obtained from 3 infant pigtailed (Macaca nemestrina) monkeys raised on a cloth surrogate mother and under conditions of social isolation. Totally implantable biotelemetry systems were used to record the sleep physiology from the unrestrained animals. Sleep stages and night-to-night variability were virtually identical to values previously found in 8 mother-reared group-living infants. Sustained alterations in the early rearing enviroment, even though considerably modifying the organism's development, did not appear to result in differences in sleep organization.

Animals↗

[Evaluation of infertile men after 1 year of andrological therapy. Results of treatment and its effect on desire for children and self-esteem].

BACKGROUND AND OBJECTIVE: Many couples have to cope with periods of involuntary childlessness and they often ask for medical help. In the Heidelberg Project of involuntary childlessness in men, andrological patients were surveyed from the time before diagnosis till the end of 1 year's andrological treatment. PATIENTS/METHODS: 145 andrological patients were interviewed and filled out questionnaires to assess their wishes for parenting and their self-esteem. RESULTS: As expected men with a normal spermiographic finding had an increased chance to father a child--even more so, when no andrological treatment was performed. For those who remained childless, the wish for parenting had a higher importance than for the eventual fathers. There was little change in self-esteem, either at the beginning of treatment or one year later--with one exception: men who became fathers and had been treated suffered from more social isolation than those who became fathers and had not been treated. CONCLUSIONS: Beyond the desired effects of medical treatment, psychological and social effects have to be considered in men with involuntary childlessness, especially with those patients whose spermiogram is not severely reduced.

Female↗

Patterns of impairment and disability related to social handicap in young people with cerebral palsy and spina bifida.

This paper explores the inter-relationships between impairment and disability in a sample of 119 teenagers in relation to their psychological adjustment and quality of social life. Poor psychological adjustment and extreme social isolation are associated not so much with individual functional limitations as with particular configurations of impairments and disabilities. It seems that social handicap is not a direct consequence of any impairment or disability but arises generally from severe functional loss and is shaped by dependency on others, restricted choices, physical barriers and adverse reactions of others.

Activities of Daily Living↗

Species-specific auditory preference of bobwhite quail chicks (Colinus virginianus) is altered by social interaction with siblings.

This study examined whether reinstating specific aspects of the normally occurring postnatal setting (ongoing social interaction with siblings during rearing and/or testing) would influence bobwhite quail chicks' attraction to their species-typical maternal call. Results revealed that incubator-reared chicks exhibit a strong preference for the species-typical bobwhite maternal call over a group of same-aged siblings in simultaneous choice tests at 24 hr and 48 hr after hatching, but only if the birds are kept in relative social isolation. No preference for the maternal call was found at 24 hr or at 48 hr if chicks were reared in a group of same-aged chicks from hatching and tested to the maternal call vs. siblings or the maternal call paired with a live adult bobwhite hen vs. siblings. These results raise doubts about the appropriateness of the usual methods of isolation rearing in the study of species-typical perceptual preferences and underscore the importance of considering features of the natural social context in the analysis of early perceptual and social behavior.

Age Factors↗

Serotonin levels and turnover in different brain areas of isolated aggressive or non-aggressive strains of mice.

After eight weeks of individual housing DBA/2 but not C57 B1/6 (C57) mice showed high levels of aggressive responses in comparison with grouped mice. Social isolation did not modify serotonin (5-HT) levels in either strain of mice, while it produced a decrease of turnover rate in amygdala, lateral hypothalamus and pons in C57 mice and in lateral hypothalamus and pons of DBA mice. When isolated mice of both C57 and DBA strains are compared, no differences in turnover rate in amygdala and pons are evident, while isolated DBA mice show significant lower turnover values in lateral hypothalamus in comparison with isolated C57 mice. A possible suggestion emerging from our results is that aggressive responses exhibited by isolated DBA mice but not by isolated C57 mice may be related to lower 5-HT turnover rate in lateral hypothalamus.

Aggression↗

Contextual determinants of auditory learning in bobwhite quail embryos and hatchlings.

This study examined the ability of bobwhite quail embryos and hatchlings to learn an individual bobwhite maternal call. Results revealed that embryos could learn an individual maternal call and remember that call for at least 24 hr following exposure. In contrast, hatchlings reared socially in groups of same-age chicks during postnatal exposure to a maternal call did not demonstrate a preference for that familiar call at 24 hr following exposure. However, individual auditory recognition was exhibited by hatchlings reared in social isolation, suggesting that the perceptual and social complexity of the postnatal situation can disrupt or interfere with early auditory learning. Additional support for this view was the finding that embryos exposed to unusually early visual stimulation during prenatal exposure to a maternal call also failed to prefer that familiar maternal call in subsequent choice tests. The idea that early auditory learning capacity is determined more by context and experience rather than the organism's specific age or stage of development is discussed.

Animal Communication↗

The relationship between post-traumatic symptoms and life in exile in a clinical group of refugees from the former Yugoslavia.

OBJECTIVE: To investigate the association between life situation factors and post-traumatic symptoms among refugees from the former Yugoslavia. METHOD: Twenty-six refugees from the former Yugoslavia were examined by the Harvard Trauma Questionnaire during psychiatric treatment, and 3 years later. At follow-up they also answered a questionnaire regarding their life situations. RESULT: A higher post-traumatic symptom level at follow-up was associated with a pattern of negative living conditions such as open unemployment, social isolation, and a high dependence on social welfare. Gender differences were found regarding the factors most related to symptom severity. CONCLUSION: The results indicate that a main problem in this patient group may be how to break vicious circles of high symptom levels and a poor life situation which suggests a need for integrated rehabilitation efforts.

Female↗

Elephant people: the phenomena of social withdrawal and self-imposed isolation of people dying with AIDS.

The phenomena of self-initiated isolation and social withdrawal of people dying from AIDS is described and explained in the context of its irony and detriment to the patients' well being, minimizing access to social support resources. The psychological and the therapeutic relevance of social support during the critical transition phase is explored. Recommendations for curbing the phenomena of self-imposed social death in PWAs, as well as suggestions for future research on the value of psychosocial support to the PWA's well being during the transition phase, are also discussed.

Acquired Immunodeficiency Syndrome↗

Design of an intervention addressing multiple levels of influence on dietary and activity patterns of low-income, postpartum women.

Low-income, multi-ethnic women are at elevated risk for obesity and chronic diseases, yet influences at different levels may act as barriers to changing risk behaviors. Following the birth of a child, childrearing and social isolation can exacerbate these influences. The social ecological framework integrates behavior-change strategies at different levels, providing a strong theoretical base for developing interventions in this high-risk population. The primary purpose of this randomized controlled trial is to test the efficacy of an educational model delivered by community-based paraprofessionals in improving diet, activity and weight loss among new mothers over a 12-month postpartum period and a 6-month maintenance period. This model fosters institutional change to support behavior changes influenced at intrapersonal and interpersonal levels, through collaboration with federal programs for low-income families: the Special Supplemental Food Program for Women, Infants and Children (WIC), and the Expanded Food and Nutrition Education Program (EFNEP). Participants are randomized to the Usual Care, e.g. WIC nutrition and breastfeeding education, or Enhanced EFNEP intervention arm, consisting of Usual WIC Care plus a sustained, multi-component intervention including home visits, group classes and monthly telephone counseling. If shown to be efficacious, this program will be readily sustainable through existing federal agencies.

Adult↗

Sources of burdens on families of individuals with mental illness.

Families of individuals with mental illness face a range of practical and emotional stresses. Studies that have addressed the sources of these burdens are limited. Literature suggests that burdens could come from the stigmatizing attitudes towards individuals with mental illness and inadequate public resources. Nevertheless, how public attitudes and availability of public resources have affected the burden on patients' families remains to be studied. This study set out to explore the relationship between stigma, accessibility of mental health facilities and family burden through individual interviews of patients' relatives in order to understand the burden on mentally ill patients' relatives from their perspectives. Ten interviewees from two out-patient psychiatric clinics were recruited and interviewed. Each interviewee had at least one family member receiving out-patient psychiatric services. Altogether 11 mentally ill patients were involved. Data analyses showed that much of the burden was related to stigma and to lack of mental health and rehabilitation services. Consequences included social isolation of the families, difficulties experienced by the mentally ill patients when trying to obtain competitive employment and financial difficulties. Subjective burden resulting from social stigma included frustration, anxiety, low self-esteem and helplessness. Implications of the findings to social policy and development of mental health services were discussed.

Adolescent↗

The social skill difficulties of young adults with physical disabilities.

Adolescence is generally considered to be a time of increased social activity and the rapid expansion of a teenager's social circle. By contrast, a young person with a physical disability is likely to lack social independence, become socially isolated and experience difficulties in maintaining social relationships. The present study indicates that while both able-bodied and physically disabled young people experience difficulties in social situations, those with physical disabilities experience difficulties that are more severe in nature. Overall, 75% of the disabled group and 70% of the comparison group experienced difficulties in social situations. However, 37% of the disabled group experienced difficulties that were severe in nature compared to only 3% of the comparison group. Whilst these problems are of sufficient magnitude to warrant intervention, programmes of social skills training for people with physical disabilities are not yet generally available. It is recommended that training programmes in social skills should be made available to teenagers with physical disabilities.

Adolescent↗

Social life factors affecting suicide in Japanese men and women.

To clarify the social life factors affecting suicide mortality in Japanese men and women, the relationship between a wide variety of social and demographic indicators and age-adjusted suicide mortality was assessed in 46 prefectures in Japan by stepwise multiple-regression analysis after classification of the indicators by factor analysis. The findings indicated that rural residence was the major factor for male mortality in both 1970 and 1975; over the interval between these years, a serious economic crisis (the oil crisis) took place, and the mortality significantly increased. In addition, in 1970 (a time of high economic growth), home help for the elderly (a possible indicator of social isolation in old people), depopulation by social mobility, and urban residence were positively associated with male mortality. In women, on the other hand, both the 5-year increase in suicide mortality and the effects of the social life factors were less significant. The unique position of Japan in comparison with Western countries regarding social risk factors for suicide is discussed in the light of these findings.

Adolescent↗

Drug defaulting in a general practice.

Different groups of patients in a general practice have been under close observation by defined methods to assess the extent of their adherence to drug schedules. Patients taking antibiotics, admitted to a short drug trial and prescribed long-term treatments, proved in most cases to be compliant. Antenatal patients taking a once-daily dosage of prophylactic iron were more co-operative than those taking divided dosages. Socially isolated patients and those of low social class were particularly likely to neglect their drugs.It is suggested that the significance and extent of the problem have been largely ignored and that all drug trials undertaken on outpatients should incorporate methods of detecting defaulters.

Anti-Bacterial Agents↗

Nutritional status influences socially regulated foraging ontogeny in honey bees.

In many social insects, including honey bees, worker energy reserve levels are correlated with task performance in the colony. Honey bee nest workers have abundant stored lipid and protein while foragers are depleted of these reserves; this depletion precedes the shift from nest work to foraging. The first objective of this study was to test the hypothesis that lipid depletion has a causal effect on the age at onset of foraging in honey bees (Apis mellifera L.). We found that bees treated with a fatty acid synthesis inhibitor (TOFA) were more likely to forage precociously. The second objective of this study was to determine whether there is a relationship between social interactions, nutritional state and behavioral maturation. Since older bees are known to inhibit the development of young bees into foragers, we asked whether this effect is mediated nutritionally via the passage of food from old to young bees. We found that bees reared in social isolation have low lipid stores, but social inhibition occurs in colonies in the field, whether young bees are starved or fed. These results indicate that although social interactions affect the nutritional status of young bees, social and nutritional factors act independently to influence age at onset of foraging. Our findings suggest that mechanisms linking internal nutritional physiology to foraging in solitary insects have been co-opted to regulate altruistic foraging in a social context.

Age Factors↗