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PubMedDate not supplied

Diagnostic work-up for faecal incontinence in daily clinical practice in the Netherlands.

BACKGROUND: To study variation in Dutch hospitals in applying diagnostic and treatment options for faecal incontinence. METHODS: Surgeons, gastroenterologists, internists and gynaecologists were contacted by phone or mail and requested to complete a questionnaire. The questionnaire asked for general information about patients with faecal incontinence, the use and availability of diagnostic techniques, the use of incontinence scores and therapeutic options. RESULTS: In total 306 specialists were contacted and data were collected from 203 specialists from 86 hospitals (response rate 66%). The most frequently applied diagnostics were sigmoidoscopy (64%), endoanal sonography (58%), evacuation proctography (56%) and/or anorectal manometry (51%). The choice seemed to be related to the availability of the techniques. Sigmoidoscopies were performed significantly more often in local hospitals (p < 0.001), while in medical academic centres significantly more endoanal MRI examinations were conducted (p < 0.05). The most stated treatment option was physiotherapy (90%), followed by dietary measures (83%), medicating (71%) and surgery (68%). However, in general, combinations of treatment options were used. CONCLUSIONS: A substantial variety exists in the diagnostic work-up of faecal incontinence. In general, at least one anorectal functional test and an imaging technique are the diagnostic techniques of choice. Pelvic floor physiotherapy is the first choice in conservative treatment.

Endosonography↗

PubMed2006

Increased use of colorectal cancer tests--United States, 2002 and 2004.

Colorectal cancer is the second leading cause of cancer-related death (after lung/bronchus cancer) in the United States. In 2002, a total of 139,534 adults in the United States had colorectal cancer diagnosed, and 56,603 died. The U.S. Preventive Services Task Force and other national organizations recommend that adults aged >/=50 years be screened for colorectal cancer with one or more of the following tests: fecal occult blood testing (FOBT) every year, sigmoidoscopy or double-contrast barium enema every 5 years, or colonoscopy every 10 years. To estimate current rates of use of colorectal cancer screening tests and to evaluate changes in test use, CDC compared data from the 2002 and 2004 Behavioral Risk Factor Surveillance System (BRFSS) surveys. This report describes the results of that comparison, which indicated that the proportion of BRFSS respondents reporting use of FOBT and/or sigmoidoscopy or colonoscopy had increased overall from 2002 to 2004. Measures to increase awareness and encourage regular colorectal cancer screening must be continued to reduce mortality from colorectal cancer.

Behavioral Risk Factor Surveillance System↗

PubMed1992

Screening for colorectal neoplasia: a multicenter study in Israel.

We report the design and results of the first Israeli multicenter screening program for colorectal neoplasia. The screening protocol comprised a risk questionnaire, fecal occult blood testing, flexible sigmoidoscopy and colonoscopy. A total of 5,601 individuals were screened in five medical centers, 55% being asymptomatic with low or average risk. Colorectal tumors were found in 12.3% of screenees, the majority being adenomas. The risk for large bowel neoplasia was greatest in persons with a personal history of colorectal neoplasia (neoplasia rate 473.2/10(3)) and was increased in those with inflammatory bowel disease, a family history of colorectal tumor, or past history of cured breast cancer. European-born Jews had a 50% greater risk than non-European-born Jews. Persons at high risk were more likely to return for repeat screening than those at low or average risk. However, approximately 15% of persons at high risk actually thought that they were of average risk. Fecal occult blood testing was markedly less reliable than flexible sigmoidoscopy and had a false-negative rate of 84.4%. The results demonstrate that existing medical facilities in Israel can be used to screen at least those individuals with increased risk for colorectal neoplasia.

Adenoma↗

PubMed1991

[Gastroenterologic findings in graft versus host disease after allogenic bone marrow transplantation].

We are reporting on a 25 years old patient with acute myelogenous leukemia, who developed an acute graft-versus-host disease (GVHD) 43 days after allogeneic bone marrow transplantation (BMT). The clinical symptoms included exanthema, diarrhea and abdominal cramps. The patient was treated with cyclosporine A and prednisone and the clinical symptoms disappeared subsequently. At day 225 post BMT the patient became icteric as the clinical manifestation of chronic GVHD. We describe in this case report endoscopical and histological findings during the episodes of acute and chronic graft-versus-host disease. The results obtained by sigmoidoscopy and liver biopsy confirmed the clinical diagnosis. The clinical work up of patients with acute or/and chronic GVHD should also include sigmoidoscopy in order to verify this transplantation related complication.

Adult↗

PubMed1991

Massive rectal bleeding from a Dieulafoy's type ulcer of the rectum: a review of this unusual disease.

Dieulafoy's ulcer is an uncommon lesion that usually presents with massive bleeding. Although it has been observed, for the most part, in the stomach, it has also been identified in the small bowel and colon. Both endoscopy and angiography have been used for diagnosis; however, endoscopy has had a high failure rate for localizing colonic disease during active bleeding. Treatment has been primarily surgical, but endoscopic coagulation and sclerotherapy have been recently employed. A 20-year-old male presented with massive lower gastrointestinal bleeding, which was found to be caused by a Dieulafoy's ulcer in the rectum. Observation of Dieulafoy's ulcer in the rectum has not been reported previously. Diagnosis was by rigid sigmoidoscopy. This lesion was treated by widely oversewing the vessel after endoscopic therapy failed. The etiology of this lesion is most likely congenital. Hemorrhage probably occurs as a result of mechanical damage of the mucosa, combined with erosion of the vessel by fecal flow. Unlike colonic Dieulafoy's ulcers, it should be possible to diagnose rectal lesions by rigid sigmoidoscopy. This diagnosis may be difficult with high rectal ulcers, and angiography may have to be employed. Endoscopic therapy failed here, as in other reports on colonic disease. Thus, we would recommend widely oversewing rectal lesions as the primary treatment. Resection should be reserved for cases that have failed this therapy.

Adult↗

PubMed1990

Feasibility of sigmoidoscopic screening for colorectal cancer in the Hunter Region.

The success of a cancer detection programme depends on the co-operation of the target population. The aim of this study was to identify factors which might influence those at average and at higher risk of developing colorectal cancer to undergo a sigmoidoscopic screening test if offered. This was addressed by means of a household survey of individuals aged 40 years and over. Overall consent to undergo screening approximated 45%. There was a significant relationship between agreement to sigmoidoscopy and each of the following: age, marital status, educational level attained, and a previous episode of rectal bleeding. Individuals who had undergone sigmoidoscopy in the past were less willing to have the test performed again. Although individuals with a family history of bowel cancer in first-degree relatives perceived themselves as being more likely to develop colorectal cancer, this had no apparent impact on their willingness to have the test. The implications of these findings for community education programmes directed at colorectal cancer are discussed.

Adult↗

PubMedDate not supplied

Feasibility of sigmoidoscopic screening for bowel cancer in a primary care setting.

Sigmoidoscopic screening for bowel cancer is controversial because of its debatable efficacy, lack of patient and physician acceptance of the procedure, and uncertainty about its practicality with the large numbers of patients in primary care settings. This study addressed patient acceptance and practicality. During an 18-month period, 75 percent of all patients aged 50 years and greater who were seen for health maintenance accepted sigmoidoscopy. The procedure was integrated into office routines without disrupting other patient care. While compliance with fecal occult blood testing was high (88 percent), sensitivity of this test for neoplastic polyps within reach of the proctosigmoidoscope was low (11 percent). These results suggest that acceptance of sigmoidoscopy by patients seen in family physicians' offices could be greater than has been anticipated.

Aged↗

PubMed1987

Dietary restrictions and fecal occult blood testing.

"Unprepped" sigmoidoscopy and fecal occult blood testing were performed simultaneously in 1,000 patients with no dietary restrictions. A total of 102 patients had a positive fecal occult blood test. Of these, 86 had visible blood in the rectum as demonstrated by sigmoidoscopy. Only two of the remaining 16 patients probably had a dietary-induced false-positive result on the occult blood test. Dietary restrictions for guaiac occult blood testing are unnecessary in more than 99 percent of patients.

Adolescent↗

PubMed1986

Establishing a flexible sigmoidoscopy/colonoscopy program for surgical residents. The University of Illinois experience.

The clinical value of lower gastrointestinal endoscopy and the requirement of the American Board of Surgery for endoscopic training mandate establishing a program in flexible sigmoidoscopy and colonoscopy for all surgical residents. In a 12-month period, the surgical residents at the authors' institution performed 599 flexible sigmoidoscopic and 116 total colonoscopic examinations under the supervision of two attending colorectal surgeons, with no mortality and a 0.03 per cent morbidity. There was an average of 42 endoscopic examinations per resident for the 3-week training period. Three hundred seventy (62%) of the flexible sigmoidoscopic examinations were for screening and 229 (38%) were for the evaluation of symptomatic patients. Colorectal polyps were identified in 68 patients (11.4%) and carcinoma in 14 patients (1.9%). Forty-nine per cent of the colonoscopic examinations were for endoscopic polypectomy. Sixty-four per cent of patients with more than one adenomatous polyp harbored polyps in different surgical segments of the colon. Every resident was able to perform flexible sigmoidoscopy safely by the end of the 3-week training period, and in addition, the residents rated their endoscopic experience as a valuable part of their surgical training.

Colonoscopy↗

PubMed1985

[Effect of an enema on the macroscopic and microscopic appearance of the rectal mucosa].

In flexible fiberoptic sigmoidoscopy the application of an enema is mandatory. By contrast, rigid sigmoidoscopy can be performed without preparation. In 16 patients we tested the influence of a hypertonic enema on the macroscopic and microscopic appearance of the rectal mucosa. As a first step in the unprepared patient the mucosa was assessed and a rectal biopsy obtained. After enema this procedure was repeated. Development of mucosal edema was observed, although the histopathologist was not always able to decide whether or not the biopsy was taken before or after the enema. Histological assessment of edema requires histometric measurements which cannot be obtained from biopsy specimens. A knowledge of these changes is particularly important in assessment of inflammatory bowel disease, where edema of the unprepared mucosa means slight proctitis, and we recommend that the histopathologist be informed if enemas are used for bowel preparation.

Adult↗

PubMed1983

[Emergency situations in pathology of the left colon: validity of fibrosigmoidoscopy in differential diagnosis].

The Authors, although not working in an emergency ward, have performed 30 fiberoptic sigmoidoscopies (FFS) in emergencies on patients hospitalized in their Institutes. The indications for the investigation were: acute bowel obstruction (22 cases); severe post-operative diarrhea (5 cases); massive rectal bleeding (8 cases). In all the patients, FFS, performed immediately, allowed diagnosis of both the type and the site of tht lesion. The Authors believe that fiberoptic sigmoidoscopy, in trained hands, in emergencies can be a valid and safe tool for a quick and sure diagnosis. In particular, as far as acute intestinal obstruction is concerned, FFS can prove useful for the defferential diagnosis between mechanical and dynamic ileus; it is also clearly indicated in order to establish, during the pre-operative phase, the neoplastic or not-neoplastic character of the lesions. FFS should, therefore, be performed every time the clinical data and the direct radiography of the abdomen suggest a left colon obstruction.

Acute Disease↗

PubMed1994

Periodic health examination, 1994 update: 2. Screening strategies for colorectal cancer. Canadian Task Force on the Periodic Health Examination.

OBJECTIVE: To make recommendations on the effectiveness of screening for colorectal cancer in asymptomatic patients over 40 years of age. OPTIONS: Multiphase screening that begins with test for fecal occult blood, uniphase screening with sigmoidoscopy and uniphase screening with colonoscopy. Options included screening repeated at different intervals and different procedures for patients with selected risk factors. OUTCOMES: Rates of death, death from cancer and cancer detection; compliance, feasibility and accuracy of each manoeuvre. EVIDENCE: A MEDLINE search for articles published between January 1966 and June 1993 with the use of MeSH terms "screening" and "colorectal neoplasia," a check with the reference sections of review articles published before June 1993 and a survey of content experts. Articles were weighted according to the Canadian Task Force on the Periodic Health Examination levels of evidence. VALUES: The highest value was assigned to manoeuvres that lowered the rate of death from cancer and had a low rate of false-positive results and acceptable cost and compliance. Recommendations were determined by consensus of the authors, members of the task force and colorectal cancer experts. BENEFITS, HARMS AND COSTS: There is evidence that annual fecal occult blood testing with the use of the rehydrated Hemoccult test has a small but significant benefit in lowering the rate of death from cancer after more than 10 years of screening; however, the high rate of false-positive results (9.8%) and the poor sensitivity of annual (49%) and biennial (38%) screening make this a poor method for detecting colorectal cancer. There is fair evidence that screening with sigmoidoscopy may improve survival rates; however, this may be due to volunteer bias. The high cost of and poor compliance with colonoscopic screening make this an unfeasible strategy.

Adult↗

PubMed1994

Screening asymptomatic patients for colorectal lesions.

PURPOSES: To determine: 1) prevalence of significant colorectal lesions by demographics and risk factors; 2) frequency of 1 and 2 or more lesions by type, location, and size; 3) relation among villous component, location, and size of adenomas; and 4) frequency of nonsignificant lesions among patients with and without significant lesions.; METHOD: One thousand asymptomatic patients, 45 years of age and older, with negative fecal occult blood tests, were screened using 60-cm flexible sigmoidoscopy and, if indicated, using colonoscopy. RESULTS: Thirty-six of the patients had 62 significant lesions (11 patients had 2 or more lesions). Fifty-four of the lesions were discovered by sigmoidoscopy in 1,000 patients, and 8 additional lesions were discovered in 5 of the 36 patients by colonoscopy. Lesions with villous components were more likely to be found in patients with 2 or more lesions (P = 0.0006). Smokers were more likely than nonsmokers to have significant lesions (P = 0.002). Among these patients, smoking and drinking were associated (P = 0.007). Males were more likely to have significant lesions than females (P = 0.006). Hemorrhoids, diverticulosis, and hyperplastic polyps were not associated with significant lesions. CONCLUSIONS: The relationship between smoking and significant lesions provides further evidence that asymptomatic patients should stop smoking. Physicians should pay particular attention to men who smoke, even if they have negative occult blood tests.

Adenocarcinoma↗

PubMed1994

The use of new technologies by rural family physicians.

BACKGROUND: Although office procedures that involve special training and office equipment are often performed by a specialist in an urban setting, they are increasingly being performed by family physicians in rural settings. This study documents the prevalence of four such procedures in rural family practice: flexible sigmoidoscopy, cardiac stress testing, colposcopy, and nasopharyngoscopy. Individual and community characteristics of physicians who perform each of the procedures are compared with those of physicians who do not. METHODS: Data were collected on office technology and the characteristics of physicians, their practices, and their communities through telephone interviews with 403 randomly selected, rural family physicians and general practitioners in eight states. Descriptive and univariate analyses were used. RESULTS: Flexible fiberoptic sigmoidoscopy was performed by 57% of the physicians in our sample. The presence of another physician in the group or in the community who performed this procedure increased the probability of a rural physician performing it. Being male, recent licensure, board certification, and patient volume were also positively associated with the performance of this procedure. CONCLUSIONS: This study found evidence of a collegial effect among rural physicians and of a significant number of rural physicians seeking postresidency training in new procedures.

Adult↗

PubMed1996

[Mass screening for colorectal cancer].

Considering the present state of knowledge, only the strategy of screening for intestinal tumours at the asymptomatic stage could reduce such a problem as colorectal cancer. Data from case-control studies provide evidence of the efficacy of screening by rigid proctosigmoidoscopy. But compliance with such a strategy is not known. The effectiveness of screening by sigmoidoscopy has yet to be demonstrated. A European controlled study of flexible sigmoidoscopy in association with the Hemoccult test versus the Hemoccult test alone has been set up. Evaluation by a randomized screening trial with a single flexible sigmoidoscopic examination at age 55 to 60 years has also been suggested. Case-control studies and a randomized study conducted among volunteers demonstrate that it is possible to reduce mortality from colorectal cancer in people who accept screening with faecal occult blood testing, using the Hemocult test. Four population-based studies have been set up in Europe (in England, Denmark, France and Sweden). They are based on a biannual Hemoccult test. Compliance in the test group ranges between 55% and 65% in the first screening campaign and remains high in the following screening campaigns. In France, to achieve this goal, the test must be proposed by GPs and then mailed to those who do not consult GPs. Reliable mortality data will be available within 1 to 3 years. The results of the European trials must be awaited to know if screening biennually is effective in reducing colorectal cancer mortality.

Aged↗

PubMed1997

Prevalence and incidence of colorectal adenomas and cancer in asymptomatic persons.

The prevalence of colorectal adenomatous polyps varies widely from country to country and is highly correlated with colorectal cancer incidence rates in each country. The prevalence of adenomas reported in older studies was based on autopsy findings and is higher than that in more recent studies based on endoscopy findings. Among asymptomatic, average-risk patients, adenoma prevalence averages approximately 10% in sigmoidoscopy studies and more than 25% in colonoscopy studies, whereas the prevalence of colorectal cancer among these patients is less than 1%. The cumulative incidence of new adenomas within 3 years after normal endoscopy averages about 7% by flexible sigmoidoscopy and 27% by colonoscopy.

Adenoma↗

PubMed1998

[Evaluation of various screening and surveillance methods in colorectal carcinoma].

Colorectal cancer is a common disease which is almost wholly preventable by early removal of adenomatous polyps. Screening should be offered to all persons without risk factors from the age of 50. Selection of the appropriate screening programme should take into account personal preference, local expertise and insurance coverage. Endoscopic screening and surveillance investigations should be strongly encouraged in all persons wit risk factors such as (1) previous treatment of colorectal adenomatous polyps or cancers, (2) ulcerative colitis, (3) patients with hereditary colorectal cancer syndromes and (4) first degree relatives of patients with colorectal cancer. The following four strategies are available for candidates > 50 years without risk factors: (1) faecal occult blood testing (annually), (2) flexible sigmoidoscopy (every 5 years), (3) a combination of both (1 + 2) strategies and (4) coloscopy (every 10 years). Coloscopy should be performed after a positive test result in strategy programs 1-3. Results from prospective randomized trials are available only for faecal occult blood testing, showing an approximately 15% reduction of mortality in the screening group. The potential for reduction of colorectal cancer mortality has been estimated at 30-70% and 60-90% for flexible sigmoidoscopy and coloscopy respectively. However, no results from prospective randomized trials are presently available. Cost-effectiveness analysis has not shown relevant differences between the four different screening strategies.

Aged↗

PubMed1977

Feasibility of fecal occult-blood testing for detection of colorectal neoplasia: debits and credits.

A screening program for colorectal cancer and adenomas has been applied to 6,579 mostly asymptomatic men and women age 40 years and older utilizing fecal occult-blood testing followed by investigation of patients with positive slides by air-contrast barium enema and colonoscopy. A control population of 7,325 patients had sigmoidoscopy only and no occult-blood testing. Approximately 1% of the patients had positive slides; most patients had only one or two slides positive. Approximately 50% of patients with positive slides had significant neoplastic lesions, including 23 patients with large adenomas and 7 patients with cancers. Pathological staging of cancers was more favorable in the screened asymptomatic group as compared with the control group. Neoplastic lesions seen on sigmoidoscopy in screened patients who had negative fecal occult-blood tests included 2 cancers and 15 large adenomas. Reasons for false negativity include possible conversion of initially positive slides to negative. Screening for colorectal cancer and adenomas with fecal occult-blood testing appears to be feasible approach with good patient compliance, and manageable rate of positive slides productive of a high percentage of neoplastic lesions. The number of false-positives seems to be low. False negativity has been observed and will require further study.

Adenoma↗