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Access to health care in South Africa--the influence of race and class.

OBJECTIVES: The first democratic government elected in South Africa in 1994 inherited huge inequities in health status and health provision across all sections of the population. This study set out to assess the impact of the new government's commitment to address these inequities and implement policies to improve population health in general and address inequalities in health care in particular. DESIGN: A 1998 household survey assessed many aspects of health delivery, including their own perceived and actual access to health care among different segments of South African society. RESULTS: Race was the main predictor of perceived changes in access to health care, with black, coloured-and Indian respondents significantly more likely to feel that access had improved since 1994, compared with white respondents. Socio-economic status (SES) was the main predictor of actual access to health care, with low and middle SES classes significantly less likely to access care when ill. CONCLUSIONS: One-third of respondents perceived health care access to have improved between 1994 and 1998, and this response was partially determined along racial lines. About one-quarter reported an inability to access health care when they required it, and this response was partially determined along socio-economic lines. This set of contrasting responses suggests that at a political level perceptions are largely influenced by race, but at the operational level actual access is influenced by SES.

Adult↗

The problem of child safety in South Africa.

In Europe and the USA accidents are regarded as a public health problem. South Africa has not kept pace with this trend, particularly in the field of child safety. The Child Safety Centre, which aims at the investigation and prevention of childhood accidents, was established in Cape Town in 1978.

Academies and Institutes↗

South Africa's new enemy.

Many South Africans long dreamed of the day when the oppressive apartheid system would end. That day has come, but now the country faces a new disaster: one of the world's worst HIV epidemics--and most confusing government responses.

Acquired Immunodeficiency Syndrome↗

Tensions in setting health care priorities for South Africa's children.

The new South African constitution commits the government to guarantee "basic health services" for every child under 18. Primary health care for pregnant women and children under six and elements of essential primary health care have received priority. At present, there is little analysis of the moral considerations involved in making choices about more advanced or costly health care which may, arguably, also be "basic". This paper illustrates some of the tensions in setting priorities for a just macro-allocation of children's health care, given the realities of need and scarce resources, and the commitment to equality of basic opportunities.

Adult↗

The role of intelligence and depression in Indian and black duodenal ulcer patients in South Africa.

In a comparison of South African Indian and Black duodenal ulcer patients and a control group of hospital patients, intelligence and depression were not found to be relevant to the incidence of duodenal ulceration. This finding emerges as part of an ongoing study on the apparent increase of duodenal ulceration in South African Indians and Blacks. The role of psychological medicine in a consultation/liaison service is discussed.

Adolescent↗

Alcoholism-its emergence in the black townships of South Africa.

Since 1962 alcoholic liquor has been freely available to all racial groups in South Africa. Now, nearly 20 years later, the problem of alcoholism is presenting as 'the hidden alcoholic' seen at the polyclinics of the Black hospitals. We discuss what we have found in this regard and what we are endeavouring to do about it.

Adult↗

Relatedness of penicillin-binding protein 1a genes from different clones of penicillin-resistant Streptococcus pneumoniae isolated in South Africa and Spain.

Penicillin-resistant strains of Streptococcus pneumoniae have been common in South Africa and Spain for several years. Multilocus enzyme electrophoresis identified one clone of capsular type 6B which was prevalent in Spain and another clone of type 23F that was present in both countries. Genes for penicillin-binding proteins (PBPs) in penicillin-resistant strains are often mosaics where parts of the pneumococcal genes are replaced by homologous genes from other species. We have compared the mosaic structures of the PBP 1a genes from the two clones as well as from genetically distinct South African isolates. Four classes of mosaic PBP 1a genes were found that contained blocks of sequences divergent by 6-22% from those of sensitive genes; two classes contained sequences coming from more than one external source. Data are presented showing that the PBP 1a genes from the 23F and the 6B clone are related, and that the two PBP 1a genes from the South African isolates are also related. We suggest that the type 23F clone originated in Spain prior to distribution into other continents.

Bacterial Proteins↗

Vector competence of Culicoides species and the seroprevalence of homologous neutralizing antibody in horses for six serotypes of equine encephalosis virus (EEV) in South Africa.

Field-collected Culicoides species (Diptera: Ceratopogonidae) were fed on horse blood-virus mixtures containing one of the six serotypes of equine encephalosis virus (EEV1 to EEV6). The virus mean titres in the bloodmeals varied between 6.1 and 7.0 log10TCID50/mL. Of 19 Culicoides species assayed after 10 days extrinsic incubation at 23.5 degrees C, five yielded the challenge virus, namely Culicoides (Avaritia) imicola Kieffer (EEV1-6), C. (A.) bolitinos Meiswinkel (EEV1, 2, 4, 6), C. (Meijerehelea) leucostictus Kiefer (EEV1, 2), C. (Culicoides) magnus Colaço (EEV1) and C. (Hoffmania) zuluensis de Meillon (EEV2). Virus recovery rates ranged from 0.5 to 13%. The mean levels of viral replication differed between serotypes and Culicoides species and ranged from 1.0 to 2.3 log10TCID50/midge. Culicoides midges shown in this study to be susceptible to oral infection with EEV are widely distributed in South Africa but differ considerably in their abundance, host preference and breeding sites. Of 1456 horses tested, 1144 (77%) had antibody to EEV. Homologous virus-neutralizing antibodies to all six serotypes were detected in individual horses from all eight geographical provinces of South Africa. The distribution, prevalence, and the rate of exposure to individual serotypes varied significantly between regions. The potential for vectoring of EEV in the field by several Culicoides species with unique ecologies and lack of cross-protection to re-infection with multiple serotypes highlights some of the mechanisms that are likely to play a role in the virus' natural maintenance cycle and the highly efficient level of countrywide transmission amongst South African horses.

Animals↗

Geographical distribution of certain cancers in South Africa, 1968-1972.

The geographical distributions of six major causes of cancer mortality in South Africa have been analysed for three population groups: White, Coloured and Asian. Because of the lack of comparable data, the majority Black population is not included. Geographical patterns are compared and discussed in the light of findings from other countries. In several cases the potential for aetiological follow-up is demonstrated.

Age Factors↗

Maternal and fetal single nucleotide polymorphisms in the epoxide hydrolase and gluthatione S-transferase P1 genes are not associated with pre-eclampsia in the Coloured population of the Western Cape, South Africa.

Oxidative stress is thought to play an important role in the pathophysiology of pre-eclampsia. A defect in certain enzymes responsible for detoxification may cause prolonged exposure to reactive by-products and contribute to maternal endothelial as well as placental damage. Two polymorphisms affecting the function of the biotransformation enzymes epoxide hydrolase and glutathione S-transferase P1 were shown previously to be associated with pre-eclampsia in a Dutch population. The aim of this study was to determine if these two polymorphisms (maternal or fetal) contribute to pre-eclampsia in an anthropologically distinct population (the Western Cape region of South Africa) with a high incidence of the disease. Genomic DNA of mother - infant pairs with severe pre-eclampsia (n = 144), a population control group (n = 156) and control mother - infant pairs with uncomplicated pregnancy outcome (n = 45) were analysed for the EPHX and GSTP1 polymorphisms by polymerase chain reaction amplification and restriction enzyme digestion. Each polymorphism had a similar distribution in case and control subjects (mother and infant). The Val105/Val105 genotype of GSTP1 occurred at a higher frequency than reported for other populations. Neither maternal nor fetal EPHX Tyr113His and GSTP1 Ile105Val polymorphisms appear to contribute significantly to the pathophysiology of pre-eclampsia in the Coloured population of the Western Cape region of South Africa.

Alleles↗

Workshop discusses priorities in veterinary helminthology for South Africa.

A workshop was held at Onderstepoort to set priorities in veterinary helminthology for South Africa. Representatives from 19 organisations attended. The workshop achieved 2 of the 3 aims set, namely to identify the problems within the field and to develop strategies to address these challenges. The 7 strategies proposed are: motivation, education, therapeutic, worm resistance, animal tolerance, biological control and diagnostic strategies. A follow-up session is being planned to formulate action plans for each sphere.

Animals↗

Molecular epidemiology of rotavirus in black infants in South Africa.

The molecular epidemiology of rotavirus infections in black infants in Ga-Rankuwa, South Africa, was investigated by polyacrylamide gel electrophoresis. Between 1983 and 1986, 14 different RNA electrophoretic patterns were observed for children with acute gastroenteritis. These electrophoretypes showed a sequential pattern of appearance, with a limited number being present at any one time. In contrast, for neonates only one RNA electrophoretype was detected, which persisted for at least 3 years.

Acute Disease↗

Presenting problems in black children referred for outpatient psychological consultation in South Africa.

An examination of outpatient referrals for psychological consultation at a psychiatric hospital in South Africa was undertaken. Over an 18-month period, 87.1% of a total of 31 children were referred with problems of poor school performance. Behaviour problems were underrepresented. The results are discussed in the context of inadequate community mental health services, which are implicated in the under-detection of childhood psychopathology.

Black or African American↗

Comparative molecular phylogeography of two Xenopus species, X. gilli and X. laevis, in the south-western Cape Province, South Africa.

Xenopus gilli is a vulnerable anuran with a patchy distribution along the south-western coast of the Cape Province, South Africa. This species is sympatric with Xenopus laevis laevis, a widespread relative found over much of southern Africa. We examined the molecular phylogeography and population structure of the contact zone between these species to obtain information about historical biogeography and conservation management of this region. Analyses of the distribution, frequency, and cladistic and phenetic relationships among mitochondrial DNA haplotypes indicate that population subdivision is present in both taxa but that long-term isolation of sets of populations has occurred in X. gilli only. Haplotype and nucleotide diversity are also considerably higher within and among X. gilli ponds than X. l. laevis ponds in this region. We attribute the genetic segregation of X. gilli populations to ancient habitat fragmentation by ocean transgression into X. gilli habitat and to continued habitat alteration by human activity. The lower level of genetic diversity in X. L. laevis in this region is likely a result of a recent arrival of this taxon to the south-western Cape region relative to X. gilli. Population structure in X. l. laevis may be a result of isolation by distance. Clear evidence exists for at least two management units within X. gilli and strongly supports the establishment of protective measures east of False Bay in order to conserve a substantial portion of this species' extant genetic diversity.

Animals↗

Perspectives on surgery in the new South Africa.

Radical changes have occurred in the health care system since the democratization of South Africa in 1994, with the emphasis on improving previously neglected community-based primary health care. Because of the resultant financial constraints, funding of tertiary academic centers has been drastically cut which has compromised their proud record of service, teaching, and research excellence. Tertiary surgery has been particularly affected and now lags in the acquisition of new technologies which form an integral part of teaching and modern day practice. The acute shortage of full-time surgeons in regional public hospitals has prompted the government to fill vacancies with surgeons from foreign countries. In stark contrast, an abundance of surgeons in the relatively small private sector enjoy the benefits of the very best of First World medicine. The ultimate goal is a seamless progression of effective health care at all levels. It behooves the main role players to ensure that the high standard of training of South African doctors, which has international recognition, is maintained during this transition period.

Education, Medical, Graduate↗

Characterisation of the pncA gene in Mycobacterium tuberculosis isolates from Gauteng, South Africa.

SETTING: The use of pyrazinamide (PZA) is important for the treatment of Mycobacterium tuberculosis as it is bactericidal to semi-dormant mycobacteria that are not affected by other drugs. The incidence of resistance to PZA and other drugs used in the treatment of M. tuberculosis is increasing in South Africa. OBJECTIVE: To characterise the pncA gene of M. tuberculosis isolates from Gauteng, South Africa, and to develop a rapid diagnostic method. DESIGN: The pncA gene and the putative regulatory gene were characterised by sequence analysis in a total of six PZA susceptible and 15 resistant isolates. The association with classical PZA susceptibility testing and PZase activity was determined. RESULTS: All PZA-resistant isolates were PZase negative as well as resistant to at least one other anti-tuberculosis drugs. Mutations were identified throughout the length of the pncA gene in 10/15 PZA-resistant isolates. Five lacked PZase activity, but the wild type pncA sequence was present. In all six PZase-positive strains, a PZA-susceptible pattern was obtained on BACTEC and the wild type pncA sequence was present. CONCLUSION: Sequencing is an effective means to identify mutations in the pncA gene in M. tuberculosis and therefore resistance to PZA. The fact that some PZA-resistant M. tuberculosis isolates lack mutations in the pncA gene suggests that alternative mechanisms for drug resistance exist. In PZase negative strains with no genetic changes which are resistant to 100 microg/ml and susceptible to 300 microg/ml, 300 microg/ml may be a more reliable breakpoint.

Africa, Southern↗

Genitourinary pathology in urban male Blacks of South Africa.

A 10-year study of genitourinary cancer in black urban male subjects in South Africa shows that all tumors of the genitourinary tract are rare except for nephroblastoma, which has a similar incidence to other population groups throughout the world. Carcinoma of the bladder is rare despite the endemicity of Bilharzia and, although carcinoma of the prostate is not infrequent in patients up to the seventh decade, after that the incidence is lower than in other population groups in which the rate increases steeply. In accord with other black groups throughout the world tumors of the testis are excessively rare. The comparative infrequency of carcinoma of the penis is ascribed to the relatively high rate of circumcision.

Adolescent↗

Meconium aspiration in South Africa.

This retrospective study of 569 cases of meconium aspiration from 11 institutions in South Africa reveals a high incidence varying from 4 to 11/1,000 and a mortality rate of 12%. Mortality was significantly related to the degree of asphyxia at birth. Twenty-five per cent of the babies (136/569) required intensive care and 36% died. Of the mothers 18-25% were unbooked and most of the babies were inborn (87%). Babies born to primiparous mothers and to mothers over 35 years of age were at greater risk of death. In order to reduce mortality and the numbers admitted to the intensive care unit simple measures for the reduction in the incidence of this disease need to be emphasised in all teaching and training programmes.

Delivery, Obstetric↗