PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “THROMBELASTOGRAPHY”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,027 records · Page 57Linked to original sources
PubMed1976

[Changes in thromboelastogram in women on hormonal contraception].

The authors have analysed changes in the thromboelastogram in 411 women on oral contraceptives and in 31 women on no hormonal contraception. Comparing the results they found no statistically significant differences because the control group was too small. In the group of women on hormonal contraception, statistically significant differences were recorded in those women whose thromboelastogram was analysed several times, the differences having been more pronounced in the women that had used hormonal contraceptives for a longer time. As the appearance of thrombo-embolic complications is a very complex process, the authors' opinion is that thromboelastogram cannot be considered as a routine method for predicting these complications.

Adult↗
PubMedDate not supplied

[Effect of actomyosin on blood coagulation and fibrinolysis].

An increase in the lysis of human and rat clot of euglobulin fraction of blood plasma was caused by an actomyosin preparation isolated from rabbit and rat muscle. Neither fibrinolytic nor activating properties of actomyosin were observed on applying of different concentration (13-0.6 mg/ml) of the protein on the fibrin films. No activation of 0.4% solution of pure plasminogen by actomyosin was observed in vitro. A decrease in fibrin clot density under the effect of actomyosin was indicated by thromboelastogramms of blood plasma and euglobulins. The phenomenon was probably determined by the physicochemical properties of the protein itself.

Actomyosin↗
PubMed1976

[Function of thrombocytes during the gestational period and puerperium and their relation to the occurence of thromboses. 2. Function of blood platelets during late pregnancy, labor and puerperium in gestosis].

Platelet functions during late pregnancy with praeeclampsia, birth and childbed were observed. There are found variations in opposition to normal pregnancy. Increase of platelet aggregation was clearest. In this observations is not conclud from increase risk developing a thromboembolic disease during toxemic pregnancy, birth and childbed. The variations of platelet functions are parts of complex appearence.

Female↗
PubMed1976

Effect of hexachlorophene on the coagulation process in beagle dogs.

In a dermal toxicological study the effect of hexachlorophene on the blood coagulation process in dogs over a period of 12 weeks was investigated. The thrombelastographic results revealed a reduction in reaction time, coagulation time and an increase in maximal amplitude supplemented with subsequent increase in the number of platelets and the enhancement of ESR.

Animals↗
PubMed1998

Preoperative evaluation and postoperative prediction of hemostatic function with thromboelastography in patients undergoing redo cardiac surgery.

BACKGROUND: Patients who receive cardiac procedures, in particular "redo" ones, often suffer complications from massive bleeding, largely due to bypass-induced coagulopathies. Cardiopulmonary bypass (CPB) may cause damage of the blood components, both in terms of quality and quantity. In order to investigate the qualitative changes of blood constituents with special regard to coagulation resulting from the complex insult of previous cardiac surgery, thromboelastography (TEG) was used to analyze the whole clotting process. METHODS: Seventy-four patients who underwent cardiac surgery with CPB were prospectively studied. Of them, 32 patients received "redo" cardiac surgery. Blood samples for routine laboratory coagulation tests (RCT) and TEG examination were drawn before and after cardiopulmonary bypass. Clinically significant bleeding was defined if the chest tube drainage was greater than 100 ml/h for 3 consecutive h or greater than 300 ml in 1 h during the first 8 h after surgery. Prebypass and postbypass coagulation parameters were compared and the percentage of accuracy, false positive and false negative rate were deduced from calculation. RESULTS: In the TEG tracings, preoperative alpha angle and maximum amplitude were significantly decreased in the "redo" group when compared with primary group, indicating less competent platelet function and platelet-fibrin interaction. Lower platelet count was also found by conventional coagulation tests in "redo" patients. Postoperatively, higher percentage of excessive hemorrhage was also noted in the "redo" group (42.8% vs. 27.5% in primary group). However, a much lower predictive accuracy was found in "redo" patients in comparison with primary cardiac patients (53.5% vs. 90%). CONCLUSIONS: We concluded that thromboelastography failed to predict postoperative hemorrhage in "redo" cardiac patients and the graphic recordings derived could not be treated as a guide of transfusion therapy. We thought that inferior preoperative hemostatic status and severer coagulopathy might be responsible for the differences between "redo" and primary cardiac patients.

Adult↗
PubMedDate not supplied

[State of the hemostasis and fibrinolysis systems in cesarean section under combined ketamine anesthesia].

The reserve potentialities of the hemostasis and fibrinolysis systems were studied by thromboelastography in 34 women with normal pregnancy aged 18-34 years at different stages of cesarean section under combined ketamine anesthesia. Three types of responses were observed: compensated, subcompensated, and decompensated. In women with subcompensated response removal of the fetus from the uterus involved in 30.1% cases depletion of the reserve potential of anticoagulant mechanisms, which led to abnormal blood loss in 34.7% cases.

Adolescent↗
PubMed1999

[Pathological changes in thrombocyte-vascular and coagulative hemostasis under the influence of lead chloride and their correction by using a synthetic analog of prostacyclin].

It has been established that plumbum chloride possesses a marked toxic action on the membranes of the formed elements, in particular, the thrombocytes, activates the release of the factors of thrombocyte aggregations, resulting in an increase of their adhesive and aggregation properties. The research studies the influence of the stable prostacycline analogue MM-706 and thrombocytic-vascular, as well as coagulative hemostasis in rats at a background of plumbum intoxication. We have discovered a marked protective action of MM-706 on the thrombocytes which is manifested through a decrease of the index of a spontaneous thrombocyte aggregation and percentage of adhesive thrombocytes, normalization of the general potential of hemocoagulation and time characteristics of a thromboelastogram.

Animals↗
PubMed1999

[Nicotinamide in combined treatment of chronic pancreatitis].

AIM: To evaluate effects of nicotinamide on insulin secretion in glucose tolerance test and on blood clotting in patients with chronic pancreatitis (CP). MATERIALS AND METHODS: 30 patients with CP of alcoholic etiology received combined treatment with enzyme medicines. In addition, some of them were administered nicotinamide as 2.5% solution for 2 weeks (1 ml twice a day). Before the treatment and during its course, measurements were made of fasting and post glucose test values of insulin secretion and thromboelastogram. RESULTS: Both basal and stimulated insulin secretion in CP patients was low compared to control subjects. Nicotinamide significantly increased basal secretion of insulin and insignificantly aroused its glucose-stimulated secretion. Nicotinamide promoted reduction of hypercoagulation and time to remission. CONCLUSION: Nicotinamide administration is thought valid for correction of endocrine pancreatic function and hemocoagulation in patients with alcoholic CP.

Adult↗
PubMed1976

Thromboelastographic changes in carcinoma: an animal model.

The dynamics of blood clotting using a thrombelastogram (TEG) are depicted after the injection of V2 carcinoma cells or control heterologous peritoneal exudates in New Zealand hares. Changes in the TEG configurations of native blood samples vs. celite activated samples run simultaneously provide a qualitative assessment of the presence of carcinoma.

Animals↗
PubMed1999

Haemorheological and fibrinolytic activity in hypertensive Nigerians.

Hypertension is the most significant cardiovascular risk factor to emerge in developing countries. 64 hypertensives (40 old hypertensives and 18 newly diagnosed hypertensives) and 40 age and sex matched normotensives controls were studied. Plasma fibrinogen concentration (PFC), euglobulin lysis time (ELT) and relative plasma viscosity (RPV) and relative whole blood viscosity (RWBV) were estimated. The PFC, RPV, RWBV and ELT were significantly higher in new and old hypertensives (P < 0.005), respectively, compared with controls, while the RPV was significantly higher (P < 0.005) in new hypertensives than old hypertensives. The significantly higher PFC, RPV and ELT in new hypertensives correspond to higher BP in the new hypertensives than old hypertensives. There were consistence significance levels in PFC, RPV and ELT in both female hypertensives and controls (P < 0.005), respectively, with higher BP in male than female. Though there were no significant mean differences between the hypertensive patients in the first two years of the disease, there were cumulative consistent increase in fibrinogen levels and euglobulin lysis time from two years; while RPV shows inconsistence variation until the 5th year. We conclude that a defective rheology and fibrin-clearing mechanism may contribute to aetiology of vascular complications in hypertensive patients especially in the long term.

Female↗
PubMedDate not supplied

The use of protease inhibitor (trasylol) and heparin in cardiorespiratory resuscitation. I. Studies of the blood clotting system.

The purpose of the study was the assessment of the effect of protease inhibitor (trasylol) and heparin on the blood clotting system during cardiorespiratory resuscitation. The studies were carried out in two experimental groups of rabbits. In group I oxygen was given, cardiac massage was applied, alkalinizing agents and drugs improving the action of the heart and the peripheral circulation were administered. In group II trasylol and heparin were given additionally. The studies proved that cardiorespiratory arrest causes development of the intravascular clotting syndrome. Resuscitation management in group I failed to correct the disturbances in the blood clotting system. On the other hand, in group II they were partly corrected. The animals in this group survived the experiment. The administration of protease inhibitor and heparin increased the efficiency of resuscitation management.

Animals↗
PubMedDate not supplied

Fibrinolysis activation after operation of spermatic cord.

The authors report a case of fibrinolytic haemorrhagic diathesis after operation of vas deferens carried out under epidural analgesia. Attention is called to the diagnostic difficulties in the rare complication of these operations. Treatment of fibrinolytic haemorrhagic diathesis is discussed stressing the advantages of trasylol, which is a drug of choice in emergency states associated with bleeding from the surface of the wound when difficulties arise in carrying out full blood clotting tests.

Adult↗