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PubMed1964

OBSERVATIONS ON ANTICOAGULANT THERAPY IN THROMBOEMBOLIC DISEASE OF THE BRAIN.

According to a recently reported study, anticoagulant therapy appears to be ineffective in thrombotic cerebrovascular disease when viewed from the standpoint of mortality, although it does control thrombosis in animals, recurrent ischemic attacks and progression of infarction in patients with stuttering strokes. The efficacy of anticoagulant therapy in preventing a catastrophic stroke is analyzed in the present report. Of 92 untreated patients followed up for an average period of 36 months, 28 suffered a recurrent stroke, only two of these being trivial. One trivial and 12 catastrophic strokes occurred in the first 16 months. Of 103 patients treated with anticoagulants for an average period of 16 months, seven had recurrent strokes, but five of these were trivial. In the first 16 months one catastrophic and four trivial strokes occurred. Anticoagulant therapy appears to be useful in preventing catastrophic strokes in selected patients in whom the risk of recurrent strokes justifies the risks involved in this treatment.

Anticoagulants↗
PubMedDate not supplied

[Electrocardiographic changes in acute and past cerebral stroke].

An analysis of 617 cases of cerebral strokes was done, including 534 acute and 83 past ones treated in the years 1966-1972. The patients were divided into 4 groups: I -- cerebral haemorrhage, II -- cerebral embolism, III -- cerebral arterial thrombosis, IV -- failure of cerebral circulation. The classification was based on clinical criteria and in dying patients also on autopsy findings. ECG changes were analysed in all patients. In the acute period of stroke the greatest proportion of cases were cerebral arterial thrombosis (197 cases --37%) and in this group acute myocardial infarctions were most frequent. This group was followed by cases of acute cerebral circulatory failure (191 cases -- 35%). The electrocardiographic correlate of the cerebral changes were in this group signs of myocardial ischaemia (84 cases -- 15%). Cerebral embolism (134 cases -- 24%) was associated with arrhythmia (109 cases --19) of various origin. In the group of cerebral haemorrhages (95 cases -- 17%) no unequivocal ECG changes were observed. In all patients with myocardial infarction during cerebral stroke atheromatous changes of coronary arteries were present. No correlation was observed between the location of the cerebral focus and the type of electrocardiographic changes.

Acute Disease↗