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PubMed1989

[Effects of ketanserin on arterial pressure at rest and during physical exercise in essential arterial hypertension].

The antihypertensive effect of ketanserin, a recent 5-hydroxytryptamine (5-HT) antagonist, which acts on the 5-HT2-subtype receptor, was evaluated in 10 patients of both sexes (age range 35-69 years) with mild to moderate essential hypertension. Blood pressure and heart rate were measured at rest, in supine and standing position at the end of two weeks of placebo washout and after 2, 4 and 8 weeks of treatment with ketanserin 20 mg twice daily as monotherapy, while the changes of blood pressure and heart rate during static (hand-grip) and dynamic (bicycle ergometer) exercise were evaluated at the end of placebo and of the fourth week of therapy. The treatment induced a highly significant reduction of supine and standing systolic and diastolic blood pressure during rest, without any significant change in heart rate. During dynamic exercise, the increase in systolic and diastolic blood pressure and heart rate was not blunted by ketanserin, while the drug reduced systolic blood pressure and heart rate increase, during static exercise, with no change of diastolic blood pressure. From these data it may be concluded that ketanserin lowers blood pressure in essential hypertension without any interference with cardiovascular reflexes related to standing or dynamic exercise, and reduces the increase of systolic blood pressure and heart rate during static exercise with favourable interference on myocardial oxygen consumption. This sparing effect on myocardial oxygen demand is particularly relevant in hypertensive patients with asymptomatic coronary disease engaged in normal daily physical activity which includes many forms of static exercise.

Adult↗
PubMed2005

A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise.

BACKGROUND: Cross-sectional data have shown that sarcopenia and fat accumulation are associated with aging and can be limited by structured physical training. However, it is often difficult to maintain a long-term compliance to training programs. It is not clear whether leisure-time physical activity is effective in preventing sarcopenia and fat accumulation. OBJECTIVES: (i) To investigate longitudinal body composition changes in a population of elderly people in good apparent health. (ii) To evaluate the impact of leisure-time physical activity on muscle mass and characteristic as reflected by total body potassium per fat-free soft tissue (TBK/FFST), and on fat accumulation. DESIGN: Longitudinal evaluation over 3 years, of body composition changes in 74 healthy men and 66 women, over 65 years old. Body fat and FFST were analyzed by dual-energy X-ray absorptiometry and TBK by whole-body (40)K counter. Physical activity was analyzed by a specific questionnaire. RESULTS: Despite a stable total body weight, FFST and appendicular skeletal muscle mass slightly decreased (-0.3+/-1.4 and -0.2+/-2.2 kg, P<0.01, respectively) as well as the TBK/FFST (-4.1+/-6.3 mmol/kg, P<0.001), over the 3-year period. Body fat increased significantly (0.6+/-2.2 kg, P<0.0001), and it accumulated mainly in the abdomen (0.4+/-1.5 kg, P<0.01). Multiple regression analysis showed that body composition changes were related mainly to body weight changes. Nevertheless, positive linear correlations were observed between the degree of engagement in leisure-time physical activity and FFST (P<0.01), appendicular skeletal muscle mass (P<0.05), TBK/FFST (P<0.05), whereas negative correlation was observed with total and truncal fat (P<0.01). CONCLUSIONS: Mild but significant decline in muscle mass and its TBK content, and body fat accumulation were observed over a 3-year period in healthy elderly subject: leisure-time physical activity does not seem to prevent them. However, a higher level of physical activity is associated with higher muscle mass and TBK content, and less total and truncal fat.

Absorptiometry, Photon↗
PubMed1995

Characteristics of the venous hemodynamics of the leg under simulated weightlessness: effects of physical exercise as countermeasure.

In order to test the hypothesis that increases in calf venous distensibility in microgravity are partly due to the changes affecting the surrounding skeletal muscles (muscular atrophy), 12 healthy volunteers were exposed for 28 d to microgravity simulated by -6 degrees head-down bed rest. Half these subjects were exposed to countermeasures during bed rest: a) repeated LBNP (Lower Body Negative Pressure) sequences starting on the 15th d with one 15 min sequence at -35 mb, every other day from the 15th until the 21st d, and then every day until the end of bed rest; b) physical training including isotonic type exercise and isometric or isokinetic work by all muscle mass of upper and lower limbs (from the 8th until the 28th d). The other six subjects forming the control group were not subjected to any countermeasure. Calf venous hemodynamics were determined by mercury strain gauge plethysmography with venous occlusion. Distensibility (delta Vmax) and venous emptying (venous outflow at the 6th s of emptying: VO6, half-emptying time: T1/2, maximum venous outflow (MVO) could also be measured. Nuclear magnetic resonance (NMR) was used to study changes in volume of calf muscles. Plethysmographic measurements made for each subject prior to, during (once a week), and after bed rest show a parallel increase in calf venous distensibility in both groups of subjects until the 20th d of bed rest. Filling and emptying times then tended to stabilize in the group treated with countermeasures (group CM) whereas high venous distensibility was observed until the end of bed rest and 5 d thereafter in the control group (group C).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2003

Physical exercise increases urinary excretion of lipoxin A4 and related compounds.

Lipoxins (LX) are lipoxygenase-derived eicosanoids with potent anti-inflammatory activities and vascular bed-dependent vasodilatory actions. LX can be formed in vitro and in vivo in a number of conditions, and we have reported that immunoreactive LXA(4) (iLXA(4)) is physiologically excreted with human urine. Using a recently developed LX extraction method coupled to an ELISA, we examined whether iLXA(4) excretion was modified by strenuous exercise, which is known to trigger potential LX-forming events. Maximal exertion significantly increased iLXA(4) urinary excretion in nine healthy volunteers (0.061 +/- 0.023 vs. 0.113 +/- 0.057 ng/mg creatinine; P = 0.028). iLXA(4) levels returned to baseline after 6 h and increased, although at a smaller extent, after 24 h. A significant correlation (r = 0.988) was denoted between iLXA(4) ELISA measurements and reversed-phase high-performance liquid chromatography quantitation of a previously described urinary tetraene, confirming its LXA(4)-related nature. These findings show for the first time that an increase in excretion of LXA(4)-related compounds can be observed in response to strenuous exercise. This may be the reflection of an enhanced LX biosynthesis, which may represent a safeguard mechanism that keeps the inflammatory reaction triggered by physical stress under control.

Adult↗
PubMed2006

Effects of a physical exercise intervention on employees'perceptions quality of life: a randomized controlled trial.

OBJECTIVES: To determine the effects of an exercise intervention in workplace health promotion, WHO multidimensional quality of life was chosen as the main outcome variable. Secondary outcomes were different physical fitness indicators. METHODS: 110 employees (83 male, 27 female, modus age group 36-45 years) volunteered to participate and were randomly allocated to intervention (n = 52) or control group (n = 58). Intervention subjects exercised 13 weeks, at leisure time, in off-worksite training facilities. Outcome measures were assessed before and after the intervention, and at 3 month follow-up. RESULTS: Significant training effects resulted for overall perception of quality of life, and for psychological and physical health sub-domains. Physical strength indicators improved significantly as well, with these changes being independent from psychological health benefits. At follow-up, elevated psychological scores held steady only for those who continued to exercise on their own. DISCUSSION: This intervention had impact on important health indicators. Since it was arranged on top of a "real world" occupational health promotion program, the observed findings should even more encourage employers to invest in their employees' health.

Adult↗