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PubMedDate not supplied

[Regional differences in hospital utilization].

Many recent studies have demonstrated that hospital utilization rates vary widely among similar areas and regions. The objective of this study is to find out the variation among the hospitalization rates in Spain across the 17 Autonomic Communities in 1988. From the Hospital Morbidity Survey we calculate the general discharge rate and the rate for 14 diagnostics. To evaluate the degree of variation we calculate the coefficient of variation, the ratio of variation and the systematic component of variation, which ranges from 0.96 (hernia) to 8.45 (varicose veins). This substantial variations are consistent with studies performed in countries with different health systems. Although new information systems which allow to perform population based studies are due to establish, these variations are too large to ignore and have to be taken account in policy making.

Data Collection↗

PubMed2002

Social capital and health (plus wealth, income inequality and regional health governance).

This article describes an empirical exploration of relationships among aspects of thirty health districts in Saskatchewan, Canada. These aspects include social capital, income inequality, wealth, governance by regional health authorities and population health, the primary dependent variable. The social capital index incorporated associational and civic participation, average and median household incomes served as proxies for wealth, the degree of skew in the distribution of household incomes assessed income inequality while the model for effective governance by District Health Boards (DHBs) focused on reflection of health needs, policy making and implementation, fiscal responsibility and the integration and co-ordination of services. I found no evidence of a relationship between social capital in health districts and the performance of DHBs. Among the determinants of health, wealth appeared unrelated to age-standardised mortality rates while income inequality was positively and social capital was negatively related to mortality. Income inequality was not as strongly related to age-standardised mortality after controlling for social capital. and vice versa, suggesting the two may be comingled somehow when it comes to population health, although they were not significantly related to one another. Of the predictors of social capital the distribution of age in districts appeared to be the most salient; of the predictors of age-standardised mortality rates the gender composition of a district was most salient.

Adolescent↗

PubMed1997

Australian economic evaluation and government decisions on pharmaceuticals, compared to assessment of other health technologies.

In this paper the first theme is the experience with the routine use of cost-effectiveness analysis in decisions by the Australian Pharmaceutical Benefits Advisory Committee on whether drug products should attract a government subsidy. As a second theme, the contrasting experience with several other health technologies is presented, with economic analysis being less frequently used in a system where there is a weaker regulatory framework. Some general points that emerge in both areas are the importance of factors other than economic evaluation in the decision-making process, and the need to make policy and administrative decisions on the basis of limited data. There is limited material available in the public domain on the interaction of economic evaluation and Australian policy on health technologies. It has been necessary, particularly in relation to the case studies presented here, to rely on input from discussion with a number of individuals and on observations made during personal involvement with some of the assessments. It is not possible to offer substantive evidence in support of this material, and indeed firm evidence in the area of impact of assessments on health policy remains difficult to collect.

Australia↗

PubMed1998

Liminality: a major category of the experience of cancer illness.

Narrative analysis is well established as a means of examining the subjective experience of those who suffer chronic illness and cancer. In a study of perceptions of the outcomes of treatment of cancer of the colon, we have been struck by the consistency with which patients record three particular observations of their subjective experience: (1) the immediate impact of the cancer diagnosis and a persisting identification as a cancer patient, regardless of the time since treatment and of the presence or absence of persistent or recurrent disease; (2) a state of variable alienation from social familiars, expressed as an inability to communicate the nature of the experience of the illness, its diagnosis and treatment; and (3) a persistent sense of boundedness, an awareness of limits to space, empowerment and available time. These subjectivities were experienced in varying degree by all patients in our study. Individual responses to these experiences were complex and variable. The experiences are best understood under the rubric of a category we call "liminality". We believe that all cancer patients enter and experience liminality as a process which begins with the first manifestations of their malignancy. An initial acute phase of liminality is marked by disorientation, a sense of loss and of loss of control, and a sense of uncertainty. An adaptive, enduring phase of suspended liminality supervenes, in which each patient constructs and reconstructs meaning for their experience by means of narrative. This phase persists, probably for the rest of the cancer patient's life. The experience of liminality is firmly grounded in the changing and experiencing body that houses both the disease and the self. Insights into the nature of the experience can be gained from the Existentialist philosophers and from the history of attitudes to death. Understanding liminality helps us to understand what it is that patients with cancer (and other serious illnesses) seek from the system to which they turn for help. Its explication should therefore be important for those who provide health care, those who educate health care workers and those concerned to study and use outcomes as administrative and policy making instruments.

Adult↗

PubMed1999

Understanding social variation in cardiovascular risk factors in women and men: the advantage of theoretically based measures.

Many studies have attempted to understand observed social variations in cardiovascular disease in terms of sets of intermediate or confounding risk factors. Tests of these models have tended to produce inconsistent evidence. This paper examines the relationships to cardiovascular risk factors or two theoretically based measures of social position. It shows that the strength of the relationships between social position and cardiovascular risk factors varies according to the definition of social position which is used: there is a closer relationship between most health behaviours and the Cambridge scale, an indicator of 'general social advantage and lifestyle', whereas the Erikson-Goldthorpe schema, which is based on employment relations and conditions, is more strongly related to work control and breathlessness. The implications of these findings for understanding the conflicting evidence in other studies of health inequalities are then discussed. The paper concludes that inconsistencies between studies may be in part due to unexamined differences between the conceptual bases of the measures of social position they use, combined with a failure to make explicit the hypothetical mechanisms of effect. If neither the conceptual basis of the measure of social position, nor the links between social position and health outcome tested in each study are clear, inconsistencies between studies will be difficult to interpret, making policy recommendations highly problematic.

Adult↗

PubMed2000

Measuring risks in humans: the promise and practice of epidemiology.

Epidemiology has been considered the fundamental science of public health policy. The use of epidemiologic data in environmental health policy has been limited particularly in the environmental regulatory arena. Epidemiologic risk assessment (ERA) is different from risk assessment and the interplay between the two has led to some misconceptions over the promise and practice of epidemiologic data. The current risk assessment process was designed in a time when the need for regulation was great and the epidemiologic information was sparse. There was little time for the consideration of conducting specific studies to improve the information base for environmental health policy. Animal bioassays could be conducted under standardized protocols within defined time periods. The limitations and uncertainties of animal studies also became standardized and risk assessors became comfortable with their models of extrapolation. As the cost of regulations have grown, the economic realities of regulating with little or no data to support actual public health benefit have become a political and legal liability. Major among epidemiology's advantages is that the information is of direct relevance. The majority of epidemiology data are observation and whether the number of studies is broad enough, the data can be generalized to major segments of the population. The uncertainties in animal-based risk assessments are likely to be greater than the uncertainties associated with epidemiologic studies. Another advantage is the range of extrapolation is often smaller. Another advantage is that epidemiologic data include the genetic diversity and variability in other endogenous factors inherent in human populations. The homogeneity of animal studies has often been cited as an advantage but is unrepresentative of the heterogeneity of the human race. Epidemiology does have its limitations. A major limitation is the time needed to obtain a database sufficient for policy-making purposes and the resources needed to conduct the research to develop the database. This has often prompted the conduct of poorly designed studies, forced the use of data collected for other purposes or improper use of existing data. Four situations where epidemiology should be pursued are discussed. Once an environmental health decision has been made, epidemiologic studies should be considered for documenting the reduction of exposure and therefore disease in the population. This traditional use of epidemiology has rarely been applied in the environmental health arena. A final consideration on the use of epidemiologic data is the need to provide a sense of perspective to set priorities in the larger context of public health priorities. The role of environmental pollutants in causing disease may in some cases be minor in comparison to other risk factors and needs to be considered in setting environmental regulations.

Epidemiologic Methods↗

PubMed2003

Long-term surveillance of bladder tumours: current practice in the United Kingdom and Ireland.

INTRODUCTION: Surveillance of transitional cell carcinoma of the bladder forms a major part of the workload of many urology units. Unfortunately, the policy for long-term surveillance of these cancers is neither clear nor agreed upon in the absence of evidence base. Our study was performed to provide current national practice data, and begin the debate on consensus guidelines. MATERIALS AND METHODS: A questionnaire was sent to Consultant Urologists (CUs) in the UK and Ireland (n=501) asking about their policy on the long-term surveillance of different bladder tumours once patients are free of recurrence. RESULTS: A 73% response rate was observed (365/501). Views varied considerably. They ranged from life long cystoscopic surveillance for low-stage low-grade tumours (pTaG1) to discharge after 5 years (or less) of a recurrence-free period for pT1G3 tumour. Once long-term surveillance with cystoscopy had been discontinued, 55% of CUs felt no role was indicated for urine cytology in further follow up, whereas 17% would use it for all tumour types and 28% are selective. CONCLUSION: Our study has shown the complete lack of consensus regarding the long-term surveillance of bladder cancer in the UK and Ireland. This has major implications for policy making, resources allocation and cancer survival. We highlight the need for national guidelines in this area for optimal surveillance of bladder cancer, as a good prospective evidence-based data will not be available for many years. We believe our study might form the basis for discussion on such guidelines.

Carcinoma, Transitional Cell↗

PubMed2003

How far is that by air? The derivation of an air: ground coefficient.

The objective of this study was to derive a simple equation to convert distances between air miles traveled by a helicopter and ground miles traveled by an ambulance. We performed a retrospective analysis of a convenience sampling of 245 "lights and sirens" ground ambulance transports between 1993 and 1997. Ground distances were recorded from odometer miles for each transport. Air miles were calculated using the Global Positioning System (GPS), measuring the distance in a straight line from the scene to the hospital. Air and ground distances were entered into a computerized spreadsheet, and the correlation coefficient and regression equation were derived. A simple approximation equation was developed and compared against the derived regression equation. There was a strong linear correlation between ground miles and air miles at virtually all distances studied (R = 0.932, R(2) = 0.869). Regression analysis revealed the following relationship: Ground miles = 0.94 + 1.25 (air miles). This was simplified to an approximation of: Ground miles = 1.3 (air miles). The approximation equation yielded an answer within 1 mile of the regression equation for distances up to 40 air miles. It is concluded that in a mixed rural and urban EMS system, one may convert air and ground mileage estimates by using the simple relationship: Ground miles = 1.3 (air miles). This conversion coefficient may prove useful for EMS personnel in designing reasonable helicopter utilization policies, making accurate transport decisions and conducting research.

Air Ambulances↗

PubMed2000

Methods for systematic reviews of economic evaluations for the Guide to Community Preventive Services. Task Force on Community Preventive Services.

OBJECTIVES: This paper describes the methods used in the Guide to Community Preventive Services: Systematic Reviews and Evidence-Based Recommendations (the Guide) for conducting systematic reviews of economic evaluations across community health-promotion and disease-prevention interventions. The lack of standardized methods to improve the comparability of results from economic evaluations has hampered the use of data on costs and financial benefits in evidence-based reviews of effectiveness. The methods and instruments developed for the Guide provide an explicit and systematic approach for abstracting economic evaluation data and increase the usefulness of economic information for policy making in health care and public health. METHODS: The following steps were taken for systematic reviews of economic evaluations: (1) systematic searches were conducted; (2) studies using economic analytic methods, such as cost analysis or cost-effectiveness, cost-benefit or cost-utility analysis, were selected according to explicit inclusion criteria; (3) economic data were abstracted and adjusted using a standardized abstraction form; and (4) adjusted summary measures were listed in summary tables. RESULTS: These methods were used in a review of 10 interventions designed to improve vaccination coverage in children, adolescents and adults. Ten average costs and 14 cost-effectiveness ratios were abstracted or calculated from data reported in 24 studies and expressed in 1997 USD. The types of costs included in the analysis and intervention definitions varied extensively. Gaps in data were found for many interventions.

Abstracting and Indexing↗

PubMed2001

Environment, genome and cancer.

Cancer is one of the most serious diseases that threaten human being today. To some degree, it is a genetic disease but environmental and other nongenetic factors clearly play a role in many stages of neoplastic process. Genetic factors by themselves are thought to explain only about 5% of all cancer. The remainder can be attributed to external, 'environment' factors that act in conjunction with both genetic and acquired susceptibility. Of note, part of the susceptibility is owing to the variety of human genome. So, environment, human genome and cancer have much to do with each other. Combining all of the information from epidemiology and from research works in laboratory with policy-making and clinical works, purifying the environment, giving special protection to the high risk population, the mortality of cancer may decrease gradually in the future.

Carcinogens, Environmental↗

PubMed2003

Levels of absolute survival benefit for systemic therapies of advanced cancer. a call for standards.

Research on systemic interventions in patients with advanced stage malignancies should be systematised with an emphasis on the absolute gain in survival for the median patient. Such information is most meaningful with relatively large-scale evidence. Here, we summarise the survival impact of 36 interventions compared against other interventions or no treatment for advanced stage malignancies in meta-analyses of individual patient data or in selected recent (2000-2002) randomised trials with >300 randomised subjects. Although 16 interventions showed a formally statistically significant survival benefit against the comparator arm, this exceeded 3 months in only 7 cases. We propose a standardised categorisation of the median survival prolongation in trials and meta-analyses. Level 0: no proven survival benefit; level I: 0-3 months; level II: >3-6 months; level III: >6-24 months; and level IV: more than 24 months. These standardised levels may be incorporated into clinical practice guidelines for individual care and policy-making.

Humans↗

PubMed2003

Traditional birth attendants in developing countries cannot be expected to carry out HIV/AIDS prevention and treatment activities.

Pregnancy and birth, fertility and fertility regulation are all greatly affected by the exigencies of HIV and AIDS, and vice versa. Women and infants can only benefit if the respective policymakers, researchers and service providers in sexual and reproductive health and HIV/AIDS, particularly those involved in prevention of mother-to-child transmission of HIV, gain greater knowledge of each others' expertise and seek to integrate the best of both into the care they each offer. The growth in access to antiretroviral treatment for mothers as well as infants, including during pregnancy and the breastfeeding period, makes such efforts even more timely and crucial. Yet there are worrying signs that specialists in both camps are making inappropriate policy and service delivery recommendations based on too little knowledge of each others' patches. As an example of this problem, this article discusses and rejects a recommendation in a recent BMJ article that traditional birth attendants could be trained to carry out HIV prevention and possibly provide HIV tests and drugs for prevention of HIV transmission during home deliveries in developing countries.

Communicable Disease Control↗

PubMed2006

Analysis of an epigenetic argument against human reproductive cloning.

Human reproductive cloning is a much disputed ethical issue. This technology is often condemned as being contrary to human dignity. However, there are also risk arguments. An ethical argument that is often put forward by scientists but seldom developed in more detail focuses on health risks in animal cloning. There is a high risk that animal clones exhibit abnormalities and these are increasingly believed to be due to errors in epigenetic reprogramming. The argument is that human reproductive cloning should not be carried out because human clones are also likely to exhibit abnormalities due to inappropriate epigenetic reprogramming. Different versions of this epigenetic argument are analysed, a categorical version and a non-categorical. The non-categorical version is suggested to be more well-considered. With regard to policy making on human reproductive cloning, the categorical version can be used to prescribe a permanent ban, while the non-categorical version can be used to prescribe a temporary ban. The implications of the precautionary principle--as interpreted in the European Union--are investigated. The conclusion is that it seems possible to support a temporary ban by reference to this principle.

Animals↗

PubMedDate not supplied

Strategies to motivate students in online learning environments.

We are happy to present the following article as a resource for readers developing or refining online courses. Much work remains to be done to identify and evaluate the relative merits of potential theoretical models for online nutrition instruction. Progress will depend on finding ways to conduct objective appraisals of theory-driven courses in university settings, where randomization is often impossible and courses are often refined in real time to meet students' immediate needs or to take advantage of rapidly evolving technology. Meanwhile, we hope that the concepts and observations described in this Special Article stimulate consideration of the motivational aspects of online courses in practice, research, and institutional policy making.

Adult↗

PubMedDate not supplied

Maintaining food sufficiency: Coping strategies identified by limited-resource individuals versus nutrition educators.

OBJECTIVE: This study's purposes were to identify food acquisition and management coping strategies used by limited-resource individuals to maintain food sufficiency, compare strategies named by the target audience to those previously identified by nutrition educators, and examine these strategies to advance grounded theory. DESIGN: Eleven focus groups, conducted with 62 limited-resource individuals, elucidated coping strategies that they or others they knew used to acquire or manage food to maintain food sufficiency. The results were compared with practices as previously identified by nutrition educators who regularly worked with this audience. SUBJECTS/SETTINGS: Subjects aged 19 to 67 from throughout New Jersey were recruited by Food Stamp agencies, low-income outreach programs, soup kitchens, welfare offices, Head Start centers, shelters, and food pantries. RESULTS: Of the 95 coping strategies identified, 83% were known from nutrition educators previously. Ten new practices (eg, selling blood) had not previously been identified by educators. Four of 10 practices were not found in the literature (eg, repeated participation in research studies). Six practices previously reported by nutrition educators were not mentioned by the study population. IMPLICATIONS: Educators who work with limited-resource individuals are a good resource for research with this audience. Study findings may be important considerations for nutrition program planning and policy making.

Adaptation, Psychological↗

PubMed2003

Analysis of emergency department utilization by elderly patients under National Health Insurance.

Elderly persons are thought to use emergency departments (EDs) disproportionately. This phenomenon has implications for policy-making as the population of the elderly continues to increase. This study aimed to characterize national ED utilization by elderly patients (> or = 65 years old), compared with that by younger patients (15-64 years old). The sample was selected from the National Health Insurance Research Database for the year 2000. There were 519,003 visits to adult EDs in the 12 medical centers sampled. The study used a secondary data analysis and included 14 variables. The elderly accounted for 28.5% of all adult ED visits. Compared with younger patients, a greater proportion of elderly patients were male (61.6% vs. 47.7%, p < 0.001), had chronic diseases (11.9% vs. 8.0%, p < 0.001), were major cases (6.7% vs. 4.1%, p < 0.001), made no co-payment (38.5% vs. 5.8%, p < 0.001), were frequent users of outpatient services (28.4% vs. 9.9%, p < 0.001), were higher-level emergencies (60.0% vs. 43.7%, p < 0.001), had longer stays in the ED (14.0% vs. 4.7%, p < 0.001), and had higher costs per visit (NT dollars 4,814 +/- 6,046 vs. 2,779 +/- 5,533, p < 0.001). In addition, elderly patients used 40.8% of total adult ED costs. Older patients have distinct patterns of ED use, and use emergency services at a higher rate than younger patients. ED staff should be knowledgeable about the unique and complex presentations of older ED patients.

Adult↗

PubMed2002

Status and potential of gene therapy in clinical medicine. Assessment of an emerging health technology through systematic survey of clinical gene therapy protocols and published results.

OBJECTIVE: Somatic gene therapy is a new method in the rapidly expanding field of molecular medicine. Due to recent encouraging results and the promising prospect for some disease groups, Norwegian health authorities wanted to assess somatic therapy with evidence-based standards for strategic use. This article presents the results of this assessment, discussed in the context of the policy-making process in Norway, including ethical and legislational considerations. METHODS: Clinical gene therapy protocols, ongoing or completed with published results, where available, were identified through a systematic survey of descriptive protocols and publications. Preclinical literature was also reviewed. RESULTS: Gene therapy is dominated by preclinical and clinical research. Most of the gene therapy protocols identified are in early phases (phases I and II) with only a few patients in each study. Of the protocols included in the assessment, only three phase III studies are represented. Except for the use of soluble antisense oligonucleotides against cytomegalovirus eye infection, gene therapy is presently not an established treatment modality. Promising results have been observed in treatment of cancer and cardiovascular diseases and, most recently, in inherited severe combined immunodeficiency and hemophilia. Several interesting principles addressing a large panel of conditions are currently being developed and tested. CONCLUSIONS: Gene therapy is developing into an important medical concept that needs to be included within the Norwegian healthcare system. It is recommended that the Norwegian Ministry of Health and Social Affairs fund a national program to boost infrastructure in selected scientific groups both in preclinical and clinical research. The national procedures regulating approval of gene therapy trials should be made more efficient while at the same time allowing for proper control and ethical considerations. It is emphasized that gene therapy trials should be carefully monitored for side effects.

Clinical Protocols↗

PubMed2005

International Master's Program in health technology assessment and management: assessment of the first edition (2001--2003).

BACKGROUND: Despite a clear call for greater input from health technology assessment (HTA) in the areas of clinical practice and policy making, there are currently very few formal training programs. The objectives of our Consortium were to (i) develop a master's level program in HTA, (ii) test its content with a group of Canadian and European students, and (iii) evaluate the Program's strengths and weaknesses. OBJECTIVES: This study presents the results of our evaluation of the first edition of the Master's Program (2001--2003). METHODS: The evaluation relied on (i) a self-administered student questionnaire for each course (n = 142), (ii) interviews with students (n = 10), and (iii) interviews with internship supervisors (n = 5). RESULTS: A vast majority of students were satisfied with the course content and particularly appreciated the exercises and materials presented in an intensive format. However, they needed more systematic feedback from faculty members and recommended increasing the methodology content. The six key characteristics of the program are (i) flexible format adapted to the needs of skilled professionals, (ii) continuous interaction between HTA users and producers, (iii) international academic and professional collaboration, (iv) partnership with HTA agencies, (v) global approach to evidence-based methods and practices, and (vi) multidisciplinary approach. CONCLUSIONS: Despite the numerous organizational barriers inherent to creating an international program and several areas for improvement in the Program itself, the Ulysses Project was successful in attaining its objectives. Because there is a growing need for human resources with special training in HTA, further efforts need to be devoted to strengthening the international research capacity in HTA.

Canada↗