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Inhibition of mengovirus RNA-dependent RNA polymerase by an isatinisothiosemicarbazone and a piperidine-thiocarbonyl-hydrazone derivative in a cell-free system.

The inhibitory action of two antiviral compounds used at the maximum tolerated dosis in a cellular system led to a complete suppression of the infectious mengovirus yield and to a 100% plaque reduction. The products of the RNA polymerase reaction catalyzed by the microsomal-mitochondrial fraction of mengovirus-infected FL cells were analyzed by linear sucrose gradient centrifugation and polyacrylamid gel electrophoresis. The results showed that the inhibitors cause a general reduction of the synthesis of single-stranded viral RNA. The influence on double-stranded viral RNA was more obvious in the case of the isatinisothiosemicarbazone derivative.

Antiviral Agents↗