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PubMed1986

Transcutaneous electrical nerve stimulation following appendicectomy: the placebo effect.

A controlled trial was undertaken to compare the efficacy of transcutaneous electrical nerve stimulation (TENS) with standard intramuscular opiate analgesia in the management of postoperative pain following appendicectomy. Consecutive patients undergoing emergency appendicectomy were randomised into control, sham TENS and active TENS groups. There was a significant decrease in pain severity and analgesic intake in both active and sham TENS groups when compared with the control group (P less than 0.01). No difference was demonstrated in pain severity between active and sham TENS groups but the active TENS group required slightly less analgesia. These results suggest that the major benefit of TENS in the postappendicectomy patient is due to its 'placebo effect' and its use in this situation cannot be recommended.

Adolescent↗
PubMed1985

Cold and performance: the effects of information load, analgesics, and the rate of cooling.

In the first experiment, 8 subjects took part in two experimental sessions--one after receiving one of two kinds of analgesic and the other after receiving a placebo. For each session, subjects completed 8- and 4-choice versions of a serial choice reaction time (SCRT) task at three times: before, during, and after exposure in a cold room at -5 degrees C. Body temperatures were monitored throughout and comfort ratings were recorded. The results indicated that cold increased error rate on the SCRT task, particularly for the 8-choice version which was also associated with faster RTs. However, a speed-accuracy tradeoff explanation for the data was discounted on the grounds that, although overall latencies were faster in the cold compared with precold, these were no faster than postcold RTs. The analgesics had no effect on comfort nor did they have an interpretable effect on performance. In experiment 2, where cooling was much slower for 5 subjects, no such increase in error rate on the SCRT task was observed. Similarly slow cooling did not impair general intellectual ability as measured by Raven's Progressive Matrices.

Adult↗
PubMedDate not supplied

[Effect of nonsteroid anti-inflammatory substances on mediators of inflammation].

The action of nonsteroid antiinflammatory substances on the content in the inflammation focus of the inflammation reaction mediators, histamine, serotonin and kinines, and some aspects of their metabolism were studied. Sodium mephenaminate and butadion are shown to bring down the histamine content in the exudate of rats with experimental pleurisy. Sodium mephenaminate depresses the histamine synthesis (by inhibiting histidine decarboxylase in the pulmonary tissue), while butadion activates decomposition of this amine (by raising histaminase activity). All the study compounds (except sodium mephenaminate) force down the serotonin level in the exudate and inhibit 5-hydroxytryptophan decarboxylase. The content of kininogen in the exudate decreases only under the influence of butadion. Sodium mephenaminate and butadion mitigate the reaction of the dermal vessels to exogenous histamine and serotonin and chingamine does so only in response to histamine.

Animals↗