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PubMed1994

Deriving passage difficulties for a tracking study via the Cloze technique.

The current report demonstrates the importance of formally accounting for passage difficulty when using the tracking procedure. Cloze responses to 82 encyclopedia excerpts (343-349 words each) were obtained from a large pool of normal-hearing adults and scored verbatim. Passage difficulty, derived via ANOVA, was then defined as the deviation of a passage's mean Cloze score from the score for all passages, corrected for differences among respondents. The passage difficulties were applied in an alternating conditions tracking experiment with one adult cochlear implant user. Conditions included conventional auditory-visual and auditory-only tracking and experimental mode-switching techniques in which the talker changed modalities during the correction phase. An ANCOVA of the word-per-minute scores was conducted, with passage difficulty as a covariate and passage adjustment values as the output. Tracking rates and percentage of words correct from the beginning and end of training were examined. Use of adjusted data reversed the interpretation of performance change, demonstrating the need for determining passage difficulties a priori.

Audiometry↗

PubMed1996

Overdose among heroin users in Sydney, Australia: I. Prevalence and correlates of non-fatal overdose.

A sample of 329 heroin users were interviewed regarding their personal experience of non-fatal heroin overdose. Experience of overdose was widespread, with two-thirds of subjects (68%) reporting having overdosed. The median number of life-time overdoses was three, with males and females equally likely to have overdosed. The majority (62%) of most recent heroin overdoses occurred in conjunction with the consumption of other central nervous system depressants (alcohol, benzodiazepines and other opioids). Logistic regression analyses indicated three independent factors associated with having overdosed: longer heroin using careers, greater heroin dependence and higher levels of alcohol consumption. Implications for the reduction in the prevalence and frequency of overdose are discussed.

Adolescent↗

PubMed1997

Spirometry.

Spirometry is the most widely used pulmonary function test. It is used for diagnosis and monitoring in a wide variety of obstructive and restrictive disease patterns. Spirometry is the primary measure in determining disability due to pulmonary disease, and is widely applied in the evaluation of bronchodilator response and airway hyperreactivity. A wide variety of spirometry equipment is currently available, from small portable units to large laboratory systems capable of multiple functions. Most spirometers rely heavily on computerization, which makes them easy to use, but require training and experience on the part of the user. Valid spirometry demands equipment that conforms to recommended standards, and performance of the tests to meet criteria for acceptability and reproducibility. Interpretation of spirometry requires attention to these standards and to careful selection of reference values.

Equipment Design↗

PubMed2006

Psychological adjustment to lower limb amputation amongst prosthesis users.

PURPOSE: Clinical reports indicate that many lower limb amputees experience problems with psychological adjustment. Although depressive responses to amputation have been well investigated, there has been insufficient attention to other aspects of adjustment. This study aimed to determine the prevalence of psychological morbidity in an amputee population and identify variables associated with increased distress. Particular attention was given to cognitive models of emotion which postulate a key role for self-consciousness and appearance-related beliefs. METHOD: A cross-sectional survey of 67 adult lower limb prosthesis users who had experienced amputation within the last five years. Outcome measures were the Psychosocial Adjustment Scale of the Trinity Amputation and Prosthesis Experience Scales, the Hospital Anxiety and Depression Scale, the Self Consciousness Scale and the Appearance Schemas Inventory. RESULTS: Using conservative cut-off scores the prevalence of anxiety and depression was 29.9 and 13.4%, respectively. Appearance-related beliefs were associated with both distress and psychosocial adjustment difficulties. Public but not private self-consciousness was associated with distress and psychosocial adjustment difficulties. CONCLUSIONS: Clinicians need to monitor amputees for distress over a longer time period than the initial post-operative phase. It is particularly important to assess for anxiety. Interventions that target appearance-related beliefs may be of benefit to this population.

Adaptation, Psychological↗

PubMed2001

The impact of side effects on family planning use among female clients of the public health services in Jamaica.

A one-year longitudinal study was undertaken in Kingston, Jamaica, to examine (i) the experience of side effects among female contraceptive users, (ii) the role of side effects in method continuation, and (iii) counselling regarding side effects. The study consisted of 463 women who utilized public health centres in Kingston and were either new users of contraceptives or who were switching contraceptive methods. They were recruited over a two-month period in 1998 and followed up for one year. All follow-up, interviews were done at the women's homes and complete interviews were obtained for 323 women. Information was collected about socio-economic characteristics, contraceptive history, service factors, experience with method and length of use. Forty-eight per cent of the women experienced side effects with the method accepted on recruitment to the study. Common side effects were irregular bleeding no period, headaches, nausea/dizziness and weight gain/loss. These side effects occurred mainly among pill and injection users. The occurrence of side effects had a negative impact on continuation rates. Forty-seven per cent of the women stated that they had received counselling regarding side effects. The level and impact of side effects among family planning acceptors at public health centres in Jamaica is of significance to the family planning programme. Method options need to be widened and counselling needs to be improved to ensure that women fully understand the issue of side effects and make informed choices about contraception.

Ambulatory Care Facilities↗

PubMed2006

The varieties of ecstatic experience: an exploration of the subjective experiences of ecstasy.

Previous investigations of the subjective effects of MDMA (material sold as ecstasy) have conducted interviews and surveys of various groups of ecstasy users within particular sub-populations. This study examined subjective drug effects reported by different sub-populations of ecstasy users and explored whether the function or purpose served by using ecstasy influenced the nature of the drug experience. Drawing on previous measures of alterations in consciousness, psychedelic drugs and cannabis, and informal interviews with ecstasy users and MDMA researchers, a 130-item survey assessing subjective effects of ecstasy/MDMA was developed. Principal components analysis of responses of ecstasy users revealed six components; perceptual alterations, entactogenic effects, prosocial effects, aesthetic effects, negative effects and sexual effects. The derived scale was used to predict ecstasy use behaviours, and functions and experiences of use. A variety of component scores were related to ecstasy use parameters; in particular, heavier users expected fewer negative, perceptual and aesthetic effects from taking the drug. The reasons given for using ecstasy (use function) also influenced reported drug effects. Abstainers expected greater negative, perceptual, aesthetic and sexual effects than users. These data indicate that the subjective ecstasy experience is influenced by a variety of extra-psychopharmacological factors. Drug intervention strategies may be made more effective by targeting particular user groups defined by reasons given for substance use, as it is likely that their experiences of ecstasy effects will differ. Future research into ecstasy may be improved by recognizing user diversity.

Adolescent↗

PubMed2006

Arabidopsis Co-expression Tool (ACT): web server tools for microarray-based gene expression analysis.

The Arabidopsis Co-expression Tool, ACT, ranks the genes across a large microarray dataset according to how closely their expression follows the expression of a query gene. A database stores pre-calculated co-expression results for approximately 21,800 genes based on data from over 300 arrays. These results can be corroborated by calculation of co-expression results for user-defined sub-sets of arrays or experiments from the NASC/GARNet array dataset. Clique Finder (CF) identifies groups of genes which are consistently co-expressed with each other across a user-defined co-expression list. The parameters can be altered easily to adjust cluster size and the output examined for optimal inclusion of genes with known biological roles. Alternatively, a Scatter Plot tool displays the correlation coefficients for all genes against two user-selected queries on a scatter plot which can be useful for visual identification of clusters of genes with similar r-values. User-input groups of genes can be highlighted on the scatter plots. Inclusion of genes with known biology in sets of genes identified using CF and Scatter Plot tools allows inferences to be made about the roles of the other genes in the set and both tools can therefore be used to generate short lists of genes for further characterization. ACT is freely available at www.Arabidopsis.leeds.ac.uk/ACT.

Algorithms↗

PubMed2003

Hierarchical analysis of large-scale two-dimensional gel electrophoresis experiments.

Large-scale two-dimensional gel experiments have the potential to identify proteins that play an important role in elucidating cell mechanisms and in various stages of drug discovery. Such experiments, typically including hundreds or even thousands of related gels, are notoriously difficult to perform, and analysis of the gel images has until recently been virtually impossible. In this paper we describe a scalable computational model that permits the organization and analysis of a large gel collection. The model is implemented in Compugen's Z4000 system. Gels are organized in a hierarchical, multidimensional data structure that allow the user to view a large-scale experiment as a tree of numerous simpler experiments, and carry out the analysis one step at a time. Analyzed sets of gels form processing units that can be combined into higher level units in an iterative framework. The different conditions at the core of the experiment design, termed the dimensions of the experiment, are transformed from a multidimensional structure to a single hierarchy. The higher level comparison is performed with the aid of a synthetic "adaptor" gel image, called a Raw Master Gel (RMG). The RMG allows the inclusion of data from an entire set of gels to be presented as a gel image, thereby enabling the iterative process. Our model includes a flexible experimental design approach that allows the researcher to choose the condition to be analyzed a posteriori. It also enables data reuse, the performing of several different analysis designs on the same experimental data. The stability and reproducibility of a protein can be analyzed by tracking it up or down the hierarchical dimensions of the experiment.

Computational Biology↗

PubMed1996

Effect of hearing aid experience on preferred insertion gain selection.

The effect of hearing aid experience (measured as years of hearing aid use and user insertion gain at octave frequencies from 250 Hz to 4000 Hz) on the selection of preferred insertion gain under six listening conditions and one vocalization condition was examined. Thirteen experienced hearing aid users selected their preferred insertion gain in each test condition using a modified simplex procedure. The results showed that for the listening conditions, preferred insertion gain was highly correlated with the subjects' hearing loss from 500 Hz to 2000 Hz. Hearing aid experience did not correlate at all with preferred insertion gain. On the other hand, user insertion gain at 250 Hz and 500 Hz correlated highly with preferred insertion gain selected during vocalization. Years of hearing aid use did not correlate with preferred insertion gain selection. These results suggest that user insertion gain can affect preferred insertion gain selection only when the test conditions are identical to those that the hearing aid wearers experience in everyday lives. In typical laboratory conditions, preferred insertion gain is likely determined by the stimulus characteristics and subjective preference.

Adult↗

PubMed1975

A new user-oriented electrocardiographic program.

A new program for electrocardiographic processing will become available in 1975, "tuned", as part of a system, to take advantage of newer computer and data acquisition hardware at the same time as past experience on other programs has been carefully retained. User flexibility is a key feature along with safe methodology. The program is undergoing modification as part of a data pool user plan.

Diagnosis, Computer-Assisted↗

PubMed2005

What is important in evaluating health care quality? An international comparison of user views.

BACKGROUND: Quality of care from the perspective of users is increasingly used in evaluating health care performance. Going beyond satisfaction studies, quality of care from the users' perspective is conceptualised in two dimensions: the importance users attach to aspects of care and their actual experience with these aspects. It is well established that health care systems differ in performance. The question in this article is whether there are also differences in what people in different health care systems view as important aspects of health care quality. The aim is to describe and explain international differences in the importance that health care users attach to different aspects of health care. METHODS: Data were used from different studies that all used a version of the QUOTE-questionnaire that measures user views of health care quality in two dimensions: the importance that users attach to aspects of care and their actual experience. Data from 12 European countries and 5133 individuals were used. They were analysed using multi-level analysis. RESULTS: Although most of the variations in importance people attach to aspects of health care is located at the individual level, there are also differences between countries. The ranking of aspects shows similarities. 'My GP should always take me seriously' was in nearly all countries ranked first, while an item about waiting time in the GP's office was always ranked lowest. CONCLUSION: Differences between countries in how health care users value different aspects of care are difficult to explain. Further theorising should take into account that importance and performance ratings are positively related, that people compare their experiences with those of others, and that general and instrumental values might be related through the institutions of the health care system.

Adult↗

PubMed2005

Areca quid chewing and methamphetamine use in Taiwanese adolescents.

The association between areca quid chewing and methamphetamine (MAMP) use in Taiwanese adolescents was examined in 200 MAMP users and 400 non-users. Subjects were interviewed individually regarding the experience of chewing areca quid and the evidence of lifetime areca quid use disorder. The ages at which they initially chewed areca quid and used MAMP were also evaluated. The results revealed that areca quid chewing and areca quid use disorders were more common in both male and female MAMP users than in non-users. Among those who chewed areca quid and used MAMP, the mean age at initial MAMP use was older than the mean age at initial chewing of areca quid in males but not in females. MAMP users who chewed areca quid were subdivided into three groups according to the sequence of initial MAMP use and chewing areca quid. Although most males and females started chewing areca quid before using MAMP, this pattern was more prevalent in males. Adolescent MAMP users need to be educated about deleterious health sequelae caused by chewing areca quid. Adolescent areca quid chewers need to be monitored for possible progression to MAMP use.

Adolescent↗

PubMed2002

MArray: analysing single, replicated or reversed microarray experiments.

UNLABELLED: MArray is a Matlab toolbox with a graphical user interface that allows the user to analyse single or paired microarray datasets by direct input of the raw data output file from image analysis packages, such as QuantArray or GenePiX. The application provides simple procedures to manually evaluate the quality of each measurement, multiple approaches to both ratio normalization (simple normalization, intensity dependent normalization) and evaluation of the reproducibility of paired experiments (using the techniques 'simple statistical method' and 'quality control ellipse' and 'significance analysis of microarrays'). Specifically, interactive spot evaluation functions are available in MArray and an online gene information database (NCBI UniGene) is linked. The application may provide a valuable aid in selecting and optimizing experimental procedures, as well as serving as an analytical tool for two-state biological comparisons, such as a study of single-dose activation. It is entirely platform independent, and only requires Matlab installed. AVAILABILITY: http://matrise.uio.no/marray/marray.html

Computer Graphics↗

PubMed2000

[The family and the mentally ill using day-hospitals: a case study].

The day-hospital, as a modality of psychiatric care, provides families with the possibility to experience greater contact with their mentally-ill relative during treatment and leads them to searching, together with such relative, for ways to facilitate the adaptation process of interaction in the family. This study aims at understanding how families and the users of day-hospitals interact out of their homes and at describing the experience narrated by a family. The family in this study was selected from one of the users of a day-hospital who had a previous history of hospital admissions for psychiatric treatment. Five members of the family under study were interviewed. Based on the experiences described by the subjects, two great thematic categories emerged: the family experiencing the day-hospital with its family member and the family-user relationships. The experiences narrated by the subjects in this study are rather significant for the construction of new possibilities in caring for the mentally-ill person's family.

Day Care, Medical↗

PubMed2001

Capitalizing on knowledge for an adaptive user interface.

Hypermedia data browsing is a mean for improving information access. However, the overload and the heterogeneity of medical information, as well as the multitude of possible navigational paths, turn the consultation of data into a difficult task. We present in this paper a solution for the development of adaptive user interfaces in a hypermedia data browsing environment. It is based on the capitalization of the users knowledge in the decision-making process, expressed in terms of navigational paths and of data presentation modes that are customized to the user's preferences. This capitalization offers the user a way to reuse the cumulative experiences in browsing through patient records. We illustrate our approach with the implementation of HEMA, a clinical workstation prototype.

Humans↗

PubMed2003

Telerehabilitation, cognition and user-accessibility.

Survivors of traumatic brain injury (TBI) often experience cognitive and physical impairments. The aims of this study were to: 1) build an internet-based, "Virtual Rehabilitation Center" (VRC) that provides rehabilitation, education and support services to individuals with TBI; and 2) to determine the relationships between the nature and severity of the participants' cognitive impairments and their ability to use the VRC. Eight individuals with brain injuries (Age: M=43, SD=15.4; Years of Education: M=13.8, SD=3.15) participated. The Neurobehavioral Cognitive Status Exam (NBCSE) was used to assess intellectual functioning. The VRC modules consisted of reaction time, functional modules, and communication capabilities. All participants learned how to use the VRC. However, those requiring more "trials to acquisition" showed greater cognitive impairment than those requiring fewer trials in: Construction (p=0.02), Reasoning-Similarities (p=0.01) and in calculation and language repetition.(i.e., a non-significant trend). Importantly, all participants learned how to use the system although learning rates varied. Moreover, one case-study demonstrated that learning on the VRC generalized to the community. Overall, impairments on the NBCSE in visual-constructional integration and executive-type functions, as well as language processing appeared to be related to how effectively participants learned how to use the VRC.

Adult↗

PubMed2005

Reasoning deficits in ecstasy (MDMA) polydrug users.

RATIONALE/OBJECTIVES: Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS: Twenty-nine ecstasy users and 25 nonecstasy user controls completed abstract syllogistic reasoning problems varying in difficulty. Pairs of premises were provided, and participants were required to generate conclusions that followed necessarily from them. RESULTS: On the easier problems, both groups performed at well above chance although nonusers achieved significantly more correct responses. Consistent with existing research, on the more difficult problems, errors by nonusers were characterised by incorrect conclusions suggesting that while nonusers have the working memory capacity to construct a single model of the premises, this is not an exhaustive representation and usually results in an erroneous conclusion. On the other hand, for all problem types, ecstasy users, rather than produce incorrect responses, were more likely to fail to generate a conclusion. CONCLUSIONS: The present results are consistent with the possibility that ecstasy users with their reduced working memory capacity may experience difficulty in constructing even a single model of the premises. While this might be attributable to the effects of 3,4-methlylenedioxymethamphetamine neurotoxicity, many of the ecstasy users in the present study were polydrug users. Thus, the possibility that other drugs including cannabis and cocaine might contribute to the present results cannot be excluded.

Adult↗

PubMed1988

The effect of CD-ROM MEDLINE on online end user and mediated searching.

Since 1970, Indiana University School of Medicine Library (IUSML) has traditionally been a high volume online searching institution. The library recently implemented an end user searching program which includes MEDLINE on CD-ROM. The effect of CD-ROM on online end user and mediated searching is discussed. Comparative statistics are provided by category of search service. CD-ROM has had a dramatic lowering effect on online end user searching and has had little effect on mediated searching. IUSML's experience with CD-ROM technology has been a positive one. Trained end users have become IUSML's greatest asset.

Computer User Training↗