[Sea and estuary bacteria--producers of vitamin B 12].
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An actinomycete stain 1569 isolated from a Siberian soil sample is described as a representative of a new species, designated as Actinoplanes cyaneus sp. nov. The actinomycete cell wall contains meso-diaminopimelic acid, arabinose, xylose and a non-identified analogue of diaminopimelic acid. The actinomycete forms spherical sporangia with mobile spores. The aerial mycelium is absent. The isolate produces a soluble blue pigment on synthetic media. The pygment investigation showed that it belonged to the group of celicomycin-actinorodine.
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Kinetic and clinical evaluation of cefotiam, a new cephalosporin, is reported. It was found that the drug is rapidly distributed to the tissues. Equilibrium between tissues and plasma is reached in about an hour. Some 90-91% of the dose administered is excreted in the urine, and accumulation does not occur. A clinical cure was obtained in 27 of a series of 35 patients (77.1%). Improvement was observed in 7 cases (20%). The antibiotic proved ineffective in the remaining cases (2.8%). Tolerance was excellent and there were no side-effects worthy of note.