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At least 1,009 records · Page 56Linked to original sources
PubMed1991

Development of monoamine oxidase activity during postnatal development of the ground squirrel (Citellus citellus).

1. Monoamine oxidase (MAO) activity in the brain and peripheral tissues of newborn ground squirrel, as well as its evolution during postnatal development were studied. 2. Monoamine oxidase activity in the brain stem and liver, at the day of birth is significantly higher (P less than 0.01; P less than 0.005) than in adults. 3. After that, enzyme activity decreases, but at the 25th day, e.g. at the day of the opening of the eyes, still remains significantly above the adult's value (P less than 0.01). 4. The results indicate some species specificity concerning the level and the evolution of cerebral and hepatic MAO activity as compared to the rats.

Aging↗
PubMed2001

[Development of the ELISA kit for the detection of Hypoderma bovis antibodies in cattle. I. Development of components].

The aim of these investigations was to prepare the antigen and control sera for the ELISA. Positive control sera were obtained from 163 cows showing clinical symptoms of H. bovis infection and negative control sera from 60 cows free from the infection. The antigen for the ELISA was obtained from H. bovis L1 larvae. Three basic fraction were isolated from whole excreted/secreted antigen by elution from gel and by preparative isoelectrofocusing. Using the Western-Blotting method it was demonstrated that Hy A (22-24 kDa and pI 4-5) had the best antigenic property. As can be seen from these investigations the developed ELISA kit for the detection of H. bovis antibodies in cows is highly specific and sensitive.

Animals↗
PubMed1991

[Reversibility of the development of malignant lymphoma with 7-years of leukemization, associated with the development of chronic myeloleukemia].

A case of typical Ph-positive chronic myelogenous leukemia developed in a 58-year old female with a 7-year history of chronic lymphoproliferative disease is described. With the second disease progression, the features of lymphoid proliferation disappeared almost completely. Possible causes of this rare combination of two diseases are discussed.

Chronic Disease↗
PubMedDate not supplied

[Professor-student relations in teaching-educational development and its influence on the formation and development of the qualities of the communist personality].

A research is carried out at the Polytechnic Health Institute, Psychiatric Hospital, Havana, surveying 48 students of Plan III General Nursing, in order to analyze relationship between professors and students, their influence on the development of educational-teaching process and acquisition of behavioral habits by the student, according to: professor-student relationship; professor-student reliability; influence of the professor on the formation of habits, discipline and right behaviour; place where influence of professor is exerted; influence of professor-student relationship on quality of classes; influence of professor on students' tasks, and opinions about how the image of professors is and how must be. An information that will allow us to raise the quality of educational-teaching process as result of a harmonious relationship between professors and students, was obtained.

Communism↗
PubMed1990

[A method for developing a controlled process. Development and execution of a program supplying culture medium components for rifamycin B biosynthesis].

The study provided data on the rate of consumption of the main nutrients by the rifamycin-producing culture in relation to their content in the initial medium. A program for feeding ammonium sulfate and cornsteep liquor and joint control of both the nutrients was developed and tested. The results of the testing confirmed the practicable precision of the feeding. The control of cornsteep liquor and ammonium sulfate concentrations with the program allowed to increase the yield of rifamycin B by 15 and 20%, respectively. The joint control increased the level of the required product by 25%.

Ammonium Sulfate↗
PubMedDate not supplied

[Response of the developing thyroid gland of rats to a single gamma-irradiation in the period of intrauterine development].

A single external exposure of pregnant rats to 2 Gy gamma-radiation caused changes in the functional status of the thyroid gland in offsprings at varying times of the postnatal development. The disturbance of the thyroid hormones balance in the blood, destruction of the thyroid gland combined with high functional tension of secretory elements, and activation of the thyrotropic function of hypophysis were revealed at remote times after irradiation.

Animals↗
PubMed1989

[The development of osteoarthrosis and the role of collagen in the pathophysiology of its development].

The work deals with the structure, chemical composition and physical properties of individual types of collagen of which thirteen has been so far described. Special attention is devoted to the types of collagen II, VI, IX and XI which are found in the articular hyaline cartilage. The main collagen type of the articular cartilage is type II which makes up approximately 90 per cent of all the collagen. The remaining three types fall into the so called minority types. Collagen of type IX differs from other types by the kink in its structure. This type of collagen represents a certain transition to proteoglycans with regard to the fact that the lateral glycoaminoglycan chain is attached. The work is supplemented with electron microscope pictures of individual molecules of these types. It describes also individual stages of biosynthesis and special attention is devoted to the aggregation of molecules into fibrils. The authors describe the cross-linking elements of lysinonorleucine and pyridinoline type. The changes which occurring in the structure and metabolism of collagen in the course of osteoarthrosis are described. The role of adhesive proteins is mentioned and the influence of the osteoarthrotic changes on nutrition and its function as well as on the development of pathogenetic mechanism is described.

Collagen↗
PubMed1988

[Relationship between the development of the health status and the activity of the health care system in developed countries].

The question of the relationship between the evolution of health status and the activity of health care system in developed countries is treated frequently through epidemiological studies. However, there are numerous methodological difficulties linked to this type of investigation and it is not possible to give a certain answer to this question. Particular difficulties concern the choice of indicators (indicators of health status and indicators of health care system). This choice may influence largely the outcome of the results. If general mortality has tended to decline over the last thirty years, some causes of death have progressed and many studies show an increase of the level of morbidity and disabilities declared in the population and an increase of social disparities in health status. The analysis concerning the role of health care systems, in order to explain this evolution, does not lead to a single conclusion. Some works show the positive effect of the activity of health care systems (especially for infant mortality). According to other authors, the growth of chronic diseases must be considered as the negative aspect of the success obtained in the struggle against mortality. But above all, interpretation of results needs a continuous reference to methodologies used and it is only on this condition that such data may be useful for public health decisions.

Aged↗
PubMedDate not supplied

The development of a comprehensive, institution-based patient risk evaluation program: I. Development, content, and data management.

There is a need for standardization of risk factor questionnaires for epidemiological research. This paper describes the development and implementation of a comprehensive cancer risk evaluation program at the University of Texas M.D. Anderson Cancer Center. A detailed self-administered questionnaire is given to all newly registered adult patients. The format of the instrument, coding systems, quality control measures, and data entry mechanisms are discussed. The criteria for the choice of a data base management system are outlined. The identification of high-risk patient subgroups is possible, and it is feasible to link this data base with clinical and biochemical data. There is considerable potential for collaborative research using this risk evaluation program, bringing together basic scientists, clinicians, and epidemiologists.

Cancer Care Facilities↗
PubMed1978

Shape regulation capacity during development: recovering capacity of embryos developing notwithstanding dramatic deformations.

1. The development was studied of embryos in which dramatic deformations were produced by physical means during the period in which they are highly susceptible to teratogenesis. 2. In spite of the deformations histogenesis as a whole as well as cytodifferentiation seems to be normal. 3. With only few exceptions the embryos showing dramatic deformations ultimately recover a normal morphology. 4. The shape recovering capacity raises the question whether morphogenesis and shape are not in fact more or less independent phenomena.

Animals↗
PubMed1974

[Several aspects of the problem of the development of hormonal regulation during prenatal development].

Some general aspects of the problem of hormonal control mechanisms in prenatal life are discussed. An analysis is performed on the basis of both the literary and author's data pertaining to the development of hypothalamo-hypophysial-adrenal, hypothalamo-hypophysial-thyroid and hypothalamo-hypophysial-gonadal functions during the foetal life. Experimental evidences of the activity of these functions in foetuses are provided. Neuroendocrine mechanisms are considered as a system of coordinated and intercontrolling links where the relative autonomy, the self-regulation of lower levels is coupled with the centralized control of higher levels. A concept is put forward to the effect that interactions between individual links play an important part in the formation of these mechanisms. If it is so, organizing influences, or stimuli, may emanate both from higher levels of control towards the lower ones and vice versa. Hormonal influences in early ontogenesis are characterized by the fact that, besides direct effects at the same developmental stage, they ensure the maturation of higher levels of neuroendocrine mechanisms which perform hormonal control in adults.

Animals↗
PubMed1984

[Effect of the polymerase activity of DNA polymerase I on the development of moderate bacteriophages Mu, lambda red- and lambda red-gam-. II. The effect of the polymerase activity of DNA polymerase I on the development of bacteriophage Mu].

The paper reports on the influence of polymerizing activity of DNA-polymerase I on different developmental stages of temperate bacteriophage Mu in Escherichia coli K-12 cells. This activity is shown to be necessary for optimization of phage Mu primary integration into cell chromosomes. The relative frequency of Mu integration into bacterial chromosomes is 5-6 times lower in polA cells than in isogenic polA+ control strains, the phage yield from cells being delayed during the phage infectious development, but not in the course of induction from the prophage state. Data have been obtained that show the process of phage Mu DNA integration into the plasmid pRP1 .2 and the process of Mu transposition from the cell chromosome into the plasmid to be independent of the polymerizing activity of DNA-polymerase I.

Adsorption↗
PubMed1993

Recombinant vaccine development: a novel approach to ectoparasite control. A review of development of a recombinant vaccine for hypodermosis based on hypodermin A.

Cattle grubs (Hypoderma lineatum and H. bovis) are obligate parasites of cattle for most of their one year life cycle. Previously exposed animals become resistant to productive reinfestation, presumably as a result of immune system involvement, suggesting potential control by vaccination. Research progress towards development and utilization of a recombinant subunit vaccine for hypodermosis is described.

Animals↗
PubMed1995

Development of hearing. Part III. Postnatal development.

As humans, we hear the way we do because of at least three major forces. The first is phylogeny, the evolutionary changes in the auditory system since its beginnings. The second is embryology, the formation of the system in each individual. Finally, there is the interaction between the biologically determined mechanism we are born with and the environment. This series of articles reviews each aspect in turn, so that we may have a fuller appreciation of how it is we come to hear the way we do. Part I examined how the auditory system evolved, and Part II outlined the sequence of ear formation in prenatal life. In this concluding article, we examine the development of auditory perception from when we first hear (in utero) through 12 months of age, which is when speech usually appears. Humans seem to come "programmed" to perform all the processes necessary to learn the language of their environment. Interaction with the environment hones our abilities to process sound and thereby optimizes language acquisition and production.

Child↗
PubMed1994

IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease.

The injection of DBA/2 (D2) spleen cells into (C57BL/6 x DBA/2)F1 mice (BDF1) induces a chronic, autoimmune graft-vs-host disease (GVHD) that is characterized by: increased production of Th2-associated cytokines; increased levels of serum Ig, including IgE; increased production of IgG anti-DNA Abs; and no detectable antihost CTL activity. Experiments were performed to determine if treatment with the cytokine IL-12, which stimulates the production of Th1-associated cytokines and inhibits Th2-associated cytokine production, would inhibit humoral autoimmunity in this system. Treatment of mice with 100 ng IL-12 per day for 5 days, starting on the day of cell transfer, resulted in: 1) near complete suppression of autoantibody production; 2) decreased serum Ig levels; 3) detectable donor antihost CTL activity; and 4) greatly reduced numbers of host splenic B and T cells. Treatment of mice with a neutralizing anti-IFN-gamma mAb did not reverse these effects of IL-12. Thirty nanograms per day resulted in reduced numbers of host B cells and reduced serum anti-DNA levels, but no detectable antihost CTL activity. IL-12 treatment initiated 7 days after cell transfer had little effect on the development of autoimmune GVHD. These observations suggest the following: 1) IL-12 inhibits humoral autoimmunity in a murine parent-->F1 GVHD model by inducing the activation of host-reactive CTLs that reject the host immune system. 2) This effect is IFN-gamma-independent. 3) IL-12 needs to be present during the initial differentiation of T cells in this system to have this effect.

Acute Disease↗
PubMed1993

[Basedow-Graves disease development in 2 patients with primary hypothyroidism: exceptional development of the autoimmune thyroid disease].

Autoimmune thyroid disease has multiple manifestations and its presentation may change with time. We report two patients with primary hypothyroidism due to Hashimoto's disease that unexpectedly, developed a hyperthyroidism due to Basedow-Graves disease. This phenomenon may be explained by variations in the types and proportions of anti TSH receptor antibodies, that can stimulate or block thyroid gland function and growth. It is deducted that the hypothyroidism of these patients was not due to a definitive gland destruction, but to the action of function blocking antibodies.

Adult↗
PubMed1995

[1984-1994: ten years of skin flaps. Improvements and conceptual developments. Development of vascular concepts, classification and clinical concepts].

After a brief review of definitions and semantics, the author recalls the state of the art before 1984 concerning arterial and venous cutaneous blood supply. Studies and concepts published since 1984 include those of Nakajima, who distinguished six types of cutaneous arteries, Gumener, who emphasized the vascular entity represented by the subcutaneous connective tissue, and Taylor. This author, after many studies on the whole body, defined forty arterial and venous cutaneous territories, border-arteries and veins oscillating at the borders of these territories, as well as a number of neurovascular entities (neurocutaneous arteries and veins). In terms of haemodynamics, the concepts of anatomical, haemodynamic and potential arterial cutaneous territories, the concepts of arteriosome and venotome and the concept of low venous pressure zones are analysed. These anatomical and concepts haemodynamic are the basis for the feasibility and reliability of the various cutaneous, musculocutaneous and fasciocutaneous flaps. A number of classifications for these various flaps have been proposed since 1984: a theoretical classification (Kunert's), classifications according to vascular systematization, including Nakajima's classification, and many others. The author proposes a practical classification which should allow a better understanding and better national and international exchange. In parallel, the design and indications of various types of flaps have also advanced since 1984. Skin flaps without a systematized blood supply do not correspond to random flaps. Musculocutaneous flaps have advanced in three directions: partial muscular harvesting when the objective of the flap is essentially cover, an increase of the skin flap surface area; substitution, in certain anatomical regions, of the concept of fasciocutaneous flap for that of musculocutaneous flap, particularly in thoracolumbar and anterior thoracic regions. The author notes the progress in fasciocutaneous flaps: distal pedicle leg flaps, development of decreased cutaneous morbidity resulting in fasciosubcutaneous flaps and proximal or distal fascial (or fascio-adipose) pedicle fasciocutaneous island flaps, progress of normal flow or reverse flow island septocutaneous flaps on the main vessels of the limbs towards to similar types of island flaps on secondary vessels, especially in peri-articular sites. The other clinical concepts analysed include grafted fascial flaps, grafted adipose and fascioadipose flaps, neurocutaneous flaps, "tailormade" flaps and chimeric flaps. This progress in vascular and clinical concepts of skin cover flaps over the last ten years is illustrated by many examples of skin cover, particularly involving the posterior aspect of the heel.

Female↗