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At least 1,009 records · Page 56Linked to original sources
PubMed1994

Mitochondrial respiratory function in multiple symmetrical lipomatosis: report of two cases.

Madelung's disease is a rare benign disorder characterized by symmetrical deposition of adipose tissue on the neck and shoulders. The cause of Madelung's disease is obscure and may be associated with mitochondrial dysfunction. In this communication, we report two cases encountered at Cardinal Tien Hospital during 1992. Besides physical check-up and laboratory examination, adipose tissue and muscle biopsies from the biceps brachii were performed. As lipid metabolism is closely related to mitochondrial respiration, biochemical studies may be of great value in clarifying the pathogenetic mechanism of Madelung's disease. We thus determined the activities of mitochondrial respiratory enzymes (NADH cytochrome c reductase, succinate cytochrome c reductase, cytochrome c oxidase) in muscle and blood cells and revealed that the electron transport functions were all elevated. Molecular analysis of mitochondrial DNA from the muscle and blood cells of both patients failed to find large-scale deletion or point mutations.

Adult↗
PubMed1996

Spinal angiolipoma mimicking extradural lipomatosis.

Spinal angiolipoma is a rare, benign tumour. More than 90% of cases arise extradurally. The authors report an extradural spinal angiolipoma in a 54-year-old man. Conventional T1-weighted and T2-weighted magnetic resonance imaging (MRI) demonstrated an excessive amount of extradural adipose tissue posteriorly, extending from the level of the third to the ninth thoracic vertebra. The signal intensity within the spinal cord was normal. These findings were initially misinterpreted as being of little clinical significance. When the patient's condition deteriorated, myelography was performed, and extradural compression of the thecal sac was demonstrated. At surgery spinal angiolipoma was confirmed. The ease with which the MRI features of this lesion can be overlooked, as well as imaging strategies to avoid this pitfall, are discussed.

Angiolipoma↗