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Implications of the space radiation environment for human exploration in deep space.

Human exploration of the solar system beyond Earth's orbit will entail many risks for the crew on these deep space missions. One of the most significant health risks is exposure to the harsh space radiation environment beyond the protection provided by the Earth's intrinsic magnetic field. Crew on exploration missions will be exposed to a complex mixture of very energetic particles. Chronic exposures to the ever-present background galactic cosmic ray (GCR) spectrum consisting of all naturally occurring chemical elements are combined with sporadic, possibly acute exposures to large fluxes of solar energetic particles, mainly protons and alpha particles. The background GCR environment is mainly a matter of concern for stochastic effects, such as the induction of cancer with subsequent mortality in many cases, and late deterministic effects, such as cataracts and possible damage to the central nervous system. Unfortunately, the actual risks of cancer induction and mortality owing to the very important high-energy heavy ion component of the GCR spectrum are essentially unknown. The sporadic occurrence of extremely large solar energetic particle events (SPE), usually associated with intense solar activity, is also a major concern for the possible manifestation of acute effects from the accompanying high doses of such radiations, especially acute radiation syndrome effects such as nausea, emesis, haemorrhaging or, possibly, even death. In this presentation, an overview of the space radiation environment, estimates of the associated body organ doses and equivalent doses and the potential biological effects on crew in deep space are presented. Possible methods of mitigating these radiations, thereby reducing the associated risks to crew are also described.

Astronauts↗

Improvement and calibration of a SSNT personal dosemeter and study of importance of albedo factor for dose calculation.

The Neutriran albedo neutron dosemeter has been improved and calibrated for neutron personal dosimetry. The Monte Carlo code MCNP4b was used to calculate the thermal neutrons backscattered from the body (albedo factor). Backscattering from the wall, ceiling and floor in calibration room was considered also via simulation by MCNP4C. A semi automated counting system applying a high-resolution scanner was used for counting of tracks. An 241Am source was used to produce similar alpha particles from 10B (n,alpha)7Li reaction for the optimisation of scanner parameters to distinguish and separate the tracks in SSNTD, which lead to a better distinction between etched alpha tracks and, consequently, a higher linear region of dose characteristic.

Algorithms↗

Time-varying alpha and particle physics.

We argue that models in which an observable variation of the fine structure constant is explained by motion of a cosmic scalar field are not stable under renormalization and require massive fine-tuning that cannot be explained by any known mechanism.

Journal Article↗

Visualization of particle flux in the human body on the surface of Mars.

For a given galactic cosmic ray (GCR) environment, information on the particle flux of protons, alpha particles, and heavy ions, that varies with respect to the topographical altitude on the Martian surface, are needed for planning exploration missions to Mars. The Mars Global Surveyor (MGS) mission with its Mars Orbiter Laser Altimeter (MOLA) instrument has been providing precise topographical surface map of the Mars. With this topographical data, the particle flux at the Martian surface level through the CO2 atmospheric shielding for solar minimum and solar maximum conditions are calculated. These particle flux calculations are then transported first through an anticipated shielding of a conceptual shelter with several water equivalent shield values (up to 50 g/cm2 of water in steps of 5 g/cm2) considered to represent a surface habitat, and then into the human body. Model calculations are accomplished utilizing the HZETRN, QMSFRG, and SUM-MARS codes. Particle flux calculations for 12 different locations in the human body were considered from skin depth to the internal organs including the blood-forming organs (BFO). Visualization of particle flux in the human body at different altitudes on the Martian surface behind a known shielding is anticipated to provide guidance for assessing radiation environment risk on the Martian surface for future human missions.

Altitude↗

Bone-seeking radionuclides for therapy.

Systemic therapy using bone-seeking radiopharmaceuticals has clear advantages for the treatment of multisite metastatic pain. Evidence supporting the use of beta-particle, electron, and alpha-particle-emitting radiopharmaceuticals is reviewed here. Appropriate patient selection relies on correlating clinical symptoms with focal abnormalities on conventional bone scintigraphy. Time to symptom relief and response duration vary with the physical half-life and dose rate of the radionuclide used, offering the opportunity to tailor radiopharmaceutical choice to individual patient circumstances. Toxicity is limited to temporary myelosuppression, governed by the administered activity and underlying bone marrow reserve. Optimal responses are achieved in patients with a modest skeletal tumor burden, suggesting that targeted therapy should be considered early in the management of bone metastases. The development of reliable dosimetric models will facilitate patient-specific prescribing to deliver enhanced symptom response within acceptable toxicity limits. It is likely that targeted therapy will be most effective in the context of multimodality tumor management. Further research is required to examine the potential of radionuclides in combination with external-beam irradiation, bisphosphonates, or chemotherapy. This approach might allow targeted therapy to progress beyond symptom palliation to early intervention for survival gain.

Animals↗

[Neutron capture therapy for cancer].

Boron neutron capture therapy (BNCT) is a selective radiotherapy using boron-10 which absorbs thermal neutrons and releases high LET alpha particles by 10B(n, alpha)7Li reaction. In this paper, the present status of BNCT for malignant melanoma was introduced. As a melanoma-targetting 10B-compound, 10B-paraboronophylalanine (BPA) was used. It was administered by multiple subcutaneous injection or intravenous drip infusion. We adopted the maximum tolerance dose to the skin as a therapeutic dose regardless of the tumor 10B concentration, because we cannot directly measure it. For this purpose, an approximation of skin concentration was made using blood data just after the administration. We treated 14 melanoma patients in this way and obtained good local control of the tumor with tolerable skin reaction. More experience with logical analysis and basic research is necessary for further development of this therapy.

Boron Compounds↗

Estimates of HZE particle contributions to SPE radiation exposures on interplanetary missions.

Estimates of radiation doses resulting from possible HZE (high energy heavy ion) components of solar particle events (SPEs) are presented for crews of manned interplanetary missions. The calculations assume a model spectrum obtained by folding measured solar flare HZE particle abundances with the measured energy spectra of SPE alpha particles. These hypothetical spectra are then transported through aluminum spacecraft shielding. The results, presented as estimates of absorbed dose and dose equivalent, indicate that HZE components by themselves are not a major concern for crew protection but should be included in any overall risk assessment. The predictions are found to be sensitive to the assumed spectral hardness parameters.

Alpha Particles↗

Analysis of the pre-flight and post-flight calibration procedures performed on the Liulin space radiation dosimeter.

Liulin, a dosimetry-radiometry system, was developed to satisfy the requirements for active flux and dose rate measurements for the flight of the second Bulgarian cosmonaut in 1988. The system consists of a compact battery-operated silicon solid state detector unit and a read/write microcomputer and telemetry unit. We describe the pre-flight calibrations with charged particles, using radioactive sources and accelerated 170 MeV/nucleon proton and alpha particles at the Dubna, Russia cyclotron. We discuss comparisons with data obtained on Mir with the French-built tissue equivalent LET spectrometer NAUSICAA. Lastly, we describe post-flight calibrations performed with 1 GeV/nucleon 56Fe ions at the Brookhaven National Laboratory AGS accelerator, where the instrument was mounted in tandem with several thin position-sensitive silicon detectors behind a stopping target. The silicon detectors provided an energy spectrum for the surviving charged nuclear fragments for which the flux and absorbed dose were recorded by Liulin.

Alpha Particles↗

A simplified approach to alpha dosimetry for small spheres labelled on the surface.

The radiation doses to spheres of radii 5-200 microns, labelled on the surface with alpha emitters were studied in order to simulate conditions of radioimmunotherapy for small tumours. The absorbed fraction of emitted energy and the mean absorbed dose per alpha particle in smaller concentric spherical targets were calculated for different source sizes. Calculations were first performed for monoenergetic emissions. We then considered the dosimetry of two common alpha emitters described in the literature (211At and 212Bi). The results agree well with different analytical approaches reported in the literature, but differ from those obtained using a Monte Carlo code. The computing features have been deliberately kept to a low level to allow for simple introduction into hospital work. Comparison of the mean absorbed dose per particle between alpha and beta emitters seems to favour the use of alpha emitters. However, their high toxicity introduces a practical radiation protection problem and our mathematical dosimetric approach is valid only for homogeneous distributions of radionuclides when, in the case of alpha emitters, the total dose delivered would be much too high to be of practical use.

Alpha Particles↗

A comparison of calculated and measured W values in tissue-equivalent gas mixtures.

We calculated the mean energy required to produce an ion pair (W) in methane-, propane- and butane-based tissue-equivalent (TE) gas mixtures from W values in pure constituent gases according to various models for energy partition among gas components. We found an agreement between the experimental and calculated W values in the methane-based TE gas regardless of the model concept. In contrast, only those models which take into account differences in the stopping powers, total ionization cross sections and model constants of gas components give acceptable results for the propane-based TE gas. The calculated W value for high-energy electrons in the isobutane-based TE gas mixture is 25.2 eV for high-energy electrons and 28.0 eV for approximately 5 MeV alpha particles.

Alpha Particles↗

Analysis of biological samples using prompt gamma radiations induced by 14.7-MeV neutrons.

We investigate a method for determining the elemental composition of biological samples that uses prompt gamma rays induced by 14.7-MeV neutrons. Alpha particles are produced simultaneously with the neutrons, which exit opposite the alpha detector through the vacuum chamber wall. The sample under investigation is irradiated and emits gamma radiations in a spectral energy distribution characteristic of the material. Barium-fluoride (BaF2) and high-purity germanium (HPGe) gamma detectors view the sample and record the spectrum of gamma radiation.

Alpha Particles↗

Alpha-emitting, hot particles in Irish sea sediments.

Alpha-emitting, hot particles have been observed in samples of liquid effluent from the nuclear fuel reprocessing plant at Sellafield, U.K. Similar particles, thought to originate from Sellafield, have been found in environmental samples from sites near the plant. The occurrence and distribution of hot particles in surface sediments from the northeastern sector of the Irish Sea are described and the implications for predicting transuranium element behaviour are discussed.

Alpha Particles↗

Complex chromatid-isochromatid exchanges following irradiation with heavy ions?

We describe a peculiar and relatively rare type of chromosomal rearrangement induced in human peripheral lymphocytes that were ostensibly irradiated in G(0) phase of the cell cycle by accelerated heavy ions, and which, to the best of our knowledge, have not been previously described. The novel rearrangements which were detected using mFISH following exposure to 500 MeV/nucleon and 5 GeV/n 56Fe particles, but were not induced by either 137Cs gamma rays or 238Pu alpha particles, can alternatively be described as either complex chromatid-isochromatid or complex chromatid-chromosome exchanges. Different mechanisms potentially responsible for their formation are discussed.

Alpha Particles↗

The centenary of the discovery of the Bragg peak.

Bragg published curves for ionization of air by radium alpha particles in December 1904 demonstrating that ionization density increased sharply near the end of range. The accepted view was that ionization would decrease exponentially with depth. This depth dose pattern is the basis for the dose distributional advantage of charged particles relative to photons.

Alpha Particles↗

Simultaneous separation and detection of actinides in acidic solutions using an extractive scintillating resin.

An extractive scintillating resin was evaluated for the simultaneous separation and detection of actinides in acidic solutions. The transuranic extractive scintillating (TRU-ES) resin is composed of an inert macroporous polystyrene core impregnated with organic fluors (diphenyloxazole and 1,4-bis-(4-methyl-5-phenyl-2-oxazolyl)benzene) and an extractant (octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide in tributyl phosphate). The TRU-ES resin was packed into FEP Teflon tubing to produce a flow cell (0.2-mL free column volume), which is placed into a scintillation detection system to obtain pulse height spectra and time series data during loading and elution of actinides onto/from the resin. The alpha-particle absolute detection efficiencies ranged from 77% to 96.5%, depending on the alpha energy and quench. In addition to the on-line analyses, off-line analyses of the effluent can be conducted using conventional detection methods. The TRU-ES resin was applied to the quantification of a mixed radionuclide solution and two actual waste samples. The on-line characterization of the mixed radionuclide solution was within 10% of the reported activities whereas the agreement with the waste samples was not as good due to sorption onto the sample container walls and the oxidation state of plutonium. Agreement between the on-line and off-line analyses was within 35% of one another for both waste samples.

Acids↗